Publications

Peer-Reviewed Manuscripts
(* denotes graduate student, · denotes undergraduate student)

Lewis, M.C.* and T. J. Gould (2007) Reversible inactivation of the entorhinal cortex
disrupts the establishment and expression of latent inhibition of cued fear conditioning in C57BL/6 mice. Hippocampus, in press.

Phillips, J.M., S. Siegel, A. Shields, F. Patterson, T.J. Gould, A. Strasser, A. Pinto, J.
Audrain-McGovern, M. Rukstalis, K.D. Perkins, J.A. Blendy, C. Lerman (2007) Translating basic science to improve pharmacotherapy for nicotine dependence. Nicotine & Tobacco Research, in press.

Davis, J.A.*, and T. J. Gould (2007) Atomoxetine reverses nicotine withdrawal-associated
deficits in contextual fear conditioning, Neuropsychopharmacology, in press.

Davis, J.A.*, and T. J. Gould (2007) β2 subunit-containing nicotinic receptors mediate the
enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice, Psychopharmacology, 190:343-52.

Gould, T.J. (2006). Nicotine and Hippocampus-Dependent Learning: Implications for Addiction. Molecular Neurobiology, 34:93-107.

Davis, J. A.*, Porter, J.·, and T. J. Gould (2006) Nicotine Enhances Both Foreground and Background Contextual Fear Conditioning. Neuroscience Letters, 394:202-5.

Davis, J.A.* and T.J. Gould (2006) The Effects of DHBE and MLA on Nicotine-Induced Enhancement of Contextual Fear Conditioning in C57BL/6 Mice. Psychopharmacology, 184:345-52.

Davis, J.A.*, J.R. James, S.J. Siegel, and T.J. Gould (2005) Withdrawal from Chronic Nicotine Impairs Contextual Fear Conditioning in C57BL/6 Mice. Journal of Neuroscience, 25:8708-13.

Gould, T.J. and M.C. Lewis* (2005) Co-Antagonism of AMPA and Nicotinic Acetylcholinergic Receptors Disrupt Fear Conditioning and Latent Inhibition of Cued Fear Conditioning. Learning & Memory, 12:389-98.

Gould, T.J. and O. Feiro* (2005) Galantamine Reverse Age-Related Deficits in the Retention of Memories for Cued Fear Conditioning. Behavioural Brain Research, 165:160-71.

Davis, J.A.* and T.J. Gould (2005) Rolipram Attenuates MK-801-Induced Deficits in Latent Inhibition. Behavioral Neuroscience, 119:595-602.

Gould, T.J., M. Rukstalis, and M.C. Lewis* (2005) Atomoxtine and Nicotine Enhance Prepulse Inhibition of Acoustic Startle in C57BL/6 Mice. Neuroscience Letters, 377:85-90.

Feiro, O.* and T.J. Gould (2005) The Interactive Effects of Nicotinic and Muscarinic Cholinergic Receptor Inhibition on Fear Conditioning in Young and Aged C57BL/6 Mice. Pharmacology, Biochemistry, and Behavior, 80:251-62.

Lewis, M.C.*, J.A. Davis*, and T.J. Gould (2004) Inhibition of the Mitogen-Activated Protein Kinase/Extracellular Signal Related Kinase (ERK) Disrupts Latent Inhibition of Cued Fear Conditioning.  Behavioral Neuroscience, 118:1444-9.

Cartford, M.C., T.J. Gould, and P.C. Bickford (2004) A Central Role for Norepinephrine in the Modulation of Cerebellar Learning Tasks. Behavioral and Cognitive Neuroscience Reviews, 3:131-8.

Lewis, M.C.* and T.J. Gould (2004) Latent Inhibition of Cued Fear Conditioning: An NMDA Receptor Dependent Process that can be Established in the Presence of Anisomycin. European Journal of Neuroscience, 20: 818-826.

Gould, T.J., O. Feiro*, and D. Moore· (2004) Nicotine Enhances Trace Cued Fear Conditioning but Not Delay Cued Fear Conditioning in C57BL/6 Mice.  Behavioural Brain Research, 155: 167-173.

Gould, T.J., S.P. Bizily, J. Tokarczyk, M.P. Kelly, S.J. Siegel, S.J. Kanes, and T. Abel (2004) Sensorimotor Gating Deficits in Transgenic Mice Expressing a Constitutively Active Form of Gsa. Neuropsychopharmacology, 29: 494-501.

Gould T.J. (2003) Alcohol Disrupts Fear Conditioning in C57BL/6 Mice. Journal of Psychopharmacology 17:77-81.

Gould T.J. and J.S. Higgins· (2003) Nicotine Enhances Contextual Fear Conditioning in C57BL/6J Mice at 1 and 7 Days Post-Training. Neurobiology of Learning & Memory, 80:147-157.

Gould T.J. and J.A. Lommock· (2003) Nicotine Enhances Contextual Fear Conditioning and Ameliorates Ethanol-Induced Deficits in Contextual Fear Conditioning. Behavioral Neuroscience, 117: 1276-1282

Gould T.J. (2003) Nicotine produces a within subject enhancement of contextual fear conditioning in C57BL/6 mice independent of sex. Integrative Physiological & Behavioral Science, 38:124-132.

Lewis, M.C.* and T.J. Gould (2003) Nicotine and Ethanol Enhancement of Acoustic Startle Reflex Are Mediated in Part by Dopamine in C57BL/6J Mice.  Pharmacology, Biochemistry & Behavior, 76:179-186.

Woodruff-Pak, D.S. and T.J. Gould (2002) Neuronal Nicotinic Acetylcholine Receptors: Involvement in Alzheimer’s Disease and Schizophrenia. Behavioral and Cognitive Neuroscience Reviews, 1:5-20.

Gould T.J., M.M. McCarthy, and R.A. Keith (2002) MK801 Disrupts Acquisition of Contextual Fear Conditioning But Enhances Memory Consolidation of Cued Fear Conditioning. Behavioural Pharmacology, 13:287-294.

Gould T.J., W.B. Rowe, K.L. Heman, M.H. Mesches, D.A. Young, G.M. Rose and P.C. Bickford (2002) Effects of Hippocampal Lesions on Patterned Motor Learning in the Rat. Brain Research Bulletin, 58:581-586.

Vogel, R.W., M. Ewers, C. Ross, T.J. Gould, and D.S. Woodruff-Pak (2002) Age-related Impairment in the 250 Millisecond Delay Eyeblink Classical Conditioning Procedure in C57BL/6 Mice.  Learning & Memory, 9:321-336.

Gould T.J., A.C. Collins, and J.M. Wehner (2001) Nicotine Enhances Latent Inhibition and Ameliorates Ethanol-Induced Deficits in Latent Inhibition. Nicotine & Tobacco Research, 3:17-24.

Tarantino, L.M., T.J. Gould, J.P. Druhan, and M. Bucan (2000)  Behavior and Mutagenesis Screens: The Importance of Baseline Analysis of Inbred Strains. Mammalian Genome, 11:555-564.

Bickford, P.C., T. Gould, L. Briederick, K. Chadman., A. Pollock, D. Young, B Shukitt-Hale, and J.Joseph (2000) Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Research, 866:211-217.

Gould T.J., R.A. Keith, and R.V. Baht (2000) Differential Sensitivity to Lithium’s Reversal of Amphetamine-Induced Open-Field Activity in Two Inbred Strains of Mice. Behavioural Brain Research, 118:95-105.

Gould T.J. and J.M. Wehner (1999) Nicotine Enhancement of Contextual Fear Conditioning is Specific for the Contextual Association but not the CS-US Association. Behavioral Brain Research, 102: 31-39.

Gould, T.J. (1999) A Review of Age-Related Changes in Cerebellar b-adrenergic Function and Associated Motor Learning. AGE,  22:19-25.

Gould T.J. and J.M. Wehner (1999) Genetic Influences on Latent Inhibition. Behavioral Neuroscience, 113:1291-1296.

Gould T.J. (1998) b-adrenergic involvement in acquisition versus extinction of a classically conditioned eye blink response in rabbits. Brain Research, 780:174-177.

Gould T.J., K. Chadman, and P.C. Bickford (1998) Antioxidant protection of cerebellar b-adrenergic receptor function in Aged F344 rats. Neuroscience Letters, 250:165-168.

Gould, T.J., C.E. Adams, and P.C. Bickford (1997) b-Adrenergic modulation of GABAergic inhibition and tyrosine hydroxylase-labeled cells in the deep cerebellar nuclei of F344 rats. Neuropharmacology, 36:75-81.

Gould T.J. and P.C. Bickford (1997) Aged-related deficits in cerebellar b-adrenergic signal transduction cascade in F344 rats. Journal of Pharmacology and Experimental Therapeutics, 281:965-971.

Gould, T.J. and J.E. Steinmetz (1996) Changes in rabbit cerebellar cortical and interpositus nucleus activity during acquisition, extinction and backward classical eyelid conditioning. Neurobio of Learning & Memory, 65:17-34.

Heron, C., T.J. Gould, and P.C. Bickford (1996) Acquisition of a novel locomotor task is impaired by a beta adrenergic antagonist in F344 rats. Behavioural Brain Research, 78:235-241.

Gould, T.J., I. Strömberg, and P.C. Bickford (1996) Decline in striatal dopamine D1 and D2 receptor activation in aged F344 rats. Neurobiology of Aging, 17:877-883.

Gould, T.J. and P.C. Bickford (1996) The effects of aging on cerebellar b-adrenergic receptor activation and motor learning in female F344 rats. Neuroscience Letters 216:53-56.

Gould, T.J., K.E. Bowenkamp, G. Larson, N.R. Zahniser, and P.C. Bickford (1995) Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats. Brain Research, 684:150-158.

Gould, T.J. and J.E. Steinmetz (1994) Multiple unit activity from rabbit cerebellar cortex and interpositus nucleus during classical discrimination/reversal eyelid conditioning.Brain Research, 652:98-106.

Gould, T.J. and P.C. Bickford (1994) The effects of chronic treatment with N-tert-butyl-a-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats. Brain Research, 660:333-336.

Gould, T.J., L.L. Sears, and J.E. Steinmetz (1993) Possible CS and US pathways for rabbit classical eyelid conditioning: electrophysiological evidence for projections from the pontine nuclei and inferior olive to cerebellar cortex and nuclei. Behavioral and Neural Biology, 60:172-185.

Gould, T.J. and J.E. Steinmetz (1991) Haloperidol impairs classical nictitating membrane conditioning in rabbits when stimulation of the pontine nucleus is used as a conditioned stimulus. Life Sciences, 49:233-240.

 

Manuscripts Submitted

Portugal, G.*, Kenny, J.*, and T. J. Gould (2006) b2 subunit-containing nicotinic acetylcholinergic receptors mediate nicotine withdrawal-associated deficits in acquisition of contextual fear conditioning.

Raybuck, J.* and T.J. Gould (2006) ERK 1&2 inhibition blocks the enhancement of contextual fear conditioning by nicotine.

Lewis, M.C.* and T.J. Gould (2006) Signal Transduction Mechanisms Within the
Entorhinal Cortex that Support Latent Inhibition of Cued Fear Conditioning.

Gulick, D.* and T.J. Gould (2006) Acute Ethanol has Biphasic Effects on Short- and
Long-Term Memory in Both Foreground and Background Contextual Fear Conditioning in C57BL/6 Mice.

 

Manuscripts in Preparation

Andre, J.*, Gulick, D.*, Portugal, G.* and T.J. Gould (2006) Nicotine withdrawal disrupts foreground and background contextual fear conditioning but not PPI in C57Bl/6 mice.

Davis, J.A.*, Kenny, J.*, and T. J. Gould (2006) Nicotine enhancement of contextual fear conditioning is mediated by high affinity nicotinic acetylcholingergic receptors in the hippocampus.

Portugal, G.*, and T. J. Gould (2006) Bupropion reverses nicotine withdrawal-associated deficits in contextual fear conditioning.

Other Manuscripts

Gould, T.J., L.L. Sears and J.E. Steinmetz (1992) Techniques used for neural recording from awake, behaving or anesthetized animals: part 2.  Kopf Carrier, 30:1-5.

Gould, T.J., L.L. Sears and J.E. Steinmetz (1991) Techniques used for neural recording from awake, behaving or anesthetized animals: part 1.  Kopf Carrier, 29:1-5.

 

MONOGRAPH and HANDBOOK CHAPTERS

 

Lerman, C., K. Perkins, and T. Gould (Submitted) Nicotine Dependence Endophenotypes
in Chronic Smokers. NCI/NIH Tobacco Control Monograph

Rogers, S.K, T. Gould, and T.B. Bake (Submitted) Mouse Models and the Genetics of
Nicotine Addiction. NCI/NIH Tobacco Control Monograph

Gould, T.J. and S.F. Logue (Submitted) Latent Inhibition. The Handbook of Behavioral
Genetics of the Mouse. Vol. 1. Genetics of Behavioral Phenotypes. Eds. Wim E. Crusio, Frans Sluyter, and Robert T. Gerlai, Cambridge University Press, Cambridge, England.

Logue, S.F. and T.J. Gould (Submitted) Executive Function. The Handbook of
Behavioral Genetics of the Mouse. Vol. 1. Genetics of Behavioral Phenotypes. Eds. Wim E. Crusio, Frans Sluyter, and Robert T. Gerlai, Cambridge University Press, Cambridge, England.

BOOKS

Gould, T.J. (contributing author) (1995) Research Ethics. editor, R.L. Penslar, Indiana
Press Bloomington, IN.

 

PUBLISHED ABSTRACTS From Presentations at Scientific Meetings
(* denotes graduate student, · denotes undergraduate student)

Davis, J. A.* and T. J. Gould (2006) Hippocampal involvement in the effects of acute, chronic, and withdrawal from chronic nicotine administration on contextual fear conditioning. Soc Neurosci Abstr 481.21.

Andre, J.M.* and T. J. Gould (2006) Nicotine reverses MK-801 induced deficits in contextual fear conditioning. Soc Neurosci Abstr 481.23.

Portugal, G.S.*, J.W. Kenney* and T. J. Gould (2006) Nicotine withdrawal deficits in contextual fear conditioning require the a4b2 nicotinic acetylcholine receptor subunit. Soc Neurosci Abstr 481.22.

Kenney, J.W.*, J.A. Davis,* and T. J. Gould (2006) a4b2 neuronal nicotinic acetylcholine receptors in the dorsal hippocampus mediate the enhancement of contextual conditioning in C57BL/6 mice by nicotine. Soc Neurosci Abstr 481.20.

Porter, J.·, J.A. Davis,* and T. J. Gould (2005) Nicotine enhances contextual fear conditioning in C57BL/6 mice regardless of whether the context is a foreground or background stimulus. Soc Neurosci Abstr 885.5.

Raybuck, J.*, J.A. Davis,* and T. J. Gould (2005) Nicotine increases ERK activation in the hippocampus, a necessary component of the enhancement of contextual fear conditioning by nicotine in C57BL/6J mice. Soc Neurosci Abstr 885.6.

Lewis, M.C.* and T. J. Gould (2005) Signal transduction mechanisms within the entorhinal cortex that support latent inhibition of cued fear conditioning. Soc Neurosci Abstr 651.15.

Gulick, D. *, M.C. Lewis,* and T. J. Gould (2005) Nicotine and atomoxetine enhancement and nicotine withdrawal disruption of prepuluse inhibition of acoustic startle response in C57Bl/6 mice. Soc Neurosci Abstr 651.15.

Davis, J. A.* and T. J. Gould (2005) Atomoxetine reverses nicotine withdrawal-induced impairments in contextual fear conditioning. Soc Neurosci Abstr 651.11.

Gould T.J. and J.A. Davis* (2005) Deficits in prepulse inhibition of the acoustic startle reflex in a7 null mutant mice are rescued by acute nicotine treatment. Soc Neurosci Abstr 651.18

Gould T.J. and J.A. Davis* (2004) a4b2 and a7 Nicotinic Receptors and Fear Conditioning. Soc Neurosci Abstr 206.3.

Davis, J. A.* and T. J. Gould (2004) Acute, chronic, and withdrawal from chronic nicotine differentially affect fear conditioning in C57BL/6 mice. Soc Neurosci Abstr 206.2.

Lewis, M.C.* and T. J. Gould (2004) Entorhinal cortex and mitogen activated protein kinase (MAPK)/extracellular signal related kinase (ERK) involvement in latent inhibition of cued fear conditioning. Soc Neurosci Abstr  206.1.

Lewis, M.C.* and T. J. Gould (2003) Nicotine and ethanol enhancement of acoustic startle reflex is mediated in part by dopamine in C57BL/6J mice.  Soc Neurosci Abstr 89.2.

Gould T.J. and M.C. Lewis* (2003) Latent inhibition of cued fear conditioning is inhibited by co-antagonism of nicotinic & AMPA receptors but is not inhibited by antagonism of either receptor subtype alone.  Soc Neurosci Abstr 721.1.

Rossebo, O.E.* and T. J. Gould (2003) Nicotine enhancement of cued trace fear conditioning but not cued delay fear conditioning in C57BL/6J mice.  Soc Neurosci Abstr 89.1.

Davis, J. A.* and T. J. Gould (2003) Rolipram attenuates the effects of MK-801 on latent inhibition of cued fear conditioning in C57BL/6J mice.  Soc Neurosci Abstr 721.6

Gould T.J. and J.S. Higgins· (2002) Nicotine produces long-lasting enhancement of contextual fear conditioning in C57BL/6 mice.  Soc Neurosci Abstr 185.2.

Lewis, M.C.*, C. Bartocci,· and T. J. Gould (2002) NMDA and protein synthesis involvement in latent inhibition: A non associative learning processes.  Soc Neurosci Abstr 684.4.

Higgins, J.S. · and T.J. Gould (2001) Long lasting enhancement of contextual fear           conditioning in C57BL/6 mice. Integrative Physiological & Behavioral Science 36:317.

Gould T.J. (2001) Hydrogen peroxide decreases nicotine-stimulate 86Rb+ efflux from C57BL/6 mouse thalamic and cortical synaptosomes. Soc Neurosci Abstr 861.3.

Woodruff-Pak, D., R. W. Vogel, and T. J. Gould (2001) Age differences in 250 ms delay eyeblink classical conditioning in C57BL/6J mice. Soc Neurosci Abstr 86.12.

Gould T.J. and T. Abel (2000) Transgenic mice that overexpress a constitutively active form of Gsa have disrupted prepulse inhibition. Soc Neurosci Abstr 25: 10790.

Bickford, P.C., T.J. Gould and G. Rose (2000) Hippocampal lesions in F344 rats disrupt retention but not acquisition of a motor learning task. Soc Neurosci Abstr 25: 2851.

Gould T.J., A.C. Collins and J.M. Wehner (1999)  Nicotine prevents ethanol associated deficits in contextual fear conditioning and latent inhibition in C57BL/6 mice. Soc Neurosci Abstr 25:2153.

Gould T.J., A.C. Collins and J.M. Wehner (1998)  Nicotine facilitates contextual fear conditioning and latent inhibition in C57BL/6 mice. Soc Neurosci Abstr 24:183.

Bickford, P.C., B. Shukitt-Hale, T.J. Gould, L. Breidrick, N. Denisova, D. Bielinski and J.A. Joseph (1998) Reversal of age-related declines in CNS neurotransmission with diets supplemented with fruit or vegetable extracts. Soc Neurosci Abstr 24:2157.

Gould T.J. and P.C. Bickford (1997)  Noradrenergic involvement in acquisition and extinction of rabbit classically conditioned eye blink response. Soc Neurosci Abstr 23:1313.

Holmes, D., T.J. Gould, C. Beehler, J. Repine and P.C. Bickford (1997)  Protection from hyperoxia and age-related deficits in cerebellar b-adrenergic function in a breed of hyperoxia resistant rats. Soc Neurosci Abstr 23:350.

Gould T.J., C.E. Adams and P.C. Bickford (1996)  Localization of b-adrenergic receptor responses and tyrosine hydroxylase positive fibers in the deep cerebellar nuclei of F344 rats.  Soc Neurosci Abstr 22:602.

Gould T.J. and P.C. Bickford (1995)  Localization of age-related b-adrenergic signal transduction deficits in cerebellar Purkinje cells from F344 rats.  Age 18:187.

Gould T.J. and P.C. Bickford (1995)  Aged-related deficits in b-adrenergic signal transduction mechanisms of cerebellar Purkinje cells from F344 rats.  Soc Neurosci Abstr 21:473.

Eckles, K.E., E.M. Dudek, T.J. Gould, P.C. Bickford and M.D. Browning (1995)  Aged animals have a deficit in phorbol ester stimulation of synapsin phosphorylation.  Soc Neurosci Abstr 21:473.

Gould T.J. and P.C. Bickford (1994)  Aged diet restricted F344 rats show better cerebellar noradrenergic receptor function than age-matched ad lib fed rats.  Soc Neurosci Abstr 20:390.

Gould T.J. and J.E. Steinmetz (1993)  Changes in conditioning-related neuronal activity in rabbit lobule HVI of cerebellar cortex and interpositus nucleus during discrimination and reversal conditioning.  Soc Neurosci Abstr 19:1006.

Gould T.J. and J.E. Steinmetz (1992)  Changes in conditioning-related neuronal activity in rabbit lobule HVI of cerebellar cortex during backward, forward, and unpaired conditioning.  Soc Neurosci Abstr 18:337.

Gould, T.J., D.P. Miller and J.E. Steinmetz (1991)  Differences in acquisition and extinction of conditioning-related neuronal activity in rabbit cerebellar cortex and interpositus nucleus.  Soc Neurosci Abstr 17:323.

Gould, T.J., L.L. Sears and J.E. Steinmetz (1990)  Rabbit cerebellar activity evoked by pontine nuclei or inferior olive stimulation--potential regions of CS-US convergence during eyelid conditioning.  Soc Neurosci Abstr 16:763.

Gould, T.J. and R.E. Kettner (1989)  A movement-sequence delay task for the study of motor control activity during arm reaching in 3D space.  Soc Neurosci Abstr 15:788.

Kettner, R.E. and T.J. Gould (1989)  A neural model of motor cortical responses during arm reaching in 3D space.  Soc Neurosci Abstr 15:788.