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College of Science and Technology 306 Barton Hall, Degree Programs: isc.temple.edu/grad/Programs
/stgrid.htm Departments: Chemistry Computer
& Information Geology Mathematics Physics
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452. Neurobiology. (3 s.h.) Prerequisite: Permission of instructor. A comparative survey of vertebrate and invertebrate neurology systems intended to acquaint the student with their structure and function at the level of the cell or small groups of cells. 454. Neurological Basis of Animal Behavior. (3 s.h.) Prerequisite: One semester neurobiology. An exploration of the relationship of neural activity and connectivity to behavior. Topics include motor control, object recognition, and learning. Examples from both vertebrate and invertebrate species. Analytic and synthetic approaches. 455. Biological Clocks. (3 s.h.) Prerequisite: One year General Biology. Biological clocks deals with the subject of the rhythms of life daily and seasonal. The nature of the clock, the means for resetting the clock, the clock's use in navigation, and the relationship of the clock to the environment. 456. Organization and Development of the Nervous System. (3 s.h.) Prerequisite: Biology 204 or permission of instructor. This course covers developmental, anatomical, and integrative aspects of the nervous system. The relationship of form to function will be studied in a variety of systems both invertebrate and vertebrate. The course is intended to complement Neurobiology 352/452 so that students will have a perspective on neuroscience ranging from the molecular to the systems level. 463. Genetic Control of Mammalian Development. (3 s.h.) Prerequisite: Biology 203 or permission of instructor. This course covers mammalian embryogenesis, and 1) macromolecular synthesis and onset of zygotic gene activity, 2) the effects of the male and female genomes on development; 3) the effect of chromosome and gene imprinting on development; 4) the production of, analysis of and use of transgenic mice; 5) the expression of protooncongenes and oncogenes during development; and 6) the expression of homeoboxes and their effects as transgenes during development. With the exception of normal development, all of the topics are taught from journal articles. 464. Biochemical Embryology. (3 s.h.) Prerequisites: Biol. 204 and 265. A study of the process of biochemical differentiation of embryonic cells. 467. Endocrinology. (3 s.h.) Prerequisites: General Biology and Organic Chemistry. Broad coverage of "chemical messengers," occurrence, biochemistry, and physiology. Vertebrate endocrinology with minor treatment of invertebrates and plants. 470. Comparative Animal Physiology. (3 s.h.) Prerequisites: Bio 0103-0104 and 0233 or equivalent; Chemistry C071-C072 or equivalent. A study of the experimental approach to understanding how animals have adapted physiologically to the unique physico-chemical conditions of different environments. Topics include comparison of metabolic rates, osmo- and thermoregulation and reproductive processes among animals living in diverse aquatic and terrestrial habitats. Animals' physiological adaptations are correlated with their morphology, life cycles and behavior. Vertebrate animals are stressed. There is an opportunity for students to do reports on particular animals or physiological systems that interest them. 471. Cell Proliferation. (3 s.h.) Prerequisites: Biology 0203 and 0204 or permission of instructor. Discussion of cell proliferation and its control; model systems, comparisons of proliferating cells with nonproliferating cells, controls of cell division and how that control is modified in proliferative diseases such as cancer and the relationships between proliferation and differentiation. Readings will be taken from the literature. 474. Physical Biochemistry. (3 s.h.) Prerequisites: Chemistry C071-C072, C073-C074, or C091-C092, two semesters of calculus, and one semester of calculus-based physics; Pre- or Corequisite: second semester physics. The course covers those aspects of computer simulation of molecular dynamics and statistical mechanics of use to biochemists and biologists interested in molecular modeling. The course is computer intensive. 475. General Biochemistry I. (3 s.h.) Prerequisites: Chemistry 0121 and Biology 0103 and 0104 or permission of instructor. Properties of water (pH and buffers); chemistry of amino acids and proteins including non-covalent interactions, carbohydrates, nucleotides and nucleic, lipids and membranes, enzyme mechanisms and kinetics; control of enzyme activity; bioenergetics and oxidative metabolism; biophysics and chemistry of photosynthesis. 476. General Biochemistry II. (3 s.h.) Prerequisite: Biochemistry I. Replication of DNA, transcription and translation. 479. Molecular Biology. (3 s.h.) Corequisites: Bio. 475 and knowledge of basic genetics. DNA replication, repair and recombination; recombinant DNA technology and gene cloning; transcription, processing and splicing of RNA; regulation of gene expression; protein synthesis and regulation; molecular biology of the immune system and oncogenesis. 481. Membrane Biochemistry and Biophysics. (3 s.h.) Prerequisite: Biology 204, 234, or permission of instructor. Elementary treatment useful for preprofessional students. Membrane equilibria, diffusion, cellular homeostasis, ionic basis of nerve and muscle function, characterization and isolation of channels, porters, and pumps. 484. Organogenesis. (3 s.h.) Prerequisite: Bio. 265. An analysis, based upon the experimental literature, of the processes which result in organogenesis during embryonic development. Emphasis is on correlations between morphological and biochemical specializations. Topics include: patterns of differentiation, morphogenetic movements, epithelialmesenchymal interactions, and role of extracellular materials in differentiation. 485. Contemporary Biology. (3 s.h.) Current research topics in selected areas of biology examined in depth. Selected readings assigned. Limited to students who are in the Graduate Program of the Department of Biology. It meets weekly to present and review current research papers in the field of biology. 703. Introduction to Biological Research. (3 s.h.) A laboratory course providing hands-on experience in common techniques of biological research. Topics covered will include laboratory safety, Ph buffers, spectroscopy, centrifugation, electrophoresis, and chromatography. Instruction will also be given in experimental design, the use of controls, and the analysis of data. Limited to graduate students. 799. Preliminary Exam Prep. (1-6 s.h.) Students in M.A. program who have completed course work but have not passed the exam. 802. Research Techniques -Biochemistry. (3 s.h.) Laboratory techniques used to investigate biological problems. Techniques include spectrophotometry, column chromatography, electrophoresis, separation of macromolecules, two-dimensional analytical protein separation, affinity chromatography, isolation of plasmid DNA, transformation, immunoassay, enzyme kinetics, radioisotope techniques, pulse labeling, and analysis of radioactive products. If time permits, students will be given a small research project. 804. Research Techniques -Neuroscience. (3 s.h.) This course is intended to give students a hands-on approach to experimental neurobiology. Sensory input, central processing and motor output will b explored using preparations that include: vital staining and synaptic plasticity of invertebrate neuromuscular units; action potentials from plants; monitoring and modifying electric discharge patterns of weakly electric fish; responses of crayfish stretch receptors; mapping and physiological properties of visual units in the frog brain; bursting cells in mollusc ganglia. Students will learn extra-cellular and intracellular single unit physiological recording and stimulating. Physiological signals will be processed by modern laboratory computers. Independent projects based on earlier preparations will be carried out towards the end of the semester. 805-806. Research Techniques. (3 s.h.) Topics will vary. 807. Research Techniques. (3 s.h.) Co- or Prerequisites: Bio. 479 and undergraduates who have had Bio 324 or permission of the instructor. Laboratory instruction in molecular biology and recombinant DNA techniques. The course will provide practical experience in modern cloning, hybridization, and DNA sequencing technology. 808. Theory and Practice of Ultra-structure Research. (4 s.h.) Theoretical background of the potential of the electron microscope for biological research; also provides practical experience in major techniques of the field. Students begin with live tissue and conclude with electron micrographs. 821-822. Seminar. (3 s.h.) Topics will vary. 825-826. Seminar. (3 s.h.) Topics will vary. 841-842. Seminar. (3 s.h.) Topics will vary. 845-846. Seminar. (3 s.h.) Topics will vary. 851. Seminar -Neuroscience. (3 s.h.) F A discussion of recent advances in the clinical and experimental Neurosciences using original research papers or reviews. Particular topics are selected on the basis of student interests and background. 861-862. Directed Reading. (variable credit) Directed study and discussion of the current research literature. 899. Pre-Dissertation Research. (1-6 s.h.) Ph.D. students who have not been admitted to candidacy. 901-902. Graduate Research.
999. Dissertation Research. (1-6 s.h.) Ph.D. students who have been admitted to candidacy.
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