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Nighttime view of Temple University Children's Medical Center Temple University Hospital in background, Kresge Hall (left) and Medical Research Building (right) in foreground Old Medical School building in foreground, Jones Hall, General Services building and Student Faculty Center to the right

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New compound shows promise in halting hiv spread

Robert J. Suhadolnik, PhDA new compound has shown promise in halting the spread of HIV by preventing the virus from replicating.  Developed by Temple researchers, 2-5AN6B could someday work as an effective treatment for HIV, especially in conjunction with current drug treatments.  Their work is published in the January issue of AIDS Research and Human Retroviruses.

 

A nucleic acid, 2-5AN6B, inhibited HIV replication in white blood cells from a group of 18 HIV-infected patients by up to 80 percent, regardless of the patients' treatment regimens.

 

"A cure for HIV infection remains an elusive goal--despite the significant impact of current treatments--because of the virus's ability to adapt to and resist those treatments, and bypass the immune system's natural defenses," said Robert J. Suhadolnik, principal investigator and Professor of Biochemistry at the School of Medicine.  "This compound prompts the body to restore its natural antiviral defense systems against the invading virus."

 

Current drugs for HIV work by blocking one of the steps toward virus replication. 

 

This new anti-HIV compound works by a very different mechanism, and would appear to offer the promise of someday being combined with existing antiviral therapies for a much more effective treatment.  It is also very important that this compound is much less likely to be defeated by the ability of the virus to mutate, a problem often encountered with existing antiviral drugs," said Thomas Rogers, co-author of the study and Professor of Pharmacology at Temple.

 

This work builds on decades of research by the Temple team,  which recently was awarded a grant from the National Institutes of Health to continue pre-clinical studies on a larger scale.  They'll be investigating the molecular mechanisms of 2-5AN6B as a potential weapon against HIV, and continue work on a new therapeutic approach involving gene therapy for the treatment of HIV infection.

 

The other researchers on the team are Dessislava Dimitrov, Nancy Reichenbach, Xiaowei Yang, Wolfgang Pfleiderer, Ramamurthy Charubula, John Gaughan, Byungse Suh and Earl Henderson, co-investigator.  The work was supported by a grant from the National Institutes of Health.

 

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By Eryn Jelesiewicz

eryn.dobeck@temple.edu

February 15, 2007