Dr. Karin Wang is an Assistant Professor of Bioengineering at Temple University. Her research program leverages principles from tissue engineering, biomaterials science, soft matter physics, and cell biology to engineer reductionist model systems that probe cell and matrix dynamics. The interdisciplinary approaches used in her lab are aimed at enhancing our fundamental understanding of structure-function relationships from the molecular to multicellular level, to understand how physical forces regulate cell-matrix interactions in health and disease.

Dr. Karin Wang received her BS in Applied Math and Statistics and BE/MS in Biomedical Engineering from Stony Brook University in 2010. She received her PhD in Biomedical Engineering from Cornell University in 2015, studying how the materials properties of matrix proteins drive tumor progression and was awarded NSF DGE GK-12 Teaching Fellowships. During her postdoctoral training from 2015-2018 to investigate the underlying physical drivers of collective cellular migration, she was a NIH NCI F32 Postdoctoral Fellow in the Molecular and Integrative Physiological Sciences Program in the T.H. Chan School of Public Health at Harvard University.

Google Scholar: Publications

Research Interests

  • Cell and matrix mechanobiology
    Structure-function relationships
    Collective migration
    Extracellular matrix remodeling
    Tissue engineered model systems

Courses Taught




BIOE 3719

Introduction to Bioengineering


BIOE 4471



BIOE 5471



BIOE 5600

Bioengineering Graduate Seminar


BIOE 5719

Introduction to Bioengineering


Selected Publications


  • Bonadio, J.D., Bashiri, G., Halligan, P., Kegel, M., Ahmed, F., & Wang, K. (2024). Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications. Adv Drug Deliv Rev, 209, p. 115303. Netherlands. doi: 10.1016/j.addr.2024.115303

  • Xue, L., Hamilton, A.G., Zhao, G., Xiao, Z., El-Mayta, R., Han, X., Gong, N., Xiong, X., Xu, J., Figueroa-Espada, C.G., Shepherd, S.J., Mukalel, A.J., Alameh, M., Cui, J., Wang, K., Vaughan, A.E., Weissman, D., & Mitchell, M.J. (2024). High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nat Commun, 15(1), p. 1884. England. doi: 10.1038/s41467-024-45422-9

  • Figueroa-Espada, C.G., Guimarães, P.P.G., Riley, R.S., Xue, L., Wang, K., & Mitchell, M.J. (2023). siRNA Lipid-Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy. Cell Mol Bioeng, 16(4), pp. 383-392. United States. doi: 10.1007/s12195-023-00774-y

  • Guimarães, P.P.G., Figueroa-Espada, C.G., Riley, R.S., Gong, N., Xue, L., Sewastianik, T., Dennis, P.S., Loebel, C., Chung, A., Shepherd, S.J., Haley, R.M., Hamilton, A.G., El-Mayta, R., Wang, K., Langer, R., Anderson, D.G., Carrasco, R.D., & Mitchell, M.J. (2023). In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy. Proc Natl Acad Sci U S A, 120(25), p. e2215711120. United States. doi: 10.1073/pnas.2215711120

  • Butowska, K., Han, X., Gong, N., El-Mayta, R., Haley, R.M., Xue, L., Zhong, W., Guo, W., Wang, K., & Mitchell, M.J. (2023). Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy. Acta Pharm Sin B, 13(4), pp. 1429-1437. Netherlands. doi: 10.1016/j.apsb.2022.07.011

  • Xue, L., Gong, N., Shepherd, S.J., Xiong, X., Liao, X., Han, X., Zhao, G., Song, C., Huang, X., Zhang, H., Padilla, M.S., Qin, J., Shi, Y.i., Alameh, M., Pochan, D.J., Wang, K., Long, F., Weissman, D., & Mitchell, M.J. (2022). Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J Am Chem Soc, 144(22), pp. 9926-9937. United States. doi: 10.1021/jacs.2c02706

  • Krohn-Grimberghe, M., Mitchell, M.J., Schloss, M.J., Khan, O.F., Courties, G., Guimaraes, P.P.G., Rohde, D., Cremer, S., Kowalski, P.S., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S.P., Wojtkiewicz, G.R., Nayar, R., Frodermann, V., Hulsmans, M., Chung, A., Hoyer, F.F., Swirski, F.K., Langer, R., Anderson, D.G., & Nahrendorf, M. (2020). Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng, 4(11), pp. 1076-1089. England. doi: 10.1038/s41551-020-00623-7