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Hong Wang, MD, PhD

Professor, Pharmacology

Telephone: 215-707-5986

Fax: 215-707-7068

Email: hong.wang@temple.edu

Department of Pharmacology

Educational Background:

MD, Jiang Xi Medical School, Nanchang, China, 1979

MSc, Peking Union Medical College, Beijing, China,1985

PhD, University of Montreal, Montreal, Canada 1996

Postdoctoral Fellow, Harvard School of Public Health, Boston, 1994-1997

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Research Interests:

Data

Research interests involve mechanisms of vascular cell growth control and the role of gene deregulation in vascular disease. Current studies are aimed at elucidating the mechanisms underlying the pathological action of homocysteine, a significant and independent risk factor for cardiovascular disease. Research approaches include genetic cloning, molecular biology, protein chemistry and immunohistochemistry. Transgenic mouse and microsurgical models have also been applied to assess endothelial regeneration, vessel function and vascular pathology.

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pubmed publications:

Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

18067449. Jamaluddin MS, Yang XF, Wang H, Hyperhomocysteinemia, DNA methylation and vascular disease. Clin Chem Lab Med 45:12(1660-6)2007

18020970. Liao D, Yang XF, Wang H, Hyperhomocysteinemia and HDL metabolism in cardiovascular disease. Clin Chem Lab Med 45:12(1652-9)2007

17698632. Jamaluddin SM, Chen I, Yang F, Jiang XH, Jan M, Liu XM, Schafer AI, Durante W, Yang XF, Wang H, Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood 110(3648-55)2007

17715404. Jiang XH, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang XF, Durante W, Wang H, Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells. Arterioscler Thromb Vasc Biol 27(1976-83)2007.

17624250. Xiong Z, Liu E, Yan Y, Silver RT, Yang F, Chen IH, Hodge I, Verstovsek S, Segura FJ, Wang H, Prchal J, Yang XF, A novel unconventional antigen MPD5 elicits anti-tumor humoral immune responses in a subset of patients with polycythemia vera. Int J Immunopathol Pharmacol 20(373-80)2007.

17408602. Liu XM, Peyton KJ, Ensenat D, Wang H, Hannink M, Alam J, Durante W, Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res 75(381-9)2007

17320844. Liu XM, Azam MA, Peyton KJ, Ensenat D, Keswani AN, Wang H, Durante W, Butulated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Cardiovasc Res 74(169-79)2007

17346430. Yan Y, Chen Y, Yang F, Chen IH, Xiong Z, Wang J, Lachman LB, Wang H, Yang XF, HLA-A2: 1-restricted T cells are reacted to SEREX-defined tumor antigen CML66L and suppressed by CD4+CD25+ regulatory T cells. Intl J Immunopathol and Pharmacol 20(75-89)2007

17166407. Yang XF, Mirkovic D, Zhang S, Zhang QE, Yan Y, Xiong Z, Yang F, Chen IH, Li L, Wang H, Processing sites are different in the generation of HLA-A2.1-restricted, T cell reactive tumor antigen epitopes and viral epitopes. Int J Immunopathol Pharmacol 19:4(853-70)2006 Oct-Dec

16931800. Liao D, Tan H, Hui R, Li Z, Jiang X, Gaubatz J, Yang F, Durante W, Chan L, Schafer AI, Pownall HJ, Yang X, Wang H, Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res 99:6(598-606)2006 Sep 15

16226235. Tan H, Jiang X, Yang F, Li Z, Liao D, Trial J, Magera MJ, Durante W, Yang X, Wang H, Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res 69:1(253-62)2006 Jan

16210565. Jiang X, Yang F, Tan H, Liao D, Bryan RM Jr, Randhawa JK, Rumbaut RE, Durante W, Schafer AI, Yang X, Wang H, Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol 25:12(2515-21)2005 Dec

15870695. Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, Mirkovic D, Nguyen J, Wang H, Yang XF, An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene 24:30(4778-88)2005 Jul 14

15830093. Yang F, Tan HM, Wang H, Hyperhomocysteinemia and atherosclerosis. Sheng Li Xue Bao 57:2(103-14)2005 Apr 25

14688378. Yan Y, Phan L, Yang F, Talpaz M, Yang Y, Xiong Z, Ng B, Timchenko NA, Wu CJ, Ritz J, Wang H, Yang XF, A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. J Immunol 172:1(651-60)2004 Jan 1

12506016. Wang H, Jiang X, Yang F, Gaubatz JW, Ma L, Magera MJ, Yang X, Berger PB, Durante W, Pownall HJ, Schafer AI, Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood 101:10(3901-7)2003 May 15

11806997. Wang H, Jiang X, Yang F, Chapman GB, Durante W, Sibinga NE, Schafer AI, Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Blood 99:3(939-45)2002 Feb 1