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Young-Jin Son, PhD

 

Young-Jin Son, PhD

 

Associate Professor, Anatomy and Cell Biology

Associate Professor, Shriners Hospitals Pediatric Research Center

Telephone: 215-926-9354 (Internal: 7-9354)

Email: yson@temple.edu

 

 

Department of Anatomy and Cell Biology

Shriners Hospitals Pediatric Research Center

 

Educational Background:

 

BS, Biology, Korea University, Seoul, Korea, 1988

 

PhD, Neuroscience (advisor: Wesley J. Thompson), University of Texas, Austin, TX, 1994

 

Postdoctoral fellowship, Department of Anatomy and Neurobiology (mentors: Joshua R. Sanes, Robert S. Wilkinson), Washington University School of Medicine, St. Louis, MO, 1994-1998

 

Postdoctoral fellowship, Department of Physiology and Biophysics (mentor: Steve S. Carlson), University of Washington School of Medicine, Seattle, WA, 1998-2000

 

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professional affiliations:

 
  • Society for Neuroscience
  • Society for Cell Biology
  • Peripheral Nerve Society

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RESEARCH INTERESTS:

 

Plasticity and Repair of Neural Connections between Spinal cord and Muscle

 

  • Sensory nerve regeneration
  • Neuromuscular junctions
  • Spinal root injuries
  • Neuromuscular disorders

My lab wants to elucidate the mechanisms that govern maintenance and regeneration of synaptic connections in the spinal cord and muscle, particularly those associated with glial cells. I discovered earlier, with Wes Thompson, that Schwann cells play pivotal roles in restoring synaptic connections in muscles, i.e., neuromuscular junctions (NMJs). I have then extended the discovery by identifying glia-associated factors that promote formation and maintenance of NMJs (e.g., mAChRs and CAMs), by investigating factors that disturb stability of mature NMJs (e.g., spinal cord injury, paralysis), and by studying roles of Schwann cells and other glia in sensory nerve regeneration (i.e., restoration of sensory synaptic connections in the spinal cord). My lab was the first to demonstrate that particular muscles paralyzed by spinal cord injury fail to maintain NMJs and therefore lose neural connections with the spinal cord. We also showed that muscarinic signaling is a novel receptor system essential for stable maintenance of NMJs. This latter finding lays the foundation for a new line of investigation of how spinal cord-muscle connections are maintained in muscles in an activity dependent manner. More recently, we have begun to utilize stem cells to restore spinal cord-muscle connections. Technically, my lab has pioneered in applying time-lapse in vivo imaging and fluorescent transgenic mice to study spinal root regeneration, asking why sensory axons fail to regenerate into spinal cord, and how to promote regeneration and synaptic connections with the spinal cord. We hope that our work, which uses various state-of-the-art molecular and cellular techniques, will lead to novel therapeutic strategies to promote repair of spinal cord-muscle connections in patients with neuromuscular, spinal cord or spinal root injury.

 

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Selected Publications:

 

24733831 O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J. B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med 2014

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25045209. Yi YS, Son YJ, Ryou C, Sung GH, Kim JH, Cho JY, Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses. Mediators Inflamm 2014:(270302)2014

24975277. Lee JY, Seo JH, Lee SJ, Son YJ, Cho YD, Kang HS, Han MH, Mid-term outcome of intracranial aneurysms treated with HydroSoft coils compared to historical controls treated with bare platinum coils: a single-center experience. Acta Neurochir (Wien) :()2014 Jul 1

24891860. Lee HS, Lee SH, Chung YS, Yang HJ, Son YJ, Park SB, Large spinal meningioma with hemorrhage after selective root block in the thoraco-lumbar spine. Korean J Spine 10:4(255-7)2013 Dec

24872911. Lee SK, Son YJ, Kim J, Kim HG, Lee JI, Kang BY, Cho HS, Lee S, Prediction Model for Health-Related Quality of Life of Elderly with Chronic Diseases using Machine Learning Techniques. Healthc Inform Res 20:2(125-34)2014 Apr

24838971. Skuba A, Manire MA, Kim H, Han SB, Son YJ, Time-lapse in vivo imaging of dorsal root nerve regeneration in mice. Methods Mol Biol 1162:(219-32)2014

24735861. Yang Y, Yang WS, Yu T, Sung GH, Park KW, Yoon K, Son YJ, Hwang H, Kwak YS, Lee CM, Rhee MH, Kim JH, Cho JY, ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract. J Ethnopharmacol 154:1(218-28)2014 May 28

24733831. O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med 211:5(801-14)2014 May 5

24705502. Kim H, Kim KJ, Yeon JT, Kim SH, Won DH, Choi H, Nam SJ, Son YJ, Kang H, Placotylene A, an inhibitor of the receptor activator of nuclear factor-?B ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp. Mar Drugs 12:4(2054-65)2014 Apr 3

24681702. Jeon JS, Kim JE, Chung YS, Oh S, Ahn JH, Cho WS, Son YJ, Bang JS, Kang HS, Sohn CH, Oh CW, A risk factor analysis of prospective symptomatic haemorrhage in adult patients with cerebral cavernous malformation. J Neurol Neurosurg Psychiatry :()2014 Mar 28

24605124. Han JW, Oh K, Yoo S, Kim E, Ahn KH, Son YJ, Kim TH, Chi YK, Kim KW, Development of the ubiquitous spaced retrieval-based memory advancement and rehabilitation training program. Psychiatry Investig 11:1(52-8)2014 Jan

24586466. Yeon JT, Kim KJ, Choi SW, Moon SH, Park YS, Ryu BJ, Oh J, Kim MS, Erkhembaatar M, Son YJ, Kim SH, Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLC?-independent Ca2+ oscillation. PLoS One 9:2(e88974)2014

24527192. Park SB, Chung CK, Lee SH, Yang HJ, Son YJ, Chung YS, The impact of menopause on bone fusion after the single-level anterior cervical discectomy and fusion. J Korean Neurosurg Soc 54:6(496-500)2013 Dec

24463570. Cho YD, Ahn JH, Jung SC, Kim CH, Kang HS, Kim JE, Son YJ, Han MH, Coil embolization in precommunicating (A1) segment aneurysms of anterior cerebral artery. Neuroradiology 56:3(219-25)2014 Mar

24412408. Jeong TH, Son YJ, Ryu HB, Koo BK, Jeong SM, Hoang P, Do BH, Song JA, Chong SH, Robinson RC, Choe H, Soluble expression and partial purification of recombinant human erythropoietin from E. coli. Protein Expr Purif 95:(211-8)2014 Mar

24292994. Jeon JS, Ahn JH, Moon YJ, Cho WS, Son YJ, Kim SK, Wang KC, Bang JS, Kang HS, Kim JE, Oh CW, Expression of cellular retinoic acid-binding protein-I (CRABP-I) in the cerebrospinal fluid of adult onset moyamoya disease and its association with clinical presentation and postoperative haemodynamic change. J Neurol Neurosurg Psychiatry 85:7(726-31)2014 Jul

24278653. Kim DH, Park SB, Lee SH, Son YJ, Chung GS, Yang HJ, Quantitative evaluation of median nerve motor function in carpal tunnel syndrome using load cell : correlation with clinical, electrodiagnostic, and ultrasonographic findings. J Korean Neurosurg Soc 54:3(232-5)2013 Sep

24278642. Kim KH, Lee CH, Son YJ, Yang HJ, Chung YS, Lee SH, Post-carotid endarterectomy cerebral hyperperfusion syndrome : is it preventable by strict blood pressure control? J Korean Neurosurg Soc 54:3(159-63)2013 Sep

24234913. Son YJ, Kim WJ, Yoo HS, Therapeutic applications of electrospun nanofibers for drug delivery systems. Arch Pharm Res 37:1(69-78)2014 Jan

24201757. Lee SC, Jeon JS, Kim JE, Chung YS, Ahn JH, Cho WS, Son YJ, Bang JS, Kang HS, Oh CW, Contralateral progression and its risk factor in surgically treated unilateral adult moyamoya disease with a review of pertinent literature. Acta Neurochir (Wien) 156:1(103-11)2014 Jan

24198362. Niu J, Ding L, Li JJ, Kim H, Liu J, Li H, Moberly A, Badea TC, Duncan ID, Son YJ, Scherer SS, Luo W, Modality-based organization of ascending somatosensory axons in the direct dorsal column pathway. J Neurosci 33:45(17691-709)2013 Nov 6

24150974. Park HY, Kim EY, Lee SE, Choi HY, Moon JJ, Park MJ, Son YJ, Lee JB, Jeong CJ, Lee DS, Riu KJ, Park SP, Effect of human adipose tissue-derived mesenchymal-stem-cell bioactive materials on porcine embryo development. Mol Reprod Dev 80:12(1035-47)2013 Dec

24144632. Kim MH, Son YJ, Lee SY, Yang WS, Yi YS, Yoon DH, Yang Y, Kim SH, Lee D, Rhee MH, Kang H, Kim TW, Sung GH, Cho JY, JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide. Biochem Pharmacol 86:12(1747-61)2013 Dec 15

24118689. Son YJ, Kim SH, Park JH, Role of depressive symptoms and self-efficacy of medication adherence in Korean patients after successful percutaneous coronary intervention. Int J Nurs Pract :()2013 Oct 11

24088178. Son YJ, Kim H, Leong KW, Yoo HS, Multifunctional nanorods serving as nanobridges to modulate T cell-mediated immunity. ACS Nano 7:11(9771-9)2013 Nov 26

24012124. Ku MJ, Park JW, Ryu BJ, Son YJ, Kim SH, Lee SY, CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells. Bioorg Med Chem Lett 23:20(5609-13)2013 Oct 15

23844351. Son YJ, Kim JE, Park SB, Lee SH, Chung YS, Yang HJ, Quantitative analysis of intraoperative indocyanine green video angiography in aneurysm surgery. J Cerebrovasc Endovasc Neurosurg 15:2(76-84)2013 Jun

23817101. Son YJ, Yoon IS, Sung JH, Cho HJ, Chung SJ, Shim CK, Kim DD, Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery. Int J Biol Macromol 61:(175-81)2013 Oct

23801087. Golshahi L, Tian G, Azimi M, Son YJ, Walenga R, Longest PW, Hindle M, The use of condensational growth methods for efficient drug delivery to the lungs during noninvasive ventilation high flow therapy. Pharm Res 30:11(2917-30)2013 Nov

23781005. Jeon JS, Ahn JH, Huh W, Son YJ, Bang JS, Kang HS, Sohn CH, Oh CW, Kwon OK, Kim JE, A retrospective analysis on the natural history of incidental small paraclinoid unruptured aneurysm. J Neurol Neurosurg Psychiatry 85:3(289-94)2014 Mar

23761891. Je HS, Yang F, Ji Y, Potluri S, Fu XQ, Luo ZG, Nagappan G, Chan JP, Hempstead B, Son YJ, Lu B, ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctions. J Neurosci 33:24(9957-62)2013 Jun 12

23730862. Park JH, Tahk SJ, Bae SH, Son YJ, Effects of a psychoeducational intervention for secondary prevention in Korean patients with coronary artery disease: a pilot study. Int J Nurs Pract 19:3(295-305)2013 Jun

23634273. Jeon JS, Lee SH, Son YJ, Chung YS, Dissecting aneurysm of vertebral artery manifestating as contralateral abducens nerve palsy. J Korean Neurosurg Soc 53:3(194-6)2013 Mar

23626916. Lee SK, Kang BY, Kim HG, Son YJ, Predictors of medication adherence in elderly patients with chronic diseases using support vector machine models. Healthc Inform Res 19:1(33-41)2013 Mar

23608613. Son YJ, Longest PW, Tian G, Hindle M, Evaluation and modification of commercial dry powder inhalers for the aerosolization of a submicrometer excipient enhanced growth (EEG) formulation. Eur J Pharm Sci 49:3(390-9)2013 Jun 14

23560176. Jeon JS, Lee SH, Son YJ, Chung YS, Slowly recovering isolated bilateral abducens nerve palsy after embolization of ruptured anterior communicating artery aneurysm. J Korean Neurosurg Soc 53:2(112-4)2013 Feb

23509596. Choi SW, Moon SH, Yang HJ, Kwon DY, Son YJ, Yu R, Kim YS, Kim SI, Chae EJ, Park SJ, Kim SH, Antiresorptive activity of bacillus-fermented antler extracts: inhibition of osteoclast differentiation. Evid Based Complement Alternat Med 2013:(748687)2013

23471640. Longest PW, Son YJ, Holbrook L, Hindle M, Aerodynamic factors responsible for the deaggregation of carrier-free drug powders to form micrometer and submicrometer aerosols. Pharm Res 30:6(1608-27)2013 Jun

23440939. Jeon JS, Lee SH, Son YJ, Yang HJ, Chung YS, Jung HW, Mobile computed tomography : three year clinical experience in Korea. J Korean Neurosurg Soc 53:1(39-42)2013 Jan

23435912. Kim YM, Ku MJ, Son YJ, Yun JM, Kim SH, Lee SY, Anti-metastatic effect of cantharidin in A549 human lung cancer cells. Arch Pharm Res 36:4(479-84)2013 Apr

23376592. Druz A, Son YJ, Betenbaugh M, Shiloach J, Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metab Eng 16:(87-94)2013 Mar

23329142. Bae JY, Koo BK, Ryu HB, Song JA, Nguyen MT, Vu TT, Son YJ, Lee HK, Choe H, Cu/Zn incorporation during purification of soluble human EC-SOD from E. coli stabilizes proper disulfide bond formation. Appl Biochem Biotechnol 169:5(1633-47)2013 Mar

23313343. Son YJ, Worth Longest P, Hindle M, Aerosolization characteristics of dry powder inhaler formulations for the excipient enhanced growth (EEG) application: effect of spray drying process conditions on aerosol performance. Int J Pharm 443:1-2(137-45)2013 Feb 25

23160430. Cho YD, Lee JY, Seo JH, Lee SJ, Kang HS, Kim JE, Son YJ, Jung KH, Kwon OK, Han MH, Does stent implantation improve the result of repeat embolization in recanalized aneurysms? Neurosurgery 71:2 Suppl Operative(ons253-9; discussion ons259)2012 Dec

23273243. Longest PW, Walenga RL, Son YJ, Hindle M, High-efficiency generation and delivery of aerosols through nasal cannula during noninvasive ventilation. J Aerosol Med Pulm Drug Deliv 26:5(266-79)2013 Oct

23269416. Shin AR, Lee KS, Lee KI, Shim TS, Koh WJ, Jeon HS, Son YJ, Shin SJ, Kim HJ, Serodiagnostic potential of Mycobacterium avium MAV2054 and MAV5183 proteins. Clin Vaccine Immunol 20:2(295-301)2013 Feb

23131005. Ahn J, Park KM, Lee H, Son YJ, Choi ES, GAL promoter-driven heterologous gene expression in Saccharomyces cerevisiae ? strain at anaerobic alcoholic fermentation. FEMS Yeast Res 13:1(140-2)2013 Feb

23055786. Han SB, Kim H, Skuba A, Tessler A, Ferguson T, Son YJ, Sensory Axon Regeneration: A Review from an in vivo Imaging Perspective. Exp Neurobiol 21:3(83-93)2012 Sep

23044006. Min CK, Lee JW, Kim CK, Kim SH, Lee SY, Lee SM, Son YJ, Insulin related compounds and identification. J Chromatogr B Analyt Technol Biomed Life Sci 908:(105-12)2012 Nov 1

23043744. Ahn J, Park KM, Lee H, Son YJ, Choi ES, GAL promoter-driven heterologous gene expression in Saccharomyces cerevisiae ?gal8 strain at anaerobic alcoholic fermentation. FEMS Yeast Res :()2012 Oct 9

23038678. Kim YP, Lee GS, Kim JW, Kim MS, Ahn HS, Lim JY, Kim HW, Son YJ, Knowles JC, Hyun JK, Phosphate glass fibres promote neurite outgrowth and early regeneration in a peripheral nerve injury model. J Tissue Eng Regen Med :()2012 Oct 5

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TRAINEES:

 

Postdoctoral Fellows and Other Scientists Supervised:

 

Wha-Ja Cho, PhD (postdoctoral fellow,  2003-2004), Research Assistant Professor, Biomedical Research Center, University of Ulsan, Korea

 

Sabiha Jawaid, PhD (postdoctoral fellow, 2004-2006), Assistant Professor, Department of Basic Sciences, Cleveland Chiropractic College, Kansas City

 

Srilatha Potluri, PhD (postdoctoral fellow, 2006-2009)

 

Jung Keun Hyun, MD, PhD (visiting scholar, 2008-2009), Assistant Professor, Department of Nanobiomedical Science, Dankook University, Korea

 

Alessandro Di Maio, PhD (Research Associate, 2008-2010), Postdoctoral fellow, Department of Cell biology and Molecular biology, University of California, Santa Barbara

 

Xiaoqing Tang, PhD (postdoctoral fellow, 2010-present)

 

Graduate Students Supervised (as Primary Advisor):

 

Megan Wright, PhD (PhD Program, 2002-2007), Assistant Professor, Department of Biology, Arcadia University, Philadelphia

 

Eva Dentcheva, BA (summer student and research technician, 2007-2008), MD program in Drexel University College of Medicine

 

Srishti Bhagat, BS (summer student and research technician, 2004-2007), MD/PhD program in Neuroscience, Duke University School of Medicine

 

Andy Skuba, BA (PhD Program, 2009-present)

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