520. Molecular and Cellular Physiology. (4 s.h.)

A quantitative biophysical and biochemical description of physiological processes at the level of individual cells. The course covers cell biology, biophysical analysis of membrane transport (membrane transport mechanisms, electrophysiology, and maintenance of cellular electrolyte composition) experimental techniques, and communication between cells. The largest component of the course is an advanced study of cellular signal transduction mechanisms (second messenger systems, receptor mechanisms, and stimulus-response coupling).

522. Renal Physiology. (1 s.h.)

Basic retnal physiology, including glomerular filtration, salt and water handling, and acid base balance.

523. Microcirculation. (2 s.h.)

An in-depth evaluation of the function of the microvasculature and of research tools used to investigate this segment of the cardiovascular system. Topics covered include blood flow regulation, neuronal control, vascular permeability. endothelial cell function, and inflammatory processes.

531. Gastrointestinal Function. (1 s.h.)

Review of the current concepts of gastrointestinal motility and secretion. Emphasis on control Systems.

537. Pulmonary Physiology. (2 s.h.)

The basic physiology of the lung. Regulation of gas exchange and mechanics of ventilation are emphasized.

540. Experimental Methods in Physiology. (2 s.h.)

Overview of selected methods in physiology. Overall description of techniques used in the physiology department. Practical approach to basic handling of chemicals and science-related material and animals. Review of basic calculations and the use of basic computer programs.

545. Cardiovascular Physiology. (2 s.h.)

In-depth study of the cardiovascular system with emphasis on the interaction of the heart and peripheral vasculature in the cardiovascular control systems.

570. Advanced Molecular Physiology. (2 s.h.)

In-depth analysis of' the design of experiments to address fundamental problems in biology at the molecular level and interpretation of the results. Aspects of molecular cloning, regulation of gene expression, structure-function correlations, heterologous expression and transgenic animal models are discussed.

799. Preliminary Examination Preparation. (1 -6 s.h.)

899. Pre-Dissertation Research. (1-6 s.h.)

994-995. Master's Thesis. (variable credit)

997-998. Physiologv Research. (variable credit)

999. Ph.D. Dissertation. (1-6 s.h.)

Research for the Ph.D. dissertation.

THE SOL SHERRY THROMBOSIS RESEARCH CENTER

Direct inquiries to: Robert W. Colman,Director, Sol Sherry Thrombosis Research Center and Professor of Medicine, Microbiology and Physiology, Temple School of Medicine, 3400 N. Broad Street, Philadelphia, PA 19140 (215) 707-4665

Email: colman(@astro.temple.edu

Graduate Faculty

Barrie Ashby, Professor of Pharmacology, Ph.D., Leeds University; Andrei Z. Budzynsky, Professor of Biochemistry, Ph.D., Polish Academy of Sciences; James L. Daniel, Professor of Pharmacology, Ph.D.,Camegie-Mellon University; Raul DeLa Cadena, Assistant Professor of Pathology, M.D., La Salle University School of Medicine, Mexico City, Mexico; Satya P. Kunapuli, Assistant ProfeFsor of Physiology, Ph.D., Indian Institute of Science, Bangalore, India; Stefan Niewiarowski, Professor of Physiology, M.D., Ph.D., Warsaw University Medical School; J. Bryan Smith, Professor and Chair of Pharmacology, Ph.D., London University; Peter N. Walsh, Professor of Medicine and Biochemistry, M.D., Washington University School of Medicine, D. Phil., The University of Oxford, England.

General Statement

The Sol Sherry Thrombosis Research Center is devoted to the multidisciplinary study of thrombosis. Experimental research programs are carried out on four broad fronts, i.e., areas related to mechanisms regulating platelet aggregation, the interaction between cells and blood coagulation, and the study of mechanisms modulating blood coagulation and the interaction of endothelial cells with coagulation and fibrinolytic proteins. Research programs on mechanisms of regulation of platelet aggregation include studies of receptors for platelet agonists and anagonists, investigation of key enzymes and receptors involved in the regulation of platelet function, delineation of the interaction between calcium and inositol phospholipid second messengers, modulation of cAMP by adenylate cyclase and phosphodiestrerases, and cloning of platelet receptors. Areas of research on the interaction between cells and blood coagulation include the study of the membrane exposure of platelet proteins and their use in detecting platelet activation in patients, studies of platelets, neutrophils and monocytes as loci for activation of the blood coagulation system and the integration of endothelial cells and their receptors with fibrinolytic enzymes. Several programs are operative, such as studies on the structural biology of kininogen, the regulation of tissue plasminogen activator, and the molecular biology of plasma protease inhibitors. The Sol Sherry Thrombosis Research Center maintains an active clinical research laboratory.

Although degree programs are not offered by the Sol Sherry Thrombosis Center, its staff participates in the training of graduate students and has an NIH training grant for this purpose. Interdisciplinary programs are conducted with Biochemistry, Microbiology, Pharmacology, Pathology, and Physiology. Facilities are open to students for dissertation research in cellular- or protein-related basic science in a multidisciplinary setting.

THE M.D./PH.D. PROGRAM

Direct inquiries to: Peter N, Walsh, M.D., D.Phil., Director, M.D./Ph.D. Program, Temple University School of Medicine, Philadelphia, PA 19140, (215) 707-4375.

An opportunity exists for students to pursue work leading to both M.D. and Ph.D. degrees. The objective of this program is to prepare students for careers in academic medicine by closely integrating a curriculum in basic sciences, original research, and clinical medicine. The duration of the program is generally seven years, which are divided into three phases. The first year and a half covers the basic biomedical sciences and is identical to the curriculum for the first and second year medical students. In addition, students participate in research during the summers before and after the first year of medical school. This experience, combined with the weekly seminar series and regular interaction with the Director and members of the M.D.-Ph.D. Program Committee, will provide the student with the information required to make a rational choice of a graduate studies department, preceptor, and research project. During the following three years, M.D.-Ph.D. students will engage in course work and a research project within the selected basic science department. Research work is expected to be completed and the thesis written by the end of the period of graduate study. During the final two years the student will receive extensive training in clinical medicine in accordance with the normal medical school curriculum, and in addition will have the opportunity to extend the period of research training for eight months during the seventh year.

M.D./Ph.D. students are subject to all academic and ethical requirements of the Medical School and the Graduate School with the added responsibilities, criteria, and requirements of the M.D./Ph.D. Program.

The M.D. is a professional program. For information contact Audrey Uknis, M.D., Assistant Dean for Admissions, (215) 707-3656.

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