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Akira Shiose, MD, PhD


Akira Shiose, MD, PhD


Assistant Professor, Surgery Associate Director, Associate Director, Mechanical Circulatory Support, Temple University Hospital
Director, ECMO, Temple University Hospital
Email: akira.shiose@tuhs.temple.edu



Department of Surgery, Division of Cardiovascular Surgery


Educational Background:


Medical degree, Kyushu University, Japan


Residency, Cardiovascular Surgery, Fukuoka Children's Hospital, Japan


Fellowship, Cardiovascular Surgery, General Surgery, Iizuka Hospital, Japan

Fellowship, Biomedical Engineering, Cleveland Clinic, OH


Fellowship, Medical and Molecular Biology, Medical Institute of Bioregulation, Kyushu University, Japan



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clinical Interests:

  • Heart and lung transplantation
  • Mechanical circulatory support for advanced cardiopulmonary diseases
  • Valve repair
  • Coronary artery bypass
  • VAD/TAH implantation
  • Organ protection and preservation

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Research Interests:


  • Organ preservation
  • Development of cardiopulmonary support devices

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25606795. Taghavi S, Jayarajan SN, Komaroff E, Shiose A, Schwartz D, Hamad E, Alvarez R, Wheatley G, Guy TS, Toyoda Y, Use of Heavy Drinking Donors in Heart Transplantation is Not Associated With Worse Mortality. Transplantation 99:6(1226-30)2015 Jun

25575787. Jayarajan S, Taghavi S, Komaroff E, Shiose A, Schwartz D, Hamad E, Alvarez R, Wheatley G, Guy TS, Toyoda Y, Long-term outcomes in heart transplantation using donors with a history of past and present cocaine use. Eur J Cardiothorac Surg 47:4(e146-50)2015 Apr

25443002. Bermudez CA, Shiose A, Esper SA, Shigemura N, D'Cunha J, Bhama JK, Richards TJ, Arlia P, Crespo MM, Pilewski JM, Outcomes of intraoperative venoarterial extracorporeal membrane oxygenation versus cardiopulmonary bypass during lung transplantation. Ann Thorac Surg 98:6(1936-42; discussion 1942-3)2014 Dec

25106683. Taghavi S, Jayarajan SN, Furuya Y, Komaroff E, Shiose A, Leotta E, Hisamoto K, Patel N, Cordova F, Criner G, Guy TS, Toyoda Y, Examining ABO compatible donors in double lung transplants during the era of lung allocation score. Ann Thorac Surg 98:4(1167-74)2014 Oct

25068106. Yoshida M, Origuchi M, Urayama S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto N, Miyauchi S, Fukuyama H, Seiyama A, fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training. Neuroimage Clin 5:(161-8)2014

25062102. Shiose A, Desai P, Criner GJ, Pai S, Steiner RM, Kaiser LR, Guy TS, Toyoda Y, One-and-a-half ventricular repair for isolated right ventricle metastatic tumor resection after lobectomy for lung cancer. Innovations (Phila) 9:4(330-3)2014 Jul-Aug

24880825. Taghavi S, Jayarajan SN, Furuya Y, Komaroff E, Shiose A, Leotta E, Hisamoto K, Patel N, Cordova F, Criner G, Guy TS, Toyoda Y, Single-lung transplantation with ABO-compatible donors results in excellent outcomes. J Heart Lung Transplant 33:8(822-8)2014 Aug

24841447. Toyoda Y, Kashem MA, Hisamoto K, Shiose A, Tricuspid valve reconstruction with the extracellular matrix tube technique: a word of caution. J Thorac Cardiovasc Surg 148:2(e141-3)2014 Aug

24504419. Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Nakagawa S, Matsuda K, McCormick F, Aburatani H, Yano T, Osuga Y, Fujii T, Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One 9:2(e87220)2014

24272485. Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H, Small molecule agonists of PPAR-? exert therapeutic effects in esophageal cancer. Cancer Res 74:2(575-85)2014 Jan 15

24118024. Fumoto H, Shiose A, Flick CR, Noble LD, Dudzinski DT, Casas F, Takaseya T, Arakawa Y, Fukamachi K, Smith WA, Duncan BW, Short-term in vivo performance of the Cleveland clinic PediPump left ventricular assist device. Artif Organs 38:5(374-82)2014 May

24107518. Shiose Y, [Current development status and prospect of dual PI3K/mTOR inhibitors for cancer therapy]. Nihon Yakurigaku Zasshi 142:4(156-61)2013 Oct

23976889. Tuna EE, Franke TJ, Bebek O, Shiose A, Fukamachi K, Cavusoglu MC, Heart Motion Prediction Based on Adaptive Estimation Algorithms for Robotic Assisted Beating Heart Surgery. IEEE Trans Robot 29:1(261-276)2013 Feb 1

23773735. Shigemura N, D'Cunha J, Bhama JK, Shiose A, Abou El Ela A, Hackmann A, Zaldonis D, Toyoda Y, Pilewski JM, Luketich JD, Bermudez CA, Lobar lung transplantation: a relevant surgical option in the current era of lung allocation score. Ann Thorac Surg 96:2(451-6)2013 Aug

23685175. Miyazaki M, Naito H, Sugimoto Y, Yoshida K, Kawato H, Okayama T, Shimizu H, Miyazaki M, Kitagawa M, Seki T, Fukutake S, Shiose Y, Aonuma M, Soga T, Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors. Bioorg Med Chem 21:14(4319-31)2013 Jul 15

23272869. Fukamachi K, Shiose A, Massiello A, Horvath DJ, Golding LA, Lee S, Starling RC, Preload sensitivity in cardiac assist devices. Ann Thorac Surg 95:1(373-80)2013 Jan

23123996. Kobayashi M, Sakurai S, Takaseya T, Shiose A, Kim HI, Fujiki M, Karimov JH, Dessoffy R, Massiello A, Borowski AG, Van Wagoner DR, Jung E, Fukamachi K, Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs. Innovations (Phila) 7:4(282-9)2012 Jul-Aug

22939448. Kobayashi M, Sakurai S, Takaseya T, Shiose A, Kim HI, Fujiki M, Karimov JH, Dessoffy R, Massiello A, Borowski AG, Van Wagoner DR, Jung EJ, Fukamachi K, Effect of epivascular cardiac autonomic nerve stimulation on cardiac function. Ann Thorac Surg 94:4(1150-6)2012 Oct

22885461. Fumoto H, Gillinov AM, Saraiva RM, Horai T, Anzai T, Takaseya T, Shiose A, Arakawa Y, Vince DG, Dessoffy R, Fukamachi K, Left atrial appendage occlusion: pilot study of a fourth-generation, minimally invasive device. Innovations (Phila) 7:3(195-200)2012 May-Jun

22747979. Kobayashi M, Horvath DJ, Mielke N, Shiose A, Kuban B, Goodin M, Fukamachi K, Golding LA, Progress on the design and development of the continuous-flow total artificial heart. Artif Organs 36:8(705-13)2012 Aug

22459544. Fukamachi K, Shiose A, Massiello AL, Horvath DJ, Golding LA, Lee S, Starling RC, Implantable continuous-flow right ventricular assist device: lessons learned in the development of a cleveland clinic device. Ann Thorac Surg 93:5(1746-52)2012 May

22447313. Takaseya T, Fujiki M, Shiose A, Kim HI, Kobayashi M, Massiello AL, Dessoffy R, Al-Ruzzeh S, Fukamachi K, Hemodynamic differences between the awake and anesthetized conditions in normal calves. J Artif Organs 15:3(225-30)2012 Sep

22437896. Horai T, Fukamachi K, Fumoto H, Takaseya T, Shiose A, Arakawa Y, Rao S, Dessoffy R, Mihaljevic T, Direct endoscopy-guided mitral valve repair in the beating heart: an acute animal study. Innovations (Phila) 6:2(122-5)2011 Mar

22198730. Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K, Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol 8:2(170-8)2011 Dec 25

21869616. Shiose A, Takaseya T, Kim HI, Kobayashi M, Horai T, Rao S, Arakawa Y, Fujiki M, McCarthy MA, Liu Y, Lewandowski JJ, Davis A, Fukamachi K, In vivo evaluation of a new surfactant polymer coating mimicking the glycocalyx of endothelial cells. ASAIO J 57:5(395-8)2011 Sep-Oct

21383019. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A, Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem 286:17(15543-55)2011 Apr 29

21256318. Arakawa Y, Shiose A, Takaseya T, Fumoto H, Kim HI, Boyle EM, Gillinov AM, Fukamachi K, Superior chest drainage with an active tube clearance system: evaluation of a downsized chest tube. Ann Thorac Surg 91:2(580-3)2011 Feb

21145069. Shiose A, Takaseya T, Fumoto H, Horai T, Kim HI, Fukamachi K, Mihaljevic T, Cardioscopy-guided surgery: intracardiac mitral and tricuspid valve repair under direct visualization in the beating heart. J Thorac Cardiovasc Surg 142:1(199-202)2011 Jul

20971290. Shiose A, Kim HI, Takaseya T, Kobayashi M, Fujiki M, Chen JF, Klatte R, Gao S, Massiello AL, Saeed D, Fukamachi K, Performance of extracorporeally adjustable ventricular assist device inflow cannula. Ann Thorac Surg 90:5(1682-7)2010 Nov

20927214. Shiose S, Yoshida S, Ishikawa K, Ishibashi T, VMD2 mutational analysis in a Japanese family with Best macular dystrophy. Oman J Ophthalmol 2:3(143-4)2009 Sep

20719728. Fumoto H, Takaseya T, Shiose A, Saraiva RM, Arakawa Y, Park M, Rao S, Dessoffy R, Chen JF, Zhou Q, Calabro A Jr, Banbury M, Fukamachi K, Mitral annular remodeling to treat functional mitral regurgitation: a pilot acute study in a canine model. Heart Surg Forum 13:4(E247-50)2010 Aug

20616704. Shiose A, Nowak K, Horvath DJ, Massiello AL, Golding LA, Fukamachi K, Speed modulation of the continuous-flow total artificial heart to simulate a physiologic arterial pressure waveform. ASAIO J 56:5(403-9)2010 Sep-Oct

20545668. Takaseya T, Fumoto H, Shiose A, Arakawa Y, Rao S, Horvath DJ, Massiello AL, Mielke N, Chen JF, Zhou Q, Dessoffy R, Kramer L, Benefit S, Golding LA, Fukamachi K, In vivo biocompatibility evaluation of a new resilient, hard-carbon, thin-film coating for ventricular assist devices. Artif Organs 34:12(1158-63)2010 Dec

20179137. Shiose A, Takaseya T, Fumoto H, Arakawa Y, Horai T, Boyle EM, Gillinov AM, Fukamachi K, Improved drainage with active chest tube clearance. Interact Cardiovasc Thorac Surg 10:5(685-8)2010 May

20137971. Takaseya T, Shiose A, Saraiva RM, Fumoto H, Arakawa Y, Juravic M, Lombardi P, Fukamachi K, Novel epicardial off-pump device for mitral regurgitation: acute evaluation. Eur J Cardiothorac Surg 37:6(1291-6)2010 Jun

20050296. Duncan BW, Fukamachi K, Noble LD Jr, Dudzinski DT, Flick CR, Fumoto H, Shiose A, Arakawa Y, Takaseya T, Casas F, Smith WA, The PediPump: a versatile, implantable pediatric ventricular assist device--update IV. Artif Organs 33:11(1005-8)2009 Nov

22437273. Takaseya T, Fumoto H, Saraiva RM, Shiose A, Arakawa Y, Park M, Rao S, Dessoffy R, Kramer LD Jr, Juravic M, Lombardi P, Fukamachi K, Acute feasibility study of a novel device for the treatment of mitral regurgitation in a normal canine model. Innovations (Phila) 5:1(28-32)2010 Jan

19959893. TSUJIMURA K, SHIOSE T, YAMANAKA T, NEMOTO M, KONDO T, MATSUMURA T, Equine herpesvirus type 1 mutant defective in glycoprotein E gene as candidate vaccine strain. J Vet Med Sci 71:11(1439-48)2009 Nov

19706596. Taniguchi K, Takeya R, Suetsugu S, Kan-O M, Narusawa M, Shiose A, Tominaga R, Sumimoto H, Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. J Biol Chem 284:43(29873-81)2009 Oct 23

19589690. Sakurai T, Kado H, Nakano T, Hinokiyama K, Shiose A, Kajimoto M, Joo K, Ueda Y, Early results of bilateral pulmonary artery banding for hypoplastic left heart syndrome. Eur J Cardiothorac Surg 36:6(973-9)2009 Dec

19458342. Maeda A, Shiose S, Okano K, Matosky M, Maeda T, Palczewski K, WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration. Invest Ophthalmol Vis Sci :()2009 Aug 13

19090781. Shiose Y, Kuga H, Ohki H, Ikeda M, Yamashita F, Hashida M, Systematic research of peptide spacers controlling drug release from macromolecular prodrug system, carboxymethyldextran polyalcohol-peptide-drug conjugates. Bioconjug Chem 20:1(60-70)2009 Jan

19089555. Shimono N, Takuma T, Tsuchimochi N, Shiose A, Murata M, Kanamoto Y, Uchida Y, Morita S, Matsumoto H, Hayashi J, An outbreak of Pseudomonas aeruginosa infections following thoracic surgeries occurring via the contamination of bronchoscopes and an automatic endoscope reprocessor. J Infect Chemother 14:6(418-23)2008 Dec

18836873. Tokunaga S, Masuda M, Shiose A, Tomita Y, Morita S, Tominaga R, Isolated pulmonary valve replacement: analysis of 27 years of experience. J Artif Organs 11:3(130-3)2008

18640363. Ando Y, Kado H, Masuda M, Nakano T, Hinokiyama K, Shiose A, Kajimoto M, "Spiral-cuff" technique for repair of anomalous left coronary artery from the pulmonary artery. Ann Thorac Surg 86:2(667-8)2008 Aug

18479932. Masuda M, Kado H, Ando Y, Shiose A, Nakano T, Fukae K, Tanoue Y, Tominaga R, Intermediate-term results after the aortic valve replacement using bileaflet mechanical prosthetic valve in children. Eur J Cardiothorac Surg 34:1(42-7)2008 Jul

18462342. Iwaki H, Masuda M, Shiokawa Y, Imoto Y, Nakano T, Sonoda H, Shiose A, Kado H, The somatic growth of autologous vessels in venous pathway after extracardiac total cavopulmonary connection. J Card Surg 23:5(454-8)2008 Sep-Oct

18411687. Nakano T, Kado H, Hinokiyama K, Shiose A, Kajimoto M, Adachi O, Sakurai H, [Long-term results of arterial switch operation]. Kyobu Geka 61:4(262-7)2008 Apr

18245701. Tokunaga S, Masuda M, Shiose A, Tomita Y, Morita S, Tominaga R, Long-term results of isolated tricuspid valve replacement. Asian Cardiovasc Thorac Ann 16:1(25-8)2008 Jan

18057727. Shiose Y, Ochi Y, Kuga H, Yamashita F, Hashida M, Relationship between drug release of DE-310, macromolecular prodrug of DX-8951f, and cathepsins activity in several tumors. Biol Pharm Bull 30:12(2365-70)2007 Dec

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