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Yoshiya Toyoda, MD, PhD


Yoshiya Toyoda, MD, PhD


Chief, Cardiovascular Surgery, Temple University Hospital
Surgical Director, Heart and Lung Transplantation, Temple University Hospital
Director, Mechanical Circulatory Support, Temple University Hospital
Co-Surgical Director, Temple Heart & Vascular Institute
Professor, Surgery

Telephone: 215-707-7692

Email: yoshiya.toyoda@tuhs.temple.edu



Department of Surgery, Division of Cardiovascular Surgery


Educational Background:


Undergraduate degree, Kobe University, Kobe, Japan, 1986


MD, Kobe University School of Medicine, Kobe, Japan, 1990


Internship, Kobe University Hospital, Kobe, Japan, 1991


Residency, Kobe University Hospital, Kobe, Japan, 1994


Fellowship, Cardiac Surgery, Massachusetts General Hospital, Boston, MA


Fellowship, Cardiopulmonary Transplant and Assist Device, University of Pittsburgh Medical Center


Fellowship, Cardiac Surgery, Kobe Children's Hospital, Kobe, Japan


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clinical Interests:

  • Surgical treatment for end-stage cardiopulmonary diseases including heart and lung transplantation
  • Mechanical circulatory support and artificial lung
  • Major cardiac surgery such as repair of aortic aneurysm and dissection, valve repair/replacement
  • Coronary artery bypass
  • Adult congenital heart surgery

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board certification(s):


  • Thoracic and Cardiac Surgery
  • Surgery

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  • American Association for Thoracic Surgery
  • Society of Thoracic Surgeons
  • International Society of Heart and Lung Transplantation

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Research Interests:


  • Myocardial protection/preservation
  • Pulmonary protection/preservation
  • Cardiac artery function, Xenotransplantation

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26177087. Rosenberger EM, DiMartini AF, DeVito Dabbs AJ, Bermudez CA, Pilewski JM, Toyoda Y, Dew MA, Psychiatric Predictors of Long-Term Transplant-Related Outcomes in Lung Transplant Recipients. Transplantation :()2015 Jul 14

25999250. Taghavi S, Ambur V, Jayarajan SN, Gaughan J, Toyoda Y, Dauer E, Sjoholm LO, Pathak A, Santora T, Goldberg AJ, Rappold J, Postoperative outcomes with cholecystectomy in lung transplant recipients. Surgery 158:2(373-8)2015 Aug

25606795. Taghavi S, Jayarajan SN, Komaroff E, Shiose A, Schwartz D, Hamad E, Alvarez R, Wheatley G, Guy TS, Toyoda Y, Use of Heavy Drinking Donors in Heart Transplantation is Not Associated With Worse Mortality. Transplantation 99:6(1226-30)2015 Jun

25575787. Jayarajan S, Taghavi S, Komaroff E, Shiose A, Schwartz D, Hamad E, Alvarez R, Wheatley G, Guy TS, Toyoda Y, Long-term outcomes in heart transplantation using donors with a history of past and present cocaine use. Eur J Cardiothorac Surg 47:4(e146-50)2015 Apr

25232769. Taghavi S, Beyer C, Vora H, Jayarajan SN, Toyoda Y, Dujon J, Sjoholm LO, Pathak A, Santora TA, Goldberg AJ, Rappold JF, Noncardiac surgery in patients on mechanical circulatory support. ASAIO J 60:6(670-4)2014 Nov-Dec

25132981. Toyoda Y, Toyoda Y, Heart-lung transplantation: adult indications and outcomes. J Thorac Dis 6:8(1138-42)2014 Aug

25106683. Taghavi S, Jayarajan SN, Furuya Y, Komaroff E, Shiose A, Leotta E, Hisamoto K, Patel N, Cordova F, Criner G, Guy TS, Toyoda Y, Examining ABO compatible donors in double lung transplants during the era of lung allocation score. Ann Thorac Surg 98:4(1167-74)2014 Oct

25062102. Shiose A, Desai P, Criner GJ, Pai S, Steiner RM, Kaiser LR, Guy TS, Toyoda Y, One-and-a-half ventricular repair for isolated right ventricle metastatic tumor resection after lobectomy for lung cancer. Innovations (Phila) 9:4(330-3)2014 Jul-Aug

25006411. George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, Champion HC, Pilewski JM, Gladwin MT, First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease. Pulm Circ 3:4(952-8)2013 Dec

24940140. Bansal A, Shigemura N, Toyoda Y, Bhama JK, Successful lung transplantation from a donor with persistent lobar atelectasis. Ochsner J 14:2(266-9)2014 Summer

24880825. Taghavi S, Jayarajan SN, Furuya Y, Komaroff E, Shiose A, Leotta E, Hisamoto K, Patel N, Cordova F, Criner G, Guy TS, Toyoda Y, Single-lung transplantation with ABO-compatible donors results in excellent outcomes. J Heart Lung Transplant 33:8(822-8)2014 Aug

24841447. Toyoda Y, Kashem MA, Hisamoto K, Shiose A, Tricuspid valve reconstruction with the extracellular matrix tube technique: a word of caution. J Thorac Cardiovasc Surg 148:2(e141-3)2014 Aug

24825527. Shigemura N, Horai T, Bhama JK, D'Cunha J, Zaldonis D, Toyoda Y, Pilewski JM, Luketich JD, Bermudez CA, Lung transplantation with lungs from older donors: recipient and surgical factors affect outcomes. Transplantation 98:8(903-8)2014 Oct 27

24157482. Bhama JK, Bansal A, Shigemura N, Toyoda Y, Reconstruction technique for a short recipient left atrial cuff during lung transplantation. Eur J Cardiothorac Surg 45:6(1106-7)2014 Jun

24145525. Minces LR, Nguyen MH, Mitsani D, Shields RK, Kwak EJ, Silveira FP, Abdel-Massih R, Pilewski JM, Crespo MM, Bermudez C, Bhama JK, Toyoda Y, Clancy CJ, Ganciclovir-resistant cytomegalovirus infections among lung transplant recipients are associated with poor outcomes despite treatment with foscarnet-containing regimens. Antimicrob Agents Chemother 58:1(128-35)2014

24056630. Jayarajan SN, Taghavi S, Komaroff E, Brann S, Horai T, Cordova F, Patel N, Guy TS, Toyoda Y, Impact of extracorporeal membrane oxygenation or mechanical ventilation as bridge to combined heart-lung transplantation on short-term and long-term survival. Transplantation 97:1(111-5)2014 Jan 15

24054808. Taghavi S, Jayarajan SN, Komaroff E, Horai T, Brann S, Patel N, Cordova F, Criner G, Sloane Guy T, Toyoda Y, Single-lung transplantation can be performed with acceptable outcomes using selected donors with heavy smoking history. J Heart Lung Transplant 32:10(1005-12)2013 Oct

23847280. Bhama JK, Bansal A, Shigemura N, Bermudez CA, Toyoda Y, Sternal-sparing approach for reoperative bilateral lung transplantation. Interact Cardiovasc Thorac Surg 17:5(835-7)2013 Nov

23781381. Chokkalingam Mani B, Mathur M, Clauss H, Alvarez R, Hamad E, Toyoda Y, Birkenbach M, Ahmed M, Strongyloides stercoralis and Organ Transplantation. Case Rep Transplant 2013:(549038)2013

23773735. Shigemura N, D'Cunha J, Bhama JK, Shiose A, Abou El Ela A, Hackmann A, Zaldonis D, Toyoda Y, Pilewski JM, Luketich JD, Bermudez CA, Lobar lung transplantation: a relevant surgical option in the current era of lung allocation score. Ann Thorac Surg 96:2(451-6)2013 Aug

23710593. Shields RK, Clancy CJ, Minces LR, Shigemura N, Kwak EJ, Silveira FP, Abdel-Massih RC, Bhama JK, Bermudez CA, Pilewski JM, Crespo M, Toyoda Y, Nguyen MH, Epidemiology and outcomes of deep surgical site infections following lung transplantation. Am J Transplant 13:8(2137-45)2013 Aug

23623543. Taghavi S, Jayarajan S, Komaroff E, Horai T, Brann S, Cordova F, Criner G, Guy TS, Toyoda Y, Double-lung transplantation can be safely performed using donors with heavy smoking history. Ann Thorac Surg 95:6(1912-7; discussion 1917-8)2013 Jun

23614963. Toyoda Y, Guy TS, Kashem A, Present status and future perspectives of heart transplantation. Circ J 77:5(1097-110)2013

23475767. Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A, Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol 304:10(L646-56)2013 May 15

23474360. Bhama JK, Shulman J, Bermudez CA, Bansal A, Ramani R, Teuteberg JJ, Shullo M, McNamara DM, Kormos RL, Toyoda Y, Heart transplantation for adults with congenital heart disease: results in the modern era. J Heart Lung Transplant 32:5(499-504)2013 May

23456986. Toyoda Y, Cadaveric donor lobar lung transplantation for patients on extracorporeal membrane oxygenation as bridge-to-transplant. Gen Thorac Cardiovasc Surg 61:4(197-200)2013 Apr

23332185. Toyoda Y, Bhama JK, Shigemura N, Zaldonis D, Pilewski J, Crespo M, Bermudez C, Efficacy of extracorporeal membrane oxygenation as a bridge to lung transplantation. J Thorac Cardiovasc Surg 145:4(1065-70; discussion 1070-1)2013 Apr

23246061. Ota T, Rocha R, Wei LM, Toyoda Y, Gleason TG, Bermudez C, Surgical outcomes after cardiac surgery in liver transplant recipients. J Thorac Cardiovasc Surg 145:4(1072-6)2013 Apr

23202531. Shigemura N, Toyoda Y, Bhama JK, Gries CJ, Crespo M, Johnson B, Zaldonis D, Pilewski JM, Bermudez CA, Donor smoking history and age in lung transplantation: a revisit. Transplantation 95:3(513-8)2013 Feb 15

23171940. Lim SH, Lee S, Noda K, Kawamura T, Tanaka Y, Shigemura N, Nakao A, Toyoda Y, Adenosine injection prior to cardioplegia enhances preservation of senescent hearts in rat heterotopic heart transplantation. Eur J Cardiothorac Surg 43:6(1202-8)2013 Jun

22986156. Shields RK, Clancy CJ, Minces LR, Kwak EJ, Silveira FP, Abdel Massih RC, Toyoda Y, Bermudez C, Bhama JK, Shigemura N, Pilewski JM, Crespo M, Hong Nguyen M, Staphylococcus aureus infections in the early period after lung transplantation: epidemiology, risk factors, and outcomes. J Heart Lung Transplant 31:11(1199-206)2012 Nov

22902635. Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao A, Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun 425:4(873-9)2012 Sep 7

22891787. Noda K, Tanaka Y, Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A, Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int 25:12(1213-22)2012 Dec

22830948. Shields RK, Nguyen MH, Shullo MA, Silveira FP, Kwak EJ, Abdel Massih RC, Toyoda Y, Bermudez CA, Bhama JK, Kormos RL, Clancy CJ, Invasive aspergillosis among heart transplant recipients is rare but causes rapid death due to septic shock and multiple organ dysfunction syndrome. Scand J Infect Dis 44:12(982-6)2012 Dec

22648925. Sugimoto R, Tanaka Y, Noda K, Kawamura T, Toyoda Y, Billiar TR, McCurry KR, Nakao A, Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury. Eur J Cardiothorac Surg 42:6(1035-41)2012 Dec

22482463. Zhu X, McTiernan CF, Rajagopalan N, Shah H, Fischer D, Toyoda Y, Letts D, Bortinger J, Gibson G, Xiang W, McCurry K, Mathier M, Glorioso JC, London B, Immunosuppression decreases inflammation and increases AAV6-hSERCA2a-mediated SERCA2a expression. Hum Gene Ther 23:7(722-32)2012 Jul

22330924. Mitsani D, Nguyen MH, Shields RK, Toyoda Y, Kwak EJ, Silveira FP, Pilewski JM, Crespo MM, Bermudez C, Bhama JK, Clancy CJ, Prospective, observational study of voriconazole therapeutic drug monitoring among lung transplant recipients receiving prophylaxis: factors impacting levels of and associations between serum troughs, efficacy, and toxicity. Antimicrob Agents Chemother 56:5(2371-7)2012 May

22300103. Shigemura N, Bhama J, Gries CJ, Kawamura T, Crespo M, Johnson B, Zaldonis D, Pilewski J, Toyoda Y, Bermudez C, Lung transplantation in patients with prior cardiothoracic surgical procedures. Am J Transplant 12:5(1249-55)2012 May

22287575. Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB, Pribis JP, Billiar TR, Sun X, Bermudez CA, Toyoda Y, Nakao A, Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res 94:1(144-53)2012 Apr 1

22245165. Dew MA, DiMartini AF, DeVito Dabbs AJ, Fox KR, Myaskovsky L, Posluszny DM, Switzer GE, Zomak RA, Kormos RL, Toyoda Y, Onset and risk factors for anxiety and depression during the first 2 years after lung transplantation. Gen Hosp Psychiatry 34:2(127-38)2012 Mar-Apr

22201609. Nakao A, Toyoda Y, Application of carbon monoxide for transplantation. Curr Pharm Biotechnol 13:6(827-36)2012 May

22192755. Horai T, Shigemura N, Gries C, Pilewski J, Bhama JK, Bermudez CA, Zaldonis D, Toyoda Y, Lung transplantation for patients with high lung allocation score: single-center experience. Ann Thorac Surg 93:5(1592-7; discussion 1597)2012 May

22186486. Shayan H, Sareyyupoglu B, Shigemura N, Thacker J, Bermudez C, Toyoda Y, Lung transplant, double valve repair, and pulmonary artery aneurysm resection. Ann Thorac Surg 93:1(e3-5)2012 Jan

22146695. Nakao A, Toyoda Y, Book Review: Gas Biology Research in Clinical Practice, edited by Toshikazu Yoshikawa and Yuji Naito. Med Gas Res 1:1(25)2011 Oct 3

22146004. Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, Nakao A, Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res 1:1(11)2011 Jun 7

22093502. Ramani R, Vela D, Segura A, McNamara D, Lemster B, Samarendra V, Kormos R, Toyoda Y, Bermudez C, Frazier OH, Moravec CS, Gorcsan J 3rd, Taegtmeyer H, McTiernan CF, A micro-ribonucleic acid signature associated with recovery from assist device support in 2 groups of patients with severe heart failure. J Am Coll Cardiol 58:22(2270-8)2011 Nov 22

21995559. Shayan H, Rocha R, Wei L, Gleason T, Zaldonis D, Pellegrini R, Toyoda Y, Shapiro R, Ahmad F, Bermudez C, Midterm outcomes of off-pump and on-pump coronary artery revascularization in renal transplant recipients. J Card Surg 26:6(591-5)2011 Nov

21982150. Bermudez CA, Rocha RV, Toyoda Y, Zaldonis D, Sappington PL, Mulukutla S, Marroquin OC, Toma C, Bhama JK, Kormos RL, Extracorporeal membrane oxygenation for advanced refractory shock in acute and chronic cardiomyopathy. Ann Thorac Surg 92:6(2125-31)2011 Dec

21979983. Ota T, Bansal A, Toyoda Y, Successful conservative management of blunt right ventricular rupture in a patient with prior cardiac surgery. Interact Cardiovasc Thorac Surg 13:6(686-7)2011 Dec

21958791. Zahr F, Genovese E, Mathier M, Shullo M, Lockard K, Zomak R, McNamara D, Toyoda Y, Kormos RL, Teuteberg JJ, Obese patients and mechanical circulatory support: weight loss, adverse events, and outcomes. Ann Thorac Surg 92:4(1420-6)2011 Oct

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