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Cagla Tukel, PhD Çagla Tükel, PhD

 

Assistant Professor, Microbiology and Immunology

Telephone:  215-707-1298

Fax:  215-707-7788

Email: ctukel@temple.edu

 

 

 

Department of Microbiology and Immunology

 

Educational Background:

 

BSc, Ankara University, Turkey, 1997

 

PhD, Ankara University, Turkey, 2004

 

Postdoctoral training, Texas A&M University System HSC, 2004-2005

 

Postdoctoral training, University of California at Davis, 2005-2009

 

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Research Interests:

 

Dr. Tükel’s research is focused on the role of amyloids during infections. Amyloids are protein deposits with a fibrillar cross beta-sheet quaternary structure, which exhibit a starch (amylose)-like ability to stain with iodine. In humans, deposition of various amyloid proteins is associated with a number of illnesses, such as Alzheimer’s disease, Parkinson's disease, prion diseases, and type-2 diabetes. Interestingly, many bacteria produce functional amyloid deposits, which are an important component of their extracellular biofilm matrix. Curli amyloid fibrils, produced by enteric bacteria such as Salmonella enterica serotype Typhimurium and E. coli, are the best-characterized bacterial amyloid fibrils to date. Amyloids of both host and bacterial origin share a number of characteristics, including an ability to trigger innate immune responses. Recently, the Tükel lab discovered that responses to host amyloids and curli amyloid fibrils are mediated through Toll-like receptor (TLR) 2. Currently, the Tükel lab is interested in:

 

  • The role of bacterial amyloids during infection
  • The mechanisms by which the host immune system responds to bacterial biofilms containing amyloids
  • Identifying other novel components of the extracellular biofilm matrix and their interaction with the host

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25422268. Rapsinski GJ, Wynosky-Dolfi MA, Oppong GO, Tursi SA, Wilson RP, Brodsky IE, Tükel C, TLR2 and NLRP3 cooperate to recognize functional bacterial amyloid curli. Infect Immun :()2014 Nov 24

24278013. Hufnagel DA, Tükel C, Chapman MR, Disease to dirt: the biology of microbial amyloids. PLoS Pathog 9:11(e1003740)2013

23548899. Rapsinski GJ, Newman TN, Oppong GO, van Putten JP, Tükel Ç, CD14 protein acts as an adaptor molecule for the immune recognition of Salmonella curli fibers. J Biol Chem 288:20(14178-88)2013 May 17

23208603. Oppong GO, Rapsinski GJ, Newman TN, Nishimori JH, Biesecker SG, Tükel Ç, Epithelial cells augment barrier function via activation of the Toll-like receptor 2/phosphatidylinositol 3-kinase pathway upon recognition of Salmonella enterica serovar Typhimurium curli fibrils in the gut. Infect Immun 81:2(478-86)2013 Feb

23027540. Nishimori JH, Newman TN, Oppong GO, Rapsinski GJ, Yen JH, Biesecker SG, Wilson RP, Butler BP, Winter MG, Tsolis RM, Ganea D, Tükel Ç, Microbial amyloids induce interleukin 17A (IL-17A) and IL-22 responses via Toll-like receptor 2 activation in the intestinal mucosa. Infect Immun 80:12(4398-408)2012 Dec

21098104. Wilson RP, Winter SE, Spees AM, Winter MG, Nishimori JH, Sanchez JF, Nuccio SP, Crawford RW, Tükel Ç, Bäumler AJ, The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Infect Immun 79:2(830-7)2011 Feb

20497180. Tükel C, Nishimori JH, Wilson RP, Winter MG, Keestra AM, van Putten JP, Bäumler AJ, Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms. Cell Microbiol 12:10(1495-505)2010 Oct

19819699. Santos RL, Raffatellu M, Bevins CL, Adams LG, Tükel C, Tsolis RM, Bäumler AJ, Life in the inflamed intestine, Salmonella style. Trends Microbiol 17:11(498-506)2009 Nov

19616765. Tükel C, Wilson RP, Nishimori JH, Pezeshki M, Chromy BA, Bäumler AJ, Responses to amyloids of microbial and host origin are mediated through toll-like receptor 2. Cell Host Microbe 6:1(45-53)2009 Jul 23

19451244. Haneda T, Winter SE, Butler BP, Wilson RP, Tükel C, Winter MG, Godinez I, Tsolis RM, Bäumler AJ, The capsule-encoding viaB locus reduces intestinal inflammation by a Salmonella pathogenicity island 1-independent mechanism. Infect Immun 77:7(2932-42)2009 Jul

18331470. Chessa D, Winter MG, Nuccio SP, Tükel C, Bäumler AJ, RosE represses Std fimbrial expression in Salmonella enterica serotype Typhimurium. Mol Microbiol 68:3(573-87)2008 May

18034866. Wilson RP, Raffatellu M, Chessa D, Winter SE, Tükel C, Bäumler AJ, The Vi-capsule prevents Toll-like receptor 4 recognition of Salmonella. Cell Microbiol 10:4(876-90)2008 Apr

17351045. Tükel C, Akçelik M, de Jong MF, Simsek O, Tsolis RM, Bäumler AJ, MarT activates expression of the MisL autotransporter protein of Salmonella enterica serotype Typhimurium. J Bacteriol 189:10(3922-6)2007 May

17048701. Tükel C, Sanlibaba P, Ozden B, Akçelik M, Identification of adsorption inhibition, restriction/modification and abortive infection type phage resistance systems in Lactococcus lactis strains. Acta Biol Hung 57:3(377-85)2006 Sep

16553804. Tükel C, Raffatellu M, Chessa D, Wilson RP, Akçelik M, Bäumler AJ, Neutrophil influx during non-typhoidal salmonellosis: who is in the driver's seat? FEMS Immunol Med Microbiol 46:3(320-9)2006 Apr

16523441. Akçelik O, Tükel C, Ozcengiz G, Akçelik M, Characterization of bacteriocins from two Lactococcus lactis subsp. lactis isolates. Mol Nutr Food Res 50:3(306-13)2006 Mar

16368953. Raffatellu M, Chessa D, Wilson RP, Tükel C, Akçelik M, Bäumler AJ, Capsule-mediated immune evasion: a new hypothesis explaining aspects of typhoid fever pathogenesis. Infect Immun 74:1(19-27)2006 Jan

16164566. Tükel C, Raffatellu M, Humphries AD, Wilson RP, Andrews-Polymenis HL, Gull T, Figueiredo JF, Wong MH, Michelsen KS, Akçelik M, Adams LG, Bäumler AJ, CsgA is a pathogen-associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll-like receptor 2. Mol Microbiol 58:1(289-304)2005 Oct

15754247. Coleri A, Cokmus C, Ozcan B, Akcelik M, Tukel C, Determination of antibiotic resistance and resistance plasmids of clinical Enterococcus species. J Gen Appl Microbiol 50:4(213-9)2004 Aug

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