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FAculty directory
Hong Wang, MD, PhD
Professor, Pharmacology Telephone: 215-707-5986 Fax: 215-707-7068 Email: hong.wang@temple.edu
Department of Pharmacology
Research interests involve mechanisms of vascular cell growth control and the role of gene deregulation in vascular disease. Current studies are aimed at elucidating the mechanisms underlying the pathological action of homocysteine, a significant and independent risk factor for cardiovascular disease. Research approaches include genetic cloning, molecular biology, protein chemistry and immunohistochemistry. Transgenic mouse and microsurgical models have also been applied to assess endothelial regeneration, vessel function and vascular pathology.
Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)
18067449. Jamaluddin MS, Yang XF, Wang H, Hyperhomocysteinemia, DNA methylation and vascular disease. Clin Chem Lab Med 45:12(1660-6)2007
18020970. Liao D, Yang XF, Wang H, Hyperhomocysteinemia and HDL metabolism in cardiovascular disease. Clin Chem Lab Med 45:12(1652-9)2007
17698632. Jamaluddin SM, Chen I, Yang F, Jiang XH, Jan M, Liu XM, Schafer AI, Durante W, Yang XF, Wang H, Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood 110(3648-55)2007
17715404. Jiang XH, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang XF, Durante W, Wang H, Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells. Arterioscler Thromb Vasc Biol 27(1976-83)2007.
17624250. Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Hodge I, Verstovsek S, Segura FJ, Wang H, Prchal J, Yang XF, A novel unconventional antigen MPD5 elicits anti-tumor humoral immune responses in a subset of patients with polycythemia vera. Int J Immunopathol Pharmacol 20(373-80)2007.
17408602. Liu XM, Peyton KJ, Ensenat D, Wang H, Hannink M, Alam J, Durante W, Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res 75(381-9)2007
17320844. Liu XM, Azam MA, Peyton KJ, Ensenat D, Keswani AN, Wang H, Durante W, Butulated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Cardiovasc Res 74(169-79)2007
17346430. Yan Y, Chen Y, Yang F, Chen IH, Xiong Z, Wang J, Lachman LB, Wang H, Yang XF, HLA-A2: 1-restricted T cells are reacted to SEREX-defined tumor antigen CML66L and suppressed by CD4+CD25+ regulatory T cells. Intl J Immunopathol and Pharmacol 20(75-89)2007
Xiaohua Jiang, MSc Laboratory manager T: 215-707-7633 F: 215-707-7068 Email address: xhjiang@temple.edu
Jian Song, MD, PhD Postdoctoral Fellow T: 215-707-7636 Email address: jiansong@temple.edu
Zhongjian Cheng, MD, PhD Postdoctoral Fellow T: 215-707-7633 Email address: zjcheng@temple.edu
Daqing Zhang, MD, PhD
Jun Zhou, MD, PhD
Pu Fang, BS
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