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Victor P. Ghidu, Ph.D.

Research Scientist

 

3307 N. Broad Street

Philadelphia, PA 19140

office Room 515A

phone (215) 707-6519

email victor.ghidu@temple.edu

Victor Ghidu

Research Focus: Medicinal Chemistry, New Synthetic Methodology, Natural Products


Education and Academic History


  • B.Sc. (1994), M.Sc. (1995), University of Bucharest, Romania
  • Ph.D. (2004), Case Western Reserve University, Cleveland, OH
  • Research Associate (2005-2008), Research Fellow (2008), Vanderbilt University, Nashville, TN
  • Research Fellow (2009-2011), Temple University School of Pharmacy, Philadelphia, PA


Publications (selected)


Ghidu, V. P.; Ilies, M. A.; Cullen, T.; Pollet, R.; Abou-Gharbia, M ."A new and efficient synthetic route for the anxiolytic agent CL285032" Bioorg. Med. Chem. Lett., 2011, 21(1), 259-261.

Thorne, C. A.; Hanson, A. J.; Schneider, J.; Tahinci, E.; Orton, D.; Cselenyi, C. S.; Jernigan, K. K.; Meyers, K. C.; Hang, B. I.; Waterson, A. G.; Kim, K.; Melancon, B.; Ghidu, V. P.; Sulikowski, G. A.; LaFleur, B.; Salic, A.; Lee, L. A.; Miller, D. M.; Lee, E. "Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α" Nat. Chem. Bio., 2010, 6(11), 829-836.

Ghidu, V. P.; Ntai, I.; Wang, J.; Jacobs, A. T.; Marnett, L. J.; Bachmann, B. O.; Sulikowski, G. A. "Combined Chemical and Biosynthetic Route to Access a New Apoptolidin Congener" Org. Lett., 2009, 11 (14), 3032-3034.

Ghidu, V. P.; Wang, J.; Wu, B.; Liu, Q.; Jacobs, A.; Marnett, L. J.; Sulikowski, G. A. "Synthesis and Evaluation of the Cytotoxicity of Apoptolidinones A and D" J. Org. Chem., 2008, 73 (13), 4949-4955.

Pearson, A. J.; Ghidu, V. P. "Iron Tricarbonyl Stabilized Pentadienyl Cation as Initiator for Cascade Polycyclizations: A Diastereoselective Entry into Octahydrophenanthrenes" J. Org. Chem., 2004, 69 (25), 8975-8978.

Presentations (selected)


August 2011, ACS National Meeting, Denver CO, "WY-50295: Improved synthesis of a starting point for Alzheimer's disease drug discovery" (poster presentation)

August 2007, ICCA-X 10th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds, Nashville, TN, "Precursor Directed Biosynthesis of Apoptolidin and Analogues thereof: toward a Biological Probe" (poster presentation)

March 2004, ACS National Meeting, Anaheim CA, "Cationic Cyclization of Iron Tricarbonyl Diene Complexes with Pendant Alkenes and Arenes" (oral presentation)