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Hong Wang, MD, PhD

Professor, Pharmacology

Professor, Sol Sherry Thrombosis Research Center

Assistant Dean, Research

Telephone:  215-707-5986

Fax:  215-707-7068

Email: hong.wang@temple.edu

Department of Pharmacology

Sol Sherry Thrombosis Research Center

MD, Jiang Xi Medical School, Nanchang, China, 1979

 

MSc, Peking Union Medical College, Beijing, China,1985

 

PhD, University of Montreal,  Montreal, Canada 1996

Postdoctoral Fellow, Harvard School of Public Health, Boston, 1994-1997

 

EMBA, The Fox School of Business, Temple University, Philadelphia, PA, 2007-2009

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Research interests involve mechanisms of vascular disease. Current studies are aimed at elucidating the mechanisms underlying the pathological action of hyperhomocysteinemia, a significant and independent risk factor for cardiovascular disease. Research approaches include genetic cloning, molecular biology, protein chemistry and immunohistochemistry. Transgenic mouse and microsurgical models have also been applied to assess endothelial regeneration, vessel function and vascular pathology.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

Zhang DQ, Jiang XH, Fang P, Yan Y, Song J, Gupta S, Schafer AI, Durante W, Kruger WD, Yang XF, Wang H, (2009) Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine β-synthase deficient mice, Circulation, (in press)

Yang, XF, Fang, P, Meng, S, Jan, M, Xiong, X, Yin, Y, Wang, H. (2009) The FOX transcription factors regulate vascular pathology, diabetes and Tregs. Frontiers in Biosci. 1:420-436 (IF 3.6)

Xiong Z, Yan Y, Song J, Fang Pu, Yin, Y, Yang, Y, Cowan A, Wang H, and Yang XF, (2009) Expression of TCTP antisense in CD25high regulatory T cells aggravates cuff-injured vascular inflammation. Atherosclerosis 203, 401-408

Cheng ZJ, Yang XF, and Wang H. (2008) Homocysteine and Endothelial Dysfunction, Current Hypertension Reviews, 5(2):000-000

Yang, XF, Yin, Y, Wang, H, (2008) Vascular inflammation and atherosclerosis are activated via receptors for PAMPs and suppressed by regulatory T cells. Drug Discovery Today, 5(2):125-14

Yan Y, Zhang S, Xiong Z, Song J, Huang YJ, Thorton A, Wang H, Yang XF, (2008) CD25high T cells with a prolonged survival inhibit development of diabetes, International Journal of Immunopathology and Pharmacology 21(4):767-780

Yang XF, Wang H. (2008) Immune responses to stem cells and cancer stem cells. In “Regulatory Networks in Stem Cells” ed. by Drs. Vinagolu Rajasekhar and Mohan Vemuri, Humana/Springer Press.

Brailoiu E, Jiang X, Brailoiu GC, Yang J, Chang JK, Wang H, Dun NJ.(2008)State-dependent calcium mobilization by urotensin-II in cultured human endothelial cells. Peptides. 29(5):721-6

Xiong Z, Song J, Yan Y, Huang YJ, Cowan A, Wang H, Yang XF, (2008) Higher expression of Bax in regulatory T cells lowers the striking threshold of vascular inflammation. Frontiers in Bioscience.13,7143-55

Ke X, Wang J, Li L, Wang H, Yang XF. (2008) Three targets of CD4+CD25+FOXP3+ Tregs in lymphomas and tumors make the treatment more complicated. Frontiers in Biosci. 13, 3986-4001

Jiang XH, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang XF, Durante W and Wang H (2007) Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells, Arterioscler. Thromb. Vasc. Biol. 27:1976-83

Jamaluddin SM, Chen I, Yang F, Jiang XH, Jan M, Liu XM, Schafer AI, Durante W, Yang XF, and Wang H, (2007) Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood 110:3648-3655

Liao D, Yang XF, Wang H, (2007) Hyperhomocysteinemia and HDL metabolism in cardiovascular disease. Clin Chem Lab Med 2007;45(12):1652–1659

Jamaluddin MS; Yang XF, Wang H, (2007) Hyperhomocysteinemia, DNA methylation and vascular disease, Clin Chem Lab Med 2007;45(12):1660–1666

Yan Y, Chen Y, Yang F, Chen IH, Xiong Z, Wang J, Lachman LB, Wang H, Yang XF. (2007) HLA-A2.1-restricted T cells are reacted to SEREX-defined tumor antigen CML66L and suppressed by CD4+CD25+ regulatory T cells. Intl J Immunopathol and Pharmacol 20:75-89

Liu, XM, Mohammed A. Azam, Peyton KJ, Ensenat D, Keswani AN, Wang H, Durante W. (2007) Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Cardiovasc. Res. 74:169-179

Liao D, Tan HM, Hui RT, Li ZH, Jiang XH, Yang F, Durante W, Chan L,Schafer AI,Pownall HJ, Yang XF, Wang H. (2006) Hyperhomocysteinemia Decreases Circulating High-Density Lipoprotein by Inhibiting Apolipoprotein A-I Protein Synthesis and Enhancing HDL Cholesterol Clearanc. Circ. Res. 99:598-606

Yang XF, Mirkovic ID, Zhang S,Zhang QE, Yan Y,Xiong Z, Yang F,Chen IH, Li L, and Wang H, (2006) Processing sites are different in the generation of HLA-A2.1-restricted, T cell reactive tumor antigen epitopes and viral epitopes, Intern J Immunopathol and Pharmacol, 19(4):853-70

Yang, F, Wang, H, Yang, XF. (2006) Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Clin Immunol, 121(2), 121-133

Tulis DA, Keswani AN, Peyton KJ, Wang H, Schafer AI, Durante W. (2005) Local administration of carbon monoxide inhibits neointima formation in balloon injured rat carotid arteries. Cell. Mol. Biol. 51:441-446, 2005

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Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, Mirkovic D, Nguyen J, Wang H, Yang XF. (2005) A N-terminal region of translationally controlled tumor protein is required for its anti-apoptotic activity. Oncogene (Nature Publishing Group) 24, 4778-4788

Yang Y, Xiong Z, Zhang S, Yan Y, Nguyen J, Ng B, Lu H, Brendese J, Yang F, Wang H, Yang X-F. (2005) Bcl-xL inhibits T cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors). Biochem J, 392(1), 135-143

Jiang XH, Yang F, Tan HM, Liao D, Bryan RM Jr., Durante W, Rumbaut RE, Yang XF, Wang H, (2005) Hyperhomocysteinemia impairs endothelial function and eNOS activity via protein kinase C activation, Arterioscler Thromb Vasc Biol., 25:2515-2521

Yang F, Tan HM, Wang H, (2005), Hyperhomocysteinemia and atherosclerosis, Acta Physiologica Sinica, (Sheng Li Xue Bao) 57(2):103-14.

Wang H, Tan HM, Yang F, (2005), Mechanisms in homocysteine-induced vascular disease. Drug Discovery Today (Disease mechanisms). 2(1):25-31

Tan HM, Jiang XH, Yang F, Li ZH, Liao D, Trial J, Magera M, Durante W, Yang XF, Wang H, (2006), Hyperhomocysteinemia inhibits post injury re-endothelialization in mice, Cardiovascular Res, 69(1):253-62s

Granada JF, Ensenat D, Keswani AN, Kaluza GL, Liu X, Peyton KJ, Azam MA, Wang H, Durante W. (2006), Single perivascular delivery of mitomycin C stimulates p21 expression and inhibits neointima formation in rat arteries. Arterioscler. Thromb. Vasc. Biol. 25:2343-2348

Yang F, Tan HM, Wang H, (2005), Hyperhomocysteinemia and atherosclerosis, Acta Physiologica Sinica, (Sheng Li Xue Bao) 57(2):103-14

Wang H, Tan HM, Yang F, (2005), Mechanisms in homocysteine-induced vascular disease. Drug Discovery Today (Disease mechanisms). 2(1):25-31

Ng B, Yang F, Huston DP, Yan Y, Yang Y, Xiong Z, Peterson, LE, Wang H, Yang XF, (2004) Increased non-canonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J Allergy Clin Immunol. 114:1463-1470

Wang H, (2003), Hyperhomocysteinemia: a risk factor for atherosclerosis, Lipid Disorders, 3(3):1-14

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Wang H, Jiang XH, Yang F, Chapman GB, Durante W, Sibinga NES, Schafer AI, (2002) Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition, Blood, 99:939-945

Lee M-E, Wang H, (1999) Homocysteine and hypomethylation: a novel link to vascular disease. Trends Cardiovasc Med. 9:49-54

Wang H, Yoshizumi M, Lai K-H, Tsai J-C, Haber E, Lee M-E (1997) Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem 272 (40) 25380-25385.

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Xiaohua Jiang M.Sc,
Laboratory manager
T: 215-707-7633
Email: xhjiang@temple.edu

Zhongjian Cheng, MD, PhD
Research Associate
T: 215-707-7633
Email: zjcheng@temple.edu

Hang Xi, MD, PhD
Research Associate
T: 215-707-3688
Email: hangxi@temple.edu

Daqing Zhang, MD, PhD
Postdoctoral Fellow
T: 215-707-4614
Email: zhangdq@temple.edu

Jun Zhou MD, PhD
Postdoctoral Fellow
T: 215-707-4614
Email: zhoujun@temple.edu

Le Li, MD, PhD
Postdoctoral Fellow
T: 215-707-4614

Pu Fang, BS
PhD Candidate
T: 215-707-4614
Email: pu.fang@temple.edu

Michael Jan, BS
MD/PhD candidate
T: 215-707-3688
Email: leek1729@gmail.com

Xingyu, Xiong, MS
PhD candidate
T: 215-707-3688
Email: tua67615@temple.edu

Shu Meng, MD MS
PhD candidate
T: 215-707-3688
Email: tua85412@temple.edu

Jingshan Liu, BS
PhD candidate
T: 215-707-4614
Email: jingshanl@temple.edu

Meghana Pansuria, MS
PhD candidate
T: 215-707-4614
Email: meghana.pansuria@temple.edu

Stanislav Sidorov, BS
Post-Baccalaureate fellow
T: 215-707-7688
Email: a9a3@temple.edu

Natalie Cheng Chen, BS
Post-Baccalaureate fellow
T: 215-707-3688
Email: chennata@gmail.com

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