Scientific publications of Dr. Marc A. Ilies
A. Articles in peer-reviewed scientific periodicals
34. M.A. Ilies, W.A. Seitz, B.H. Johnson, E.L. Ezell, A.L.
Miller, E.B. Thompson, A.T. Balaban, “Lipophilic Pyrylium
Salts in the Synthesis of Efficient Pyridinium-Based
Cationic Lipids, Gemini Surfactants, and Lipophilic
Oligomers for Gene Delivery”, J. Med. Chem., 49, 3872-3887
(2006).
33. V. Percec, M. Peterca, M.J. Sienkowska, M.A. Ilies, E.
Aqad, J. Smidrkal, P.A. Heiney, “Synthesis and
Retrostructural Analysis of Libraries of AB3 and
Constitutional Isomeric AB2 Phenylpropyl Ether-Based
Supramolecular Dendrimers”, J. Am. Chem. Soc., 128,
3324-3334 (2006).
32. M.A. Ilies, B.H. Johnson, F. Makori, A. Miller, W.A.
Seitz, E.B. Thompson, A.T. Balaban, “Pyridinium cationic
lipids in gene delivery: An in vitro and in vivo comparison
of transfection efficiency versus a tetraalkylammonium
congener”, Arch. Biochem. Biophys., 435, 217-226 (2005).
31. M.A. Ilies, W.A. Seitz, I. Ghiviriga, B.H. Johnson, A.
Miller, E.B. Thompson, A.T. Balaban, “Pyridinium cationic
lipids in gene delivery: a structure-activity correlation
study”, J. Med. Chem., 47, 3744-3754 (2004).
30. M.A. Ilies, B. Masereel, S. Rolin, A. Scozzafava, G.
Cāmpeanu, V. Cīmpeanu, C.T. Supuran, “Carbonic anhydrase
inhibitors: Aromatic and heterocyclic sulfonamides
incorporating adamantyl moieties with strong anticonvulsant
activity”, Bioorg. Med. Chem., 12, 2717-2726 (2004).
29. M.A. Ilies, W.A. Seitz, M.T. Caproiu, M. Wentz, R.E.
Garfield and A.T. Balaban, “Pyridinium-Based Cationic Lipids
as Gene Transfer Agents”, Eur. J. Org. Chem., 14, 2645-2655
(2003).
28. [M.A. Ilies] “Novel tripeptide inhibitors of hepatitis C
virus NS3 serine protease. Bristol-Myers Squibb Co.:
WO02060926”, Expert Opin. Ther. Patents, 13 (2), 267-272
(2003) – patent evaluation.
27. M.A. Ilies, D. Vullo, J. Pastorek, A. Scozzafava, M.
Ilies, M.T. Caproiu, S. Pastorekova and C.T. Supuran,
“Carbonic anhydrase inhibitors. Inhibition of
tumor-associated isozyme IX by halogenosulfanilamide and
halogeno-aminobenzolamide derivatives”, J. Med. Chem., 46,
2187-2196 (2003).
26. M. Ilies, M.D. Banciu, A. Scozzafava, M.A. Ilies, M.T.
Caproiu, and C.T. Supuran, “Protease inhibitors: Synthesis
of bacterial collagenase and matrix metalloproteinase
inhibitors incorporating arylsulfonylureido and
5-dibenzo-suberenyl/suberyl moieties”, Bioorg. Med. Chem.,
11, 2227-2239 (2003).
25. M.A. Ilies, W.A. Seitz and A.T. Balaban, “Cationic
lipids in gene delivery: principles, vector design and
therapeutical applications”, Curr. Pharm. Des., 8 (27),
2441-2473 (2002).
24. M.A. Ilies, A. Scozzafava and C.T. Supuran, “Therapeutic
applications of serine protease inhibitors”, Expert Opin.
Ther. Patents, 12 (8), 1181-1214 (2002).
23. M. Ilies, M.D. Banciu, M.A. Ilies, A. Scozzafava, M.T.
Caproiu and C.T. Supuran, “Carbonic anhydrase activators:
Design of high affinity isozymes I, II and IV activators,
incorporating tri-/tetrasubstituted-pyridinium-azole
moieties”, J. Med. Chem., 45 (2), 504-510 (2002).
22. M.A. Ilies and A.T. Balaban, “Recent developments in
cationic lipid-mediated gene delivery and gene therapy”,
Expert Opin. Ther. Patents, 11 (11), 1729-1752 (2001);
21. [M.A. Ilies], "Novel N-substituted-2-cyanopyrrolidines
as potent inhibitors of dipeptidyl peptidase IV in the
treatment of non-insulin-dependent diabetes mellitus",
Expert Opin. Ther. Patents, 10(12), 1937-1942 (2000);
20. A. Casini, A. Scozzafava, F. Mincione, L. Menabuoni,
M.A. Ilies, C.T. Supuran, "Carbonic Anhydrase Inhibitors:
Water-Soluble 4-Sulfamoylphenylthioureas as Topical
Intraocular Pressure-Lowering Agents with Long-Lasting
Effects", J. Med. Chem., 43 (25), 4884-4892 (2000);
19. A. Casini, F. Mincione, M.A. Ilies, L. Menabuoni, A.
Scozzafava, C.T. Supuran, "Carbonic anhydrase inhibitors:
Synthesis and inhibition against isozymes I, II and IV of
topically acting antiglaucoma sulfonamides incorporating
cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties", J.
Enzyme Inhib., 16 (2), 113-123 (2001);
18. C.T. Supuran, A. Scozzafava, M.A. Ilies, F. Briganti,
"Carbonic anhydrase inhibitors: synthesis of sulfonamides
incorporating
2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties
possessing membrane-impermeability and in vivo selectivity
for the membrane-bound (CA IV) versus the cytosolic (CA I
and CA II) isozymes", J. Enzyme Inhib., 15(4), 381-401
(1999);
17. M.A. Ilies, C.T. Supuran, A. Scozzafava, "Metal
complexes of heterocyclic sulfonamides as potential
pharmacological agent in the treatment of gastric acid
secretion imbalances", Metal Based Drugs, 7 (2), 57-62
(2000);
16. A. Scozzafava, M.A. Ilies, C.T. Supuran, "Carbonic
anhydrase inhibitors. Part 89. Metal complexes of
benzolamide with strong enzyme inhibitory and putative
antiulcer properties", Rev. Roum. Chim., 45 (7-8), 771-778
(2000);
15. A. Scozzafava, M.A. Ilies, G. Manole, C.T. Supuran,
"Protease inhibitors. Part 12. Synthesis of potent matrix
metalloproteinase and bacterial collagenase inhibitors
incorporating sulfonylated N-4-nitrobenzyl--alanine
hydroxamate moieties", Eur. J. Pharm. Sci., 11(1), 69-79
(2000);
14. A. Scozzafava, F. Briganti, M.A. Ilies, C.T. Supuran,
“Carbonic anhydrase inhibitors: Synthesis of
membrane-impermeant low molecular weight sulfonamides
possessing in vivo selectivity for the membrane-bound versus
the cytosolic isozymes”, J. Med. Chem, 43, 292-300 (2000);
13. Gh. Campeanu, M. Pele, M. Cimpeanu, M. Ilies, M.A.
Ilies, “Evaluation of The Activity of Horseradish Peroxidase
and Mushroom Polyphenoloxidase on Some Phenols”, Roum.
Biotech. Lett., 4, 319-326 (1999);
12. I. Fenesan, R. Popescu, A. Scozzafava, V. Crucin, E.
Mateiciuc, R. Bauer, M.A. Ilies, C.T. Supuran, “Carbonic
Anhydrase Inhibitors. Phosphoryl-sulfonamides - A New Class
of High Affinity Inhibitors of Izozymes I and II”, J. Enzyme
Inhib., 15, (3), 297-310 (2000);
11. C.T. Supuran, F. Briganti, A. Scozzafava, M.A. Ilies,
“Protease Inhibitors: Part 4. Synthesis of Weakly Basic
Thrombin Inhibitors Incorporating
Pyridinium-Sulfanilylaminoguanidine Moieties”, J. Enzyme
Inhib., 15, 335-356 (2000);
10. C.T. Supuran, A. Scozzafava, F. Briganti, M.A. Ilies, A.
Jitianu, "Carbonic Anhydrase Inhibitors. Part 55. Metal
Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In
Vitro Inhibition Studies With Carbonic Anhydrase Isozyme I,
II and IV", Metal Based Drugs, 5, 103-114 (1998);
9. M. Ganciu, S. Udrea, M.C. Penache, I. Vata, I.
Iovitz-Popescu, M.A. Ilies, M. Corcimaru, A. Papoiu, B.
Serban, A.T. Balaban, "Corona Discharge Controlled
Aggregation and Segregation of Solid Materials in Liquids
and Associated EHD Phenomena", Rom. J. Phys, 43, 67-77
(1998); partially presented by french TV-channel ARTE on 22
september 1998
(http://www.arte-tv.com/hebdo/archimed/19980922/ftext/sujet3.html);
8. C.T. Supuran, A. Scozzafava, M.A. Ilies, B. Iorga, T.
Cristea, F. Briganti, F. Chiraleu, M.D. Banciu, “Carbonic
Anhydrase Inhibitors. Part 53. Synthesis of
Substituted-Pyridinium Derivatives of Aromatic Sulfonamides:
The First Non-Polymeric Membrane-Impermeable Inhibitors with
Selectivity for Isozyme IV”, Eur. J. Med. Chem., 33, 577-594
(1998);
7. C.T. Supuran, F. Mincione, A. Scozzafava, F. Briganti, G.
Mincione, M.A. Ilies, “Carbonic Anhydrase Inhibitors. Part
52. Metal Complexes of Heterocyclic Sulfonamides: A New
Class of Strong Topical Intraocular Pressure-lowering Agents
With Potential Use as Antiglaucoma Drugs”, Eur. J. Med.
Chem., 33, 247-254 (1998);
6. C.T. Supuran, A. Scozzafava, B.C. Jurca, M.A. Ilies, “
Carbonic Anhydrase Inhibitors. Part 49. Synthesis of
Substituted- Ureido and Thioureido Derivatives of Aromatic/
Heterocyclic Sulfonamides with Increased Affinities for
Isozyme I”, Eur. J. Med. Chem., 33, 83-93 (1998);
5. M.A. Ilies, M.D. Banciu, M. Ilies, F. Chiraleu, F.
Briganti, A. Scozzafava, C.T. Supuran, “Carbonic Anhydrase
Activators. Part 17. Synthesis and activation study of
1-(1,2,4- triazole- (1H)-3- yl)-2,4,6- trisubstituted-
pyridinium salts against isozymes I, II, IV”, Eur. J. Med.
Chem., 32 (11), 911-918 (1997);
4. M. Brezeanu, D. Marinescu, M. Badea, N. Stanica, M.A.
Ilies, C.T. Supuran, “1,3,4- Thiadiazole derivatives. Part
8. Binuclear complexes of Cu (II), Mn (II), Co(II), Ni(II),
and Zn(II) with a Schiff base derived from 5-
amino-1,3,4-thiadiazole-2-sulfonamide”, Rev. Roum. Chim., 42
(9), 727-732 (1997);
3. C.T. Supuran, M.A. Ilies, A. Scozzafava, “Carbonic
anhydrase inhibitors. Part 29. Interaction of isozymes I, II
and IV with benzolamide-like derivatives, possible
precursors of inhibitors with applications in positron
emission tomography imaging”, Eur. J. Med. Chem., 33,
739-751 (1998);
2. A. Jitianu, M.A. Ilies, F. Briganti, A. Scozzafava, C.T.
Supuran “Complexes with biologically active ligands. Part 9.
Metal complexes of 5-benzoylamino and
5-(3-benzoylamino)-1,3,4-thiadiazole-2-sulfonamide as
carbonic anhydrase inhibitors”, Metal Based Drugs, 4(1), 1-8
(1997);
1. A. Jitianu, M.A. Ilies, A. Scozzafava, C.T. Supuran,
“Complexes with biologically active ligands. Part 8.
Synthesis and carbonic anhydrase inhibitory activity of 5-
benzoylamido- and
5-(3-nitrobenzoylamido)-1,3,4-thiadiazole-2-sulfonamide and
their metal complexes”, Main Group Metal Chem, 20, 151-156
(1997);
B. Book chapters
1. M.A. Ilies and M.D. Banciu, “Non-sulfonamide carbonic
anhydrase inhibitors” in “Carbonic Anhydrase, Its Inhibitors
and Activators”, C.T. Supuran, A. Scozzafava, J. Conway
Eds., CRC Press, Boca Raton, 2004, pp. 207-239.
C. Laboratory textbooks
1. G. Campeanu, M. Ilies, M.A. Ilies, and C. Voaides,
“Laboratory works in inorganic chemistry”, Relal Promex Ed.,
Bucharest, 2003, 87 pages (in Romanian).
2. G. Campeanu, M. Ilies, M.A. Ilies, and C. Voaides,
“Experimental Techniques and Laboratory Experiments of
Organic Chemistry”, Relal Promex Ed., Bucharest, 2002, 121
pages (in Romanian).
D. Patents:
1. A. T. Balaban, W.A. Seitz, M.A. Ilies, E.B. Thompson,
R.E. Garfield, B. H. Johnson, A. Miller, M. Wentz,
“Pyridinium cationic lipids as gene transfer agents”, U.S.
Patent 20050196863 A1.
E. International Conferences and Congresses, Invited
Lectures
- Oxford, UK (1995): Vth International Congress On Carbonic
Anhydrases (poster);
- Brasov, Romania (1995): The International Congress on
Nuclear Magnetic Resonance;
- Lille, France (1996): “Journees Francophones des Jeunes
Physico - Chimistes” (poster);
- Brasov, Romania (1997): International Conference on
Imaging NMR Spectrometry;
- Neptun, Romania (1998): “Modern Spectrometric Techniques
in Biophysics”;
- Halkidiki, Greece (1999): First International Conference
of Balkans' National Chemical Societies (poster);
- Calimanesti-Caciulata, Romania (1999): XXVth National
Chemical Conference (with international participation)
(poster);
- Calimanesti-Caciulata, Romania (2000): XXVIth National
Chemical Conference (with international participation) -
(plenary lecture: “Pyridinium Carbonic Anhydrase Inhibitors
with Selectivity Against Membrane-Bound Isozyme CA IV”)
- Florence, Italy (2001): Invited lecture at the University
of Florence, Department of Chemistry – “Selective Carbonic
Anhydrase Inhibitors and Activators”;
- Boston, MA (2001): Drug Discovery Technology 2001 (2
posters);
- Houston, TX (2001): The Welch Conference 2001;
- Galveston, TX (2002): Symposium of Structural Biology
2002;
- Houston, TX (2002): The Keck/GCC 2002 Bioinformatics
Symposium;
- Santa Clara, CA (2002): Biophex/Interphex 2002 (2
posters);
- Houston, TX (2002): The Welch Conference 2002;
- Florence, Italy (2002): Invited lecture at the University
of Florence, Department of Chemistry – “Pyridinium Group - A
Versatile Moiety in Drug Targeting”;
- New Orleans, LA (2003): 225th ACS National Meeting
(lecture in the Division of Medicinal Chemistry
“Heterocyclic Cationic Lipids As Gene Transfer Agents” –
A.T. Balaban, M.A. Ilies, W.A. Seitz, M. Wentz, and R.E.
Garfield);
- Galveston, TX (2003): Symposium of Structural Biology
2003;
- Houston, TX (2003): The Welch Conference 2003;
- Anaheim, CA (2004): 227th ACS National Meeting (lecture in
the Division of Colloid and Surface Chemistry “Lipophilic
pyrylium salts in the synthesis of pyridinium-based cationic
lipids and gemini surfactants for gene transfer”– M.A.
Ilies, W.A. Seitz, B.H. Johnson, A. Miller, E.B. Thompson,
A.T. Balaban); also one poster in the Division of Medicinal
Chemistry
- Galveston, TX (2004): Symposium of Structural Biology
2004; (poster)
- Minneapolis, MN (2004): American Society of Gene Therapy’s
7th Annual Meeting; (poster);
- Philadelphia, PA (2004): 228th ACS National Meeting;
(poster);
- St. Louis, MO (2005): American Society of Gene Therapy’s
8th Annual Meeting; (poster).
- Long Beach, CA (2007): Controlled Release Society National
Meeting; (poster)
- Boston, MA (2007): 234th ACS National Meeting; (lecture in
the Division of Polymer and Material Science and
Engineering). |
