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Evgeny Krynetskiy, Ph.D., D.Sc.

Associate Professor, Department of Pharmaceutical Sciences


3307 N. Broad Street

Philadelphia, PA 19140

office Room 538A

phone (215) 707-4257

email evgeny.krynetskiy@temple.edu

Biosketch | Research Interests | Teaching | Recent Publications


Recent Publications


Phadke MS, Krynetskaia NF, Mishra AK, Krynetskiy E. GAPDH depletion induces cell cycle arrest and resistance to antimetabolites in human carcinoma cell lines. J. Pharm. Exp. Therapy (2009) 331: 77-86.


Krynetskiy, E., and Calligaro, I.L. Introducing Pharmacy Students to Pharmacogenomic Analysis. Am. J. Pharm. Education (2009) 73 (4) article 71.


Krynetskaia NF, Phadke MS, Jadhav SH, Krynetskiy EY. Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Molecular Cancer Therapeutics (2009) 8: 864-872.


Samochatova EV, Chupova NV, Rudneva A, Makarova O, Nasedkina TV, Fedorova OE, Glotov AS, Kozhekbaeva Zh, Maiorova OA, Roumyantsev AG, Krynetski EY, Krynetskaia NF, Evans WE, Ribeiro RC. TPMT genetic variations in populations of the Russian Federation. Pediatr Blood Cancer. 2009 52(2):203-8.


Krynetskaia NF, Xie M, Vucetic S., Obradovic Z, Krynetskiy EY. High mobility group protein B1 is an activator of apoptotic response to the chemotherapeutic agents 5-fluorouracil, cytosine arabinoside, and mercaptopurine. Mol. Pharmacology, 73 (1) 260-269 (2008).


Krynetskiy E. and McDonnell P. Building Individualized Medicine: Prevention of Adverse Reactions to Warfarin Therapy. Journal of Pharmacology and Experimental Therapeutics (invited review) 322 (2):427-434 (2007).


Nasedkina TV, Fedorova OE, Glotov AS, Chupova NV, Samochatova EV, Maiorova OA, Zemlyakova VV, Roudneva AE, Chudinov AV, Yurasov RA, Kozhekbaeva JM, Barsky VE, Krynetskiy EY, Krynetskaia NF, Cheng C, Ribeiro RC, Evans WE, Roumyantsev AS, Zasedatelev AS.. Rapid genotyping of common deficient thiopurine S-methyltransferase (TPMT) alleles using the DNA-microchip technique. Eur J Hum Genet. 14: 991-998 (2006).


Brown VM, Krynetski EY, Krynetskaia NF, Grieger D, Mukatira ST, Murti KG, Slaughter CA, Park H-W, Evans WE. A Novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress. J Biol Chem 279(7): 5984-5992, 2004.


Krynetski EY, Evans WE. Drug methylation in cancer therapy: lessons from the TPMT polymorphism. Oncogene 22, 7403-7413, 2003.


Krynetski EY, Krynetskaia NF, Bianchi ME, Evans WE. A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues. Cancer Res 63(1):100-106, 2003.


Somerville L, Krynetski EY, Krynetskaia NF, Beger RD, Zhang W, Marhefka CA, Evans WE, Kriwacki RW.  Structure and dynamics of thioguanine-modified duplex DNA. J Biol Chem 278(2): 1005-1011, 2003.


Krynetskaia NF, Feng JY, Krynetski EY, Garcia JV, Panetta JC, Anderson KS, Evans WE. Deoxythioguanosine triphosphate impairs HIV replication: A new mechanism for an old drug.  FASEB J 15:1902-1908, 2001.


Krynetskaia NF, Cai X, Nitiss JL, Krynetski EY, Relling MV. Thioguanine substitution alters DNA cleavage mediated by topoisomerase II. FASEB J 14:2339-2344, 2000.


Relling MV, Hancock ML, Rivera GK, Sandlund JT, Ribeiro RC, Krynetski EY, Pui CH, Evans WE.  Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst 91:2001-2008, 1999.


Belkov VM, Krynetski EY, Schuetz JD, Yanishevski Y, Masson E, Mathew S, Raimondi S, Pui CH, Relling MV, Evans WE. Reduced folate carrier expression in acute lymphoblastic leukemia: A mechanism for ploidy but not lineage differences in methotrexate accumulation. Blood 93:1643-1650, 1999.


Yates CR, Krynetski EY, Loennechen T, Fessing MY, Tai HL, Pui CH, Relling MV, Evans WE. Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance. Ann Intern Med 126:608-614, 1997.


Tai HL, Krynetski EY, Schuetz EG, Yanishevski Y, Evans WE. Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity. Proc Natl Acad Sci USA 94:6444-6449, 1997.


Krynetski EY, Schuetz JD, Galpin AJ, Pui PH, Relling MV, Evans WE. A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase. Proc Natl Acad Sci USA 92:949-953, 1995.