Biography

Dr. Mohammad F. Kiani is Professor of the Department of Mechanical Engineering. Dr. Kiani’s expertise is in biofluid mechanics, targeted drug delivery, and radiation oncology. Dr. Kiani co-founded Engineering World Health with Dr. Robert Malkin, served as its president for several years, and currently serves on its board of directors.

Research Interests

  • Microfluidic Systems
  • Targeted Drug Delivery
  • Leukocyte Biology

Courses Taught

Number

Name

Level

ENGR 3001

Engineering Economics

Undergraduate

Selected Publications

  • Kilpatrick, L.E. & Kiani, M.F. (2020). Experimental approaches to evaluate leukocyte-endothelial cell interactions in sepsis and inflammation. Shock, 53(5), pp. 585-595. doi: 10.1097/SHK.0000000000001407

  • Soroush, F., Tang, Y., Mustafa, O., Sun, S., Yang, Q., Kilpatrick, L.E., & Kiani, M.F. (2020). Neutrophil-endothelial interactions of murine cells is not a good predictor of their interactions in human cells. FASEB Journal, 34(2), pp. 2691-2702. doi: 10.1096/fj.201900048R

  • Silvani, G., Scognamiglio, C., Caprini, D., Marino, L., Chinappi, M., Sinibaldi, G., Peruzzi, G., Kiani, M.F., & Casciola, C.M. (2019). Reversible Cavitation-Induced Junctional Opening in an Artificial Endothelial Layer. Small, 15(51). doi: 10.1002/smll.201905375

  • Soroush, F., Tang, Y., Guglielmo, K., Engelmann, A., Liverani, E., Patel, A., Langston, J., Sun, S., Kunapuli, S., Kiani, M.F., & Kilpatrick, L.E. (2019). Protein Kinase C-Delta (PKCd) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation. Shock (Augusta, Ga.), 51(5), pp. 538-547. doi: 10.1097/SHK.0000000000001247

  • Yang, Q., Langston, J.C., Tang, Y., Kiani, M.F., & Kilpatrick, L.E. (2019). The role of tyrosine phosphorylation of protein kinase C delta in infection and inflammation. International Journal of Molecular Sciences, 20(6). doi: 10.3390/ijms20061498

  • Soroush, F., Tang, Y., Zaidi, H.M., Sheffield, J.B., Kilpatrick, L.E., & Kiani, M.F. (2018). PKCd inhibition as a novel medical countermeasure for radiation-induced vascular damage. FASEB Journal, 32(12), pp. 6436-6444. doi: 10.1096/fj.201701099

  • Tang, Y., Soroush, F., Sun, S., Liverani, E., Langston, J.C., Yang, Q., Kilpatrick, L.E., & Kiani, M.F. (2018). Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage. Journal of Neuroinflammation, 15(1). doi: 10.1186/s12974-018-1342-y

  • Yang, F., Soroush, F., Deng, G., Yu, S., Chu, P., Kiani, M.F., & Ling, H. (2018). Multiple neutrophils tracking in vitro array using high-order temporal information. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2018-July, pp. 814-817. doi: 10.1109/EMBC.2018.8512342

  • Soroush, F., Tang, Y., Sun, S., Langston, J., Kilpatrick, L.E., & Kiani, M.F. (2018). NEUTROPHIL-ENDOTHELIAL INTERACTIONS IN MICE DO NOT ALWAYS PREDICT THEIR INTERACTIONS IN HUMANS. SHOCK, 49(6), pp. 55-56. Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Soroush, F., Liverani, E., Sun, S., Langston, J.C., Kilpatrick, L.E., & Kiani, M.F. (2018). PROTEIN KINASE C-DELTA INHIBITION PROTECTS THE BRAIN FROM SEPSIS-INDUCED VASCULAR DAMAGE. SHOCK, 49(6), pp. 28-28. Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Soroush, F., Sheffield, J.B., Wang, B., Prabhakarpandian, B., & Kiani, M.F. (2017). A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems. Scientific Reports, 7(1). doi: 10.1038/s41598-017-09815-9

  • Zheng, X., Soroush, F., Long, J., Hall, E.T., Adishesha, P.K., Bhattacharya, S., Kiani, M.F., & Bhalla, V. (2017). Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. PLoS ONE, 12(9). doi: 10.1371/journal.pone.0185250

  • Tehrani, R., Helferty, J.J., Kiani, M.F., Suh, W.H., & Bellas, E. (2017). A project based approach to introduction to engineering. 2017 FYEE Conference.

  • Luca, R.D.e., Silvani, G., Scognamiglio, C., Sinibaldi, G., Peruzzi, G., Chinappi, M., Kiani, M.F., & Casciola, C.M. (2017). Towards cavitation-enhanced permeability in blood vessel on a chip. AIP Conference Proceedings, 1873. doi: 10.1063/1.4997139

  • Kiani, M.F., Soroush, F., Tang, Y., Prabhakarpandian, B., & Kilpatrick, L.E. (2017). MODELING PKC-DELTA REGULATION OF NEUTROPHIL-ENDOTHELIAL INTERACTIONS WITH A NOVEL MICROFLUIDICS DEVICE. SHOCK, 47(6), pp. 29-29. Retrieved from http://gateway.webofknowledge.com/

  • Kiani, M.F., Tang, Y., Soroush, F., Prabhakarpandian, B., & Kilpatrick, L.E. (2017). MICROVASCULAR NETWORK ON A CHIP. SHOCK, 47(6), pp. 25-25. Retrieved from http://gateway.webofknowledge.com/

  • Cheheltani, R., Pichamuthu, J.E., Rao, J., Weinbaum, J.S., Kiani, M.F., Vorp, D.A., & Pleshko, N. (2017). Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients. Cardiovascular Engineering and Technology, 8(1), pp. 70-80. doi: 10.1007/s13239-016-0289-3

  • Tang, Y., Soroush, F., Tong, Z., Kiani, M.F., & Wang, B. (2017). Targeted multidrug delivery system to overcome chemoresistance in breast cancer. International Journal of Nanomedicine, 12, pp. 671-681. doi: 10.2147/IJN.S124770

  • Soroush, F., Zhang, T., King, D.J., Tang, Y., Deosarkar, S., Prabhakarpandian, B., Kilpatrick, L.E., & Kiani, M.F. (2016). A novel microfluidic assay reveals a key role for protein kinase C d in regulating human neutrophil-endothelium interaction. Journal of Leukocyte Biology, 100(5), pp. 1027-1035. doi: 10.1189/jlb.3MA0216-087R

  • Tang, Y., Wang, Y., Kiani, M.F., & Wang, B. (2016). Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer. Clinical Breast Cancer, 16(5), pp. 335-343. doi: 10.1016/j.clbc.2016.05.012

  • Tang, Y., Soroush, F., Deosarkar, S., Wang, B., Prabhakarpandian, B., & Kiani, M. (2016). A physiological model of the tumor microenvironment for screening drug delivery systems. CANCER RESEARCH, 76. doi: 10.1158/1538-7445.AM2016-3382

  • Soroush, F., Tang, Y., Deosarkar, S., Pandian, P., Kilpatrick, L.E., & Kiani, M.F. (2016). THE ROLE OF PKC delta IN HUMAN NEUTROPHIL-ENDOTHELIAL INTERACTIONS DURING ACUTE INFLAMMATION. SHOCK, 45(6), pp. 62-62. Retrieved from http://gateway.webofknowledge.com/

  • Tang, Y., Soroush, F., Deosarkar, S., Wang, B., Pandian, P., & Kiani, M.F. (2016). A Novel Synthetic Tumor Platform for Screening Drug Delivery systems. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/

  • Deosarkar, S.P., Prabhakarpandian, B., Wang, B., Sheffield, J., Krynska, B., & Kiani, M. (2016). A Novel Neonatal Blood-Brain Barrier on a Chip Closely Approximates the In Vivo Microenvironment. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/

  • Soroush, F., Tang, Y., Pandian, P., Kilpatrick, L.E., & Kiani, M.F. (2016). A Novel Bioinspired Microfluidic Assay for Investigation of the Role of Protein Kinase C-delta (PKC delta) in Human Neutrophil-Endothelium Interaction During Acute Inflammation. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/

  • Zheng, X., Soroush, F., Hall, E., Adishesha, P., Bhattacharya, S., Kiani, M., & Bhalla, V. (2016). Dynamic Regulation of Endothelial Cell-Specific Molecule 1 in Diabetic Mouse Kidney. FASEB JOURNAL, 30. Retrieved from http://gateway.webofknowledge.com/