The Signal Transduction Lab

Welcome to the Signal Transduction Lab!

Welcome to the STL homepage, and thank you for taking your time to learn about us. The Signal Transduction Laboratory (STL) is involved in defining the molecular mechanisms of the G protein mediated signal transduction pathways. The Laboratory focuses on the two different aspects of G-protein signaling: The first one focuses on defining the molecular components involved in G-protein signaling while the second one focuses on utilizing such knowledge to develop a diagnostic biosensor.

Having a central role in signal transduction, a defective G-protein signaling program has been implicated in several pathological conditions. It has been well documented that an error in the expression or regulation of a G-protein program can cause aberrant cell growth and oncogenesis. As the precise mechanism by which these mutant G-proteins disrupt normal cell growth is not fully understood, our efforts are focused on identifying the mechanisms underlying the oncogenic pathways activated by these G-proteins.

Other major area of research in the laboratory is to develop a sensitive diagnostic biosensor for different chemical and biological molecules of interest, using the G-protein coupled olfactory receptor system.

The Laboratory consists of faculty, postdoctoral fellows and graduate students from different programs within the Temple University College of Medicine. The mission of the Laboratory is to create an interdisciplinary research program in which young scientists can be trained towards identifying newer therapeutic targets for different diseases - including cancer- and to develop better diagnostic tools.

The Team	Research
Our laboratory has immensely benefited from a wonderful set of scientists and graduate students who have through the years been a huge inspiration behind the work that is being done here.  Please check our STL Team Page for further details on our team members. More..	Signal Transduction                                      as as envisioned by Audre Geras.
Fels Research Day	Our Sponsoring Agencies
Please go to the Fels Day page to see schedule, program of events and online abstract submissions.	STL is proud to acknowledge the support and and encouragement received from two                  leading research agencies. DARPA National Institute of Health Our Collaborators Atto Biosciences