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Rosario Scalia, MD, PhD

Associate Professor, Physiology

Telephone:  215-707-3248

Email: rscalia@temple.edu

Department of Physiology

MD, University of Catania, Catania, Italy, 1986

 

Internship, Department of Pharmacology and Clinical Pharmacology, University of Catania, Italy, 1985-1987

 

Resident Physician and PhD Student, Department of Pharmacology and Clinical Pharmacology, University of Catania, Italy, 1988-1992

 

PhD, Vascular Biology, Universities of Catania-Cagliari, Florence, Italy, 1992

 

Research Fellowship in Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, 1994

 

Research Fellowship in Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, 1995-1999

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• American Physiological Society, 1999
• Shock Society, 1999
• American Association for the Advancement of Science, 2000
• American Diabetes Association, 2001
• American Heart Association, 2004
• The Microcirculatory Society, 2005

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Dr. Scalia’s laboratory is interested in the pathophysiology of the endothelial dysfunction and the vascular complications occurring in chronic metabolic disorders such as obesity and diabetes. Dr. Scalia’s laboratory has implemented novel technology to study in vivo important functions of the vascular endothelium/vascular wall, such as 1) release of nitric oxide (NO) and oxidative stress; 2) expression levels of cell adhesion molecules; 3) vascular permeability of the microcirculation; and 4) key enzymatic activities by fluorescence confocal microscopy.

Major research interests are:

• Regulation of leukocyte-endothelium interactions in the microcirculation.
• Contribution of leukocyte trafficking to endothelial dysfunction and organ damage in obesity, diabetes and ischemia-reperfusion injury.
• Regulation of endothelial cell adhesion molecules in hypercholesterolemia, diabetes and aging.
• Regulation of endothelial nitric oxide synthase during acute and chronic inflammation.
• Role of the calcium-dependent protease µ-calpain in endothelial dysfunction and vascular inflammation.
• Role of adipocyte hormones (e.g., adiponectin) in the regulation of endothelial function in obesity and diabetes.
  

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Amanda Smolock, visiting student from Thomas Jefferson  University amanda.smolock@temple.edu

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Brin E. Freund,Lab Assistant     

brin.freund@temple.edu

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19029992. Goldstein BJ, Scalia RG, Ma XL, Protective vascular and myocardial effects of adiponectin. Nat Clin Pract Cardiovasc Med 6:1(27-35)2009 Jan

18292599. Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Völkers M, Heierhorst J, Øie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P, Endothelial S100A1 modulates vascular function via nitric oxide. Circ Res 102:7(786-94)2008 Apr 11

18292388. Xu SQ, Mahadev K, Wu X, Fuchsel L, Donnelly S, Scalia RG, Goldstein BJ, Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling. Arterioscler Thromb Vasc Biol 28:5(899-905)2008 May

18287675. Scalia R, Evaluation of endothelial function by in vivo microscopy. Methods Mol Med 139:(225-35)2007

17549259. Ouedraogo R, Gong Y, Berzins B, Wu X, Mahadev K, Hough K, Chan L, Goldstein BJ, Scalia R, Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 117:6(1718-26)2007 Jun

17446533. Scalia R, Gong Y, Berzins B, Zhao LJ, Sharma K, Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain. Diabetes 56:7(1842-9)2007 Jul

17254515. Goldstein BJ, Scalia R, Adipokines and vascular disease in diabetes. Curr Diab Rep 7:1(25-33)2007 Feb

16731851. Ouedraogo R, Wu X, Xu SQ, Fuchsel L, Motoshima H, Mahadev K, Hough K, Scalia R, Goldstein BJ, Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 55:6(1840-6)2006 Jun

15901204. Scalia R, Statins and the response to myocardial injury. Am J Cardiovasc Drugs 5:3(163-70)2005

15793253. Stalker TJ, Gong Y, Scalia R, The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes 54:4(1132-40)2005 Apr

15319269. Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK, Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol 24:10(1842-7)2004 Oct

15181024. Goldstein BJ, Scalia R, Adiponectin: A novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 89:6(2563-8)2004 Jun

12824289. Stalker TJ, Skvarka CB, Scalia R, A novel role for calpains in the endothelial dysfunction of hyperglycemia. FASEB J 17:11(1511-3)2003 Aug

12765944. Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ, Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52:6(1355-63)2003 Jun

12483541. Scalia R, Stalker TJ, Microcirculation as a target for the anti-inflammatory properties of statins. Microcirculation 9:6(431-42)2002 Dec

11978656. Booth G, Stalker TJ, Lefer AM, Scalia R, Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes 51:5(1556-64)2002 May

11382730. Scalia R, Gooszen ME, Jones SP, Hoffmeyer M, Rimmer DM 3rd, Trocha SD, Huang PL, Smith MB, Lefer AM, Lefer DJ, Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice. Circulation 103:21(2598-603)2001 May 29

11375257. Stalker TJ, Lefer AM, Scalia R, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol 133:3(406-12)2001 Jun

11350766. Booth G, Stalker TJ, Lefer AM, Scalia R, Elevated ambient glucose induces acute inflammatory events in the microvasculature: effects of insulin. Am J Physiol Endocrinol Metab 280:6(E848-56)2001 Jun

11196344. Ikeda Y, Young LH, Scalia R, Lefer AM, Cardioprotective effects of citrulline in ischemia/reperfusion injury via a non-nitric oxide-mediated mechanism. Methods Find Exp Clin Pharmacol 22:7(563-71)2000 Sep

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