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Yoshiya Toyoda, MD, PhD

Vice Chief, Cardiovascular Surgery

Surgical Director, Heart and Lung Transplantation

Director, Mechanical Circulatory Support

Professor, Surgery

Telephone: 215-707-7692

Email: yoshiya.toyoda@tuhs.temple.edu

Department of Surgery, Section of Cardiovascular Surgery

Undergraduate degree, Kobe University, Kobe, Japan, 1986

 

MD, Kobe University School of Medicine, Kobe, Japan, 1990

 

Internship, Kobe University Hospital, Kobe, Japan, 1991

 

Residency, Kobe University Hospital, Kobe, Japan, 1994

 

Fellowship, Cardiac Surgery, Massachusetts General Hospital, Boston, MA

 

Fellowship, Cardiopulmonary Transplant and Assist Device, University of Pittsburgh Medical Center

 

Fellowship, Cardiac Surgery, Kobe Children's Hospital, Kobe, Japan

 

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• Surgical treatment for end-stage cardiopulmonary diseases including heart and lung transplantation
• Mechanical circulatory support and artificial lung
• Major cardiac surgery such as repair of aortic aneurysm and dissection, valve repair/replacement
• Coronary artery bypass
• Adult congenital heart surgery

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• Thoracic and Cardiac Surgery
• Surgery

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• American Association for Thoracic Surgery
• Society of Thoracic Surgeons
• International Society of Heart and Lung Transplantation

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• Myocardial protection/preservation
• Pulmonary protection/preservation
• Cardiac artery function, Xenotransplantation

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23623543. Taghavi S, Jayarajan S, Komaroff E, Horai T, Brann S, Cordova F, Criner G, Guy TS, Toyoda Y, Double-Lung Transplantation Can Be Safely Performed Using Donors With Heavy Smoking History. Ann Thorac Surg :()2013 Apr 25

23614963. Toyoda Y, Guy TS, Kashem A, Present status and future perspectives of heart transplantation. Circ J 77:5(1097-110)2013 Apr 25

23474360. Bhama JK, Shulman J, Bermudez CA, Bansal A, Ramani R, Teuteberg JJ, Shullo M, McNamara DM, Kormos RL, Toyoda Y, Heart transplantation for adults with congenital heart disease: Results in the modern era. J Heart Lung Transplant 32:5(499-504)2013 May

23456986. Toyoda Y, Cadaveric donor lobar lung transplantation for patients on extracorporeal membrane oxygenation as bridge-to-transplant. Gen Thorac Cardiovasc Surg 61:4(197-200)2013 Apr

23332185. Toyoda Y, Bhama JK, Shigemura N, Zaldonis D, Pilewski J, Crespo M, Bermudez C, Efficacy of extracorporeal membrane oxygenation as a bridge to lung transplantation. J Thorac Cardiovasc Surg 145:4(1065-70; discussion 1070-1)2013 Apr

23246061. Ota T, Rocha R, Wei LM, Toyoda Y, Gleason TG, Bermudez C, Surgical outcomes after cardiac surgery in liver transplant recipients. J Thorac Cardiovasc Surg 145:4(1072-6)2013 Apr

23202531. Shigemura N, Toyoda Y, Bhama JK, Gries CJ, Crespo M, Johnson B, Zaldonis D, Pilewski JM, Bermudez CA, Donor smoking history and age in lung transplantation: a revisit. Transplantation 95:3(513-8)2013 Feb 15

23171940. Lim SH, Lee S, Noda K, Kawamura T, Tanaka Y, Shigemura N, Nakao A, Toyoda Y, Adenosine injection prior to cardioplegia enhances preservation of senescent hearts in rat heterotopic heart transplantation. Eur J Cardiothorac Surg :()2012 Nov 26

22986156. Shields RK, Clancy CJ, Minces LR, Kwak EJ, Silveira FP, Abdel Massih RC, Toyoda Y, Bermudez C, Bhama JK, Shigemura N, Pilewski JM, Crespo M, Hong Nguyen M, Staphylococcus aureus infections in the early period after lung transplantation: epidemiology, risk factors, and outcomes. J Heart Lung Transplant 31:11(1199-206)2012 Nov

22902635. Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao A, Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun 425:4(873-9)2012 Sep 7

22891787. Noda K, Tanaka Y, Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A, Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int 25:12(1213-22)2012 Dec

22830948. Shields RK, Nguyen MH, Shullo MA, Silveira FP, Kwak EJ, Abdel Massih RC, Toyoda Y, Bermudez CA, Bhama JK, Kormos RL, Clancy CJ, Invasive aspergillosis among heart transplant recipients is rare but causes rapid death due to septic shock and multiple organ dysfunction syndrome. Scand J Infect Dis 44:12(982-6)2012 Dec

22648925. Sugimoto R, Tanaka Y, Noda K, Kawamura T, Toyoda Y, Billiar TR, McCurry KR, Nakao A, Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury. Eur J Cardiothorac Surg 42:6(1035-41)2012 Dec

22482463. Zhu X, McTiernan CF, Rajagopalan N, Shah H, Fischer D, Toyoda Y, Letts D, Bortinger J, Gibson G, Xiang W, McCurry K, Mathier M, Glorioso JC, London B, Immunosuppression decreases inflammation and increases AAV6-hSERCA2a-mediated SERCA2a expression. Hum Gene Ther 23:7(722-32)2012 Jul

22330924. Mitsani D, Nguyen MH, Shields RK, Toyoda Y, Kwak EJ, Silveira FP, Pilewski JM, Crespo MM, Bermudez C, Bhama JK, Clancy CJ, Prospective, observational study of voriconazole therapeutic drug monitoring among lung transplant recipients receiving prophylaxis: factors impacting levels of and associations between serum troughs, efficacy, and toxicity. Antimicrob Agents Chemother 56:5(2371-7)2012 May

22300103. Shigemura N, Bhama J, Gries CJ, Kawamura T, Crespo M, Johnson B, Zaldonis D, Pilewski J, Toyoda Y, Bermudez C, Lung transplantation in patients with prior cardiothoracic surgical procedures. Am J Transplant 12:5(1249-55)2012 May

22287575. Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB, Pribis JP, Billiar TR, Sun X, Bermudez CA, Toyoda Y, Nakao A, Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res 94:1(144-53)2012 Apr 1

22245165. Dew MA, DiMartini AF, DeVito Dabbs AJ, Fox KR, Myaskovsky L, Posluszny DM, Switzer GE, Zomak RA, Kormos RL, Toyoda Y, Onset and risk factors for anxiety and depression during the first 2 years after lung transplantation. Gen Hosp Psychiatry 34:2(127-38)2012 Mar-Apr

22201609. Nakao A, Toyoda Y, Application of carbon monoxide for transplantation. Curr Pharm Biotechnol 13:6(827-36)2012 May

22192755. Horai T, Shigemura N, Gries C, Pilewski J, Bhama JK, Bermudez CA, Zaldonis D, Toyoda Y, Lung transplantation for patients with high lung allocation score: single-center experience. Ann Thorac Surg 93:5(1592-7; discussion 1597)2012 May

22186486. Shayan H, Sareyyupoglu B, Shigemura N, Thacker J, Bermudez C, Toyoda Y, Lung transplant, double valve repair, and pulmonary artery aneurysm resection. Ann Thorac Surg 93:1(e3-5)2012 Jan

22146695. Nakao A, Toyoda Y, Book Review: Gas Biology Research in Clinical Practice, edited by Toshikazu Yoshikawa and Yuji Naito. Med Gas Res 1:1(25)2011 Oct 3

22146004. Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, Nakao A, Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res 1:1(11)2011 Jun 7

22093502. Ramani R, Vela D, Segura A, McNamara D, Lemster B, Samarendra V, Kormos R, Toyoda Y, Bermudez C, Frazier OH, Moravec CS, Gorcsan J 3rd, Taegtmeyer H, McTiernan CF, A micro-ribonucleic acid signature associated with recovery from assist device support in 2 groups of patients with severe heart failure. J Am Coll Cardiol 58:22(2270-8)2011 Nov 22

21995559. Shayan H, Rocha R, Wei L, Gleason T, Zaldonis D, Pellegrini R, Toyoda Y, Shapiro R, Ahmad F, Bermudez C, Midterm outcomes of off-pump and on-pump coronary artery revascularization in renal transplant recipients. J Card Surg 26:6(591-5)2011 Nov

21982150. Bermudez CA, Rocha RV, Toyoda Y, Zaldonis D, Sappington PL, Mulukutla S, Marroquin OC, Toma C, Bhama JK, Kormos RL, Extracorporeal membrane oxygenation for advanced refractory shock in acute and chronic cardiomyopathy. Ann Thorac Surg 92:6(2125-31)2011 Dec

21979983. Ota T, Bansal A, Toyoda Y, Successful conservative management of blunt right ventricular rupture in a patient with prior cardiac surgery. Interact Cardiovasc Thorac Surg 13:6(686-7)2011 Dec

21958791. Zahr F, Genovese E, Mathier M, Shullo M, Lockard K, Zomak R, McNamara D, Toyoda Y, Kormos RL, Teuteberg JJ, Obese patients and mechanical circulatory support: weight loss, adverse events, and outcomes. Ann Thorac Surg 92:4(1420-6)2011 Oct

21956195. Buchholz BM, Masutani K, Kawamura T, Peng X, Toyoda Y, Billiar TR, Bauer AJ, Nakao A, Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation 92:9(985-92)2011 Nov 15

21931001. Hoppo T, Jarido V, Pennathur A, Morrell M, Crespo M, Shigemura N, Bermudez C, Hunter JG, Toyoda Y, Pilewski J, Luketich JD, Jobe BA, Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation. Arch Surg 146:9(1041-7)2011 Sep

21872213. Bermudez CA, Rocha RV, Zaldonis D, Bhama JK, Crespo MM, Shigemura N, Pilewski JM, Sappington PL, Boujoukos AJ, Toyoda Y, Extracorporeal membrane oxygenation as a bridge to lung transplant: midterm outcomes. Ann Thorac Surg 92:4(1226-31; discussion 1231-2)2011 Oct

21801961. Kawamura T, Huang CS, Peng X, Masutani K, Shigemura N, Billiar TR, Okumura M, Toyoda Y, Nakao A, The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery 150:2(240-9)2011 Aug

21700686. Shigemura N, Sareyyupoglu B, Bhama J, Bonde P, Thacker J, Bermudez C, Gries C, Crespo M, Johnson B, Pilewski J, Toyoda Y, Combining tricuspid valve repair with double lung transplantation in patients with severe pulmonary hypertension, tricuspid regurgitation, and right ventricular dysfunction. Chest 140:4(1033-9)2011 Oct

21693326. Shigemura N, Bermudez C, Bhama J, Bonde P, Thacker J, Toyoda Y, Successful lung retransplantation after extended use of extracorporeal membrane oxygenation as a bridge. Transplant Proc 43:5(2063-5)2011 Jun

21524451. Ota T, Gleason TG, Salizzoni S, Wei LM, Toyoda Y, Bermudez C, Midterm surgical outcomes of noncomplicated active native multivalve endocarditis: single-center experience. Ann Thorac Surg 91:5(1414-9)2011 May

21524442. Singh M, Shullo M, Kormos RL, Lockard K, Zomak R, Simon MA, Bermudez C, Bhama J, McNamara D, Toyoda Y, Teuteberg JJ, Impact of renal function before mechanical circulatory support on posttransplant renal outcomes. Ann Thorac Surg 91:5(1348-54)2011 May

21507918. Luong ML, Clancy CJ, Vadnerkar A, Kwak EJ, Silveira FP, Wissel MC, Grantham KJ, Shields RK, Crespo M, Pilewski J, Toyoda Y, Kleiboeker SB, Pakstis D, Reddy SK, Walsh TJ, Nguyen MH, Comparison of an Aspergillus real-time polymerase chain reaction assay with galactomannan testing of bronchoalvelolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in lung transplant recipients. Clin Infect Dis 52:10(1218-26)2011 May

21497229. Bhama JK, Pilewski JM, Zaldonis D, Fontes PA, DeVera ME, Shullo MA, Shigemura N, Bermudez CA, Toyoda Y, McCurry KR, Does simultaneous lung-liver transplantation provide an immunologic advantage compared with isolated lung transplantation? J Thorac Cardiovasc Surg 141:5(e36-8)2011 May

21473852. Huang CS, Kawamura T, Peng X, Tochigi N, Shigemura N, Billiar TR, Nakao A, Toyoda Y, Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun 408:2(253-8)2011 May 6

21420318. Shyu S, Dew MA, Pilewski JM, DeVito Dabbs AJ, Zaldonis DB, Studer SM, Crespo MM, Toyoda Y, Bermudez CA, McCurry KR, Five-year outcomes with alemtuzumab induction after lung transplantation. J Heart Lung Transplant 30:7(743-54)2011 Jul

21353436. Shields RK, Kwak EJ, Potoski BA, Doi Y, Adams-Haduch JM, Silviera FP, Toyoda Y, Pilewski JM, Crespo M, Pasculle AW, Clancy CJ, Nguyen MH, High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. Diagn Microbiol Infect Dis 70:2(246-52)2011 Jun

21352993. Lee S, Huang CS, Kawamura T, Shigemura N, Billiar TR, Nakao A, Toyoda Y, Histidine-tryptophan-ketoglutarate or celsior: which is more suitable for cold preservation for cardiac grafts from older donors? Ann Thorac Surg 91:3(755-63)2011 Mar

21348909. Minces LR, Bhama JK, Abdel-Massih R, Kwak EJ, Haider SS, Nguyen MH, Toyoda Y, Silveira FP, Successful double lung transplantation in a patient with bilateral pulmonary and sinus aspergillomas. Transpl Infect Dis 13:5(485-8)2011 Oct

21303417. Khandhar SJ, Shah HV, Shullo MA, Zomak R, Navoney M, McNamara DM, Kormos RL, Toyoda Y, Teuteberg JJ, Long-term effects on renal function of dose-reduced calcineurin inhibitor and sirolimus in cardiac transplant patients. Clin Transplant 26:1(42-9)2012 Jan-Feb

21280186. Scouras NE, Matsusaki T, Boucek CD, Wells C, Cooper EA, Planinsic RM, Sullivan EA, Bermudez CA, Toyoda Y, Sakai T, Portopulmonary hypertension as an indication for combined heart, lung, and liver or lung and liver transplantation: literature review and case presentation. Liver Transpl 17:2(137-43)2011 Feb

21256326. Horai T, Bhama JK, Fontes PA, Toyoda Y, Combined heart and liver transplantation in a patient with situs ambiguous. Ann Thorac Surg 91:2(600-1)2011 Feb

21239188. Mitsani D, Nguyen MH, Girnita DM, Spichty K, Kwak EJ, Silveira FP, Toyoda Y, Pilewski JM, Crespo M, Bhama JK, Abdel-Massih R, Zaldonis D, Zeevi A, Clancy CJ, A polymorphism linked to elevated levels of interferon-? is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center. J Heart Lung Transplant 30:5(523-9)2011 May

21189337. Shields RK, Clancy CJ, Vadnerkar A, Kwak EJ, Silveira FP, Massih RC, Pilewski JM, Crespo M, Toyoda Y, Bhama JK, Bermudez C, Nguyen MH, Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy. Antimicrob Agents Chemother 55:3(1308-11)2011 Mar

21184683. Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N, Buchholz BM, Kloke JD, Billiar TR, Toyoda Y, Nakao A, Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care 14:6(R234)2010

21144769. Vadnerkar A, Toyoda Y, Crespo M, Pilewski J, Mitsani D, Kwak EJ, Silveira FP, Bhama J, Shields R, Bermudez C, Clancy CJ, Nguyen MH, Age-specific complications among lung transplant recipients 60 years and older. J Heart Lung Transplant 30:3(273-81)2011 Mar

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