Courses

Pharmaceutical Sciences

Note:Courses Numbered P100-P199 Require First Professional Year Status; P200-P299 Require Second Professional Year Status; P300-P399 Require Third Professional Year Status; P400-P499 Require Fourth Professional Year Status

0405. PRIN OF DRUG ACTION/PHAR   (3 s.h.)

Presents the fundamental principles of pharmacology, medicnal chemistry and pharmacokinetics.

0406. PHARM MFG I:PREFORM/FORM   (3 s.h.)

Presents techniques relevant to all aspects of preformulation and formulation phases, as well as principles and mechanisms of incompatibilty and stability testing.

0407. Pharmaceutical Manufacturing II   (3.0 s.h.)

Presents processing and principles that apply to solid dosage form design and product development

0410. Applied Biopharmaceutics   (3.0 s.h.)

Presents the interrelationships of the physicochemical properties of the drug and the dosage form, to the route of administration and to the rate and extent of systemic absorption.

0411. PHARMACEUTICAL ANALYSIS   (3 s.h.)

Presents the applications of chemical analysis to pharmaceuticals and pharmaceutical manufacturing.

0449. Radioisotope Methodology   (3 s.h.)

Introductory discussion of the characteristics and properties of ionizing radiation, methods of detection (gas ionization, scintillation, both liquid and solid spectroscopy), radiation standards for safety and protection, and basic evaluation of biological hazards and effects.

0460. Metabolism of Drugs and Chemicals   (3 s.h.)

The course deals with the metabolism and detoxification of drugs, toxic substances, and other organic compounds, with particular attention to the influence these processes exert on drug therapy.

0464. Abuses of Drugs and Chemicals   (3 s.h.)

Pharmacology of drugs of abuse and related chemicals, the extent of drug abuse, factors fostering drug abuse, and treatment methods.

0471. Introduction to Toxicology   (4 s.h.)

Presents aspects of molecular, clinical and forensic toxicology. Provides an understanding of the principles of toxicology including routes of exposure, toxicant dose response relationships, adverse effects, absorption, excretion, and mutagensis.

0475. Pharmaceutical Biotechnology   (3 s.h.)

This course will introduce students to pharmaceutical biotechnology, biophysical, and chemical aspects of biotech products and their pharmaceutical formulations and clinical applications. Amino acids, proteins, peptides, and nucleotides are of particular interest. The principles of pharmaceutical formulation of biotech products and physicochemical evaluation of formulations will be extensively discussed. Also, pharmacokinetics of biologics and current analytical methods used in pharmaceutical biotechnology will be focused.

0478. Modified Release Dosage Forms   (3 s.h.)

The fundamentals involved in various extended release dosage forms and their modification for use in particular dosage formulations. Biopharmaceutical and pharmacokinetic aspects of extended-release dosage forms are discussed as well. Overview of polymeric excipients used in the formulation of extended-release dosage forms. Current commercial products under development will be discussed.

0485. Physical Pharmacy I   (3 s.h.)

Application of the concepts of physical chemistry and thermodynamics to pharmaceutical systems, including solutions, heterogeneous systems, biochemical transformations, and membranes. Introductory level.

0487. CRRNT GOOD MANUFACT PRAC   (3 s.h.)

0492. Sterile Products:Parenterals   (3 s.h.)

A study of the theory and principles involved in the preparation of sterile, pyrogen-free products. Understanding the manufacturing procedures related to sterile products. Clinical applications as well as aseptic technique.

0493. STERILIZATION PROCESSES   (3 s.h.)

0499. Drug Dosage Forms   (3 s.h.)

Overview of drug dosage form design and manufacturing technology. Principles of pharmaceutical processing, pharmaceutical dosage form design, including preformulation and biopharmaceutics. Various dosage forms will be discussed, e.g., tablets, capsules, modified dosage forms, semi-solid products, transdermal delivery systems, etc.

0502. Advanced Pharmacokinetic Modeling I.   (3 s.h.)

Fundamental mathematical skills necessary to develop PK/PD models.

0503. Advanced Pharmacokinetic Modeling II.   (3 s.h.)

This course is designed for students who have taken Advanced Pharmacokinetics Modeling I. More advanced mathematical skills to develop pharmacokinetic/pharmacodynamic models and reviews more sophisticated methodology and operation of the methods available in the literature. The underlying assumptions, advantages, and limitations of each method as well as the state-of-the-art of data handling will be presented and discussed to add insight into improved experimental design to obtain optimal pharmacokinetic data and parameters.

0509. PRIN OF PHARMACOKINETICS   (3 s.h.)

Provides the fundamental mathematical basics for the development of pharmacokinetic models. The underlying assumptions, advantages, and limitations of each model, as well as state-of-the-art data handling will be discussed. Homework problems will be handled using PCNONLIN, and students will be expected to do monoexponential disposition, AUC calculations, moment analysis, computer methods/PCNONLIN, renal clearance, and infusional kinetics.

0530. Advanced Medicinal Chemistry I.   (3 s.h.)

In-depth discussion of the synthesis and structure activity relationships of the major therapeutic classification of drugs.

0532. Advanced Medicinal Chemistry II.   (3 s.h.)

Discussions of the organic chemistry of drug action and drug design. Current topics in the field are discussed using examples from the recent literature. Synthesis and structure-activity relationships of some current and potential therapeutic drug classes.

0577. Pharmacodynamics   (3 s.h.)

This course covers the theoretical underpinnings and practical aspects of quantitative pharmacology. A key feature of the course is its concentration on the integrated study of a drug's pharmacokinetics (transport to its site of action: including absorption, distribution, biotransformation, and excretion) and its mechanism of action at the site of action. Emphasis is placed on the mathematical foundations of such topics as drug-receptor theory, Schild analysis, Furchgott's method, radioligand binding studies, PK/PD modeling, and isobolographic analysis of drug combinations.

0582. Physical Pharmacy II   (3 s.h.)

Includes the colloidal, interfacial and rheological aspects of disperse systems (suspension, gels, and emulsions), and polymer solutions, surfactants, aerosols and membranes. Physicochemical principles governing the preparation and properties of colloidal systems emphasized.

0588. Topics in Pharmaceutical Sciences   (1-3 s.h.)

Topics vary; specific topic(s) announced prior to the start of the semester.

0699. Master's Research   (1-6 s.h.)

0799. Preliminary Exam Preparation   (1-6 s.h.)

0899. Pre-Dissertation Research   (1-6 s.h.)

0999. Dissertation Research   (1-6 s.h.)