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Weidong Xiao, PhD

Associate Professor, Microbiology and Immunology

Associate Professor, Sol Sherry Thrombosis Research Center

Telephone:  215-707-6392

Email: wxiao@temple.edu

Department of Microbiology and Immunology

Sol Sherry Thrombosis Research Center

BS, Chemistry, Xiangtan University, China, 1989

 

PhD, Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 1996

 

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My research has been focused on the basic biology of adeno-associated virus (AAV) and its application as a gene transfer vector for basic research and human gene therapy.

On AAV vector biology, my lab is working on two issues that are critical for the gene therapy field. One is AAV integration frequency, which has implications for AAV vector safety and its feasibility as a vector for stem cells. The other project is to understand AAV transduction mechanisms through tracking the status of AAV DNA genomes.

In addition, my lab is developing new strategies to engineer and deliver coagulation factors using AAV vectors for gene therapy of hemophilia A. Further applications of AAV vectors are also being explored.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19904236. Dong B, Nakai H, Xiao W, Characterization of Genome Integrity for Oversized Recombinant AAV Vector. Mol Ther :()2009 Nov 10

19835381. Yao N, Xiao W, Meza L, Tseng H, Chuck M, Lam KS, Structure -activity relationship studies of targeting ligands against breast cancer cells. J Med Chem 52:21(6744-51)2009 Nov 12

19127250. Chen L, Lu H, Wang J, Sarkar R, Yang X, Wang H, High KA, Xiao W, Enhanced factor VIII heavy chain for gene therapy of hemophilia A. Mol Ther 17:3(417-24)2009 Mar

19055415. Yao N, Xiao W, Wang X, Marik J, Park SH, Takada Y, Lam KS, Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method. J Med Chem 52:1(126-33)2009 Jan 8

18712382. Xiao W, Yao N, Peng L, Liu R, Lam KS, Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin. Eur J Nucl Med Mol Imaging 36:1(94-103)2009 Jan

18558750. Luo J, Zhang H, Xiao W, Kumaresan PR, Shi C, Pan CX, Aina OH, Lam KS, Rainbow beads: a color coding method to facilitate high-throughput screening and optimization of one-bead one-compound combinatorial libraries. J Comb Chem 10:4(599-604)2008 Jul-Aug

18500941. Lu H, Chen L, Wang J, Huack B, Sarkar R, Zhou S, Xu R, Ding Q, Wang X, Wang H, Xiao W, Complete correction of hemophilia A with adeno-associated viral vectors containing a full-size expression cassette. Hum Gene Ther 19:6(648-54)2008 Jun

18260149. Yao N, Wu CY, Xiao W, Lam KS, Discovery of high-affinity peptide ligands for vancomycin. Biopolymers 90:3(421-32)2008

18253862. Li H, Li X, Lam KS, Tam S, Xiao W, Xu R, Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats. J Biomed Sci 15:4(487-97)2008 Jul

18245670. Peng L, Liu R, Andrei M, Xiao W, Lam KS, In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against alpha4beta1 integrin. Mol Cancer Ther 7:2(432-7)2008 Feb

17729417. Diao Y, Ma J, Xiao WD, Luo J, Li XY, Chu KW, Fung PW, Habib N, Farzaneh F, Xu RA, Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin. World J Gastroenterol 13:34(4615-9)2007 Sep 14

17664425. Wang J, Xie J, Lu H, Chen L, Hauck B, Samulski RJ, Xiao W, Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction. Proc Natl Acad Sci U S A 104:32(13104-9)2007 Aug 7

17653101. Chen L, Zhu F, Li J, Lu H, Jiang H, Sarkar R, Arruda VR, Wang J, Zhao J, Pierce GF, Ding Q, Wang X, Wang H, Pipe SW, Liu XQ, Xiao X, Camire RM, Xiao W, The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene. Mol Ther 15:10(1856-62)2007 Oct

17239162. Arruda VR, Xiao W, It's all about the clothing: capsid domination in the adeno-associated viral vector world. J Thromb Haemost 5:1(12-5)2007 Jan

16409124. Hauck B, Xu RR, Xie J, Wu W, Ding Q, Sipler M, Wang H, Chen L, Wright JF, Xiao W, Efficient AAV1-AAV2 hybrid vector for gene therapy of hemophilia. Hum Gene Ther 17:1(46-54)2006 Jan

16230049. Schuettrumpf J, Zou J, Zhang Y, Schlachterman A, Liu YL, Edmonson S, Xiao W, Arruda VR, The inhibitory effects of anticoagulation on in vivo gene transfer by adeno-associated viral or adenoviral vectors. Mol Ther 13:1(88-97)2006 Jan

15599280. Harrop JS, Poulsen DJ, Xiao W, Freese A, During MJ, Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytes. Spine (Phila Pa 1976) 29:24(2787-92)2004 Dec 15

15564477. Hauck B, Zhao W, High K, Xiao W, Intracellular viral processing, not single-stranded DNA accumulation, is crucial for recombinant adeno-associated virus transduction. J Virol 78:24(13678-86)2004 Dec

14502222. Gao G, Zhou X, Alvira MR, Tran P, Marsh J, Lynd K, Xiao W, Wilson JM, High throughput creation of recombinant adenovirus vectors by direct cloning, green-white selection and I-Sce I-mediated rescue of circular adenovirus plasmids in 293 cells. Gene Ther 10:22(1926-30)2003 Oct

12969984. Arruda VR, Schuettrumpf J, Herzog RW, Nichols TC, Robinson N, Lotfi Y, Mingozzi F, Xiao W, Couto LB, High KA, Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1. Blood 103:1(85-92)2004 Jan 1

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