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Young-Jin Son, PhD


Young-Jin Son, PhD


Associate Professor, Anatomy and Cell Biology

Associate Professor, Shriners Hospitals Pediatric Research Center

Telephone: 215-926-9354 (Internal: 7-9354)

Email: yson@temple.edu



Department of Anatomy and Cell Biology

Shriners Hospitals Pediatric Research Center


Educational Background:


BS, Biology, Korea University, Seoul, Korea, 1988


PhD, Neuroscience (advisor: Wesley J. Thompson), University of Texas, Austin, TX, 1994


Postdoctoral fellowship, Department of Anatomy and Neurobiology (mentors: Joshua R. Sanes, Robert S. Wilkinson), Washington University School of Medicine, St. Louis, MO, 1994-1998


Postdoctoral fellowship, Department of Physiology and Biophysics (mentor: Steve S. Carlson), University of Washington School of Medicine, Seattle, WA, 1998-2000


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professional affiliations:

  • Society for Neuroscience
  • Society for Cell Biology
  • Peripheral Nerve Society

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Plasticity and Repair of Neural Connections between Spinal cord and Muscle


  • Sensory nerve regeneration
  • Neuromuscular junctions
  • Spinal root injuries
  • Neuromuscular disorders

My lab wants to elucidate the mechanisms that govern maintenance and regeneration of synaptic connections in the spinal cord and muscle, particularly those associated with glial cells. I discovered earlier, with Wes Thompson, that Schwann cells play pivotal roles in restoring synaptic connections in muscles, i.e., neuromuscular junctions (NMJs). I have then extended the discovery by identifying glia-associated factors that promote formation and maintenance of NMJs (e.g., mAChRs and CAMs), by investigating factors that disturb stability of mature NMJs (e.g., spinal cord injury, paralysis), and by studying roles of Schwann cells and other glia in sensory nerve regeneration (i.e., restoration of sensory synaptic connections in the spinal cord). My lab was the first to demonstrate that particular muscles paralyzed by spinal cord injury fail to maintain NMJs and therefore lose neural connections with the spinal cord. We also showed that muscarinic signaling is a novel receptor system essential for stable maintenance of NMJs. This latter finding lays the foundation for a new line of investigation of how spinal cord-muscle connections are maintained in muscles in an activity dependent manner. More recently, we have begun to utilize stem cells to restore spinal cord-muscle connections. Technically, my lab has pioneered in applying time-lapse in vivo imaging and fluorescent transgenic mice to study spinal root regeneration, asking why sensory axons fail to regenerate into spinal cord, and how to promote regeneration and synaptic connections with the spinal cord. We hope that our work, which uses various state-of-the-art molecular and cellular techniques, will lead to novel therapeutic strategies to promote repair of spinal cord-muscle connections in patients with neuromuscular, spinal cord or spinal root injury.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26611237. Kim S, Son YJ, Chiu YC, Jeffers MA, Yang CY, Impact of road environment on drivers' behaviors in dilemma zone: Application of agent-based simulation. Accid Anal Prev :()2015 Nov 20

26587188. Lee HS, Lee SH, Chung YS, Yang HJ, Son YJ, Park SB, Usefulness of Fracture Risk Assessment Tool Using Lumbar Bone Mineral Density in Prediction of Osteoporotic Vertebral Fracture. J Korean Neurosurg Soc 58:4(346-349)2015 Oct

26518617. Lee JH, Subhadra B, Son YJ, Kim DH, Park HS, Kim JM, Koo SH, Oh MH, Kim HJ, Choi CH, Phylogenetic group distributions, virulence factors and antimicrobial resistance properties of uropathogenic Escherichia coli strains isolated from patients with urinary tract infections in South Korea. Lett Appl Microbiol :()2015 Oct 30

26473138. Son YJ, Lee MJ, Koh H, Kim S, Asymptomatic Bile Duct Dilatation in Children: Is It a Disease? Pediatr Gastroenterol Hepatol Nutr 18:3(180-6)2015 Sep

26413242. Kim HR, Lee JY, Kim YK, Park H, Kim HJ, Son YJ, Jeon BS, Dural Arteriovenous Fistula-Associated Reversible Parkinsonism with Presynaptic Dopaminergic Loss. J Mov Disord 8:3(141-3)2015 Sep

26406791. Jeon JP, Kim JE, Ahn JH, Cho WS, Cho YD, Son YJ, Bang JS, Kang HS, Sohn CH, Chung HT, Oh CW, Kim DG, Long-term treatment outcome of venous-predominant arteriovenous malformation. J Neurosurg :(1-7)2015 Sep 25

26315815. Kim HS, Yoon S, Son YJ, Park Y, Jung YM, Yoo HS, High-yield clicking and dissociation of doxorubicin nanoclusters exhibiting differential cellular uptakes and imaging. J Control Release 217:(64-73)2015 Nov 10

26293650. Yu T, Yang Y, Yin Q, Hong S, Son YJ, Kim JH, Cho JY, TBK1 inhibitors: a review of patent literature (2011 - 2014). Expert Opin Ther Pat :(1-12)2015 Aug 21

26273291. Kim KJ, Leutou AS, Yeon JT, Choi SW, Kim SH, Yee ST, Choi KH, Nam SJ, Son YJ, The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis. Int J Endocrinol 2015:(132436)2015

26208796. Kim KJ, Yeon JT, Choi SW, Moon SH, Ryu BJ, Yu R, Park SJ, Kim SH, Son YJ, Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts. Bone 81:(208-16)2015 Dec

26208638. Yeon JT, Kim KJ, Chun SW, Lee HI, Lim JY, Son YJ, Kim SH, Choi SW, KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK-NFATc1 signaling axis. J Cell Sci 128:18(3411-9)2015 Sep 15

26159133. Song Y, Son YJ, Oh D, Methodological Issues in Questionnaire Design. J Korean Acad Nurs 45:3(323-8)2015 Jun

26139616. Kim CK, Lee SB, Son YJ, Large-Scale Refolding and Enzyme Reaction of Human Preproinsulin for Production of Human Insulin. J Microbiol Biotechnol 25:10(1742-50)2015 Oct 28

26074678. Yang WS, Son YJ, Kim MY, Kim S, Kim JH, Cho JY, AP-1-Targeted Anti-Inflammatory Activities of the Nanostructured, Self-Assembling S5 Peptide. Mediators Inflamm 2015:(451957)2015

26054884. Kelamangalath L, Tang X, Bezik K, Sterling N, Son YJ, Smith GM, Neurotrophin selectivity in organizing topographic regeneration of nociceptive afferents. Exp Neurol 271:(262-78)2015 Sep

26054575. You MA, Choe MH, Park GO, Kim SH, Son YJ, Perceptions regarding medication administration errors among hospital staff nurses of South Korea. Int J Qual Health Care 27:4(276-83)2015 Aug

26053132. Son YJ, Kim Y, Kim WJ, Jeong SY, Yoo HS, Antibacterial Nanofibrous Mats Composed of Eudragit for pH-Dependent Dissolution. J Pharm Sci 104:8(2611-8)2015 Aug

25974308. Son YJ, Han J, Lee JY, Kim H, Chun T, Improved efficacy of soluble human receptor activator of nuclear factor kappa B (RANK) fusion protein by site-directed mutagenesis. Immunopharmacol Immunotoxicol 37:3(221-7)2015 Jun

25942492. Choi YH, Park HK, Ahn KH, Son YJ, Paik NJ, A Telescreening Tool to Detect Aphasia in Patients with Stroke. Telemed J E Health 21:9(729-34)2015 Sep

25929894. Jeon JP, Yun T, Jin X, Cho WS, Son YJ, Bang JS, Kang HS, Oh CW, Kim JE, Park S, 1H-NMR-based metabolomic analysis of cerebrospinal fluid from adult bilateral moyamoya disease: comparison with unilateral moyamoya disease and atherosclerotic stenosis. Medicine (Baltimore) 94:17(e629)2015 May

25892136. Watters AK, Rom S, Hill JD, Dematatis MK, Zhou Y, Merkel SF, Andrews AM, Cena J, Potula R, Skuba A, Son YJ, Persidsky Y, Ramirez SH, Identification and dynamic regulation of tight junction protein expression in human neural stem cells. Stem Cells Dev 24:12(1377-89)2015 Jun 15

25885639. Son YJ, Jeong S, Kang BG, Kim SH, Lee SK, Visualization of e-Health Research Topics and Current Trends Using Social Network Analysis. Telemed J E Health 21:5(436-42)2015 May

25878717. Hossen MJ, Kim SC, Son YJ, Baek KS, Kim E, Yang WS, Jeong D, Park JG, Kim HG, Chung WJ, Yoon K, Ryou C, Lee SY, Kim JH, Cho JY, AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis. Evid Based Complement Alternat Med 2015:(608126)2015

25878571. Son YJ, Synapsing with NG2 cells (polydendrocytes), unappreciated barrier to axon regeneration? Neural Regen Res 10:3(346-8)2015 Mar

25855362. Jeon HS, Shin AR, Son YJ, Kim JM, Jang Y, Kim S, Lee KI, Choi CH, Park JK, Kim HJ, An evaluation of the use of immunoglobulin A antibody response against mycobacterial antigens for the diagnosis of Mycobacterium bovis infection in cattle. J Vet Diagn Invest 27:3(344-51)2015 May

25839376. Cho WS, Hong HS, Kang HS, Kim JE, Cho YD, Kwon OK, Bang JS, Hwang G, Son YJ, Oh CW, Han MH, Stability of Cerebral Aneurysms After Stent-Assisted Coil Embolization: A Propensity Score-Matched Analysis. Neurosurgery 77:2(208-16; discussion 216-7)2015 Aug

25807193. Lee W, Lee SY, Son YJ, Yun JM, Gallic Acid Decreases Inflammatory Cytokine Secretion Through Histone Acetyltransferase/Histone Deacetylase Regulation in High Glucose-Induced Human Monocytes. J Med Food 18:7(793-801)2015 Jul

25737735. Hwang YH, Kim KJ, Kim JJ, Kang KY, Lee SJ, Jeong GY, Choi KH, Son YJ, Yee ST, Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice. Evid Based Complement Alternat Med 2015:(373145)2015

25734761. Yeon JT, Choi SW, Ryu BJ, Kim KJ, Lee JY, Byun BJ, Son YJ, Kim SH, Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. J Nat Prod 78:4(776-82)2015 Apr 24

25723125. You MA, Nam SM, Son YJ, Parental Experiences of Medication Administration to Children at Home and Understanding of Adverse Drug Events. J Nurs Res 23:3(189-96)2015 Sep

25549739. Son YJ, Song Y, Park SY, Kim JI, A psychometric evaluation of the Korean version of the evidence-based practice questionnaire for nurses. Contemp Nurse 49:(4-14)2014

25429908. Son YJ, Song Y, Park SY, Kim JI, A Psychometric evaluation of the Korean version of the evidence based practice questionnaire for nurses. Contemp Nurse :(5163-5187)2014 Nov 28

25361479. Cho WS, Chung YS, Kim JE, Jeon JP, Son YJ, Bang JS, Kang HS, Sohn CH, Oh CW, The natural clinical course of hemodynamically stable adult moyamoya disease. J Neurosurg 122:1(82-9)2015 Jan

25348723. Shin J, Hwang SY, Lee HJ, Park CJ, Kim YJ, Son YJ, Seo JS, Kim JJ, Lee JE, Lee IM, Koh BY, Hong SG, Comparison of CPR quality and rescuer fatigue between standard 30:2 CPR and chest compression-only CPR: a randomized crossover manikin trial. Scand J Trauma Resusc Emerg Med 22:(59)2014 Oct 28

25248982. Park SJ, Lee SH, Kim KJ, Kim SG, Kim H, Choe H, Lee SY, Yun JM, Cho JY, Chun J, Choi KS, Son YJ, Soluble expression and purification of receptor activator of nuclear factor-kappa B ligand using Escherichia coli. J Microbiol Biotechnol 25:2(274-9)2015 Feb 28

25216923. Yeon JT, Ryu BJ, Choi SW, Heo JC, Kim KJ, Son YJ, Kim SH, Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways. Amino Acids 46:11(2605-14)2014 Nov

25184359. Cho WS, Kim JE, Kim CH, Ban SP, Kang HS, Son YJ, Bang JS, Sohn CH, Paeng JC, Oh CW, Long-term outcomes after combined revascularization surgery in adult moyamoya disease. Stroke 45:10(3025-31)2014 Oct

25048207. Son YJ, Kwon M, Ro DK, Kim SU, Enantioselective microbial synthesis of the indigenous natural product (-)-a-bisabolol by a sesquiterpene synthase from chamomile (Matricaria recutita). Biochem J 463:2(239-48)2014 Oct 15

25045209. Yi YS, Son YJ, Ryou C, Sung GH, Kim JH, Cho JY, Functional roles of Syk in macrophage-mediated inflammatory responses. Mediators Inflamm 2014:(270302)2014

24975277. Lee JY, Seo JH, Lee SJ, Son YJ, Cho YD, Kang HS, Han MH, Mid-term outcome of intracranial aneurysms treated with HydroSoft coils compared to historical controls treated with bare platinum coils: a single-center experience. Acta Neurochir (Wien) 156:9(1687-94)2014 Sep

24891860. Lee HS, Lee SH, Chung YS, Yang HJ, Son YJ, Park SB, Large spinal meningioma with hemorrhage after selective root block in the thoraco-lumbar spine. Korean J Spine 10:4(255-7)2013 Dec

24872911. Lee SK, Son YJ, Kim J, Kim HG, Lee JI, Kang BY, Cho HS, Lee S, Prediction Model for Health-Related Quality of Life of Elderly with Chronic Diseases using Machine Learning Techniques. Healthc Inform Res 20:2(125-34)2014 Apr

24838971. Skuba A, Manire MA, Kim H, Han SB, Son YJ, Time-lapse in vivo imaging of dorsal root nerve regeneration in mice. Methods Mol Biol 1162:(219-32)2014

24735861. Yang Y, Yang WS, Yu T, Sung GH, Park KW, Yoon K, Son YJ, Hwang H, Kwak YS, Lee CM, Rhee MH, Kim JH, Cho JY, ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract. J Ethnopharmacol 154:1(218-28)2014 May 28

24733831. O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med 211:5(801-14)2014 May 5

24705502. Kim H, Kim KJ, Yeon JT, Kim SH, Won DH, Choi H, Nam SJ, Son YJ, Kang H, Placotylene A, an inhibitor of the receptor activator of nuclear factor-?B ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp. Mar Drugs 12:4(2054-65)2014 Apr 3

24681702. Jeon JS, Kim JE, Chung YS, Oh S, Ahn JH, Cho WS, Son YJ, Bang JS, Kang HS, Sohn CH, Oh CW, A risk factor analysis of prospective symptomatic haemorrhage in adult patients with cerebral cavernous malformation. J Neurol Neurosurg Psychiatry 85:12(1366-70)2014 Dec

24605124. Han JW, Oh K, Yoo S, Kim E, Ahn KH, Son YJ, Kim TH, Chi YK, Kim KW, Development of the ubiquitous spaced retrieval-based memory advancement and rehabilitation training program. Psychiatry Investig 11:1(52-8)2014 Jan

24586466. Yeon JT, Kim KJ, Choi SW, Moon SH, Park YS, Ryu BJ, Oh J, Kim MS, Erkhembaatar M, Son YJ, Kim SH, Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLC?-independent Ca2+ oscillation. PLoS One 9:2(e88974)2014

24527192. Park SB, Chung CK, Lee SH, Yang HJ, Son YJ, Chung YS, The impact of menopause on bone fusion after the single-level anterior cervical discectomy and fusion. J Korean Neurosurg Soc 54:6(496-500)2013 Dec

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Postdoctoral Fellows and Other Scientists Supervised:


Wha-Ja Cho, PhD (postdoctoral fellow,  2003-2004), Research Assistant Professor, Biomedical Research Center, University of Ulsan, Korea


Sabiha Jawaid, PhD (postdoctoral fellow, 2004-2006), Assistant Professor, Department of Basic Sciences, Cleveland Chiropractic College, Kansas City


Srilatha Potluri, PhD (postdoctoral fellow, 2006-2009)


Jung Keun Hyun, MD, PhD (visiting scholar, 2008-2009), Assistant Professor, Department of Nanobiomedical Science, Dankook University, Korea


Alessandro Di Maio, PhD (Research Associate, 2008-2010), Postdoctoral fellow, Department of Cell biology and Molecular biology, University of California, Santa Barbara


Xiaoqing Tang, PhD (postdoctoral fellow, 2010-present)


Graduate Students Supervised (as Primary Advisor):


Megan Wright, PhD (PhD Program, 2002-2007), Assistant Professor, Department of Biology, Arcadia University, Philadelphia


Eva Dentcheva, BA (summer student and research technician, 2007-2008), MD program in Drexel University College of Medicine


Srishti Bhagat, BS (summer student and research technician, 2004-2007), MD/PhD program in Neuroscience, Duke University School of Medicine


Andy Skuba, BA (PhD Program, 2009-present)

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