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Gil Yosipovitch, MDgil yosipovitch, md


Chair, Department of Dermatology

Professor, Dermatology

Phone: 215-707-5460

Email: gil.yosipovitch@tuhs.temple.edu


Department of Dermatology




Educational Background:


BSc., Hadassah Hebrew University Medical School, Jerusalem, Israel, 1985


MD, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 1990


Internship, Ichilov Hospital, Tel Aviv, Israel, 1989


Residency, Internal Medicine, Beilinson Medical Center, Petah Tiqva, Israel, 1994


Fellowship, Dermatology, UCSF Medical Center, San Francisco, CA, 1995


Residency, Dermatology, Rabin Medical Center, Petah Tiqva, Israel, 1999

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Research Interests:

  • Itch
  • Skin neurophysiology
  • Brain imaging of itch
  • Itch psychophysics
  • Skin pharmacology

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board certification(s):


  • Dermatology, Internal Medicine

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professional affiliations:


  • American Academy of Dermatology
  • Society for Investigative Dermatology
  • Founder, International Society for the Study of Itch
  • American Dermatology Association

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Selected Publications:




Yosipovitch G, Kwatra S. Living with Itch: A Patient's Guide. John Hopkins Press 2013.


Yosipovitch G, Greaves M, McGlone F, Fleischer A. eds. Itch Basic Mechanisms and Therapy. Mercell Dekker 2004.


Book Chapters


Yosipovitch G. Thermal sensory analyzer. In: Baran R, Maibach HI. eds Cosmetic
Dermatology Martin Dunitz Second Edition 1998;549-552.


Yosipovitch G, Maibach HI. Thermal Sensory Analyzer (TSA): Boon to study of the C and A-Delta Fibers. In: Elsner P, Barel A, Berardesca E, Gabard B, Serup J. eds Advances in Skin Bioengineering Karger Basel 1998;84-89.


Yosipovitch G, Yarnitsky D. Quantitative sensory testing. In: Maibach HI, Marzulli FN. eds Dermatotoxicology Methods The Laboratory Workers vade mecum 1998;313-318.


Yosipovitch G. Methodological approaches for testing anti-itch and related substances. In: Gabard B, Surber C, Treffel P, Elsner P. eds Dermatopharmacology of topical preparations Springer Verlag 1999;231-239.


Yosipovitch G, Ng SK. Subjective adverse contact reactions. In: Ng See Ket. eds Principles and Practice of Contact and Occupational Dermatology in the Asia Pacific Region World Scientific 2001;36-37.


Yosipovitch G. Bioengineering techniques in contact dermatitis. In: Ng See Ket eds Principles and Practice of Contact and Occupational Dermatology in the Asia Pacific Region World Scientific 2001;217-221.


Ang P, Chua SH, Gan SL, Goon TJ, Khoo BP, Khoo SW, Koh D, Kwok YK, Leow YH, Ng P, Ng SK, Tan E, Tann HH, Tan SC, Tan SH, Yosipovitch G. Allergens and Irritants. In: Ng See Ket eds Principles and Practice of Contact and Occupational Dermatology in the Asia Pacific Region World Scientific 2001;74-116.

Yosipovitch G. Active ingredients in cosmetic preparations. In: Shai A, Maibach HI, Baran R, eds Hand Book of Cosmetics and Skin Care Martin Dunitz 2001;167-180.


Yosipovitch G. Itch Definitions. In: Yosipovitch G, Greaves M, McGlone F, Fleischer A. eds Itch Basic Mechanisms and Therapy Mercel Dekker 2004; 1-4.


Yosipovitch G. Itch Questionnaires – As a Tool for Itch Evaluation. In: Yosipovitch G, Greaves M, McGlone F, Fleischer A. eds Itch Basic Mechanisms and Therapy Mercel Dekker 2004; 169-182.


Yosipovitch G. Epidemiology of Itching in Skin and Systemic Diseases. In: Yosipovitch G, Greaves M, McGlone F, Fleischer A. eds Itch Basic Mechanisms and Therapy Mercel Dekker 2004; 183-193.


Yosipovitch G, Goodkin R, Wingard E, Bernhard JD. Neuropathic Itch. In: Yosipovitch G, Greaves M, McGlone F, Fleischer A. eds Itch Basic Mechanisms and Therapy 2004; 231-240.


Yiung Hian Leow, Yosipovitch G. Pruritus in Lichen Simplex Chronicus and Lichen Aneyloidoses. In: Yosipovitch g, Greaves M, McGlone F, Fleischer A. eds Itch Basic Mechanisms and Therapy 2004; 255-258.


Duque M, Yosipovitch G, Pegram S. Itch in HIV patients. In: Yosipovitch G, Greaves M, McGlone F, Fleischer A. eds Itch Basic Mechanisms and Therapy 2004; 218-230.


Melamed Y, Yosipovitch G. Itching as a focus of mental disturbance. In: Yosipovitch G, Greaves M, McGlone F, Fleischer A. eds Itch Basic Mechanisms and Therapy 2004; 369-376.


Yosipovitch G. Xerotic skin and impairment of barrier function associated with itch. In: Fluhr J, Elsner E, Berardesca E, Maibach HI. eds Bioengineering of the skin; water and stratum corneum 2nd Ed. CRC press 2005;369-374.


Yosipovitch G. Thermal sensory testing a tool for evaluation of sensory irritation of cosmetic products and sensitive skin. In: Baran R, Maibach HI. Eds Text book of Cosmetic Dermatology 3rd Ed. Francis & Taylor 2005;569-571.


Patel M, Yosipovitch G. Ethnic Sensitive Skin in Berardesca E, Fluhr J, Maibach H. Eds. Sensitive Skin Syndrome Taylor & Francis 2006;47-52.


Guzman D, Yelverton C, Yosipovitch G. Ethnic Itch in Berardesca E, Leveque J. Eds. Ethnic Skin Ethnic Skin CRC Press 2007


Summey B, Yosipovitch G, Itch Associated with Dryness of the Skin: the Pathophysiology and Influence of Moisturizers. In Loden M, Maibach H Eds. Dry Skin and Moisturizers; Chemistry and Function Taylor & Francis. 2005; 127-134.


Yosipovitch G, Dawn AG, Greaves MW. Neurobiology of pruritus in Bolognia JL, Jorizzo JL, Rapini RP Eds. Dermatology 2nd Edition Mosby 2008:81-90.


Yosipovitch G, Dawn AG, Greaves MW. Pathophysiology and Clinical Aspects of Pruritus in Fitzpatrick 7th Ed. Dermatology in General Medicine Des Wolff, K, Goldsmith L, Katz S, Gilchrest B, Paller A, Leffell D .Mc Graw Hill 2008 ch102pp902-911


Yosipovitch G, Ishiuji Y. Neurophysiology of itch in Neuroimmunology of the skin Basic Science to Clinical Practice Reference Eds Granstein RD, Luger T in Springer 2009:178-186.


Yosipovitch G. Pruritus in Callen J, Jorizzo J, Bolognia J, Piette W, Zone J. Eds. Dermatological Signs of Internal Disease 4th Ed. Saunders Elsevier 2009:75-80.


Namazi MR, Yosipovitch G. Diabetes Mellitus in Callen J, Jorizzo J, Bolognia J, Piette W, Zone J. Eds. Dermatological Signs of Internal Disease 4th Ed. Saunders Elsevier 2009: 189-198.


Patel TJ, Yosipovitch G. Central Transmission: From Skin to Brain in Pruritus, Eds Misery L, Stander, Springer Verlag London 2010:23-26.


Tey HL, Yosipovitch G, Bernhard J. Pruritus ACP Medicine. Dec 2011:1-14.


Yosipovitch G, Patel TS, Pathophysiology and Clinical Aspects of Pruritus in Goldsmithl L, Katz S, Gilchrest B, Paller A, Lefell D, Wolff eds. Fitzpatrick Dermatology in General Medicine 8th Ed. New York, McGraw Hill 2012:1146-1158.


Yosipovith G, Papoiu AP. Neurobiology of Pruritis in Bolognia JL, Jorizzo JL. Rapini RP eds. Dermatology 3rd Ed. Mosby 2012;81-90.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26576620. Schut C, Mollanazar NK, Sethi M, Nattkemper LA, Valdes-Rodriguez R, Lovell MM, Calzaferri GL, Yosipovitch G, Psychological Stress and Skin Symptoms in College Students: Results of a Cross-sectional Web-based Questionnaire Study. Acta Derm Venereol :()2015 Nov 18

26416212. Rowe B, Yosipovitch G, Malignancy-associated pruritus. Eur J Pain :()2015 Sep 28

26090537. Cowan A, Yosipovitch G, Preface. Handb Exp Pharmacol 226:(v-vi)2015

26076316. Mochizuki H, Papoiu AD, Nattkemper LA, Lin AC, Kraft RA, Coghill RC, Yosipovitch G, Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch Patients. J Invest Dermatol 135:11(2814-23)2015 Nov

26073701. Schut C, Mollanazar NK, Kupfer J, Gieler U, Yosipovitch G, Psychological Interventions in the Treatment of Chronic Itch. Acta Derm Venereol :()2015 Jun 15

25931325. Mollanazar NK, Smith PK, Yosipovitch G, Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out? Clin Rev Allergy Immunol :()2015 May 1

25861788. Leslie TA, Greaves MW, Yosipovitch G, Current topical and systemic therapies for itch. Handb Exp Pharmacol 226:(337-56)2015

25861774. Yosipovitch G, Mochizuki H, Neuroimaging of itch as a tool of assessment of chronic itch and its management. Handb Exp Pharmacol 226:(57-70)2015

25762519. Cedeno-Laurent F, Singer EM, Wysocka M, Benoit BM, Vittorio CC, Kim EJ, Yosipovitch G, Rook AH, Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities. Clin Immunol 158:1(1-7)2015 May

25717300. Schut C, Grossman S, Gieler U, Kupfer J, Yosipovitch G, Contagious itch: what we know and what we would like to know. Front Hum Neurosci 9:(57)2015

25693757. Valdes-Rodriguez R, Stull C, Yosipovitch G, Chronic pruritus in the elderly: pathophysiology, diagnosis and management. Drugs Aging 32:3(201-15)2015 Mar

25612128. Gelman A, Valdes-Rodriguez R, Bhattacharyya S, Yosipovitch G, A case of primary cutaneous mucormycosis caused by minor trauma. Dermatol Online J 21:1()2015 Jan 15

25611305. Yong AA, Cao T, Tan V, Yosipovitch G, Tey HL, Skin physiology in pruritus of advanced ageing. J Eur Acad Dermatol Venereol :()2015 Jan 21

25607755. Lloyd DM, McGlone FP, Yosipovitch G, Somatosensory pleasure circuit: from skin to brain and back. Exp Dermatol 24:5(321-4)2015 May

25594427. Roblin D, Yosipovitch G, Boyce B, Robinson J, Sandy J, Mainero V, Wickramasinghe R, Anand U, Anand P, Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis. Acta Derm Venereol 95:5(542-8)2015 May

25562855. Gelman AB, Norton SA, Valdes-Rodriguez R, Yosipovitch G, A review of skin conditions in modern warfare and peacekeeping operations. Mil Med 180:1(32-7)2015 Jan

25522660. Nattkemper LA, Lee HG, Valdes-Rodriguez R, Mollanazar NK, Sanders KM, Yosipovitch G, Cholinergic induction of perspiration attenuates nonhistaminergic pruritus in the skin of patients with atopic dermatitis and healthy controls. Br J Dermatol 173:1(282-4)2015 Jul

25419762. Kannangara AP, Yosipovitch G, Fleischer AB Jr, Proposed classification for Koebner, Wolf isotopic, Renbok, Koebner nonreaction, isotopic nonreaction and other related phenomen. Dermatol Online J 20:11()2014 Nov 15

25211175. Papoiu AD, Kraft RA, Coghill RC, Yosipovitch G, Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei: a pharmacological fMRI study. J Invest Dermatol 135:2(560-8)2015 Feb

25203328. Valdes-Rodriguez R, Mollanazar NK, González-Muro J, Nattkemper L, Torres-Alvarez B, López-Esqueda FJ, Chan YH, Yosipovitch G, Itch prevalence and characteristics in a Hispanic geriatric population: a comprehensive study using a standardized itch questionnaire. Acta Derm Venereol 95:4(417-21)2015 Apr

25179683. Weisshaar E, Weiss M, Mettang T, Yosipovitch G, Zylicz Z, Paraneoplastic itch: an expert position statement from the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI). Acta Derm Venereol 95:3(261-5)2015 Mar

25128128. Gathings RM, Lewallen R, Yosipovitch G, Use of the Unna sleeve for severe, treatment-resistant idiopathic pruritus. J Am Acad Dermatol 71:3(e71-2)2014 Sep

25055194. Yosipovitch G, Mills KC, Nattkemper LA, Feneran A, Tey HL, Lowenthal BM, Pearce DJ, Williford PM, Sangueza OP, D'Agostino RB Jr, Association of pain and itch with depth of invasion and inflammatory cell constitution in skin cancer: results of a large clinicopathologic study. JAMA Dermatol 150:11(1160-6)2014 Nov

25047038. Gibson RA, Robertson J, Mistry H, McCallum S, Fernando D, Wyres M, Yosipovitch G, A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers. PLoS One 9:7(e100610)2014

24944217. Papoiu AD, Emerson NM, Patel TS, Kraft RA, Valdes-Rodriguez R, Nattkemper LA, Coghill RC, Yosipovitch G, Voxel-based morphometry and arterial spin labeling fMRI reveal neuropathic and neuroplastic features of brain processing of itch in end-stage renal disease. J Neurophysiol 112:7(1729-38)2014 Oct 1

24830004. Mochizuki H, Papoiu ADP, Yosipovitch G, Brain Processing of Itch and Scratching :()2014

24820241. Gathings R, Lewallen R, Yosipovitch G, Immunotherapy-induced leukoderma from treatment of melanoma with IL-2: a case report and a review of the literature. Acta Derm Venereol 95:2(197-200)2015 Feb

24767731. Lacouture ME, Wolchok JD, Yosipovitch G, Kähler KC, Busam KJ, Hauschild A, Ipilimumab in patients with cancer and the management of dermatologic adverse events. J Am Acad Dermatol 71:1(161-9)2014 Jul

24503217. Kaushik SB, Cerci FB, Miracle J, Pokharel A, Chen SC, Chan YH, Wilkin A, Yosipovitch G, Chronic pruritus in HIV-positive patients in the southeastern United States: its prevalence and effect on quality of life. J Am Acad Dermatol 70:4(659-64)2014 Apr

24438964. Roblin D, Wickramasinghe R, Yosipovitch G, Pruritus severity in patients with psoriasis is not correlated with psoriasis disease severity. J Am Acad Dermatol 70:2(390-1)2014 Feb

24324781. Papoiu AD, Nattkemper LA, Sanders KM, Kraft RA, Chan YH, Coghill RC, Yosipovitch G, Brain's reward circuits mediate itch relief. a functional MRI study of active scratching. PLoS One 8:12(e82389)2013

24124862. Cerci FB, Kapural L, Yosipovitch G, Intractable erythromelalgia of the lower extremities successfully treated with lumbar sympathetic block. J Am Acad Dermatol 69:5(e270-2)2013 Nov

23839260. Bin Saif GA, Al-Balbeesi AO, Binshabaib R, Alsaad D, Kwatra SG, Alzolibani AA, Yosipovitch G, Quality of life in family members of vitiligo patients: a questionnaire study in Saudi Arabia. Am J Clin Dermatol 14:6(489-95)2013 Dec

26064507. Yates JE, Bleyer AJ, Yosipovitch G, Sangueza OP, Murea M, Erratum: Enigmatic pruritus in a kidney transplant patient. Clin Kidney J 6:3(363)2013 Jun

23711071. Olivry T, Bizikova P, Paps JS, Dunston S, Lerner EA, Yosipovitch G, Cowhage can induce itch in the atopic dog. Exp Dermatol 22:6(435-7)2013 Jun

23698099. Singer EM, Shin DB, Nattkemper LA, Benoit BM, Klein RS, Didigu CA, Loren AW, Dentchev T, Wysocka M, Yosipovitch G, Rook AH, IL-31 is produced by the malignant T-cell population in cutaneous T-Cell lymphoma and correlates with CTCL pruritus. J Invest Dermatol 133:12(2783-5)2013 Dec

23614588. Yosipovitch G, Bernhard JD, Clinical practice. Chronic pruritus. N Engl J Med 368:17(1625-34)2013 Apr 25

23558404. Nattkemper LA, Zhao ZQ, Nichols AJ, Papoiu AD, Shively CA, Chen ZF, Yosipovitch G, Overexpression of the gastrin-releasing peptide in cutaneous nerve fibers and its receptor in the spinal cord in primates with chronic itch. J Invest Dermatol 133:10(2489-92)2013 Oct

23551372. Rimoin LP, Kwatra SG, Yosipovitch G, Female-specific pruritus from childhood to postmenopause: clinical features, hormonal factors, and treatment considerations. Dermatol Ther 26:2(157-67)2013 Mar-Apr

23551371. Pfab F, Schalock PC, Napadow V, Athanasiadis GI, Yosipovitch G, Ring J, Complementary integrative approach for treating pruritus. Dermatol Ther 26:2(149-56)2013 Mar-Apr

23551364. Yosipovitch G, Introduction for understanding and treating itch. Dermatol Ther 26:2(83)2013 Mar-Apr

26019849. Yates JE, Bleyer AJ, Yosipovitch G, Sangueza OP, Murea M, Enigmatic pruritus in a kidney transplant patient. Clin Kidney J 6:2(194-8)2013 Apr

23528208. Kim HS, Yosipovitch G, An aberrant parasympathetic response: a new perspective linking chronic stress and itch. Exp Dermatol 22:4(239-44)2013 Apr

23474847. Papoiu AD, Valdes-Rodriguez R, Nattkemper LA, Chan YH, Hahn GS, Yosipovitch G, A novel topical formulation containing strontium chloride significantly reduces the intensity and duration of cowhage-induced itch. Acta Derm Venereol 93:5(520-6)2013 Sep 4

23432064. Valdes-Rodriguez R, Kaushik SB, Yosipovitch G, Transient receptor potential channels and dermatological disorders. Curr Top Med Chem 13:3(335-43)2013

23383856. Dalgard F, Halvorsen JA, Kwatra SG, Yosipovitch G, Acne severity and itch are associated: results from a Norwegian survey of 3775 adolescents. Br J Dermatol 169:1(215-6)2013 Jul

23374230. Kwatra SG, Stander S, Bernhard JD, Weisshaar E, Yosipovitch G, Brachioradial pruritus: a trigger for generalization of itch. J Am Acad Dermatol 68:5(870-3)2013 May

23322028. Ali SM, Yosipovitch G, Skin pH: from basic science to basic skin care. Acta Derm Venereol 93:3(261-7)2013 May

23278237. Kaushik SB, Kwatra SG, McLean TW, Powers A, Atala AJ, Yosipovitch G, Segmental ulcerated perineal hemangioma of infancy: a complex case of PELVIS syndrome successfully treated using a multidisciplinary approach. Pediatr Dermatol 30:6(e257-8)2013 Nov-Dec

23247491. Mills KC, Kwatra SG, Feneran AN, Pearce DJ, Williford PM, D'Agostino RB, Yosipovitch G, Itch and pain in nonmelanoma skin cancer: pain as an important feature of cutaneous squamous cell carcinoma. Arch Dermatol 148:12(1422-3)2012 Dec