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Sivakumar Annadurai, Ph.D.

Post Doctoral Fellow

 

3307 N. Broad Street

Philadelphia, PA 19140

office Room 537

phone (215) 707-5195

email sannadur@temple.edu

Biosketch

 

Sivakumar Annadurai received his B.S. in Pharmacy from The Tamilnadu Dr.MGR Medical University, Chennai, India in 1998 and M.S. in Pharmaceutical Chemistry from Birla Institute of Technology, Mesra, Ranchi, India in 2000. He worked as a Lecturer in Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Chennai, India for four years. Then he moved to Temple University School of Pharmacy, Philadelphia where he completed his Ph.D in Pharmaceutical Sciences under the guidances of Dr. Daniel Canney and Dr. Magid Abou-Gharbia. His dissertation titled “Lead generation using a privileged structure-based approach” involved the synthesis, characterization and testing of a structurally diverse compound library (60 compounds) based on a privileged structure. Several promising leads displaying a wide range of biological activity (antimicrobial, modulators of muscarinic and serotonin receptors) were identified. During his graduate studies he was also involved in another project involving the development of a capillary electrophoresis mobility shift assay (CEMSA) for screening inhibitors of high mobility group protein Box1 (HMGB1)/double stranded DNA (dsDNA) complex formation. Preliminary assay results indicated that the inhibition of DNA-HMGB1 binding by glycyrrhizin and its derivatives occurs via interaction with micelles/aggregates rather than individual triterpene molecules. He is presently a Postdoctoral Research Fellow in the Moulder Center for Drug Discovery Research at Temple University School of Pharmacy. His present research involves the synthesis and brain pharmacokinetic studies of 5-Lipoxygenase (5-LO) inhibitors. The inhibitors with favorable physicochemical properties will be chosen for the development of PET ligands for imaging 5-LO in the brain.

 

Publications

  • Annadurai, S., Krynetskaia, Phadke, M.S., Krynetskiy, E., Canney, D.J. Inhibition of sequence independent DNA-binding activity of human recombinant HMGB1 protein with natural triperpines. Der Pharmacia Lettre, 2010, 2(3): 432-443
  • Annadurai, S., Canney, D.J., Lebo, D., Krynetskaia, N., Krynetskiy, E. Are glycyrrhizin derivatives specific inhibitors of HMGB1/DNA interactions? Der Pharmacia Lettre, 2011, 3(3):470-477
  • Annadurai, S., Martinez, R., Eidem, T., Dunman, P., Canney, D.J., Abou-Gharbia, M. Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 7719-7725
  • Annadurai, S., Martinez, R., Canney, D.J., Abou-Gharbia, M. Lead generation using a privileged structure-based approach (in preparation)

 

Abstracts/Posters/Oral

  • Annadurai, S., Martinez, R., Dunman, P., Canney, D.J., Abou-Gharbia, M., Lead generation using a privileged structure-based approach, 242nd ACS National Meeting, Aug 28-Sept 1, 2011, Denver, CO, USA (selected for Sci-Mix interdivisional poster session)
  • Annadurai, S., Krynetskaia, Canney, D. J.,Krynetskiy, E. Aggregate based inhibition of HMGB1/double stranded DNA complex formation, AAPS annual meeting and exposition, Nov 8-12, 2009, Los Angeles, CA, USA
  • Annadurai, S., Krynetskaia, N., Krynetskiy, E., Canney, D. J. Design, synthesis and screening of novel inhibitors of HMGB1/DNA complex formation, 235th ACS National Meeting, April 6-10, 2008, New Orleans, LA, USA
  • Annadurai, S., Gao, R., Canney, D.J., Krynetskaia, N., Krynetskiy, E., Development of a Capillary Electrophoresis Mobility Shift Assay (CEMSA) for Screening Inhibitors of DNA/HMGB1 Complex. GRASP, 27th Annual Meeting, June 2007, Piscataway, NJ, USA
  • Annadurai, S., Krynetskaia, N., Krynetskiy, E., Canney, D. J. Glycyrrhetinic Acid Derivatives as Inhibitors of HMGB1/DNA Complex Formation, Sixth Annual Dawn B. Marks Research Conference, December, 2006, Temple University, School of Medicine, Philadelphia, PA, USA
  • Annadurai, S., Basu. S.P., Application of Mathematical Models in Drug Research, National Seminar on the application of mathematics in social and industrial sectors in the next millennium, 1999, Birla Institue of technology, India