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Daniel J. Canney, Ph.D., R.Ph.

Associate Professor of Medicinal Chemistry

Director of Graduate Studies

Department of Pharmaceutical Sciences

 

3307 N. Broad Street

Philadelphia, PA 19140

office Room 516

phone (215) 707-6924

email daniel.canney@temple.edu

Biosketch | Teaching | Students/Lab Life | Publications

 

Book Chapters 


  • Canney, D.J.: Chapter 71:  Cholinomimetic Drugs in Remington: The Science and Practice of Pharmacy, 22nd Edition, A.R. Gennaro (ed.), Pharmaceutical Press, London, UK, 2012.

  • Canney, D.J.: Chapter 73:  Antimuscarinic and Antispasmodic Drugs in Remington: The Science and Practice of Pharmacy, 22nd Edition, A.R. Gennaro (ed.), Pharmaceutical Press, London, UK,2012.

  • Canney, D.J.: Chapter 71:  Cholinomimetic Drug in Remington: The Science and Practice of Pharmacy, 21st Edition, A.R. Gennaro (ed.), Lippincott, Williams & Wilkins, Baltimore, MD, 2005.

  • Canney, D.J.: Chapter 73:  Antimuscarinic and Antispasmodic Drugs in Remington: The Science and Practice of Pharmacy, 21st Edition, A.R. Gennaro (ed.), Lippincott, Williams & Wilkins, Baltimore, MD, 2005.

Peer-reviewed journal articles

  1. Nantogmah, S., Desai, S., Bhandare, R., Gabriel, J., Soprano, D., Canney, D.J.  Synthesis and Preliminary Evaluation of Affinity for Retinoic Acid Receptors for Novel Organosilicon-Based retinoids.  Pharmaceutical Chemistry Journal, 2011, in press.

  2. Annadurai, S., Canney, D.J., Lebo, D, Krynetskaia, N., Krynetskiy, E.,  Are glycyrrhizin derivatives specific inhibitors of HMGB1/DNA interactions?  Der Pharmacia Lettre, 2011, in press.

  3. Gao, R., Canney, D.J.  A Versatile and Practical Microwave Assisted Synthesis of Sterically Hindered N-Aryl Piperazines,J. Org. Chem., 2010, 75 (21), pp 7451–7453

  4. Annadurai, S., Krynetskaia, Phadke, M.S., Krynetskiy, E., Canney, D.J.  Inhibition of sequence independent DNA-binding activity of human recombinant HMGB1 protein with natural triperpines.  Der Pharmacia Lettre, 2010, 2(3): 432-443. 

  5. Bhandare, R.R., Canney, D.J.  Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands. Medicinal Chemistry Research, 2010, 20 (5), 558-565

  6. Crismon, M.L., Albright, F.S., Canney, D.J., Das, N,G,, Mehanna, A,S,, Welage, L,S,, Wu-Pong, S., Miller, K.W.  The role of dual-degree programs in colleges and schools of pharmacy: the report of the 2008-09 Research and Graduate Affairs Committee.  Am J Pharm Educ. 2009;73, Suppl:S6.

  7. Gao, R., Canney, D.J.  A modified Prins reaction for the facile synthesis of structurally diverse substituted 5-(2-hydroxyethyl)-3,3-dihydrofurane-2(3H)-ones.  Tetrahedron Lett., 2009, 50;43, 5914-5916. 

  8. Sun, W., Carroll, P.J., Soprano, D., Canney, D.J.Identification of a Chromone-Based Retinoid Containing a Polyolefinic Side Chain via Facile Synthetic Routes.  Bioorg. Med Chem Lett. 2009, 19:15, 4339-42.

  9. Desai, S., Sun, W., Gabriel, J. L., and Canney, D. J.  The Synthesis and Preliminary Evaluation of Substituted Chromones, Coumarins, Chromanones, and Benzophenomones as Retinoic Acid Receptor Ligands.  Heterocyclic Communications, 2008, 14:3, 129-137.

  10. Sun, W., Desai, S., Piao, H., Carroll, P., and Canney, D.J.  Wittig-Horner-Emmons  Reactions of Triethyl-3-methyl-phosphonocrotonate with 3-Formylchromones en Route to Benzophenone-Based Retinoid Candidates.  Heterocycles, 2007, 71:3, 557–567.

  11. Tao, X., Piao, H., Canney, D. J. , Borenstein, M.R., Nnane, I.P.  Biotransformation of Letrazole in Rat Microsomes: Effects of Gender and Tamoxifen.  J. Pharmaceutical and Biomed Analysis,2006, 43, 1078-1085.

  12. Ahungena, A., Canney, D. J.  Synthesis and Evaluation of Homologous Analogs of Anticonvulsant 5-Substituted 3,3-Diethyl-4,5-Dihydro-2(3)-Furanones.  Medicinal Chemistry Research, 2005, 14:7, 404-428. 

  13. Sun, W., Blanton, M. P., Gabriel, J. L., Canney, D. J.  .Bioisosteric Replacement in the Design and Synthesis of Ligands for Nicotinic Acetylcholine Receptors. Medicinal Chemistry Research, 2005, 14:5, 241-259. 

  14. Ahungena, A., Gabriel, J. L., Canney, D. J.  Synthesis and Evaluation of 5-Substituted Derivatives of 4,5 Dihydro-3,3,-Diethyl-2-(3H)-Furanone as Subtype-Selective Muscarinic Leads.  Medicinal Chemistry Research, 2003, 12:9, 481-511.


Abstracts


  1. Sharan, S., Iwuchukwu, O. F., Canney, D.J., Nagar, S.  Pharmacokinetics of resveratrol (t-Res) and its preformed sulfated and glucuronidated metabolites in vivo.  A.A.P.S. National Meeting, Washington DC, 2011.

  2. Bhandare, R., Canney, D.J.,  Investigations into bioisosteric replacements for the 4,5-dihydro-2(3H)-furanone moiety of lead muscarinic acetylcholine receptor ligands.  A.A.P.S. National Meeting, Washington DC, 2011.

  3. Gao, R., Canney, D.J.  Synthesis and preliminary evaluation of substituted N-aryl-piperazine based compounds as muscarinic ligands.  American Chemical Society (ACS) National Meeting, Denver, CO, August, 2011.

  4. Annadurai, S., Martinez, R., Dunman, P., Canney, D.J., Abou-Gharbia, M.  Lead generation using a privileged structure-based approach.  American Chemical Society (ACS) National Meeting, Denver, CO, August, 2011

  5. Argikar, A., Iwuchukwu, O. F., Canney, D.J., Nagar, S.  Evaluating the activity of resveratrol and its conjugated metabolites in a normal, a preneoplastic and a neoplastic cell line.  Research Recognition Day, Temple University School of Pharmacy, Feb, 2011.

  6. Iwuchukwu, O. F., Canney, D.J., Nagar, S.  Contribution of glucuronidation to resveratrol's pharmacologic effects and low systemic bioavailability.  Resveratrol 2010: The 1st international scientific conference of Resveratrol and Health, Elsinore, Denmark, Sept., 13-15, 2010.

  7. Gao, R., Canney, D.J.  Synthesis and evaluation of a homologous series of 3,5-trisubstituted gamma-butyrolactones as potential muscarinic ligands.  American Chemical Society (ACS) National Meeting, Boston, MA, August, 2010

  8. Gao, R., Canney, D.J.  An improved route to a homologous series of 5-substituted gamma-butyrolactones.  American Chemical Society (ACS) National Meeting, Washington D.C., Sept., 2009.

  9. Bhandare, R., Canney, D.J., Five-substituted 3,3 diethyl-4,5-dihydro-2(3H)-furanones as muscarinic receptor ligands,  American Chemical Society (ACS) National Meeting, Washington D.C., Sept., 2009.

  10. Caggiano, J., Canney, D.J.,  The Impact of a PharmD Curriculum on Student Knowledge and Attitudes Regarding Controlled Substances and Substance Abuse.  Journal of the American Pharmacists Association, 49:2, March–April, Abstract 321, p333, 2009.

  11. Bhandare, R., Canney, D.J.,  Development of Benzylpiperazines as Subtype Selective Muscarinic Ligands. American Chemical Society (ACS) National Meeting, Philadelphia, PA, August, 2008

  12. Gao, R, Canney, D.J., Five-substituted 4,5-dihydro-3,3-diethyl-2(3H)-furanones as Muscarinic Ligands:  Synthesis and Preliminary Evaluation, American Chemical Society (ACS) National Meeting, Philadelphia, PA, August, 2008

  13. Annadurai S., Krynetskaia,N., Krynetskiy, E., Canney, D.J. Design, Synthesis and Screening of Novel Inhibitors of HMGB1/DNA Complex Formation.  ACS National Meeting, New Orleans, April, 2008.

  14. Thoma, B., Dragic, M., Appel, D., Canney, D.J., Student pharmacists' awareness and attitudes toward addiction and chemical dependency.  Journal of the American Pharmacists Association, 48: 2, March–April, Abstract 296, p 307, 2008.

  15. Thoma, B., Dragic, M., Appel, D., Canney, D.J., Effectiveness of a substance abuse/chemical dependency roundtable discussion in educating student pharmacists and influencing attitudes. Journal of the American Pharmacists Association, 48:2, March–April, Abstract 294, p 307, 2008.

  16. Iwuchukwu,O., Canney, D.J.., Nagar, S.  Resveratrol Glucuronidation Exhibits Atypical Kinetic Profiles with Different Recombinant UGT1A Isoforms.  American Association of Pharmaceutical Scientists (AAPS), National Meeting, San Diego, November 2007

  17. Iwuchukwu, O., Canney, D.J., Nagar, S.  Contribution of Metabolic Conjugation to Decreased Bioavailabilty of Resveratrol.  GRASP, 27th Annual Meeting, June 2007, Piscataway, N.J., USA.

  18. Desai, S. Sun, W., Carroll, P.J.,  Gabriel, J.L.,  Dianne Soprano, and Canney, D.J.  Wittig reactions and rearrangements leading to benzophenone- and chromone-based ligands for evaluation as potential Retinoids. 233rd ACS National Meeting Exposition, March 25-29, 2007, Chicago, IL, USA