Text Version |Site map | Contact Us | Temple University | FAQs | Search
Prospective Students | Current Students | Faculty/Preceptors | Alumni

 

 

 

 

 

 

 

 

Why Temple School of Pharmacy

Read more...
cGMP Services
cGMP Services
Moulder Center
QA/RA

Faculty & Staff Directory

 

 

 

Benjamin Blass

Assistant Professor of Medicinal Chemistry, Moulder Center

 

3307 N. Broad Street

Philadelphia, PA 19140

office Room 544

phone (215) 707-1085

email benjamin.blass@temple.edu

 

 

Biosketch | Patents and Patent Applications
Publications and Presentations | Invited Lectures

 

 

Publications and Presentations:

 

  1. Development of a novel non-radiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreenÃ’ technology, Cassel, J. A.; Blass, B. E.; Reitz, A. B.; Pawlyk, A. C. J. Biomol. Screen. 2010, in press.
  2. Development of a novel non-radiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology. Pawlyk A.C.; Cassel J.A.; Blass B.E.; Reitz A.B., Society for Neuroscience, San Diego, CA, 2010.
  3. Selective Kv1.5 blockers: Development of KVI-020/WYE-160020 as a potential treatment for atrial arrhythmia, Blass, B. E.; Fensome, A.; Trybulski, E.; Magolda, R.; Gardell, S.; Liu, K.; Samuel, M.; Feingold, I.; Huselton, C.; Jackson, C.; Djandjighian, L.; Ho, D.; Hennan, J.; Janusz, J. J. Med. Chem. 2009, 52, 21, 6531-6534.
  4. Selective Kv1.5 blockers: Development of KVI-020 as a potential treatment for atrial arrhythmia, Blass, B. E.;  Coghlan, R.; Fensome, A.; Steffan, R.; Trybulski, E.; Vera, M.; Vu, A.; Webb, M.; Cross, J; Unwalla,R.; Hennan, J.; Liu, K.; Samuel, M.; Eta, J.; Feingold, I.; Huselton, C.; Kao, J.; Tio, C.; Vlasuk, G.; Morgan, G.; Swillo, R.; Rossman, E. I.; Janusz, J. M.; Jackson, C. M.; Djandjighian, L.; Hedges, R. 238th American Chemical Society National Meeting, Aug. 16-20, 2009.
  5. Kv1.5 inhibitor, WYE-160020, reduces atrial fibrillation/flutter inducibility in post-operative sterile pericarditis and simultaneous atrial/ventricular tachypacing canine models, Rossman, E.I.; Morgan, G.A.; Swillo, R.E.; Liu, K.; Blass, B. E.; Jackson, C. M.; Janusz, J. M.; Fensome, A.; Trybulski, E. J.; Gardell, S. J.; Vlasuk, G. P.; Hennan, J.K., 30th Annual Heart Rhythm Society Meeting, Boston, MA, May 13-16th, 2009.
  6. 1,4-Dihydro-1-(phenylmethyl)-3-pyridinecarboxamide, Blass, B.E. Encyclopedia of Reagents for Organic Synthesis, 2008.
  7. Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias, Jackson, C. M.; Blass, B.; Coburn, K.; Djandjighian, L.; Fadayel, G.; Fluxe, A. J.; Hodson, S. J.; Janusz, J. M.; Murawsky, M.; Ridgeway, J. M.; White, R. E.; Wu, S. Biorg. Med. Chem. Lett. 2007, 17, 1, 282-284.
  8. Synthesis of 1-aminoimidazolidin-4-one and 1-aminoimidazolidin-2-one based compounds: An interesting divergence in methodology, Blass, B. E.; Coburn, K.; Fairweather, N.; Fluxe, A.; Hodson, S.; Jackson, C.; Janusz, J.; Lee, W.; Ridgeway, J.; White, R.; Wu, S. Tetrahedron Lett. 2006, 47, 42, 7497-7499.
  9. Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation, Blass, B. E.; Coburn, K.; Lee, W.; Fairweather, N.; Fluxe, A.; Wu, S.; Janusz, J. M.; Murawsky, M.; Fadayel, G.; Fang, B.; Hare, M.; Ridgeway, J.; White, R.; Jackson, C.; Djandjighian, L.;  Hedges, R.;  Wireko, F. C.; Ritter, A. Biorg. Med. Chem. Lett. 2006, 16, 17, 4629-4632.
  10. Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 inhibitors, Wu, S.; Blass, B. E.; Coburn, K.; Lee, W.; Fairweather, N.; Fluxe, A.; Janusz, J. M.; Murawsky, M.; Fadayel, G.; Fang, B.; Hare, M.; Ridgeway, J.; White, R.; Jackson, C.; Djandjighian, L.;  Hedges, R.;  Wireko, F. C.; Ritter, A. Biorg. Med. Chem. Lett. 2006, 16, 24, 6213-6218.
  11. Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers, Wu, S.; Blass, B. E.; Coburn, K.; Lee, W.; Fairweather, N.; Fluxe, A.; Janusz, J. M.; Murawsky, M.; Fadayel, G.; Fang, B.; Hare, M.; Ridgeway, J.; White, R.; Jackson, C.; Djandjighian, L.;  Hedges, R.;  Wireko, F. C.; Ritter, A. Biorg. Med. Chem. Lett. 2006, 16, 22, 5859-5863.
  12. A facile, KF/Al2O3 mediated method for the preparation of functionalized pyrido[2,3-d]pyrimidin-7(8H)-ones, Blass, B. E.; Coburn, K. R.;Fairweather, N.; Sabat, M.; West, L., Tetrahedron Lett. 2006, 47, 18, 3177-3180.
  13. Solid-phase approach towards the synthesis of functionalized imidazo [1,2-b] pyrazol-2-ones, Blass, B. E.; Srivastava, A.; Coburn, K. R.; Faulkner, A. L.; Janusz, J. J.; Ridgeway, J. M.; Seibel, W. L. Tetrahedron Lett. 2004, 45, 6, 1275-77.
  14. Solution phase synthesis of imidazo [1,2-b] pyrazol-2-one, an interesting 5,5-fused heterocyclic ring system, Blass, B. E.; Srivastava, A.; Coburn, K. R.; Faulkner, A. L.; Janusz, J. J.; Ridgeway, J. M.; Seibel, W. L. Tetrahedron Lett. 2004, 45, 3, 619-621.
  15. A simple method for the preparation and selective functionalization of4,5-diaminopyrazoles, Blass, B.E.; Coburn, K. R.; Faulkner, A. L.; Seibel,W. L.; Srivastava, A. Tetrahedron Lett. 2003, 44, 14, 3009-3011.
  16. Applications of solid supported azide anion: A one-pot, two-step preparation of functionalized 1,2,3-triazoles, Blass, B.E.; Coburn, K. R.: Faulkner, A. L.; Seibel, W. L.; Srivastava, A. Tetrahedron Lett. 2003, 44, 10, 2153-2155.
  17. KF/Al2O3 mediated organic synthesis, Blass, B.E. Tetrahedron, 2002 58, 46, 9301-9320.
  18. Solid phase synthesis of funtionalized 1,2,4-triazin-6-ones, Blass, B. E.; Coburn, K. R., Faulkner, A. L.; Liu, S.; Ogden, A.; Portlock, D .E.; Srivastava, A.; Tetrahedron Lett. 2002, 43, 45, 8165-8167.
  19. Solid phase synthesis of funtionalized 1,2,3-triazoles, Blass, B. E.; Coburn, K. R., Faulkner, A. L.; Hunn, C. L.; Natchus, M. G.; Parker, M.S.;  Portlock, D .E.; Tullis, J. S.; Wood, R. Tetrahedron Lett. 2002, 43, 4059-4061.
  20. A facile, selective KF/ Al2O3 mediated method for the deprotection of aryl silyl ethers and preparation of aryl SEM ethers, Blass, B. E.; Harris, C. L.; Portlock, D. E. Tetrahedron Lett. 2001, 42, 1611-1613.
  21. Development and optimization of a solid phase route to 1-aminohydantoins, Li.M; Wilson, L. J.; Portlock, D. E.; Blass, B. E.; Harris, C.; Russell, A. Abstr. Pap. Am. Chem. Soc. 2000, 220, 233.
  22. Synthesis of a-Boc-hydrazino acid resin esters in the preparation of 1-aminohydantoin libraries, Harris, C. L.; Blass, B. E.; Wilson, L. J.; Li, M.; Chen, J. J.; Rupnik, K. J.; Portlock, D. E.; Burt, T. M. Abstr. Pap. Am. Chem. Soc. 2000, 220, 225.
  23. Parallel synthesis and evaluation of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines as Na+/K+ ATPase inhibitors, Blass, B. E.; Huang, C. T.; Kawamoto, R. M.; Li, M.; Liu, S.; Portlock, D. E.;Rennells, W. M.; Simmons, M. Bioorg. Med. Chem. Lett. 2000, 10, 14,1543-1545.
  24. A facile KF/ Al2O3 mediated, selective alkylation of benzodiazepin 2,5-diones Blass, B.E.; Burt, T.M.; Liu, S.; Portlock, D.E.; Swing, E.M. Tetrahedron Lett. 2000, 41, 2063.
  25. A facile KF/ Al2O3 mediated method for the synthesis of substituted oxazolidinones Blass, B.E.; Drowns, M.; Harris, C.L.; Liu, S.; Portlock, D.E. Tetrahedron Lett. 1999, 40, 6545.
  26. Enantioselective total synthesis of Didesepoxyrhizoxin, Kende, A.S.; Blass, B.E., Henry, J.R. Tetrahedron Lett. 1995, 36, 4741.
  27. A new paradigm for alkene epoxidation: Activation of hydrogen peroxide by organophosphorous electrophiles, Kende, A.S.; Delair, P.; Blass, B.E. Tetrahedron Lett. 1994, 35, 8123.
  28. Studies directed towards the total synthesis of Rhizoxin: Synthesis of the macrolactone core, Blass, B. Ph.D. Thesis, University of Rochester, 1994.
  29. A novel dyatropic rearrangement of a-N,N-dibenzylamino b,g-dehydro-N-formylamino acid esters, Kende, A. S.; Brands, K. M. J.; Blass, B. Tetrahedron Lett., 1993, 34, 579.

Invited lectures:


  1. Patent Law in the Pharmaceutical Industry, Drexel College of Medicine, 2010.
  2. Voltage-gated potassium channels as therapeutic targets, Pennsylvania Biotechnology Center, 2010.
  3. Combinatorial chemistry and the practical chemist's tool box, Villanova University guest lecturer, 2008.