Courses at the 500 level are offered in alternate years.

501-502. Molecular Genetics of the Eukaryotic Cell. (3 s.h.)

This two-semester core course will provide the student with a foundation in the basics of molecular and cell biology, and will incorporate developments on oncogenes, tumor suppressor genes, transcription factors, cell cycle analysis, signal transduction and other major areas . important to become a well-versed molecular-cell biologist.

504. Molecular Genetics of Cell Proliferation, Differentiation, Growth Arrest and Apoptosis (3 s.h.)

This is an advanced level course utilizing various developmental systems, including C. elegans, yeast, Drosophilia, and mouse embryos, and specialized tissues, including muscle, nerve and blood cells, to address the latest developments in cell proliferation, differentiation, growth arrest, and programmed cell death.

505. Cancer Biology. (3 s.h.)

This course focuses on the process of cancer as a disease. Course lecturers include pathologies, nurses, oncologists and pharmaceutical scientists, as well as basic scientists from a variety of disciplines, including genetics, virology, cell biology, molecular biology and biochemistry. The disease is considered in terms of the underlying molecular mechanisms, the behavior of cancer cells, the physiology of disease progression, diagnosis, treatment and the effects of the disease on individuals, families and communities.

512-513. Research Molecular Biology and Genetics. (1-9 s.h.)

560. Principles of Development. (3 s.h.) This course covers the fundamental developmental mechanisms which are responsible for creating a new individual from a fertilized egg. Processes such as fertilization, cleavage, gastriculation, axis determination, organogenesis, differentiation, and pattern formation are covered at the cellular and molecular levels.

605-607. Molecular Biology and Genetics Seminar. (I s.h.)

Oral presentations describing current research findings from the scientific literature.

899. Pre-Dissertation Research. (1-6 s.h.)

999. Ph.D. Dissertation. (1-6 s.h.)

PATHOLOGY

Direct inquiries to: James Platt, Department of Pathology, Temple University School of Medicine, 3420 N. Broad St., Phila. PA 19140,(215)707-4063.

Email: jplatt@nimbus.ocis.temple.edu

Graduate Faculty

Raghbir Athwal, Professor, Ph.D., University of Missouri; Raul DelaCadena, Associate Professor, MD, FACP, La Salle University School of Medicine (Mexico); Nahum J. Duker, Professor, MD, University of Illinois; Marc Hansen, Associate Professor, Ph.D., University of Cincinnati School of Medicine; Rajendra P. Kandpal, Assistant Professor, Ph.D., Indian Institute of Science, Bangalore, India; Phillip Lazarus, Associate Professor, Ph.D., McGill University, Montreal; A. Koneti Rao, Associate Professor, MD, Old India Institute of Medical Sciences, New Delhi; Carmen Sapienza, Professor, Ph.D., Dalhousie University, Halifax; Rachel Sheppard, Assistant Professor, Ph.D., Albert Einstein College of Medicine; Henry Simpkins, Professor and Chair, Ph.D., King's College, London; MD, University of Miami Medical School; Peter M.C. Wong, Associate Professor and Director, Ph.D., McMaster University, Ontario; John M. Wurzel, Associate Professor, MD, University of Pennsylvania.

General Statement

The Department of Pathology offers graduate work leading to the Doctor of Philosophy degree. The program provides a basic knowledge of the fields of general and experimental pathology, especially etiology and pathogenesis of disease, and teaches experimental design and methodology, with particular regard to cellular and molecular pathology and their application to the study of human disease and appropriate model systems.

Areas of Concentration

Possible areas of study include: molecular and cellular pathology; pathophysiology, pathogenesis and etiology applied to abnormalities of growth, including cancer, inflammation and repair, and metabolic disease. Methods used include electron microscopy, cytogenetics, tissue culture, optical techniques, histopathology, autoradiography, biochemistry, and molecular biology.

Application Deadlines

July 1 for fall admission, and November 1 for spring admission.

Financial Aid

The Pathology Department offers graduate assistantships.

Doctor of Philosophy

Admission Requirements

Applicants must hold a B.S. or other appropriate degree. A background in histology, embryology, physiology, and biochemistry is required; integral and differential calculus and physical chemistry are strongly recommended.

Students must submit scores from the Graduate Record Examination (GRE) general and subject test in biology, chemistry, mathematics, physics, or engineering, and are required to arrange an interview. Two letters of recommendation and transcripts from undergraduate and graduate course work, including Temple University, are required.

Degree Requirements

Students must complete eight courses specified by the department (including Biochemistry 523, 527 and 534), and two or three others chosen in consultation with an adviser, and must pass a qualifying examination, a comprehensive examination, and, after submitting an acceptable dissertation, an oral final examination. Reading ability in one of the following languages is required: French, German, Russian, Japanese. A suitable computer language may also be required.

Course Descriptions -Pathology

501. General Medical Pathology. (3 s.h.)

The pathogenesis, etiology, and pathophysiology of disease with reference to the biochemical and morphological alterations basic to all. (Not required of students with an L.C.M.E. M.D.)

503. Systemic Medical Pathology. (6 s.h.)

Disease patterns in the systems of the human body.

509-510. Research Seminar. (2 s.h.)

Student and staff oral presentations describing current research findings or interests in selected topics.

Elective courses:

799. Preliminary Examination Preparation. (1-6 s.h.)

899. Pre-Dissertation Research. (1-6 s.h.)

997. Exceptional Pathology Research. (1-9 s.h.)

999. Ph.D. Dissertation. (1-6 s.h.)

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