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Ronald Tuma, PhD

G. H. Stewart Professor, Physiology

Associate Professor, Neurosurgery

Telephone:  215-707-5485

Fax:  215-707-4003

Office: Old Medical School room 231

Email: ronald.tuma@temple.edu

Department of Physiology

Department of Neurosurgery

Center for Substance Abuse Research

BS, Muhlenberg College

PhD, Temple University School of Medicine

 

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Research in our laboratory is directed at investigations of inflammatory reactions that contribute central nervous system injury following stroke, trauma or autoimmune disease. Experimental models utilized in these investigations include animal models of stroke, head injury, spinal cord injury and multiple sclerosis.

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Ronald F. Tuma, Walter N. Duran and Klaus Ley.  Handbook of Physiology: Microcirculation.  Academic Press 2008

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19332079. Zhang M, Adler MW, Abood ME, Ganea D, Jallo J, Tuma RF, CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury. Microvasc Res 78:1(86-94)2009 Jun

19255856. Zhang M, Martin BR, Adler MW, Razdan RJ, Kong W, Ganea D, Tuma RF, Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke. J Neuroimmune Pharmacol 4:2(249-59)2009 Jun

18579212. Levene HB, Mohamed FB, Faro SH, Seshadri AB, Loftus CM, Tuma RF, Jallo JI, Small mammal MRI imaging in spinal cord injury: a novel practical technique for using a 1.5 T MRI. J Neurosci Methods 172:2(245-9)2008 Jul 30

18504922. Levene HB, Erb CJ, Gaughan JP, Loftus CM, Tuma RF, Jallo JI, Hypertonic saline as a treatment for acute spinal cord injury: effects on somatic and autonomic outcomes as observed in a mouse model. Clin Neurosurg 54:(213-9)2007

18304750. Zhang M, Martin BR, Adler MW, Razdan RK, Ganea D, Tuma RF, Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury. Neuroscience 152:3(753-60)2008 Mar 27

19248685. Baty DE, Zhang M, Li H, Erb CJ, Adler MW, Ganea D, Loftus CM, Jallo JI, Tuma RF, Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury. Clin Neurosurg 55:(172-7)2008

18076998. Elliott MB, Jallo JJ, Tuma RF, An investigation of cerebral edema and injury volume assessments for controlled cortical impact injury. J Neurosci Methods 168:2(320-4)2008 Mar 15

17574682. Levene HB, Zhang M, Erb CJ, Jallo JI, Loftus CM, Tuma RF, Method to perform IV injections on mice using the facial vein. J Neurosci Methods 164:2(304-7)2007 Aug 30

17548652. Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, Ganea D, The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis. J Immunol 178:12(8138-47)2007 Jun 15

17263683. Elliott MB, Jallo JJ, Gaughan JP, Tuma RF, Effects of crystalloid-colloid solutions on traumatic brain injury. J Neurotrauma 24:1(195-202)2007 Jan

17245417. Zhang M, Martin BR, Adler MW, Razdan RK, Jallo JI, Tuma RF, Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model. J Cereb Blood Flow Metab 27:7(1387-96)2007 Jul

15124761. Ni X, Geller EB, Eppihimer MJ, Eisenstein TK, Adler MW, Tuma RF, Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. Mult Scler 10:2(158-64)2004 Apr

12042091. Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, Bullock MR, Choi SC, Clifton GL, Contant CF, Coplin WM, Dietrich WD, Ghajar J, Grady SM, Grossman RG, Hall ED, Heetderks W, Hovda DA, Jallo J, Katz RL, Knoller N, Kochanek PM, Maas AI, Majde J, Marion DW, Marmarou A, Marshall LF, McIntosh TK, Miller E, Mohberg N, Muizelaar JP, Pitts LH, Quinn P, Riesenfeld G, Robertson CS, Strauss KI, Teasdale G, Temkin N, Tuma R, Wade C, Walker MD, Weinrich M, Whyte J, Wilberger J, Young AB, Yurkewicz L, Clinical trials in head injury. J Neurotrauma 19:5(503-57)2002 May

11969309. Weaver M, Leshley K, Sands H, Gritman KR, Legos JJ, Tuma RF, LEX032, a novel recombinant serpin, protects the brain after transient focal ischemia. Microvasc Res 63:3(327-34)2002 May

11846943. Legos JJ, Gritman KR, Tuma RF, Young WF, Coadministration of methylprednisolone with hypertonic saline solution improves overall neurological function and survival rates in a chronic model of spinal cord injury. Neurosurgery 49:6(1427-33)2001 Dec

11152342. Sumas ME, Legos JJ, Nathan D, Lamperti AA, Tuma RF, Young WF, Tonicity of resuscitative fluids influences outcome after spinal cord injury. Neurosurgery 48:1(167-72; discussion 172-3)2001 Jan

10996707. Young WF, Tuma R, O'Grady T, Intraoperative measurement of spinal cord blood flow in syringomyelia. Clin Neurol Neurosurg 102:3(119-23)2000 Sep

10964586. Ni X, Gritman KR, Eisenstein TK, Adler MW, Arfors KE, Tuma RF, Morphine attenuates leukocyte/endothelial interactions. Microvasc Res 60:2(121-30)2000 Sep

10955677. Spera PA, Vasthare US, Tuma RF, Young WF, The effects of hypertonic saline on spinal cord blood flow following compression injury. Acta Neurochir (Wien) 142:7(811-7)2000

10826005. Thompson MK, Tuma RF, Young WF, The effects of pentoxifylline on spinal cord blood flow after experimental spinal cord injury. J Assoc Acad Minor Phys 10:1(23-6)1999

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Postdoctoral Students:

Ming Zhang, M.D. Ph.D.

Joshua L. Heller, M.D.

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