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Note: Unless otherwise noted, all prerequisite courses must be passed with a grade of C- or higher.

0401. Teaching of Biology   (3 s.h.)

Required of all first-year teaching assistants. Instruction in the art of teaching laboratories and recitations.

0402. Teaching of Biology   (3 s.h.)

Required of all first-year teaching assistants. Instruction in the art of teaching laboratories and recitations.

0410. Evolution   (3 s.h.)

Prerequisite: completion of Biology 203 (or equivalent majors-level genetics course) with a grade of C- or better.

A lecture and discussion for upper-level science majors and graduate students. Topics covered include Darwinism and neo-Darwinian theory, theories and experimental evidence for micro-revolution (population genetics, adaptation, natural selection, sexual selection, speciation) and macro-evolution (classical and molecular techniques used to understand the evolution of groups of organisms).

0416. Tropical Marine Biology   (4 s.h.)

An overview of marine biology with focus on reef biota and the largest coral barrier reef in the Atlantic Ocean. Lectures given on Temple`s main campus, including meetings during the fall semester and between fall and spring semesters, are complimented by an 8-day field experience on Ambergris Caye in Belize (Central America). Coursework in Belize consists of lectures, daily field trips and field projects. Project papers and oral presentations are due upon return to Philadelphia.

Note: Additional requirements include cost of air travel to a foreign country between fall and spring semesters, a current passport, and snorkeling equipment.

0427. Immunology   (3 s.h.)

Prerequisite: completion of Biology 203 and 204 or equivalent Genetics and Cell Biology courses.

Provides a comprehensive overview of the immune system. The lectures will describe the general properties and development of immunity, the condition of being protected from infection by microorganisms or the effects of foreign molecules. They will provide systemic coverage of immune responses to viruses, bacteria, protozoa and roundworms as well as the practical aspects of vaccine development. Additional lectures will include a description of various types of primary immunodeficiencies, most prevalent autoimmune disease and cancer.

0428. Virology   (3 s.h.)

The role of viruses in human diseases, and their potential as tools for research and clinical interventions. The course will focus on virus-induced diseases in man (including polio, rabies, hepatitis, herpes, and influenza); recently discovered viruses such as HIV and HTLV-1 will also be studied. Virus-host interactions and the mechanisms involved in disease progression, therapeutic strategies, and vaccines, strategies for viral entry, evasion of the immune system, transmission, and the subversion of host-cell machinery will be emphasized. Potential uses of viruses as vector for gene therapy of genetic disorders, cancers, and infectious diseases will also be discussed.

0429. Developmental Genetics   (3 s.h.)

Prerequisite: Biology 203 or equivalent.

The role of genes in the determination and differentiation of invertebrates and lower Vertebrates. Emphasis is on the regulation of gene function and on the genetic and molecular interactions which control early development in Drosphilia, C. elegans, Amphibia, and chick embryos. Together with Biology 463, these courses provide an overall picture of the genetic control of development.

0430. Cell Biology   (3 s.h.)

Prerequisite: Biology 204.

Recent developments in cell biology. Topics may include the cytoskeleton, cell motility, the cell cycle, endo- and exocytosis.

0433. Advanced Techniques in Microscopy   (3 s.h.)

A survey of modern techniques in microscopy. Students will acquire a thorough grounding in general principles of optics and conventional microscopy, and learn the theory of many methods current in biology and medicine. Hands-on laboratory experiences include fluorescence, confocal microscopy, video, microscopy and digital image processing and analysis.

Note: This course includes extensive laboratory experience

0440. Advanced Invertebrate Biology   (3 s.h.)

Prerequisite: Bio 241-242 or permission of instructor.

A study of the mechanisms of development using invertebrates as model systems. The class will address developmentally significant questions relevant to both vertebrates and invertebrates, including: role of lineage vs. position in determination, induction of polarity, genetics and molecular biology of segmentation and path finding in the nervous system. Emphasis is on the advantages of comparative biology and invertebrate systems for analyzing patterns in development.

0452. Neurobiology   (3 s.h.)

Prerequisite: Permission of instructor.

A comparative survey of vertebrate and invertebrate neurology systems intended to acquaint the student with their structure and function at the level of the cell or small groups of cells.

0454. Neurological Basis of Animal Behavior   (3 s.h.)

Prerequisite: One semester neurobiology.

An exploration of the relationship of neural activity and connectivity to behavior. Topics include object recognition, motor control, attention, sensory resolution, and feedback. Examples from both vertebrate and invertebrate species. Analytic and synthetic approaches.

0456. Organization and Development of the Nervous System   (3 s.h.)

Prerequisite: Biology 204 or permission of instructor.

This course covers developmental, anatomical, and integrative aspects of the nervous system. Two questions are covered in depth: What are the principles that enable the nervous system, both vertebrate and invertebrate, to develop from earliest stages to full adult form? How is the vertebrate nervous system organized? The course is intended to complement Neurobiology 452 so that students will have a perspective on neuroscience ranging from the molecular to the systems level.

0463. Genetic Control of Mammalian Development   (3 s.h.)

Prerequisite: Biology 203 or permission of instructor.

This course covers mammalian embryogenesis, and 1) macromolecular synthesis and onset of zygotic gene activity, 2) the effects of the male and female genomes on development; 3) the effects of specific genes, such as wnt genes, on development; 4) the effect of chromosome and gene imprinting on development; 5) the production of, analysis of and use of transgenic and knock-out mice; 6) the expression of protooncongenes and oncogenes during development; and 7) the expression of homeoboxes and their effects as transgenes during development. With the exception of normal development, all of the topics are taught from journal articles.

0467. Endocrinology   (3 s.h.)

Prerequisites: General Biology and Organic Chemistry.

Broad coverage of "chemical messengers," occurrence, biochemistry, and physiology. Vertebrate endocrinology with minor treatment of invertebrates and plants.

0470. Comparative Animal Physiology   (3 s.h.)

Prerequisites: Bio 0103-0104 and 0233 or equivalent; Chemistry C071-C072 or equivalent.

A study of the experimental approach to understanding how animals have adapted physiologically to the unique physico-chemical conditions of different environments. Topics include comparison of metabolic rates, osmo- and thermoregulation and reproductive processes among animals living in diverse aquatic and terrestrial habitats. Animals' physiological adaptations are correlated with their morphology, life cycles and behavior. Vertebrate animals are stressed. There is an opportunity for students to do reports on particular animals or physiological systems that interest them.

0471. Cell Proliferation   (3 s.h.)

Prerequisites: Biology 0203 and 0204 or permission of instructor.

Discussion of cell proliferation and its control; model systems, comparisons of proliferating cells with nonproliferating cells, controls of cell division and how that control is modified in proliferative diseases such as cancer and the relationships between proliferation and differentiation. Readings will be taken from the literature.

0474. Physical Biochemistry   (3 s.h.)

Prerequisites: Chemistry C071-C072, C073-C074, or C091-C092, two semesters of calculus. One semester of calculus-based physics will be useful..

The course covers introduction to probability and applications; computer programing to solve probability problems; an introduction to the use of computers to solve problems in genomics and proteomics (structure analysis of proteins); and introduction to statistical mechanics.

0475. General Biochemistry I.   (3 s.h.)

Prerequisites: Chemistry 0121 and Biology 0103 and 0104 or permission of instructor.

Properties of water (pH and buffers); chemistry of amino acids and proteins including non-covalent interactions, carbohydrates, nucleotides and nucleic, lipids and membranes, enzyme mechanisms and kinetics; control of enzyme activity; bioenergetics and oxidative metabolism; biophysics and chemistry of photosynthesis.

0476. General Biochemistry II.   (3 s.h.)

Prerequisite: Biochemistry I.

Emphasis on the biochemical reactions in various metabolic pathways. Biosynthesis and degradation of carbohydrates, lipids, proteins and amino acids. Regulation and integration of metabolic pathways. Bioenergetics and oxidative phosphorylation. Signal transduction. Transcription, translation and their control.

0479. Molecular Biology   (3 s.h.)

Prerequisite: Corequisites: Biology 475 and knowledge of basic genetics.

Macromolecular structure; recombinant DNA technology and gene cloning; advanced DNA replication and DNA repair; artificial chromosomes, chromatin structure and histone modifications; transcription factor complexes; RNA splicing and catalytic RNA; translational control; gene regulation and regulatory protein structure; RNA interference; genomics and proteomics; transposons and retrotransposons; molecular biology of the immune system.

0484. Organogenesis   (3 s.h.)

Prerequisite: Biology 265.

An analysis, based upon the experimental literature, of the processes which result in organogenesis during embryonic development. Emphasis is on correlations between morphological and biochemical specializations. Topics include: patterns of differentiation, morphogenetic movements, epithelialmesenchymal interactions, and role of extracellular materials in differentiation.

0485. Contemporary Biology   (3 s.h.)

Current research topics in selected areas of biology examined in depth. Selected readings assigned. Limited to students who are in the Graduate Program of the Department of Biology. It meets weekly to present and review current research papers in the field of biology.

0489. Biotechnology   (3 s.h.)

This course is designed to survey current issues in technologies including therapeutics and diagnostics, and to examine consequences of developments in thees areas. The course is designed in a "Problem Based Learning" format, where students research critical areas and provide oral and written reports for other members in the class. The course is organized by topics including Concepts in Genetics, Cloning and Ethics, Gene Therapy, Prenatal Diagnosis, Gene Therapy for Cancer, Cell Replacement Therapy, Genomics and Proteomics, Vaccines, Forensics, Plant Biotechnology, and Instrumentation. At the end of the course, each student makes a formal presentation on a specific advance in biotechnology.

0703. Introduction to Biological Research   (3 s.h.)

A laboratory course providing hands-on experience in common techniques of biological research. Topics covered will include laboratory safety, Ph buffers, spectroscopy, centrifugation, electrophoresis, and chromatography. Instruction will also be given in experimental design, the use of controls, and the analysis of data. Limited to graduate students.

0799. Preliminary Exam Preparation   (1-6 s.h.)

Students in M.S. program who have completed coursework but have not yet passed the exam.

0802. Research Techniques: Biochemistry   (3 s.h.)

Laboratory techniques used to investigate biological problems. Techniques include spectrophotometry, column chromatography, electrophoresis, separation of macromolecules, two-dimensional analytical protein separation, affinity chromatography, isolation of plasmid DNA, transformation, immunoassay, enzyme kinetics, radioisotope techniques, pulse labeling, and analysis of radioactive products. If time permits, students will be given a small research project.

0804. Research Techniques: Neuroscience   (3 s.h.)

This course is intended to give students a hands-on approach to experimental neurobiology. Sensory input, central processing and motor output will b explored using preparations that include: vital staining and synaptic plasticity of invertebrate neuromuscular units; action potentials from plants; monitoring and modifying electric discharge patterns of weakly electric fish; responses of crayfish stretch receptors; mapping and physiological properties of visual units in the frog brain; bursting cells in mollusc ganglia. Students will learn extra-cellular and intracellular single unit physiological recording and stimulating. Physiological signals will be processed by modern laboratory computers. Independent projects based on earlier preparations will be carried out towards the end of the semester.

0805. Research Techniques   (3 s.h.)

Topics will vary.

0806. Research Techniques   (3 s.h.)

Topics will vary.

0807. Research Techniques   (3 s.h.)

Prerequisite(s): Biology 479 and undergraduates who have had Bio 324 or permission of the instructor.

Laboratory instruction in molecular biology and recombinant DNA techniques. The course will provide practical experience in modern cloning, hybridization, and DNA sequencing technology.

0808. Theory and Practice of Ultra-structure Research   (4 s.h.)

Theoretical background of the potential of the electron microscope for biological research; also provides practical experience in major techniques of the field. Students begin with live tissue and conclude with electron micrographs.

0821. Seminar   (3 s.h.)

Topics will vary.

0822. Seminar   (3 s.h.)

Topics will vary.

0825. Seminar   (3 s.h.)

Topics will vary.

0826. Seminar   (3 s.h.)

Topics will vary.

0841. Seminar   (3 s.h.)

Topics will vary.

0842. Seminar   (3 s.h.)

Topics will vary.

0845. Seminar   (3 s.h.)

Topics will vary.

0846. Seminar   (3 s.h.)

Topics will vary.

0851. Seminar: Neuroscience   (3 s.h.)

A discussion of recent advances in the clinical and experimental Neurosciences using original research papers or reviews. Particular topics are selected on the basis of student interests and background.

0861. Directed Reading   (1-9 s.h.)

Directed study and discussion of the current research literature.

0862. Directed Reading   (1-9 s.h.)

Directed study and discussion of the current research literature.

0899. Pre-Dissertation Research   (1-6 s.h.)

Ph.D. students who have not yet been elevated to candidacy.

0901. Graduate Research   (1-9 s.h.)

0902. Graduate Research   (1-9 s.h.)

0904. Graduate Research   (1-9 s.h.)

0999. Dissertation Research   (1-6 s.h.)

Limited to Ph.D. students who have been elevated to candidacy.