Moulder Center for Drug Discovery Research (MCDDR)
Biology Capabilities
In vivo :
- Stereotaxic surgery (allows precise micro injection and sampling in brain regions)
- Micro dissection
- Microanalysis
- Seizure activity (vertebrates and invertebrates)
- Behavioral assessment
- Locomotor activity and behavioral sensitization (for abuse potential)
- Conditioned place preference (for abuse potential)
- Analgesia and tolerance
- Anxiety
- Depression
- Thermoregulation
Ex vivo :
- Radio ligand
- Homogenate binding
- Autoradiography
- Rubidium efflux
- Neurotransmitter release
- Receptor profiling
- Drug affinities
- Functional responses
- Subunit composition
- Quantification and distribution
- Protein and neuron characterization
- Western blotting
- Immunohistochemistry
- HPLC
- Synaptosomal preparations
Other Specialized Capabilities : - Pharmacogenomic Analysis of SNP's
- Copy Number Variations
- Cell-based assays such as cytotoxicity, apoptosis, caspase activation, cell viability
- In-vitro metabolism
- Pre-clinical PK
