Convenience and accessibility are two of the benefits that draw people to Temple's Main Campus. Thanks to its location in the heart of Philadelphia, Main Campus affords ease-of-access to a number of city amenities and locations. The major facilities of Main Campus are located between 10th and 16th Streets and between Oxford and Diamond Streets.

Temple's Main Campus can be reached easily by public transportation using SEPTA bus routes 4 or 16 on Broad Street, the Broad Street Subway (Cecil B. Moore Avenue stop), AMTRAK at North Broad Street Station, and SEPTA Commuter Rail Lines at the Temple/Cecil B. Moore Station, Ninth and Berks Streets.