Prerequisite: a previous course in general biochemistry.

Topics in biochemistry of special relevance to modern pharmacology are covered.

533. Pharmacology of the Cell Membrane. (2 s.h.)

A discussion of the role of the plasma membrane in drug action, including: mechanisms by which drugs penetrate the membrane; effects of pharmacological agents on transport mechanisms; role of the cell membrane as a site for drug receptors.

541. Principles of Cellular Pharmacology. (4 s.h.)

General principles of drug-cell interactions, including molecular and mathematical aspects of drug receptor theory and mechanisms of drug action. Mechanisms of stimulus-response coupling. G. proteins, second messengers, protein phosphorylation.

542. Experimental Pharmacology. (3 s.h.)

Various experimental methods used in the study of pharmacology. Lectures on the scientific studies associated with, and the theory behind, each method. Labs devoted to the practical use of each experimental method.

543. Pharmacology Journal Club. (1 s.h.)

Review of research papers; presentation by graduate students; discussion of new analytical techniques.

799. Preliminary Examination Preparation. (1-6 s.h.)

899. Pre-Dissertation Research. (1-6 s.h.)

990-991. Master's Thesis. (variable credit)

997. Pharmacology Research. (variable credit)

999. Ph.D. Dissertation. (1-6 s.h.)

PHYSIOLOGY

Direct inquiries to.- Dr. John A. Drees, Associate Professor and Graduate Program Coordinator Department of Physiology, Temple University School of Medicine, 3420 N. Broad Street, Philadelphia, PA 19140-5104, (215) 707-3197.

E-mail: jdrees@astro.ocis.temple.edu

Graduate Faculty

Steven P. Driska, Associate Professor, Ph.D., Carnegie Mellon University; James L. Heckman, Associate Professor, Ph.D., Temple University School of Medicine; Steven R. Houser, Professor, Ph.D., Temple University School of Medicine; Satya P. Kunapuli, Assistant Professor, Ph.D., Indian Institute of Science (India); John S. Martin, Associate Professor, Ph.D., Thomas Jefferson University; Stefan Niewiarowski, Professor, M.D., Ph.D., Warsaw University Medical School; James P. Ryan, Professor, Ph.D., Hahnemann Medical College; Thomas H. Shaffer, Professor, Ph.D., Drexel University; Ronald E Tuma, Professor and Chair, Ph.D., Temple University School of Medicine; Michael B. Wang, Professor, Ph.D., State University of New York at Downstate Medical Center; Roy L. White, Associate Professor, Ph.D., University of Illinois; Marla R. Wolfson, Associate Professor Ph.D., Temple University School of Medicine.

General Statement

The Department of Physiology offers graduate programs leading to either an M.S. or Ph.D. degree. Graduate students can pursue a wide variety of research interests in physiology from the molecular level to whole animals. The Physiology Department has faculty members conducting research and publishing in the areas of cardiac, cardiovascular, gastrointestinal, pulmonary physiology, membrane transport, platelets, smooth muscle, and gap junctions. Graduate programs with emphasis on exercise physiology are provided in collaboration with the research faculty of the Kinesiology Department.

Areas of Concentration

Areas of specialization include membrane biophysics, membrane transport, cardiovascular, gastrointestinal, respiratory, hemostasis, cellular electrophysiology, smooth and

Application Deadline

Applications must be received before May 1for the fall semester.

Financial Aid

The Department of Physiology awards financial aid, as well as nominates students for University-wide fellowships.

Master of Science

Admission Requirements

Applicants must hold the bachelor's degree, preferably with a major in science. They must submit transcripts (including Temple University), two letters of recommendation, and scores from the general Graduate Record Examination (GRE). Students are encouraged to take the biology subject test as well, although it is not a requirement for admission. Interviews will be arranged for qualified students.

Degree Requirements

Students must complete a minimum of 24 credits of course work. The actual course requirements will be determined on an individual basis. A thesis must be submitted and defended before graduation. Generally, two years of study are necessary to meet all the requirements.

Doctor of Philosophy

Admission Requirements

These are the same as for the Master of Science degree.

Degree Requirements

Students must complete courses in molecular biology and biochemistry in addition to basic and advanced courses in physiology. A written and oral examination must be passed and a dissertation must be written and defended. Generally, five years are required to complete the program.

Course Descriptions-Physiology

500. Physiology. (6 s.h.)

Designed for medical students. A broad survey of the major organ systems. The material is presented in lecture, laboratory, demonstration and conference. With special permission, graduate students with the necessary background can register for selected parts of the following courses:

500a. Physiology Lecture. (3 s.h.)

500b. Physiology Laboratory. (3 s.h.)

501-502. Physiology Journal Club. (1 s.h.)

Student discussions on current physiological literature. Students obtain experience in contemporary bibliographic searching techniques, and in presenting experimental data in a seminar format. Critical evaluation of scientific literature is fostered through classroom exercises.

505-506. Preceptorial in Physiology. (1 to 3 s.h.)

Prerequisite: graduate committee permission.

An intensive study of an area of physiology under the direction of a faculty member.

508. Advanced Physiology. (1 s.h.)

The course probes more deeply into the areas covered in the medical physiology course. Only students enrolled in M500 can register.

511. Ion Channels in Nerve and Muscle. (2 s.h.)

In-depth study of basic principles of membrane phenomenon. Focus is on basic properties of single ion channels in nerve and muscle.

514. Neurophysiology. (2 s.h.)

A survey of selected topics in neurophysiology. Each topic presented will include a cursory overview of the subject and an in-depth discussion of one aspect of the area under consideration.

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