My program is focused on the experimental therapeutics of brain tumors. We utilize a variety of in vitro [cell-based] and in vivo [rodent models] techniques and strategies to devise and optimize new drug treatment strategies. Essentially all studies are built upon pharmacokinetic [PK] and pharmacodynamic [PD] principles with the goals to understand the mechanism underlying drug disposition and dynamics in tumors. We really like to build PK-PD models that characterize the measured data [drug concentrations, protein expression] that will facilitate our understanding of the variables impacting on drug distribution and pharmacological activity, but also to extrapolate our models to clinical settings whereby we can predict the PKs and PDs of drugs in tumors, the target site.

We have a number of projects related to combination chemotherapy, signal transduction, and drug transport across the blood-brain barrier [BBB] and blood-cerebrospinal fluid-barrier [BCSFB]. Check out our recent publications under Biosketch......we're working hard!