Temple Times Online Edition
    SEPTEMBER 8, 2005
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Bioanalysis center supports drug research at Temple

Pharmacokineticist James Gallo (left) and Ping Guo, associate director of the Bioanalytical and Pharmacokinetic Facility, observe the School of Pharmacy’s new tandem mass spectrometer. Gallo directs the bioanalytical and pharmacokinetic center, which enables researchers to conduct analyses on how the body absorbs, distributes, metabolizes and eliminates various drugs. 

Scientists at Temple and beyond can now turn to the School of Pharmacy for a crucial step in the drug development process.

The school’s new bioanalysis and pharmacokinetics facility, outfitted with a new tandem mass spectrometer and directed by renowned pharmacokineticist James Gallo, further strengthens the University’s growing research infrastructure.

Early on the path to discovery of a new drug, researchers must conduct a pharmacokinetic analysis to determine how the body absorbs, distributes, metabolizes and eliminates the drug.

The findings reveal important data about the optimal dose of a drug: how much, how often and when.

“Each drug follows a unique path to perform its action,” Gallo explained. “Pharmacokinetics, a major part of the drug development process, reveals the course that a drug takes over time by measuring its presence in human fluids.

“We need to understand this path to be able to design the safest, most effective drug dosages.”
School of Pharmacy faculty member Ellen Walker recently requested an analysis of morphine in brain tissue for her research on drug addiction. The team at the facility worked with her to design the most appropriate analysis methods and then conducted the analysis using the mass spectrometer, a sophisticated, precise tool used to measure exceedingly small amounts of drugs. In Walker’s case, this information served as crucial preliminary supporting information for a major National Institutes of Health grant submission.

Together with a Good Manufacturing Practices facility, which will produce tablets and capsules for drug research, the facility is expected to bring in new revenue for the school.

The new facility also is a boon for pharmacy students, enabling more opportunities for research and graduate fellowships. And with Gallo’s expertise, the school is now able to offer students a concentration in pharmacokinetics.

According to Ken Soprano, vice president of research and graduate studies, “This facility is an important resource to support our life science researchers. Our goal is to provide a stimulating, supportive environment where research can thrive and grow and where investigators can be successful researchers at all stages of their careers.”

For more information, contact Gallo at 215-707-9699.

- By Eryn Jelesiewicz