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Changcheng Song, PhD

 

Assistant Professor, Center for Inflammation, Translational and Clinical Lung Research (CILR)

Telephone: 215-707-7921

Email: songc@temple.edu

 

 

Center for Inflammation, Translational and Clinical Lung Research (CILR)

 

Educational Background:

 

BS, Biochemistry, Shandong University, Jinan, China, 1992

 

PhD, Molecular Cell Biology, Beijing Normal University, Beijing, China, 1994

 

Fellowship, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, 2006

 

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professional affiliations:

 
  • American Thoracic Society
  • Society on Neurolmmune Pharmacology
  • American Society for Cell Biology
  • Chinese Pharmaceutical and Biotechnology Association
  • American Association for the Advancement of Science

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RESEARCH INTERESTS:

 

The role of proteostasis imbalance in the pathogenesis of Chronic Obstructive Lung Disease (COPD):

 

Proteostasis regulates the functional properties of the proteome. Derailed proteostasis leads to protein misfolding and aggregation that is the underlying origin of many devastating human diseases including COPD. A molecular chaperone named valosin containing protein (VCP) plays a critical role in coordinating the proteostasis machinery which mediates protein degradation and the processing of protein aggregates. Our structural and functional studies have shown that VCP plays a critical role in the maintenance of proteostasis by facilitating proteasoma degradation and aggresome formation. We are currently investigating the mechanism underlying the disruption in the biological function of VCP which occurs in the lungs of COPD patients as a result of exposure to cigarette smoke, and smoke components including cadmium. We believe this research should contribute to the development of novel therapeutic strategies for the treatment of COPO.

 

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BOOKS, MONOGRAPHS, Chapters

Investigation and Research Report of Development Strategy in Natural Science: Cell Biology, By Jiang, H, Ke, S, Song, C. Science Publishing Press, Beijing, China, 1997.

 

Chemokine receptors and NeuroAIDS. By Meucci, O. (Ed.) Part 3, 319-335pp, Happel, C, Song, C, Rogers, TJ, Interaction between opioid and chemokine receptors in immune cells: implications for HIV infection. New York, Springer Press, 2009.

 

The relationship between oxidative stress responses and lung inflammation with cigarette smoking. Song C and Kelsen SO. In Rogers TJ, Criner OJ, Cornwell WD (Eds.) Smoking and Lung Inflammation (pp. 99-127). New York: Springer, 2013.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24778447. Bednar F, Song C, Bardi G, Cornwell W, Rogers TJ, Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1. J Immunol 192:11(5305-13)2014 Jun 1

24598059. Song CZ, Wang QW, Song CC, Does acupuncture modulate anti-inflammation via haemorphin in obesity? Acupunct Med 32:2(205-6)2014 Apr

23906980. Song CZ, Wang QW, Song CC, Does needling stimulate erythrocyte-based local analgesia? Acupunct Med 31:4(451-2)2013 Dec

23220007. Song CZ, Wang QW, Song CC, Erythrocyte-based analgesic peptides. Regul Pept 180:(58-61)2013 Jan 10

22464998. Song CZ, Wang QW, Song CC, Diminution of hemoglobin-derived hemorphin: an underlying risk factor for cognitive deficit in diabetes. J Neurol Sci 317:1-2(157-8; author reply 159)2012 Jun 15

22154669. Song CZ, Wang QW, Liu H, Song CC, Inhibition of intraerythrocytic proteasome retards the generation of hemorphins. Peptides 33:1(170-3)2012 Jan

21953447. Song CZ, Wang QW, Song CC, Hemorphin as a prognostic biomarker and potential drug for breast cancer? Int J Cancer 131:4(1011-2)2012 Aug 15

21454526. Song C, Rahim RT, Davey PC, Bednar F, Bardi G, Zhang L, Zhang N, Oppenheim JJ, Rogers TJ, Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5. J Biol Chem 286:23(20354-65)2011 Jun 10

20496295. Cornwell WD, Kim V, Song C, Rogers TJ, Pathogenesis of inflammation and repair in advanced COPD. Semin Respir Crit Care Med 31:3(257-66)2010 Jun

18261755. Song C, Xiao Z, Nagashima K, Li CC, Lockett SJ, Dai RM, Cho EH, Conrads TP, Veenstra TD, Colburn NH, Wang Q, Wang JM, The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation. Toxicol Appl Pharmacol 228:3(351-63)2008 May 1

18044963. Song C, Wang Q, Li CC, Characterization of the aggregation-prevention activity of p97/valosin-containing protein. Biochemistry 46:51(14889-98)2007 Dec 25

16216872. Wang Q, Song C, Irizarry L, Dai R, Zhang X, Li CC, Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein. J Biol Chem 280:49(40515-23)2005 Dec 9

15037236. Wang Q, Song C, Li CC, Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions. J Struct Biol 146:1-2(44-57)2004 Apr-May

14760764. Song CZ, Wang QW, Song CC, Bai ZL, Viral replication modulated by synthetic peptide derived from hepatitis B virus X protein. World J Gastroenterol 10:3(389-92)2004 Feb 1

12854155. Song CZ, Bai ZL, Song CC, Wang QW, Aggregate formation of hepatitis B virus X protein affects cell cycle and apoptosis. World J Gastroenterol 9:7(1521-4)2003 Jul

12807884. Wang Q, Song C, Yang X, Li CC, D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP. J Biol Chem 278:35(32784-93)2003 Aug 29

12504076. Wang Q, Song C, Li CC, Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities. Biochem Biophys Res Commun 300:2(253-60)2003 Jan 10

12446676. Song C, Wang Q, Li CC, ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity. J Biol Chem 278:6(3648-55)2003 Feb 7

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