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Stephen ArnoffYi Wu, MD, PhD


Assistant Professor, Sol Sherry Thrombosis Research Center

Telephone:  215-707-4423

Fax:  215-707-2783

Email: yiwu@temple.edu


Sol Sherry Thrombosis Research Center


Educational Background:


Hebei Medical University, China

1984-1987, M.D.


Hebei Medical University, China

1987-1990, Internal Medicine Internship & Residency

1990-1992, Fellow in Cardiology


Yamanashi University School of Medicine, Japan

1998-2002, Ph.D., Biochemistry


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Research Interests:


My research interests are:

  1. Signal transduction of adhesion receptors;
  2. Signaling crosstalk between adhesion receptors and growth factor receptors;
  3. Biological function of adhesion receptors in thrombosis, inflammation, and angiogenesis, and relevant interference strategy.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25949215. Wu Y, Contact pathway of coagulation and inflammation. Thromb J 13:(17)2015

25426118. Kimani SG, Geng K, Kasikara C, Kumar S, Sriram G, Wu Y, Birge RB, Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity. Front Immunol 5:(566)2014

24984152. Zhu X, Zheng X, Wu Y, Cleaved high molecular weight kininogen stimulates JNK/FOXO4/MnSOD pathway for induction of endothelial progenitor cell senescence. Biochem Biophys Res Commun 450:4(1261-5)2014 Aug 8

24599920. Xie Z, Dai J, Yang A, Wu Y, A role for bradykinin in the development of anti-collagen antibody-induced arthritis. Rheumatology (Oxford) 53:7(1301-6)2014 Jul

20886177. Colman RW, Wu Y, Liu Y, Mechanisms by which cleaved kininogen inhibits endothelial cell differentiation and signalling. Thromb Haemost 104:5(875-85)2010 Nov

19874467. Wu Y, Dai J, Schmuckler NG, Bakdash N, Yoder MC, Overall CM, Colman RW, Cleaved high molecular weight kininogen inhibits tube formation of endothelial progenitor cells via suppression of matrix metalloproteinase 2. J Thromb Haemost 8:1(185-93)2010 Jan

18062965. Liu Y, Sainz IM, Wu Y, Pixley R, Espinola RG, Hassan S, Khan MM, Colman RW, The inhibition of tube formation in a collagen-fibrinogen, three-dimensional gel by cleaved kininogen (HKa) and HK domain 5 (D5) is dependent on Src family kinases. Exp Cell Res 314:4(774-88)2008 Feb 15

17585065. Wu Y, Rizzo V, Liu Y, Sainz IM, Schmuckler NG, Colman RW, Kininostatin associates with membrane rafts and inhibits alpha(v)beta3 integrin activation in human umbilical vein endothelial cells. Arterioscler Thromb Vasc Biol 27:9(1968-75)2007 Sep

16902163. Khan MM, Bradford HN, Isordia-Salas I, Liu Y, Wu Y, Espinola RG, Ghebrehiwet B, Colman RW, High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes. Arterioscler Thromb Vasc Biol 26:10(2260-6)2006 Oct

16529932. Wu Y, Tibrewal N, Birge RB, Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol 16:4(189-97)2006 Apr

15673687. Wu Y, Singh S, Georgescu MM, Birge RB, A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci 118:Pt 3(539-53)2005 Feb 1

12393736. Wu Y, Asazuma N, Satoh K, Yatomi Y, Takafuta T, Berndt MC, Ozaki Y, Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 101:9(3469-76)2003 May 1

11669637. Ohmori T, Yatomi Y, Wu Y, Osada M, Satoh K, Ozaki Y, Wheat germ agglutinin-induced platelet activation via platelet endothelial cell adhesion molecule-1: involvement of rapid phospholipase C gamma 2 activation by Src family kinases. Biochemistry 40:43(12992-3001)2001 Oct 30

11389024. Wu Y, Suzuki-Inoue K, Satoh K, Asazuma N, Yatomi Y, Berndt MC, Ozaki Y, Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling. Blood 97:12(3836-45)2001 Jun 15

11038351. Suzuki-Inoue K, Ozaki Y, Kainoh M, Shin Y, Wu Y, Yatomi Y, Ohmori T, Tanaka T, Satoh K, Morita T, Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation. J Biol Chem 276:2(1643-52)2001 Jan 12

10838156. Wu Y, Ozaki Y, Inoue K, Satoh K, Ohmori T, Yatomi Y, Owadab K, Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn. Biochim Biophys Acta 1497:1(27-36)2000 Jun 2

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