Daniel J. Canney, Ph.D., R.Ph.
Interim Chair, Department of Pharmaceutical Sciences
Associate Professor of Medicinal Chemistry
Director of Graduate Studies
3307 N. Broad Street
Philadelphia, PA 19140
office Room 516
phone (215) 707-6924
After receiving his B.S. degree in Pharmacy, Dr. Canney went on to earn a PhD in Medicinal Chemistry at Temple University. He then accepted a position as a postdoctoral fellow in the Department of Pharmacology and Molecular Biology at Washington University School of Medicine, St. Louis working on the development of novel anticonvulsant agents. He later joined the University of Pennsylvania's Department of Radiology (Section of Radiopharmaceutical Chemistry) as a research assistant professor where he worked on the development of organ and receptor-specific imaging agents for use in SPECT imaging studies (technetium and radioiodinated ligands).
Dr. Canney's current research interests include structure-activity relationship (SAR) studies involving molecules that modulate pharmacologically important protein targets. Examples include novel ligands for muscarinic and nicotinic receptor (see below) subtypes and ligands for retinoic acid receptor (RAR) subtypes (see below).
X-Ray crystal structures of ATRA-ligand
ATRA in the RARy binding pocket
The synthesis and evaluation of drug metabolites is underway also. The development of efficient and versatile synthetic routes to pharmacologically useful building blocks is another interest of the group (see below). Dr. Canney continues to collaborate with scientists in the pharmaceutical industry and in academia in order to further our understanding of the relationship between ligand structure and biological activity. Information pertaining to the specific research areas mentioned above can be found under Publications.
A modified Prins reaction for the facile synthesis of structurally diverse substituted lactones
A Versatile and Practical Microwave Assisted Synthesis of Sterically Hindered N-Aryl Piperazines
Dr. Canney serves on the international Board of Associate Editors of Life Sciences, on the Editorial Advisory Boards of Medicinal Chemistry and Perspectives in Medicinal Chemistry and as a reviewer for journals in the areas of organic synthesis and medicinal chemistry. Additional faculty responsibilities include service as the Director of Graduate Studies, teaching at the professional (Medicinal Chemistry II and III) and graduate levels (Advanced Medicinal Chemistry I and II, Pharmaceutical Analysis) and the direction of graduate students in his lab (M.S. and Ph.D.) In the Pharm.D. program he serves as the Faculty Advisor for the Rho Chi Pharmaceutical Honor Society and the Committee on Addiction and Substance Abuse (C.A.S.A. Rx).