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Akira Shiose, MD, PhD


Akira Shiose, MD, PhD


Assistant Professor, Surgery Associate Director, Associate Director, Mechanical Circulatory Support, Temple University Hospital
Director, ECMO, Temple University Hospital
Email: akira.shiose@tuhs.temple.edu



Department of Surgery, Division of Cardiovascular Surgery


Educational Background:


Medical degree, Kyushu University, Japan


Residency, Cardiovascular Surgery, Fukuoka Children's Hospital, Japan


Fellowship, Cardiovascular Surgery, General Surgery, Iizuka Hospital, Japan

Fellowship, Biomedical Engineering, Cleveland Clinic, OH


Fellowship, Medical and Molecular Biology, Medical Institute of Bioregulation, Kyushu University, Japan



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clinical Interests:

  • Heart and lung transplantation
  • Mechanical circulatory support for advanced cardiopulmonary diseases
  • Valve repair
  • Coronary artery bypass
  • VAD/TAH implantation
  • Organ protection and preservation

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Research Interests:


  • Organ preservation
  • Development of cardiopulmonary support devices

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25606795. Taghavi S, Jayarajan SN, Komaroff E, Shiose A, Schwartz D, Hamad E, Alvarez R, Wheatley G, Guy TS, Toyoda Y, Use of Heavy Drinking Donors in Heart Transplantation is Not Associated With Worse Mortality. Transplantation 99:6(1226-30)2015 Jun

25575787. Jayarajan S, Taghavi S, Komaroff E, Shiose A, Schwartz D, Hamad E, Alvarez R, Wheatley G, Guy TS, Toyoda Y, Long-term outcomes in heart transplantation using donors with a history of past and present cocaine use. Eur J Cardiothorac Surg 47:4(e146-50)2015 Apr

25443002. Bermudez CA, Shiose A, Esper SA, Shigemura N, D'Cunha J, Bhama JK, Richards TJ, Arlia P, Crespo MM, Pilewski JM, Outcomes of intraoperative venoarterial extracorporeal membrane oxygenation versus cardiopulmonary bypass during lung transplantation. Ann Thorac Surg 98:6(1936-42; discussion 1942-3)2014 Dec

25106683. Taghavi S, Jayarajan SN, Furuya Y, Komaroff E, Shiose A, Leotta E, Hisamoto K, Patel N, Cordova F, Criner G, Guy TS, Toyoda Y, Examining ABO compatible donors in double lung transplants during the era of lung allocation score. Ann Thorac Surg 98:4(1167-74)2014 Oct

25062102. Shiose A, Desai P, Criner GJ, Pai S, Steiner RM, Kaiser LR, Guy TS, Toyoda Y, One-and-a-half ventricular repair for isolated right ventricle metastatic tumor resection after lobectomy for lung cancer. Innovations (Phila) 9:4(330-3)2014 Jul-Aug

24880825. Taghavi S, Jayarajan SN, Furuya Y, Komaroff E, Shiose A, Leotta E, Hisamoto K, Patel N, Cordova F, Criner G, Guy TS, Toyoda Y, Single-lung transplantation with ABO-compatible donors results in excellent outcomes. J Heart Lung Transplant 33:8(822-8)2014 Aug

24841447. Toyoda Y, Kashem MA, Hisamoto K, Shiose A, Tricuspid valve reconstruction with the extracellular matrix tube technique: a word of caution. J Thorac Cardiovasc Surg 148:2(e141-3)2014 Aug

24118024. Fumoto H, Shiose A, Flick CR, Noble LD, Dudzinski DT, Casas F, Takaseya T, Arakawa Y, Fukamachi K, Smith WA, Duncan BW, Short-term in vivo performance of the Cleveland clinic PediPump left ventricular assist device. Artif Organs 38:5(374-82)2014 May

23976889. Tuna EE, Franke TJ, Bebek O, Shiose A, Fukamachi K, Cavusoglu MC, Heart Motion Prediction Based on Adaptive Estimation Algorithms for Robotic Assisted Beating Heart Surgery. IEEE Trans Robot 29:1(261-276)2013 Feb 1

23773735. Shigemura N, D'Cunha J, Bhama JK, Shiose A, Abou El Ela A, Hackmann A, Zaldonis D, Toyoda Y, Pilewski JM, Luketich JD, Bermudez CA, Lobar lung transplantation: a relevant surgical option in the current era of lung allocation score. Ann Thorac Surg 96:2(451-6)2013 Aug

23272869. Fukamachi K, Shiose A, Massiello A, Horvath DJ, Golding LA, Lee S, Starling RC, Preload sensitivity in cardiac assist devices. Ann Thorac Surg 95:1(373-80)2013 Jan

23123996. Kobayashi M, Sakurai S, Takaseya T, Shiose A, Kim HI, Fujiki M, Karimov JH, Dessoffy R, Massiello A, Borowski AG, Van Wagoner DR, Jung E, Fukamachi K, Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs. Innovations (Phila) 7:4(282-9)2012 Jul-Aug

22939448. Kobayashi M, Sakurai S, Takaseya T, Shiose A, Kim HI, Fujiki M, Karimov JH, Dessoffy R, Massiello A, Borowski AG, Van Wagoner DR, Jung EJ, Fukamachi K, Effect of epivascular cardiac autonomic nerve stimulation on cardiac function. Ann Thorac Surg 94:4(1150-6)2012 Oct

22885461. Fumoto H, Gillinov AM, Saraiva RM, Horai T, Anzai T, Takaseya T, Shiose A, Arakawa Y, Vince DG, Dessoffy R, Fukamachi K, Left atrial appendage occlusion: pilot study of a fourth-generation, minimally invasive device. Innovations (Phila) 7:3(195-200)2012 May-Jun

22747979. Kobayashi M, Horvath DJ, Mielke N, Shiose A, Kuban B, Goodin M, Fukamachi K, Golding LA, Progress on the design and development of the continuous-flow total artificial heart. Artif Organs 36:8(705-13)2012 Aug

22459544. Fukamachi K, Shiose A, Massiello AL, Horvath DJ, Golding LA, Lee S, Starling RC, Implantable continuous-flow right ventricular assist device: lessons learned in the development of a cleveland clinic device. Ann Thorac Surg 93:5(1746-52)2012 May

22447313. Takaseya T, Fujiki M, Shiose A, Kim HI, Kobayashi M, Massiello AL, Dessoffy R, Al-Ruzzeh S, Fukamachi K, Hemodynamic differences between the awake and anesthetized conditions in normal calves. J Artif Organs 15:3(225-30)2012 Sep

22437896. Horai T, Fukamachi K, Fumoto H, Takaseya T, Shiose A, Arakawa Y, Rao S, Dessoffy R, Mihaljevic T, Direct endoscopy-guided mitral valve repair in the beating heart: an acute animal study. Innovations (Phila) 6:2(122-5)2011 Mar

21869616. Shiose A, Takaseya T, Kim HI, Kobayashi M, Horai T, Rao S, Arakawa Y, Fujiki M, McCarthy MA, Liu Y, Lewandowski JJ, Davis A, Fukamachi K, In vivo evaluation of a new surfactant polymer coating mimicking the glycocalyx of endothelial cells. ASAIO J 57:5(395-8)2011 Sep-Oct

21256318. Arakawa Y, Shiose A, Takaseya T, Fumoto H, Kim HI, Boyle EM, Gillinov AM, Fukamachi K, Superior chest drainage with an active tube clearance system: evaluation of a downsized chest tube. Ann Thorac Surg 91:2(580-3)2011 Feb

21145069. Shiose A, Takaseya T, Fumoto H, Horai T, Kim HI, Fukamachi K, Mihaljevic T, Cardioscopy-guided surgery: intracardiac mitral and tricuspid valve repair under direct visualization in the beating heart. J Thorac Cardiovasc Surg 142:1(199-202)2011 Jul

20971290. Shiose A, Kim HI, Takaseya T, Kobayashi M, Fujiki M, Chen JF, Klatte R, Gao S, Massiello AL, Saeed D, Fukamachi K, Performance of extracorporeally adjustable ventricular assist device inflow cannula. Ann Thorac Surg 90:5(1682-7)2010 Nov

20719728. Fumoto H, Takaseya T, Shiose A, Saraiva RM, Arakawa Y, Park M, Rao S, Dessoffy R, Chen JF, Zhou Q, Calabro A Jr, Banbury M, Fukamachi K, Mitral annular remodeling to treat functional mitral regurgitation: a pilot acute study in a canine model. Heart Surg Forum 13:4(E247-50)2010 Aug

20616704. Shiose A, Nowak K, Horvath DJ, Massiello AL, Golding LA, Fukamachi K, Speed modulation of the continuous-flow total artificial heart to simulate a physiologic arterial pressure waveform. ASAIO J 56:5(403-9)2010 Sep-Oct

20545668. Takaseya T, Fumoto H, Shiose A, Arakawa Y, Rao S, Horvath DJ, Massiello AL, Mielke N, Chen JF, Zhou Q, Dessoffy R, Kramer L, Benefit S, Golding LA, Fukamachi K, In vivo biocompatibility evaluation of a new resilient, hard-carbon, thin-film coating for ventricular assist devices. Artif Organs 34:12(1158-63)2010 Dec

20179137. Shiose A, Takaseya T, Fumoto H, Arakawa Y, Horai T, Boyle EM, Gillinov AM, Fukamachi K, Improved drainage with active chest tube clearance. Interact Cardiovasc Thorac Surg 10:5(685-8)2010 May

20137971. Takaseya T, Shiose A, Saraiva RM, Fumoto H, Arakawa Y, Juravic M, Lombardi P, Fukamachi K, Novel epicardial off-pump device for mitral regurgitation: acute evaluation. Eur J Cardiothorac Surg 37:6(1291-6)2010 Jun

20050296. Duncan BW, Fukamachi K, Noble LD Jr, Dudzinski DT, Flick CR, Fumoto H, Shiose A, Arakawa Y, Takaseya T, Casas F, Smith WA, The PediPump: a versatile, implantable pediatric ventricular assist device--update IV. Artif Organs 33:11(1005-8)2009 Nov

22437273. Takaseya T, Fumoto H, Saraiva RM, Shiose A, Arakawa Y, Park M, Rao S, Dessoffy R, Kramer LD Jr, Juravic M, Lombardi P, Fukamachi K, Acute feasibility study of a novel device for the treatment of mitral regurgitation in a normal canine model. Innovations (Phila) 5:1(28-32)2010 Jan

19706596. Taniguchi K, Takeya R, Suetsugu S, Kan-O M, Narusawa M, Shiose A, Tominaga R, Sumimoto H, Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. J Biol Chem 284:43(29873-81)2009 Oct 23

19589690. Sakurai T, Kado H, Nakano T, Hinokiyama K, Shiose A, Kajimoto M, Joo K, Ueda Y, Early results of bilateral pulmonary artery banding for hypoplastic left heart syndrome. Eur J Cardiothorac Surg 36:6(973-9)2009 Dec

19089555. Shimono N, Takuma T, Tsuchimochi N, Shiose A, Murata M, Kanamoto Y, Uchida Y, Morita S, Matsumoto H, Hayashi J, An outbreak of Pseudomonas aeruginosa infections following thoracic surgeries occurring via the contamination of bronchoscopes and an automatic endoscope reprocessor. J Infect Chemother 14:6(418-23)2008 Dec

18836873. Tokunaga S, Masuda M, Shiose A, Tomita Y, Morita S, Tominaga R, Isolated pulmonary valve replacement: analysis of 27 years of experience. J Artif Organs 11:3(130-3)2008

18640363. Ando Y, Kado H, Masuda M, Nakano T, Hinokiyama K, Shiose A, Kajimoto M, "Spiral-cuff" technique for repair of anomalous left coronary artery from the pulmonary artery. Ann Thorac Surg 86:2(667-8)2008 Aug

18479932. Masuda M, Kado H, Ando Y, Shiose A, Nakano T, Fukae K, Tanoue Y, Tominaga R, Intermediate-term results after the aortic valve replacement using bileaflet mechanical prosthetic valve in children. Eur J Cardiothorac Surg 34:1(42-7)2008 Jul

18462342. Iwaki H, Masuda M, Shiokawa Y, Imoto Y, Nakano T, Sonoda H, Shiose A, Kado H, The somatic growth of autologous vessels in venous pathway after extracardiac total cavopulmonary connection. J Card Surg 23:5(454-8)2008 Sep-Oct

18411687. Nakano T, Kado H, Hinokiyama K, Shiose A, Kajimoto M, Adachi O, Sakurai H, [Long-term results of arterial switch operation]. Kyobu Geka 61:4(262-7)2008 Apr

18245701. Tokunaga S, Masuda M, Shiose A, Tomita Y, Morita S, Tominaga R, Long-term results of isolated tricuspid valve replacement. Asian Cardiovasc Thorac Ann 16:1(25-8)2008 Jan

17954072. Nakano T, Kado H, Tachibana T, Hinokiyama K, Shiose A, Kajimoto M, Ando Y, Excellent midterm outcome of extracardiac conduit total cavopulmonary connection: results of 126 cases. Ann Thorac Surg 84:5(1619-25; discussion 1625-6)2007 Nov

17405542. Shiose A, Kado H, [Long-term results of the Ross procedure]. Nihon Geka Gakkai Zasshi 108:2(80-4)2007 Mar

16934994. Nishida T, Masuda M, Tomita Y, Tokunaga S, Tanoue Y, Shiose A, Morita S, Tominaga R, The logistic EuroSCORE predicts the hospital mortality of the thoracic aortic surgery in consecutive 327 Japanese patients better than the additive EuroSCORE. Eur J Cardiothorac Surg 30:4(578-82; discussion 582-3)2006 Oct

16040349. Tanabe M, Rådmark O, Watanabe T, Shiose A, Sumimoto H, Cloning of rat p47phox and comparison with human p47phox. DNA Seq 16:1(65-8)2005 Feb

15475822. Inokuchi K, Ito A, Fukumoto Y, Matoba T, Shiose A, Nishida T, Masuda M, Morita S, Shimokawa H, Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery. J Cardiovasc Pharmacol 44:3(275-7)2004 Sep

11032835. Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, Hattori M, Sakaki Y, Sumimoto H, A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem 276:2(1417-23)2001 Jan 12

10788501. Shiose A, Sumimoto H, Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase. J Biol Chem 275:18(13793-801)2000 May 5

9642817. Kaku H, Masuda M, Fukae H, Suzuki M, Kanegae Y, Matsumoto T, Murayama E, Shiose A, Yasui H, [Strategy for univentricular repair for complication of atrioventricular valve regurgitation, total anomalous pulmonary venous connection, and ventricular outflow obstruction]. Jpn J Thorac Cardiovasc Surg 46 Suppl:(132-3)1998 Apr

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