Course Descriptions -Microbiology and Immunology

Courses at the 500 level are usually offered in alternate years.

Required Courses

403. Presentation of Scientific Information. (1 s.h.)

Discussion of seminar presentation. Presentation of scientific information is discussed in conference.

404-406, 407-408, 409-410. Microbiology and Immunology Graduate Student Seminar. (1 s.h.)

Graduate students present before the Department. Four s.h. required for M.S. students and 5 s.h. for Ph.D. students.

413. Microbial Physiology and Genetics. (2 s.h.)

Lecture course which includes nature and structure of microorganisms; microbial physiology, biosynthesis of macromolecules, microbial growth, microbial and molecular genetics. A core course.

415. Fundamentals of Immunology. (2 s.h.)

Lecture course which emphasizes the fundamental principles of molecular and cellular immunobiology and immunochemistry. A core course.

417. Principles of Immunology. (2 s.h.)

Prerequisite: permission of instructor.

Consists of lectures and conferences covering the basic elements of Immunology. This course includes discussion of both molecular and cellular immunology.

433. Cellular and Molecular Basis of Host-Pathogen Interactions. (3 s.h.)

An introduction to the cellular and molecular basis for pathogenesis and host defense mechanism. Selected microorganisms will be covered as models of experimental infections and diseases. Examples will be drawn from all major groups of pathogens, including bacteria, fungi, protozoans and viruses. Includes lecture and laboratory. A core course.

Advanced Courses

505. Topics in Clinical Immunology. (1 s.h.)

This course deals with the molecular basis of important immunological disease states. Topics will include discussions of the role of cells of the immune system in defense against tumors, and the functions of T cells (and T cell receptors) in autoimmune diseases. Gene therapy approaches will also be discussed.

506. Virology. (3 s.h.)

Prerequisite: M.&I. 431.

Lecture and conference course with emphasis on recent advances in acute and chronic viral infections including malignancy. The laboratory includes basic techniques in the growth and assay of viruses.

508. Microbial Genetics. (3 s.h.)

Prerequisite: M.&I. 413 or equivalent.

Lecture and conference course which covers gene transfer, recombination, genetic analysis with transposons and genetically engineered DNA, and analysis of the regulation of gene expression in simple and complex systems.

515. Critique of Scientific Information. (1 s.h.)

This course is designed to teach graduate students to critically evaluate scientific publications. The students will be given scientific articles and asked to evaluate the data.

516. The Infectious Process. (3 s.h.)

Prerequisite: M.&I. 431, and 415 or 417.

Lecture and conference course dealing with molecular mechanisms of microbial pathogenesis and host response. Microbial toxins and their action, microbe-phagocyte interactions with PMNs and macrophages, genetic basis of host resistance, microbial products as regulators of the immune response.

520. Recombinant DNA Techniques in Molecular Biology. (3 s.h.)

Prerequisite: M.&I. 413.

An in-depth analysis of recombinant DNA technology and its application to basic problems of biology; limitations of the methodologies; role of classical microbiology, virology, nucleic acids, and biochemistry in the development of the methodologies; vectors, cloning, blotting, sequencing, etc.

526. Cellular Action of Antibiotics. (2 s.h.)

Prerequisite: M.&I. 413 or equivalent.

In-depth discussion of the mode of action of antimicrobial agents at the molecular and cellular levels. Includes methods used for the screening and testing of antibiotics.

534. Procaryotic Cell. (1 s.h.)

Discussion of the structure and function of organelles found in common, well-studied organisms will be used as the foundation to consider modification and function of these structures in unusual procaryotes.

545. Comprehensive Immunology. (3 s.h.)

Prerequisite: M.&I. 415.

Comprehensive lecture course on advanced molecular and cellular immunology. A core course.

546. Molecular Aspects of the Immune System. (2 s.h.)

Prerequisite: M.&I. 415 or 417.

Course covers B-cell development; immunochemistry of immunoglobulin molecules; structure, organization and rearrangement of immunoglobulin genes; regulation of expression of immunoglobulin genes; the T-cell receptor; and molecular mechanisms of cytotoxic killing.

Seminar Courses

899. Pre-Dissertation Research. (1-6 s.h.)

997-998. Research in Microbiology and Immunology. (variable credit)

999. Ph.D. Dissertation. (1-6 s.h.)

MOLECULAR BIOLOGY AND GENETICS

Direct inquiries to: Ms. Catherine Nimchuk, Graduate Program Coordinator, Program in Molecular Biology and Genetics, Fels Institute for Cancer Research and Molecular Biology, 3307 N. Broad St., Phila. PA 19140, (215) 707-4302.

Email: felsgrad@sgil.fels.temple.edu

E. Premkumar Reddy, Director of the Fels Institute and Chairman of Biochemistry

Graduate Faculty

David E. Ash, Professor of Biochemistry, Ph.D., University of Pennsylvania; Raghbir S. Athwal, Professor of Pathology, Ph.D., University of Missouri, Columbia; Jimmy H. Collins, Professor of Biochemistry, Ph.D., University of Texas at Austin; Danny N. Dhanasekaran, Assistant Professor of Biochemistry, Ph.D., I.I.Sc. University (India); Nahum J. Duker, Professor of Pathology, M.D., University of Illinois; Xaviar Grana, Professor of Biochemistry, Ph.D., Barcelona (Spain); Charles Grubmeyer, Associate Professor of Biochemistry, Ph.D., University of Alberta, Canada; Mark F. Hansen, Associate Professor of Pathology, Ph.D., Cincinnati School of Medicine; Earl E. Henderson, Professor of Microbiology and Immunology, Ph.D., University of Chicago; Barbara Hoffman, Associate Professor of Biochemistry, Ph.D. University of Michigan; Rajendra Kandpal, Assistant Professor of Pathology, Ph.D., Indian Institute of Science (India), Keith A. Latham, Assistant Professor of Biochemistry, Ph.D., University of Virginia; Dan Liebermann, Associate Professor of Biochemistry, Ph.D., Weizmann Institute of Science (Israel); Judith Litvin, Assistant Professor of Anatomy, Ph.D., University of North Carolina; Walter Long, Professor of Microbiology and Immunology, Ph.D., University of Illinois; Thomas A. Marino, Professor of Anatomy and Cell Biology, Ph.D., Temple University; Warren E. Masker, Professor of Biochemistry, Ph.D., University of Rochester; Elizabeth Moran, Associate Professor of Biochemistry, Ph.D., New York Medical College; Emilla L. Oleszak, Assistant Professor of Biochemistry, Ph.D., Polish Academy of Sciences (Poland); Stephen Pilder, Assistant Professor of Anatomy, Ph.D., Princeton University; Chris D. Platsoucas, Professor and Chair of Microbiology, Ph.D., Massachusetts Institute of Technology; E. Premkumar Reddy, Director of the Fels Institute and Chairman of Biochemistry, Ph.D., Osmania University (India); Thomas J. Rogers, Professor of Microbiology, Ph.D., University of Wisconsin-Madison; Carmen Sapienza, Professor of Pathology, Ph.D., Dalhousie University, Halifax; Arthur G. Schwartz, Professor of Microbiology, Ph.D., Harvard University; Scott K. Shore, Associate Professor of Biochemistry, Ph.D., Drexel University; Henry Simpkins, Professor and Chair, Ph.D., King's College (London), M.D., University of Miami Medical School; Dianne R. Soprano, Professor of Biochemistry, Ph.D., Rutgers University; Kenneth J. Soprano, Professor of Microbiology and Immunology, Ph.D., Rutgers University; Barbara L. Stitt, Associate Professor of Biochemistry, Ph.D., California Institute of Technology; Robert J. Suhadolnik, Professor of Biochemistry, Ph.D., Pennsylvania State University; Peter M. Wong, Associate Professor of Pathology, Ph.D., McMasters University (Canada).

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