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FAculty directory
Hong Wang, MD, PhD, EMBA
Associate Dean, Research Professor, Pharmacology Professor, Sol Sherry Thrombosis Research Center Professor, Cardiovascular Research Center Medical Education and Research Building, Room 1060 3500 N. Broad Street Philadelphia, PA 19140 Telephone: 215-707-5986 Fax: 215-707-5737 Email: hong.wang@temple.edu
Department of PharmacologySol Sherry Thrombosis Research CenterCardiovascular Research Center
Dr. Hong Wang’s research focuses on identifying biochemical mechanisms of vascular disease and discovering therapeutic targets and strategies. Current studies are aimed at elucidating the mechanisms underlying the pathological action of hyperhomocysteinemia (HHcy), a significant and independent risk factor for cardiovascular disease. The Wang laboratory has dynamic model systems for fundamental mechanistic study, including genetic cloning, viral particle constriction, molecular biology, protein chemistry, cell biological and immunohistochemistry. Multiple transgenic mouse lines, metabolic and microsurgical models are used for pathological and physiological functional assessment of cardiovascular system, and therapeutically potential.
Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)
11806997. Wang H, Yoshizumi M, Lai K-H, Tsai J-C, Haber E, Lee M-E Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem (1997) 272:25380-25385
11806997. Wang H‡, Jiang XH, Yang F, Chapman GB, Durante W, Sibinga NES, Schafer AI, Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition, Blood, (2002) 99:939-945, ‡ Corresponding author,
12506016. Wang H‡, Jiang XH, Yang F, Gaubatz JW, Ma L, Magera MJ, Yang XF, Berger PB, Durante W, Pownall HJ, Schafer AI, Hyperhomocysteinemia accelerates atherosclerosis in cystathionine -synthase and apolipoprotein E double knockout mice with and without dietary perturbation, Blood, (2004) 101:3901-3907, ‡ Corresponding author
16226235. Tan HM, Jiang XH, Yang F, Li ZH, Liao D, Trial J, Magera M, Durante W, Yang XF, Wang H, Hyperhomocysteinemia inhibits post injury re-endothelialization in mice, Cardiovascular Res, (2006) 69:253-262
16226235. Jiang XH, Yang F, Tan HM, Liao D, Bryan RM Jr., Durante W, Rumbaut RE, Yang XF, Wang H, Hyperhomocysteinemia impairs endothelial function and eNOS activity via protein kinase C activation, Arterioscler Thromb Vasc Biol., (2005) 25:2515-2521
16931800. Liao D, Tan HM, Hui RT, Li ZH, Jiang XH, Yang F, Gaubatz JW, Durante W, Chan L, Schafer AI, Pownall HJ, Yang XF, Wang H. Hyperhomocysteinemia Decreases Circulating High-Density Lipoprotein by Inhibiting Apolipoprotein A-I Protein Synthesis and Enhancing HDL Cholesterol Clearance. Circ. Res. (2006) 99:598-606, [Accompanied by an Editorial: Circ. Res. 99:565-566]
17715404. Jiang XH, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang XF, Durante W and Wang H, Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells, Arterioscler. Thromb. Vasc. Biol. (2007) 27:1976-83
17698632. Jamaluddin SM, Chen I, Yang F, Jiang XH, Jan M, Liu XM, Schafer AI, Durante W, Yang XF, and Wang H, Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood (2007) 110:3648-3655, [Accompanied by an Editorial: Blood,110:3495-3496]
19578482. Yang, XF, Yin, Y, Wang, H, Vascular inflammation and atherosclerosis are activated via receptors for PAMPs and suppressed by regulatory T cells. Drug Discovery Today, (2008)5:125-142
19858416. Zhang, D, Jiang, X, Pu, F, Yan Y, Song, J, Gupta, S, Schafer, AI, Durante, W, Kruger, W, Yang, XF and Wang, H., Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic CBS deficient mice. Circulation (2009) 120:1893-1902
20305127. Chen NC, Yang F, Capecci LM, Gu ZY, Schafer AI, Durante W, Yang XF, Wang H, Regulation of homocysteine metabolism and methylation in human and mouse tissues, The FASEB Journal, (2010) 24(8):2804-17
21653942. Cheng ZJ, Jiang XH, Kruger WD, Praticò D, Gupta S, Mallilankaran K, Muniswamy M, Schafer AI, Durante W, Yang XF, Wang H, Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta-synthase-deficient mice, Blood, (2011) 118:1998-2006 [Accompanied by an Editorial: Blood,118:1717-1719
22202099. Pansuria M, Xi H, Li L, Yang XF, Wang H. (2012) Insulin resistance, metabolic stress, and atherosclerosis, Frontiers in Bioscienc 1;4:916-31. 22628578. Zhang DQ, Fang P, Jiang XH, Nelson J, Moore JK, Kruger WD, Berretta RM, Houser SR, Yang XF, Wang H, Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice, (2012) Circ Res, 111:37-49,
Xiaohua Jiang M.Sc,
Zhongjian Cheng, MD, PhD
Jun Nelson, MD, PhD
Michael Jan, BS
Shu Meng, MD MS
Huimin Shan, MD Assistant Scientist T: 215-707-7633 Email: huimin-shan@temple.edu
Lixiao Zhang, BS PhD candidate T: 215-707-7633 Email: lixiao.zhang@temple.edu
Ramon Cueto, MD Assistant Scientist T: 215-707-7633 Email: ramon.cueto@temple.edu
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