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Thomas Shaffer, MSE, PhDThomas H. Shaffer, MSE, PhD


Professor Emeritus, Physiology

Professor Emeritus, Pediatrics

Telephone:  215-707-3239

Fax:  215-707-4003

Office: Medical Research Building Room 211

Email: thomas.shaffer@temple.edu


Department of Physiology


Educational Background:


BS, Drexel University, Philadelphia, PA, 1968


Penn State University (Mathematics), State College, PA, 1968


MSE, Drexel University, Philadelphia, PA 1970


PhD, Drexel University, 1972


Postdoctoral Fellowship, University of Pennsylvania, Philadelphia, PA, 1972

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Research Interests:


Thomas H. Shaffer, MS.E., Ph.D., is Professor Emeritus of Physiology and Pediatrics.  He also holds the position of Professor of Pediatrics at Thomas Jefferson Medical College.  Dr. Shaffer received his doctorate from Drexel University in Philadelphia, Pennsylvania, did postdoctoral work at the University of Pennsylvania School of Medicine, and has been a member of the faculty of the Temple University School of Medicine since 1976. Dr. Shaffer has 28 years of experience as an active scientist in pulmonary research with special attention to the needs of the neonatal and pediatric populations.  Dr. Shaffer’s revolutionary work with the use of perfluorochemicals for liquid ventilation for respiratory distress syndrome, blood substitutes and imaging is known world-wide, and he is considered an international expert in this field.  In addition, he is reknown for his work in developmental airway physiology and clinical pulmonary function evaluation in neonates.


Since 1974, Dr. Shaffer has been continuously supported by NIH grants (17) and academic, corporate and private institutional awards (42 total).  His early NIH grants were awarded during a period when corporate sponsors were not readily supporting work in his area of interest, and the resultant science acted as a catalyst for procuring many other grants from the private and corporate sectors.  The excellence of his corporate-sponsored research has resulted in 12 licensed patents.   In September, 2004, Dr. Shaffer was awarded a Center for Biomedical Research Excellent (COBRE) grant from the National Institutes of Health for the development of a Center for Pediatric Research at the Alfred I. duPont Hospital for Children in Wilmington, Delaware.  He serves as the Director of the new Center and administers its staff, revenues and research.  Dr. Shaffer clearly understands translational research, having moved multiple intellectual properties from the bench top to the clinic and on to industry.


Dr. Shaffer’s contribution to the literature has been significant.  He has published 67 book chapters, 220 peer-reviewed manuscripts (with another 20 in review or in press), and 420 abstracts.  His clinical manuscripts have been published in Lancet, The New England Journal of Medicine, the Journal of Pediatrics, Pediatrics, Critical Care Medicine and many more highly respected and well-read periodicals.  In addition, he has published basic science manuscripts in the Journal of Applied Physiology, the American Journal of Physiology, and the American Journal of Circulatory Research.  He serves on the Editorial Boards of three scientific journals and is a journal reviewer for another 22 publications.


In his faculty role at the Temple University School of Medicine and the University of Pennsylvania School of Medicine, Dr. Shaffer has mentored 42 graduate students and 36 post-doctoral Fellows during the past 26 years.  Many of these former students now hold faculty positions in prestigious medical schools at the University of Pennsylvania,, Columbia University, the University of California at Davis, SUNY in Buffalo, New York, the Temple University School of Medicine, Bowman Gray, and the University of Washington.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26167395. McQueen M, Rojas J, Sun SC, Tero R, Ives K, Bednarek F, Owens L, Dysart K, Dungan G, Shaffer TH, Miller TL, Safety and Long Term Outcomes with High Flow Nasal Cannula Therapy in Neonatology: A Large Retrospective Cohort Study. J Pulm Respir Med 4:6()2014 Dec

26116954. Kubaski F, Tomatsu S, Patel P, Shimada T, Xie L, Yasuda E, Mason R, Mackenzie WG, Theroux M, Bober MB, Oldham HM, Orii T, Shaffer TH, Non-invasive pulmonary function test on Morquio patients. Mol Genet Metab 115:4(186-92)2015 Aug

25557228. Theroux MC, Fisher AO, Rodriguez ME, Brislin RP, Reichard KW, Shah SA, McCoy M, Brown M, Dabney KW, Mackenzie WG, Katz DA, Shaffer TH, Prophylactic methylprednisolone to reduce inflammation and improve outcomes from one lung ventilation in children: a randomized clinical trial. Paediatr Anaesth 25:6(587-94)2015 Jun

25445931. Rodriguez E, Sakowski L, Hobson GM, Armani MH, Kreiger PA, Zhu Y, Waldman SA, Shaffer TH, Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation. Pulm Pharmacol Ther 30:(22-31)2015 Feb

25218882. Rodriguez E, Barthold JS, Kreiger PA, Armani MH, Wang J, Michelini KA, Wolfson MR, Boyce R, Barone CA, Zhu Y, Waldman SA, Shaffer TH, The orl rat is more responsive to methacholine challenge than wild type. Pulm Pharmacol Ther 29:2(199-208)2014 Dec

24500982. Jassar RK, Vellanki H, Zhu Y, Hesek A, Wang J, Rodriguez E, Wu J, Shaffer TH, Wolfson MR, High flow nasal cannula (HFNC) with Heliox decreases diaphragmatic injury in a newborn porcine lung injury model. Pediatr Pulmonol 49:12(1214-22)2014 Dec

24071905. de Jongh BE, Locke R, Mackley A, Emberger J, Bostick D, Stefano J, Rodriguez E, Shaffer TH, Work of breathing indices in infants with respiratory insufficiency receiving high-flow nasal cannula and nasal continuous positive airway pressure. J Perinatol 34:1(27-32)2014 Jan

23887895. Levenbrown Y, Penfil S, Rodriguez E, Zhu Y, Hossain J, Bhat AM, Hesek A, O'Neil KB, Tobin K, Shaffer TH, Use of insulin to decrease septic shock-induced myocardial depression in a porcine model. Inflammation 36:6(1494-502)2013 Dec

23691308. Rodriguez E, Bullard CM, Armani MH, Miller TL, Shaffer TH, Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques. Pulm Med 2013:(618576)2013

23304496. Giordano K, Rodriguez E, Green N, Armani M, Richards J, Shaffer TH, Attia MW, Pulmonary function tests in emergency department pediatric patients with acute wheezing/asthma exacerbation. Pulm Med 2012:(724139)2012

24839594. Tomatsu S, Mackenzie WG, Theroux MC, Mason RW, Thacker MM, Shaffer TH, Montaño AM, Rowan D, Sly W, Alméciga-Díaz CJ, Barrera LA, Chinen Y, Yasuda E, Ruhnke K, Suzuki Y, Orii T, Current and emerging treatments and surgical interventions for Morquio A syndrome: a review. Res Rep Endocr Disord 2012:2(65-77)2012 Dec

22988501. Chidekel A, Zhu Y, Wang J, Mosko JJ, Rodriguez E, Shaffer TH, The effects of gas humidification with high-flow nasal cannula on cultured human airway epithelial cells. Pulm Med 2012:(380686)2012

22821059. Wolfson MR, Wu J, Hubert TL, Gregory TJ, Mazela J, Shaffer TH, Lucinactant attenuates pulmonary inflammatory response, preserves lung structure, and improves physiologic outcomes in a preterm lamb model of RDS. Pediatr Res 72:4(375-83)2012 Oct

22777738. Shaffer TH, Alapati D, Greenspan JS, Wolfson MR, Neonatal non-invasive respiratory support: physiological implications. Pediatr Pulmonol 47:9(837-47)2012 Sep

22431368. Olivant Fisher A, Husain K, Wolfson MR, Hubert TL, Rodriguez E, Shaffer TH, Theroux MC, Hyperoxia during one lung ventilation: inflammatory and oxidative responses. Pediatr Pulmonol 47:10(979-86)2012 Oct

22328548. Rodriguez E, Bober MB, Davey L, Zamora A, Li Puma AB, Chidekel A, Shaffer TH, Respiratory mechanics in an infant with perinatal lethal hypophosphatasia treated with human recombinant enzyme replacement therapy. Pediatr Pulmonol 47:9(917-22)2012 Sep

21171186. Frizzola M, Miller TL, Rodriguez ME, Zhu Y, Rojas J, Hesek A, Stump A, Shaffer TH, Dysart K, High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol 46:1(67-74)2011 Jan

21142524. Hubert TL, Lindemann R, Wu J, Agnew C, Shaffer TH, Wolfson MR, Prototype hybrid systems for neonatal warming: in vitro comparisons to standard of care devices. Biomed Instrum Technol 44:6(523-7)2010 Nov-Dec

20948883. Zhu Y, Chidekel A, Shaffer TH, Cultured human airway epithelial cells (calu-3): a model of human respiratory function, structure, and inflammatory responses. Crit Care Res Pract 2010:()2010

20575094. Rodriguez ME, Mackenzie WG, Ditro C, Miller TL, Chidekel A, Shaffer TH, Skeletal dysplasias: evaluation with impulse oscillometry and thoracoabdominal motion analysis. Pediatr Pulmonol 45:7(679-86)2010 Jul

20375754. Oshodi A, Dysart K, Cook A, Rodriguez E, Zhu Y, Shaffer TH, Miller TL, Airway injury resulting from repeated endotracheal intubation: Possible prevention strategies. Pediatr Crit Care Med 12:1(e34-9)2011 Jan

19919624. Theroux MC, Fisher AO, Horner LM, Rodriguez ME, Costarino AT, Miller TL, Shaffer TH, Protective ventilation to reduce inflammatory injury from one lung ventilation in a piglet model. Paediatr Anaesth 20:4(356-64)2010 Apr

19434687. Laudadio RE, Wolfson MR, Shaffer TH, Driska SP, Developmental differences in the contractile response of isolated ovine tracheal smooth muscle cells. Pediatr Pulmonol 44:6(602-12)2009 Jun

18841530. Wolfson MR, Funanage VL, Kirwin SM, Pilon AL, Shashikant BN, Miller TL, Shaffer TH, Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome. Am J Perinatol 25:10(637-45)2008 Nov

18768046. Theroux MC, Olivant A, Lim D, Bernardi JP, Costarino AT, Shaffer TH, Miller TL, Low dose methylprednisolone prophylaxis to reduce inflammation during one-lung ventilation. Paediatr Anaesth 18:9(857-64)2008 Sep

18720322. Miller TL, Zhu Y, Markwardt S, Singhaus CJ, Chidekel AS, Shaffer TH, Dissociation between the effects of oxygen and pressure on matrix metalloproteinase-2, -7, and -9 expression in human airway epithelial cells. Am J Perinatol 25:8(481-9)2008 Sep

18496275. Wolfson MR, Hirschl RB, Jackson JC, Gauvin F, Foley DS, Lamm WJ, Gaughan J, Shaffer TH, Multicenter comparative study of conventional mechanical gas ventilation to tidal liquid ventilation in oleic acid injured sheep. ASAIO J 54:3(256-69)2008 May-Jun

18477937. Zhu Y, Miller TL, Singhaus CJ, Shaffer TH, Chidekel A, Effects of oxygen concentration and exposure time on cultured human airway epithelial cells. Pediatr Crit Care Med 9:2(224-9)2008 Mar

18391844. Zhu Y, Miller TL, Chidekel A, Shaffer TH, KL4-surfactant (Lucinactant) protects human airway epithelium from hyperoxia. Pediatr Res 64:2(154-8)2008 Aug

18266110. Wolfson MR, Malone DJ, Wu J, Hoffman J, Rozenberg A, Shaffer TH, Barbut D, Intranasal perfluorochemical spray for preferential brain cooling in sheep. Neurocrit Care 8:3(437-47)2008

17436327. Cullen AB, Cooke PH, Driska SP, Wolfson MR, Shaffer TH, Correlation of tracheal smooth muscle function with structure and protein expression during early development. Pediatr Pulmonol 42:5(421-32)2007 May

17344649. Singhaus CJ, Utidjian LH, Akins RE, Miller TL, Shaffer TH, Touch SM, Growth and development in a heliox incubator environment: a long-term safety study. Neonatology 91:1(28-35)2007

17149150. Miller TL, Shashikant BN, Pilon AL, Pierce RA, Shaffer TH, Wolfson MR, Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress. Pediatr Crit Care Med 8:1(40-6)2007 Jan

17123318. Miller TL, Zhu Y, Altman AR, Dysart K, Shaffer TH, Sequential alterations of tracheal mechanical properties in the neonatal lamb: effect of mechanical ventilation. Pediatr Pulmonol 42:2(141-9)2007 Feb

17045275. Miller TL, Altman AR, Tsuda T, Shaffer TH, An ultrasound imaging method for in vivo tracheal bulk and Young's moduli of elasticity. J Biomech 40:7(1615-21)2007

16950944. Miller TL, Cox T, Blackson T, Paul D, Weiss K, Shaffer TH, Pulmonary function assessment in an infant with Barnes syndrome: proactive evaluation for surgical intervention. Pediatrics 118:4(e1264-7)2006 Oct

16534184. Cullen AB, Cooke PH, Driska SP, Wolfson MR, Shaffer TH, The impact of mechanical ventilation on immature airway smooth muscle: functional, structural, histological, and molecular correlates. Biol Neonate 90:1(17-27)2006

16531948. Miller TL, Singhaus CJ, Sherman TI, Greenspan JS, Shaffer TH, Physiologic implications of helium as a carrier gas for inhaled nitric oxide in a neonatal model of Bethanecol-induced bronchoconstriction. Pediatr Crit Care Med 7:2(159-64)2006 Mar

16395077. Miller TL, Touch SM, Shaffer TH, Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression profiles in tracheal aspirates do not adequately reflect tracheal or lung tissue profiles in neonatal respiratory distress: observations from an animal model. Pediatr Crit Care Med 7:1(63-9)2006 Jan

16319450. Miller TL, Touch SM, Singhaus CJ, Ramesh Babu PB, Chidekel A, Shaffer TH, Expression of matrix metalloproteinases 2, 7 and 9, and their tissue inhibitors 1 and 2, in developing rabbit tracheae. Biol Neonate 89:4(236-43)2006

16276338. Miller TL, Shashikant BN, Melby JM, Pilon AL, Shaffer TH, Wolfson MR, Recombinant human Clara cell secretory protein in acute lung injury of the rabbit: effect of route of administration. Pediatr Crit Care Med 6:6(698-706)2005 Nov

16210850. Miller TL, Shashikant BN, Pilon AL, Pierce RA, Shaffer TH, Wolfson MR, Effects of an intratracheally delivered anti-inflammatory protein (rhCC10) on physiological and lung structural indices in a juvenile model of acute lung injury. Biol Neonate 89:3(159-70)2006

16081627. Shashikant BN, Miller TL, Welch RW, Pilon AL, Shaffer TH, Wolfson MR, Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: physiological, inflammatory, and kinetic profiles. J Appl Physiol (1985) 99:6(2204-11)2005 Dec

15911457. Wolfson MR, Shaffer TH, Pulmonary applications of perfluorochemical liquids: ventilation and beyond. Paediatr Respir Rev 6:2(117-27)2005 Jun

15891342. Shashikant BN, Miller TL, Jeng MJ, Davis J, Shaffer TH, Wolfson MR, Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury. Crit Care Med 33:5(1096-103)2005 May

15730607. Babu PB, Chidekel A, Shaffer TH, Hyperoxia-induced changes in human airway epithelial cells: the protective effect of perflubron. Pediatr Crit Care Med 6:2(188-94)2005 Mar

15678504. Miller TL, Palmer C, Shaffer TH, Wolfson MR, Neonatal chest wall suspension splint: a novel and noninvasive method for support of lung volume. Pediatr Pulmonol 39:6(512-20)2005 Jun

15530478. Babu PB, Chidekel A, Shaffer TH, Association of interleukin-8 with inflammatory and innate immune components in bronchoalveolar lavage of children with chronic respiratory diseases. Clin Chim Acta 350:1-2(195-200)2004 Dec

15390348. Miller TL, Blackson TJ, Shaffer TH, Touch SM, Tracheal gas insufflation-augmented continuous positive airway pressure in a spontaneously breathing model of neonatal respiratory distress. Pediatr Pulmonol 38:5(386-95)2004 Nov

15313144. Babu PB, Chidekel A, Shaffer TH, Protein composition of apical surface fluid from the human airway cell line Calu-3: effect of ion transport mediators. Clin Chim Acta 347:1-2(81-8)2004 Sep

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