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Martyn K. White, PhD

Assistant Professor, Neuroscience

Assistant Professor, Neurovirology

Location: Room 756 MERB

Telephone:  215-707-8309

Fax:  215-707-4888

Email: whitem@temple.edu

Department of Neuroscience

Center for Neurovirology

BA, Biochemistry - 1979

University of Oxford

United Kingdom

 

MS, Biochemistry - 1982

University of Oxford

United Kingdom

 

PhD, Cell Biology - 1983

University of Oxford

United Kingdom

 

Postdoctoral Fellowship - 1984

University of Oxford

United Kingdom

 

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Interaction of polyomaviruses and host cells; mechanism involved in reactivation of JC virus by the immune system.

Research Summary
The focus of our research lies in the area of mechanisms of regulation of JC virus (JCV) replication and transcription during the course of infection of glial cells. In particular, alterations in cytokine profiles that are associated with immunosuppressive states may play a role in the reactivation of JCV from latency in progressive multifocal leukoencephalopathy (PML). Attention is being focused on the effects of factors produced by activated T-cells that are able to suppress JCV replication when supplied to glial cell cultures. These effects are mediated by the upregulation of expression of a protein designated GBP-i that binds to a GGA/C-rich region (GRS) encompassing the JCV origin of DNA replication (5112 to +4). We are currently engaged in purifying this protein for identification by mass spectrometry. Other research includes investigation of dysregulation of cell-cycle checkpoints and cellular DNA repair processes leading to the accumulation of DNA damage during JCV infection. Evidence points to the involvement of the JCV proteins T-antigen and agnoprotein and their interactions with cellular proteins such as p53, IRS-1, Rad51 and Ku70. Cellular DNA damage accrued by oligodendrocytes and astrocytes likely contributes to cytotoxicity in PML and viral destruction of areas of white matter within the brain that is characteristic of PML pathogenesis. The ability of JCV T-antigen and agnoprotein to dysregulate cell growth and cause DNA damage may also contribute to malignant progression in tumors that express these proteins.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19747512. Romagnoli L, Wollebo HS, Deshmane SL, Mukerjee R, Del Valle L, Safak M, Khalili K, White MK, Modulation of JC virus transcription by C/EBPbeta. Virus Res 146:1-2(97-106)2009 Dec

19640999. White MK, Safak M, Khalili K, Regulation of gene expression in primate polyomaviruses. J Virol 83:21(10846-56)2009 Nov

19282432. Basile A, Darbinian N, Kaminski R, White MK, Gentilella A, Turco MC, Khalili K, Evidence for modulation of BAG3 by polyomavirus JC early protein. J Gen Virol 90:Pt 7(1629-40)2009 Jul

19182532. White MK, Johnson EM, Khalili K, Multiple roles for Puralpha in cellular and viral regulation. Cell Cycle 8:3(1-7)2009 Feb 1

18927497. Kaminski R, Darbinyan A, Merabova N, Deshmane SL, White MK, Khalili K, Protective role of Puralpha to cisplatin. Cancer Biol Ther 7:12(1926-35)2008 Dec

18719392. Mukerjee R, Deshmane SL, Fan S, Del Valle L, White MK, Khalili K, Amini S, Sawaya BE, Involvement of the p53 and p73 transcription factors in neuroAIDS. Cell Cycle 7:17(2682-90)2008 Sep 1

18648329. Del Valle L, White MK, Khalili K, Potential mechanisms of the human polyomavirus JC in neural oncogenesis. J Neuropathol Exp Neurol 67:8(729-40)2008 Aug

18630497. Wang H, White MK, Kaminski R, Darbinian N, Amini S, Johnson EM, Khalili K, Rappaport J, Role of Puralpha in the modulation of homologous recombination-directed DNA repair by HIV-1 Tat. Anticancer Res 28:3A(1441-7)2008 May-Jun

18379198. White MK, Amini S, Khalili K, Kogan M, Donaldson K, Darbinian N, Development of a bidirectional caspase-3 expression system for the induction of apoptosis. Cancer Biol Ther 7:6(945-54)2008 Jun

18353421. Romagnoli L, Sariyer IK, Tung J, Feliciano M, Sawaya BE, Del Valle L, Ferrante P, Khalili K, Safak M, White MK, Early growth response-1 protein is induced by JC virus infection and binds and regulates the JC virus promoter. Virology 375:2(331-41)2008 Jun 5

17989177. Merabova N, Kaniowska D, Kaminski R, Deshmane SL, White MK, Amini S, Darbinyan A, Khalili K, JC virus agnoprotein inhibits in vitro differentiation of oligodendrocytes and promotes apoptosis. J Virol 82:3(1558-69)2008 Feb

17389301. Khalili K, White MK, Lublin F, Ferrante P, Berger JR, Reactivation of JC virus and development of PML in patients with multiple sclerosis. Neurology 68:13(985-90)2007 Mar 27

17368705. Darbinyan A, White MK, Akan S, Radhakrishnan S, Del Valle L, Amini S, Khalili K, Alterations of DNA damage repair pathways resulting from JCV infection. Virology 364:1(73-86)2007 Jul 20

17201119. White MK, Skowronska A, Gordon J, Del Valle L, Deshmane SL, Giordano A, Khalili K, Analysis of a mutant p53 protein arising in a medulloblastoma from a mouse transgenic for the JC virus early region. Anticancer Res 26:6B(4079-92)2006 Nov-Dec

16936749. White MK, Khalili K, Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses. Oncogene 25:38(5286-93)2006 Aug 28

16741955. Claudio PP, Cui J, Ghafouri M, Mariano C, White MK, Safak M, Sheffield JB, Giordano A, Khalili K, Amini S, Sawaya BE, Cdk9 phosphorylates p53 on serine 392 independently of CKII. J Cell Physiol 208:3(602-12)2006 Sep

16741925. Darbinian N, White MK, Khalili K, Regulation of the Pur-alpha promoter by E2F-1. J Cell Biochem 99:4(1052-63)2006 Nov 1

16725168. White MK, Gorrill TS, Khalili K, Reciprocal transactivation between HIV-1 and other human viruses. Virology 352:1(1-13)2006 Aug 15

16690919. Gorrill T, Feliciano M, Mukerjee R, Sawaya BE, Khalili K, White MK, Activation of early gene transcription in polyomavirus BK by human immunodeficiency virus type 1 Tat. J Gen Virol 87:Pt 6(1557-66)2006 Jun

16629416. Khalili K, White MK, Human demyelinating disease and the polyomavirus JCV. Mult Scler 12:2(133-42)2006 Apr

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