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Kevin Jon Williams, MD

 

Kevin Jon Williams, MD

 

Section Chief, Endocrinology, Diabetes and Metabolism

Professor, Medicine

Professor, Physiology

Professor, Cardiovascular Research Center

Telephone:  215-707-4746

FAX: 215-707-5599

Email:  kjwilliams@temple.edu

 

Department of Medicine, Section of Endocrinology, Diabetes and Metabolism

Department of Physiology

Cardiovascular Research Center

 

Educational Background:

 

MD, Johns Hopkins University, Baltimore, MD, 1980

 

Residency,  Internal Medicine, University of Chicago Medical Center, Chicago, IL, 1983

 

Fellowship, Clinical Endocrinology, Yale-New Haven Hospital, New Haven, CT, 1984

 

Fellowship, Metabolism, Columbia University, New York City, NY, 1985

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clinical Interests:

  • Lipid and lipoprotein abnormalities, particularly in insulin resistence and type 2 diabetes
  • Cause, prevention and reversal of atherosclerotic cardiovascular disease

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research Interests:

 

An avid researcher with many published works to his credit, Dr. Williams has performed groundbreaking studies in the area of lipoproteins and atherosclerosis. He is the principal investigator on several NIH-funded projects and holds 11 patents issued since 1998. Dr. Williams has served as an ad hoc reviewer for many journals, and is currently a consulting editor for the Journal of Clinical Investigation. Additionally, he serves on the editorial board of Arteriosclerosis, Thrombosis and Vascular Biology (an American Heart Association journal) and Rambam (Maimonides) Medical Journal.

 

His research in atherosclerosis and diabetes encompasses the following areas:

 

  • Widely accepted work on the origin of atherosclerosis, focusing on the retention of LDL and related lipoproteins within arterial walls and the subsequent development of plaque, plaque ruptures and clot formation. Williams’s work has provided a basis for a new unity among basic research, epidemiologic, pharmacologic and clinical approaches to cardiovascular disease, the leading killer worldwide.
  • The inability of the liver in patients with diabetes to rapidly and safely dispose of postprandial triglyceride-rich remnant lipoproteins. The result is diabetic dyslipidemia, a substantial factor in elevating atherosclerotic cardiovascular disease. Williams’s laboratory is currently exploring corrective strategies.
  • The essential, but previously unsuspected, role that particular proteins play in the insulin-signaling cascade. The Williams laboratory reported his initial, novel findings in June 2009 at the American Diabetes Association’s annual scientific sessions.

Explaining his research focus, Williams says, “Atherosclerosis kills about 50 percent of the people living in Western societies, and about 80 percent of people with diabetes will suffer from cardiovascular events. As more of the world adopts Western lifestyles, these problems are growing in both the U.S. and worldwide, and both of these common diseases hit the population Temple serves particularly hard.”

 

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board certification(s):

Internal Medicine

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professional affiliations:

  • Fellow, Council on Arteriosclerosis, Thrombosis & Vascular Biology of the American Heart Association
  • Past-president and member of the New York Lipid and Vascular Biology Research Club
  • Member, Philadelphia Lipid Research Club

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25281618. Bola BM, Chadwick AL, Michopoulos F, Blount KG, Telfer BA, Williams KJ, Smith PD, Critchlow SE, Stratford IJ, Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol Cancer Ther :()2014 Oct 3

25234098. Williams KJ, Ward MP, Dhungyel OP, Daily variations in Escherichia coli O157 shedding patterns in a cohort of dairy heifers at pasture. Epidemiol Infect :(1-10)2014 Sep 19

25201720. Bryant JL, Meredith SL, Williams KJ, White A, Targeting hypoxia in the treatment of small cell lung cancer. Lung Cancer :()2014 Aug 27

25131443. Lavorel S, Colloff MJ, Mcintyre S, Doherty MD, Murphy HT, Metcalfe DJ, Dunlop M, Williams RJ, Wise RM, Williams KJ, Ecological mechanisms underpinning climate adaptation services. Glob Chang Biol :()2014 Aug 18

25128202. Wouters A, Pauwels B, Burrows N, Baay M, Deschoolmeester V, Vu TN, Laukens K, Meijnders P, Van Gestel D, Williams KJ, Van den Weyngaert D, Vermorken JB, Pauwels P, Peeters M, Lardon F, The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein. BMC Cancer 14:(594)2014 Aug 16

25093698. Tang T, Thompson JC, Wilson PG, Yoder MH, Müeller J, Fischer JW, Williams KJ, Tannock LR, Biglycan deficiency: Increased aortic aneurysm formation and lack of atheroprotection. J Mol Cell Cardiol 75:(174-80)2014 Oct

25064268. Williams KJ, Ward MP, Dhungyel OP, Hall EJ, Van Breda L, A longitudinal study of the prevalence and super-shedding of Escherichia coli O157 in dairy heifers. Vet Microbiol 173:1-2(101-9)2014 Sep 17

24977432. Williams KJ, Ward MP, Dhungyel OP, Hall EJ, Risk factors for Escherichia coli O157 shedding and super-shedding by dairy heifers at pasture. Epidemiol Infect :(1-12)2014 Jun 30

24925981. Stack A, Derksen FJ, Williams KJ, Robinson NE, Jackson WF, Lung region and racing affect mechanical properties of equine pulmonary microvasculature. J Appl Physiol (1985) 117:4(370-6)2014 Aug 15

24853520. Williams KJ, Ward MP, Dhungyel O, Van Breda L, Relative sensitivity of Escherichia coli O157 detection from bovine feces and rectoanal mucosal swabs. J Food Prot 77:6(972-6)2014 Jun

24852568. Raveendran VV, Kassel KM, Smith DD, Luyendyk JP, Williams KJ, Cherian R, Reed GA, Flynn CA, Csanaky IL, Lickteig AL, Pratt-Hyatt MJ, Klaassen CD, Dileepan KN, H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. Am J Physiol Gastrointest Liver Physiol 307:2(G219-28)2014 Jul 15

24722790. Williams K, Moore H, Davies A, Haemodynamic changes with the use of neuromuscular electrical stimulation compared to intermittent pneumatic compression. Phlebology :()2014 May 2

24651811. Boden G, Cheung P, Salehi S, Homko C, Loveland-Jones C, Jayarajan S, Stein TP, Barrero CA, Merali S, Williams KJ, Liu ML, Response to comment on Boden et al. Insulin regulates the unfolded protein response in human adipose tissue. Diabetes 2014;63:912-922. Diabetes 63:4(e2)2014 Apr

24633426. Joshi N, Kopec AK, Towery K, Williams KJ, Luyendyk JP, The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J Pharmacol Exp Ther 349:3(383-92)2014 Jun

24630609. Williams KJ, Buckley DL, Jones GD, Establishment of the National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Biomarker Support Network. Clin Oncol (R Coll Radiol) 26:6(356)2014 Jun

24602562. Hammond EM, Asselin MC, Forster D, O'Connor JP, Senra JM, Williams KJ, The meaning, measurement and modification of hypoxia in the laboratory and the clinic. Clin Oncol (R Coll Radiol) 26:5(277-88)2014 May

24569614. Williams KJ, Gammaherpesviruses and pulmonary fibrosis: evidence from humans, horses, and rodents. Vet Pathol 51:2(372-84)2014 Mar

24515056. Hutchinson MN, Harmon SR, Urick VJ, Williams KJ, Analysis of magnitude and relative phase of photodiode IMD2 using amplitude matched MZM-distortion cancellation technique. Opt Express 22:1(962-71)2014 Jan 13

24509712. Burrows MT, Schoeman DS, Richardson AJ, Molinos JG, Hoffmann A, Buckley LB, Moore PJ, Brown CJ, Bruno JF, Duarte CM, Halpern BS, Hoegh-Guldberg O, Kappel CV, Kiessling W, O'Connor MI, Pandolfi JM, Parmesan C, Sydeman WJ, Ferrier S, Williams KJ, Poloczanska ES, Geographical limits to species-range shifts are suggested by climate velocity. Nature 507:7493(492-5)2014 Mar 27

24410403. Bassan P, Mellor J, Shapiro J, Williams KJ, Lisanti MP, Gardner P, Transmission FT-IR chemical imaging on glass substrates: applications in infrared spectral histopathology. Anal Chem 86:3(1648-53)2014 Feb 4

24364785. Roman J, Brown KK, Olson A, Corcoran BM, Williams KJ, An official American thoracic society workshop report: comparative pathobiology of fibrosing lung disorders in humans and domestic animals. Ann Am Thorac Soc 10:6(S224-9)2013 Dec

24339435. Hassing HC, Surendran RP, Derudas B, Verrijken A, Francque SM, Mooij HL, Bernelot Moens SJ, Hart LM, Nijpels G, Dekker JM, Williams KJ, Stroes ES, Van Gaal LF, Staels B, Nieuwdorp M, Dallinga-Thie GM, SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus. Obesity (Silver Spring) 22:5(1309-16)2014 May

24290974. Kadirvel M, Fairclough M, Cawthorne C, Rowling EJ, Babur M, McMahon A, Birkket P, Smigova A, Freeman S, Williams KJ, Brown G, Detection of apoptosis by PET/CT with the diethyl ester of [¹8F]ML-10 and fluorescence imaging with a dansyl analogue. Bioorg Med Chem 22:1(341-9)2014 Jan 1

24286369. Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM, Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res 15:5(R92)2013 Oct 1

24153255. Kotze HL, Armitage EG, Sharkey KJ, Allwood JW, Dunn WB, Williams KJ, Goodacre R, A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions. BMC Syst Biol 7:(107)2013 Oct 23

24147074. Williams KJ, Robinson NE, Lim A, Brandenberger C, Maes R, Behan A, Bolin SR, Experimental induction of pulmonary fibrosis in horses with the gammaherpesvirus equine herpesvirus 5. PLoS One 8:10(e77754)2013

24130338. Boden G, Cheung P, Salehi S, Homko C, Loveland-Jones C, Jayarajan S, Stein TP, Williams KJ, Liu ML, Barrero CA, Merali S, Insulin regulates the unfolded protein response in human adipose tissue. Diabetes 63:3(912-22)2014 Mar

24096037. Kwekel JC, Forgacs AL, Williams KJ, Zacharewski TR, o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats. Toxicol Appl Pharmacol 273:3(532-41)2013 Dec 15

24043554. Williams KJ, Hayes AJ, A guide to oncological management of soft tissue tumours of the abdominal wall. Hernia 18:1(91-7)2014 Feb

24019948. Gupte M, Tuck AN, Sharma VP, Williams KJ, Major differences between tumor and normal human cell fates after exposure to chemotherapeutic monofunctional alkylator. PLoS One 8:9(e74071)2013

23977896. Stack A, Derksen FJ, Sordillo LM, Williams KJ, Stick JA, Brandenberger C, Steibel JP, Robinson NE, Effects of exercise on markers of venous remodeling in lungs of horses. Am J Vet Res 74:9(1231-8)2013 Sep

23908300. Robinson NE, Williams KJ, Stack A, Derksen FJ, Hauptman J, Millerick-May M, DeFeijter-Rupp H, Reply to Pancheva, Panchev, and Pancheva. J Appl Physiol (1985) 115:3(413)2013 Aug 1

23891094. Burrows N, Telfer B, Brabant G, Williams KJ, Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity. Radiother Oncol 108:3(548-53)2013 Sep

23819599. Williams KJ, Bryant WA, Jenkins VA, Barton GR, Witney AA, Pinney JW, Robertson BD, Deciphering the response of Mycobacterium smegmatis to nitrogen stress using bipartite active modules. BMC Genomics 14:(436)2013 Jul 2

23787625. Urick VJ, Hutchinson MN, Singley JM, McKinney JD, Williams KJ, Suppression of even-order photodiode distortions via predistortion linearization with a bias-shifted Mach-Zehnder modulator. Opt Express 21:12(14368-76)2013 Jun 17

23761611. Williams KJ, Al-Sakkal MN, Alsafi A, Davies AH, Massive localised lymphoedema: a rare vascular malformation. BMJ Case Rep 2013:()2013 Jun 12

23642041. Jenkins VA, Barton GR, Robertson BD, Williams KJ, Genome wide analysis of the complete GlnR nitrogen-response regulon in Mycobacterium smegmatis. BMC Genomics 14:(301)2013 May 4

23640455. Simpson KL, Cawthorne C, Zhou C, Hodgkinson CL, Walker MJ, Trapani F, Kadirvel M, Brown G, Dawson MJ, MacFarlane M, Williams KJ, Whetton AD, Dive C, A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis 4:(e613)2013 May 2

23563690. Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ, Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol 14:5(489-99)2013 May

23533263. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS, De-repression of PDGFRß transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov 3:5(534-47)2013 May

23525115. Chen K, Williams KJ, Molecular mediators for raft-dependent endocytosis of syndecan-1, a highly conserved, multifunctional receptor. J Biol Chem 288:20(13988-99)2013 May 17

23519056. Stovold R, Meredith SL, Bryant JL, Babur M, Williams KJ, Dean EJ, Dive C, Blackhall FH, White A, Neuroendocrine and epithelial phenotypes in small-cell lung cancer: implications for metastasis and survival in patients. Br J Cancer 108:8(1704-11)2013 Apr 30

23499464. Li CJ, Liu Y, Chen Y, Yu D, Williams KJ, Liu ML, Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke. Am J Pathol 182:5(1552-62)2013 May

23440422. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ, An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res 73:9(2850-62)2013 May 1

23427298. Cawthorne C, Burrows N, Gieling RG, Morrow CJ, Forster D, Gregory J, Radigois M, Smigova A, Babur M, Simpson K, Hodgkinson C, Brown G, McMahon A, Dive C, Hiscock D, Wilson I, Williams KJ, [18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941. Mol Cancer Ther 12:5(819-28)2013 May

23402413. Boudreau B, Nelson LL, Carey SA, Williams KJ, Spontaneous pneumothorax secondary to reactive bronchopneumopathy in a dog. J Am Vet Med Assoc 242:5(658-62)2013 Mar 1

23391514. Edelbrock MA, Kaliyaperumal S, Williams KJ, Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res 743-744:(53-66)2013 Mar-Apr

23372148. Williams KJ, Robinson NE, Defeijter-Rupp H, Millerick-May M, Stack A, Hauptman J, Derksen FJ, Distribution of venous remodeling in exercise-induced pulmonary hemorrhage of horses follows reported blood flow distribution in the equine lung. J Appl Physiol (1985) 114:7(869-78)2013 Apr

23363279. Hamer SA, Amuzie CJ, Williams KJ, Smedley RC, Pathology in practice. Infectious laryngotracheitis in laying chickens. J Am Vet Med Assoc 242:4(477-9)2013 Feb 15

23352854. Williams KJ, Bennett MH, Barton GR, Jenkins VA, Robertson BD, Adenylylation of mycobacterial Glnk (PII) protein is induced by nitrogen limitation. Tuberculosis (Edinb) 93:2(198-206)2013 Mar

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