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Xiao-Feng Yang, MD, PhD

Associate Professor, Pharmacology

Telephone:  215-707-5985

Fax:  215-707-7068

Email: xfyang@temple.edu

Department of Pharmacology

M.D., Clinical Medicine, JiangXi Medical University, China 1979      

 

M.S., Immunology, Chinese National Academy of Medical Sciences and Peking Union Medical University 1982    

 

Ph.D., Biochemistry and Molecular Biology, University of Montreal, Canada 1994 

 

Fellowship, Immunology and oncology, Harvard Medical School, 1999

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Dr. Xiao-Feng Yang’s laboratory focuses on studying the regulatory mechanisms of immune responses: The First issue is the regulation of immune responses by modulating T lymphocyte survival and apoptosis. Our publications have demonstrated that a novel interplay between Bcl-xL apoptosis-regulatory family members, such as Bcl-xL, and a novel cytosolic anti-apoptotic protein TCTP plays an essential role in the regulation of T cell apoptosis. Identification of the interplays in the apoptosis regulatory pathways in T cell subsets could lead to novel therapeutic intervention to autoimmune diseases and tumors. The second issue is the regulation of autoimmune and anti-tumor immune responses by modulating self-antigen repertoire. Our results have demonstrated that alternative splicing and overexpression are among the key molecular events in selection of the self-antigen repertoire. We have proposed for the first time a new model of stimulation-responsive splicing as one of the general mechanisms of autoantigen selection. Elucidation of the mechanisms underlying selection of autoantigens and self-tumor antigens provides important foundation for future development of antigen-specific immunotherapies as well as diagnostic and prognostic tools for tumors and autoimmune diseases.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19505385. Yin Y, Yan Y, Jiang X, Mai J, Chen NC, Wang H, Yang XF, Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol 22:2(311-22)2009 Apr-Jun

19482711. Yang XF, Fang P, Meng S, Jan M, Xiong X, Yin Y, Wang H, The FOX transcription factors regulate vascular pathology, diabetes and Tregs. Front Biosci (Schol Ed) 1:(420-36)2009 Jun 1

19144262. Yan Y, Xiong Z, Zhang S, Song J, Huang Y, Thornton AM, Wang H, Yang XF, CD25high T cells with a prolonged survival inhibit development of diabetes. Int J Immunopathol Pharmacol 21:4(767-80)2008 Oct-Dec

18789801. Xiong Z, Yan Y, Song J, Fang P, Yin Y, Yang Y, Cowan A, Wang H, Yang XF, Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation. Atherosclerosis 203:2(401-8)2009 Apr

18508723. Xiong Z, Song J, Yan Y, Huang Y, Cowan A, Wang H, Yang XF, Higher expression of Bax in regulatory T cells increases vascular inflammation. Front Biosci 13:(7143-55)2008 May 1

19578482. Yang XF, Yin Y, Wang H, VASCULAR INFLAMMATION AND ATHEROGENESIS ARE ACTIVATED VIA RECEPTORS FOR PAMPs AND SUPPRESSED BY REGULATORY T CELLS. Drug Discov Today Ther Strateg 5:2(125-142)2008

17981643. Yang XF, Factors regulating apoptosis and homeostasis of CD4+ CD25(high) FOXP3+ regulatory T cells are new therapeutic targets. Front Biosci 13:(1472-99)2008 Jan 1

17715404. Jiang X, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang X, Durante W, Wang H, Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells. Arterioscler Thromb Vasc Biol 27:9(1976-83)2007 Sep

17698632. Jamaluddin MD, Chen I, Yang F, Jiang X, Jan M, Liu X, Schafer AI, Durante W, Yang X, Wang H, Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood 110:10(3648-55)2007 Nov 15

17624250. Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Hodge I, Verstovsek S, Segura FJ, Wang H, Prchal J, Yang XF, A novel unconventional antigen MPD5 elicits anti-tumor humoral immune responses in a subset of patients with polycythemia vera. Int J Immunopathol Pharmacol 20:2(373-80)2007 Apr-Jun

17601370. Yang XF, Immunology of stem cells and cancer stem cells. Cell Mol Immunol 4:3(161-71)2007 Jun

17346430. Yan Y, Chen Y, Yang F, Chen IH, Xiong Z, Wang J, Lachman LB, Wang H, Yang XF, HLA-A2.1-restricted T cells react to SEREX-defined tumor antigen CML66L and are suppressed by CD4+CD25+ regulatory T cells. Int J Immunopathol Pharmacol 20:1(75-89)2007 Jan-Mar

17166407. Yang XF, Mirkovic D, Zhang S, Zhang QE, Yan Y, Xiong Z, Yang F, Chen IH, Li L, Wang H, Processing sites are different in the generation of HLA-A2.1-restricted, T cell reactive tumor antigen epitopes and viral epitopes. Int J Immunopathol Pharmacol 19:4(853-70)2006 Oct-Dec

17113348. Xiong Z, Yan Y, Liu E, Silver RT, Verstovsek S, Yang F, Wang H, Prchal J, Yang XF, Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera. Clin Immunol 122:3(279-87)2007 Mar

16982933. Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Chen Y, Verstovsek S, Wang H, Prchal J, Yang XF, An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions. J Immunol 177:7(4907-16)2006 Oct 1

16931800. Liao D, Tan H, Hui R, Li Z, Jiang X, Gaubatz J, Yang F, Durante W, Chan L, Schafer AI, Pownall HJ, Yang X, Wang H, Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res 99:6(598-606)2006 Sep 15

16890493. Yang F, Chen IH, Xiong Z, Yan Y, Wang H, Yang XF, Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Clin Immunol 121:2(121-33)2006 Nov

16800912. Ke XY, Wang J, Yang XF, [New principles in tumor antigens and their significance in future immunotherapies for lymphomas and other malignancies--editorial] Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:3(419-26)2006 Jun

16574722. Xiong Z, Shaibani A, Li YP, Yan Y, Zhang S, Yang Y, Yang F, Wang H, Yang XF, Alternative splicing factor ASF/SF2 is down regulated in inflamed muscle. J Clin Pathol 59:8(855-61)2006 Aug

16368059. Yang F, Yang XF, New concepts in tumor antigens: their significance in future immunotherapies for tumors. Cell Mol Immunol 2:5(331-41)2005 Oct