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Stephen ArnoffWilliam Santamore, PhD


Professor, Medicine

Telephone:  215-707-4239

Fax:  215-707-0170

Office: Old Medical School 233

Email: william.santamore@temple.edu


Department of Medicine, Section of Cardiology

Cardiovascular Research Center


Educational Background:


Manhattan College             BS       Electrical Engineering

Drexel University                 MS       Biomedical Engineering

Temple University              PhD      Pysiology


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Research Interests:


Our current medical system is designed to address acute episodic care.  Chronic disease management, which requires consistent application and frequent monitoring of patient status, is problematic and inconsistent. According to the Institute of Medicine, a disconnect exists between the availability of comprehensive chronic disease management programs and their effective utilization – a real chasm. Especially in underserved populations, lack of surveillance and risk assessment allows these conditions to persist until an actual event occurs (heart attack, new angina or sudden death, stroke). Our objective is to develop and test new innovative approaches to address the goals of Healthy People 2010 and close this chasm in a proactive fashion.  Thus, we have developed a Telemedicine System, which facilitates chronic medical management.  We are currently testing this Telemedicine system in three chronic medical management situations (chronic heart failure, cardiovascular disease risk reduction, and gestational diabetes mellitus) and at two different locations (underserved inner city and rural populations). In each study, patients are randomized to standard of care or telemedicine group. We hypothesize 1) - that in chronic heart failure patients that the Telemedicine system will decrease the number of days for re-hospitalization, 2) - that in underserved patient populations with treatable cardiovascular risk factors (hypertension, hyperlipidemia) the Telemedicine system will reduce CVD risk status and reduce the progression toward epidemic CVD in this population, and 3) – that in patients with gestational diabetes mellitus, the Telemedicine system will reduce the rate of macrosomia (high birth weight).


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23666439. Kothapalli P, Bove AA, Santamore WP, Homko C, Kashem A, Factors affecting frequency of patient use of Internet-based telemedicine to manage cardiovascular disease risk. J Telemed Telecare 19:4(205-8)2013 Jun

23537980. Bove AA, Homko CJ, Santamore WP, Kashem M, Kerper M, Elliott DJ, Managing hypertension in urban underserved subjects using telemedicine--a clinical trial. Am Heart J 165:4(615-21)2013 Apr

23051994. Santamore WP, Holloway-Owens L, Petersen S, Tedaldi EM, E-mail health message service. J Cardiovasc Nurs 27:6(467)2012 Nov-Dec

22512287. Homko CJ, Deeb LC, Rohrbacher K, Mulla W, Mastrogiannis D, Gaughan J, Santamore WP, Bove AA, Impact of a telemedicine system with automated reminders on outcomes in women with gestational diabetes mellitus. Diabetes Technol Ther 14:7(624-9)2012 Jul

21809159. Bove AA, Santamore WP, Homko C, Kashem A, Cross R, McConnell TR, Shirk G, Menapace F, Treatment of patients with intermediate cardiovascular risk: Are clinical measures enough? J Nucl Cardiol 18:6(1021-5)2011 Dec

21315219. Bove AA, Santamore WP, Homko C, Kashem A, Cross R, McConnell TR, Shirk G, Menapace F, Reducing cardiovascular disease risk in medically underserved urban and rural communities. Am Heart J 161:2(351-9)2011 Feb

20436354. McConnell TR, Santamore WP, Larson SL, Homko CJ, Kashem M, Cross RC, Bove AA, Rural and urban characteristics impact cardiovascular risk reduction. J Cardiopulm Rehabil Prev 30:5(299-308)2010 Sep-Oct

20360597. Homko CJ, Zamora L, Santamore WP, Kashem A, McConnell T, Bove AA, Gender differences in cardiovascular risk factors and risk perception among individuals with diabetes. Diabetes Educ 36:3(483-8)2010 May-Jun

18953207. Santamore WP, Homko CJ, Understanding how the patient interacts with Internet intervention is key to advancing telemedicine. J Cardiovasc Nurs 23:6(472-3)2008 Nov-Dec

18596496. Homko CJ, Santamore WP, Zamora L, Shirk G, Gaughan J, Cross R, Kashem A, Petersen S, Bove AA, Cardiovascular disease knowledge and risk perception among underserved individuals at increased risk of cardiovascular disease. J Cardiovasc Nurs 23:4(332-7)2008 Jul-Aug

18570561. Santamore WP, Homko CJ, Kashem A, McConnell TR, Menapace FJ, Bove AA, Accuracy of blood pressure measurements transmitted through a telemedicine system in underserved populations. Telemed J E Health 14:4(333-8)2008 May

18356476. Santamore WP, Bove AA, Why are arteries the size they are? J Appl Physiol (1985) 104:5(1259)2008 May

18325458. Kashem A, Droogan MT, Santamore WP, Wald JW, Bove AA, Managing heart failure care using an internet-based telemedicine system. J Card Fail 14:2(121-6)2008 Mar

18002801. Santamore WP, Homko CJ, Kashem A, McConnell TR, Bove AA, Using a telemedicine system to decrease cardiovascular disease risk in an underserved population: design, use, and interim results. Conf Proc IEEE Eng Med Biol Soc 2007:(3701-4)2007

17905267. Santamore WP, Gefen N, Avramovich A, Berger P, Kashem A, Barnea O, Right atrial effects on right ventricular ejection fraction derived from thermodilution measurements. J Cardiothorac Vasc Anesth 21:5(644-9)2007 Oct

17570062. Sheffer L, Santamore WP, Barnea O, Cardiovascular simulation toolbox. Cardiovasc Eng 7:2(81-8)2007 Jun

17561800. Homko CJ, Santamore WP, Whiteman V, Bower M, Berger P, Geifman-Holtzman O, Bove AA, Use of an internet-based telemedicine system to manage underserved women with gestational diabetes mellitus. Diabetes Technol Ther 9:3(297-306)2007 Jun

17543243. Kashem A, Cross RC, Santamore WP, Bove AA, Management of heart failure patients using telemedicine communication systems. Curr Cardiol Rep 8:3(171-9)2006 May

17270928. Santamore WP, Homko C, Marble J, Wald J, Bove AA, Improving heart failure care by using a telemedicine system. Conf Proc IEEE Eng Med Biol Soc 4:(3076-9)2004

16942416. Kashem A, Droogan MT, Santamore WP, Wald JW, Marble JF, Cross RC, Bove AA, Web-based Internet telemedicine management of patients with heart failure. Telemed J E Health 12:4(439-47)2006 Aug

16478414. Masucci MM, Homko C, Santamore WP, Berger P, McConnell TR, Shirk G, Menapace F, Bove AA, Cardiovascular disease prevention for underserved patients using the Internet: bridging the digital divide. Telemed J E Health 12:1(58-65)2006 Feb

12957615. Kashem A, Kashem S, Santamore WP, Crabbe DL, Margulies KB, Melvin DB, Goldman BI, Early and late results of left ventricular reshaping by passive cardiac-support device in canine heart failure. J Heart Lung Transplant 22:9(1046-53)2003 Sep

12930271. Kashem A, Santamore WP, Hassan S, Melvin DB, Crabbe DL, Margulies KB, Goldman BI, Llort F, Krieger C, Lesniak J, CardioClasp changes left ventricular shape acutely in enlarged canine heart. J Card Surg 18 Suppl 2:(S49-60)2003 Jul-Aug

12878939. He KL, Shimizu J, Yi GH, Gu A, Kashem MA, Crabbe DL, Popilskis S, Wu EX, Santamore WP, Melvin D, Wang J, Left ventricular systolic performance in failing heart improved acutely by left ventricular reshaping. J Thorac Cardiovasc Surg 126:1(56-65)2003 Jul

12579110. Kashem A, Hassan S, Crabbe DL, Melvin DB, Santamore WP, Left ventricular reshaping: effects on the pressure-volume relationship. J Thorac Cardiovasc Surg 125:2(391-9)2003 Feb

12058999. Kashem A, Santamore WP, Hassan S, Crabbe DL, Marculies KB, Melvin DB, CardioClasp: a new passive device to reshape cardiac enlargement. ASAIO J 48:3(253-9)2002 May-Jun

11730206. Kashem A, Santamore WP, Hassan S, Chiang B, Slatert AD, Can latissimus dorsi muscle stimulation benefit heart during training period after vascular delay? ASAIO J 47:6(655-61)2001 Nov-Dec

11426760. Kashem A, Santamore WP, Chiang B, Unger L, Ali AT, Slater AD, Vascular delay and intermittent stimulation: keys to successful latissimus dorsi muscle stimulation. Ann Thorac Surg 71:6(1866-73)2001 Jun

10807283. Chiang BB, Roberts AM, Kashem AM, Santamore WP, Chien S, Gray L Jr, Dowling R, Chemoreflexes: an experimental study. Arch Surg 135:5(577-81)2000 May

10485426. Hakami A, Santamore WP, Stremel RW, Tobin G, Hjortdal VE, Evaluation of stimulation parameters on aortomyoplasty, using Latissimus Dorsi muscle in a goat model: an acute study. Eur J Cardiothorac Surg 16:2(228-32)1999 Aug

10445744. Chiang BB, Ali A, Kashem A, Unger L, Chien S, Santamore WP, Slater AD, Gray LA Jr, Two step cardiomyoplasty with vascular delay: effect of stimulation of latissimus dorsi muscle on diastolic function. ASAIO J 45:4(350-5)1999 Jul-Aug

10355402. Ali AT, Santamore WP, Chiang BY, Dowling RD, Tobin GR, Slater AD, Vascular delay of the latissimus dorsi provides an early hemodynamic benefit in dynamic cardiomyoplasty. Ann Thorac Surg 67:5(1304-11)1999 May

9761442. Ali AT, Chiang BY, Santamore WP, Dowling RD, Slater AD, Preconditioning of the latissimus dorsi muscle in cardiomyoplasty: vascular delay or chronic electrical stimulation. Eur J Cardiothorac Surg 14:3(304-10)1998 Sep

9760295. Barnea O, Santamore WP, Rossi A, Salloum E, Chien S, Austin EH, Estimation of oxygen delivery in newborns with a univentricular circulation. Circulation 98:14(1407-13)1998 Oct 6

9680274. Ransbaek F, Hansen SB, Austin EH, Santamore WP, Effects of positive pressure ventilation and inspired oxygen on pulmonary vascular resistance and tissue oxygen delivery in neonatal pigs. Cardiol Young 8:1(71-8)1998 Jan

9486276. Santamore WP, Barnea O, Riordan CJ, Ross MP, Austin EH, Theoretical optimization of pulmonary-to-systemic flow ratio after a bidirectional cavopulmonary anastomosis. Am J Physiol 274:2 Pt 2(H694-700)1998 Feb

9449957. Dell'Italia LJ, Santamore WP, Can indices of left ventricular function be applied to the right ventricle? Prog Cardiovasc Dis 40:4(309-24)1998 Jan-Feb

9449956. Santamore WP, Dell'Italia LJ, Ventricular interdependence: significant left ventricular contributions to right ventricular systolic function. Prog Cardiovasc Dis 40:4(289-308)1998 Jan-Feb

9444840. Cheever EA, Thompson DR, Cmolik BL, Santamore WP, George DT, A versatile microprocessor-based multichannel stimulator for skeletal muscle cardiac assist. IEEE Trans Biomed Eng 45:1(56-67)1998 Jan

9423979. Chiang BB, Ali AT, Storey J, Riordan C, Ballen J, Montgomery W, Slater AD, Santamore WP, Variable effects of cardiomyoplasty on left ventricular function. Artif Organs 21:12(1277-83)1997 Dec

9402511. Santamore WP, Austin EH 3rd, Gray L Jr, Overcoming right ventricular failure with left ventricular assist devices. J Heart Lung Transplant 16:11(1122-8)1997 Nov

9360154. Chiang BB, Ali AT, Unger LS, Slater AD, Santamore WP, Cardiomyoplasty: hemodynamic benefit to normal and depressed canine left ventricular function. ASAIO J 43:5(M786-90)1997 Sep-Oct

9332923. Montgomery WD, Vitolla G, Ali A, Pagni S, Ballen JL, Santamore WP, Calafiore AM, Spence PA, What in-vitro method should surgeons use to evaluate the clinical behavior of arterial bypass conduits. Eur J Cardiothorac Surg 12:3(436-42)1997 Sep

9292488. George DT, Binder-Macleod SA, Delosso TN, Santamore WP, Variable-frequency train stimulation of canine latissimus dorsi muscle during shortening contractions. J Appl Physiol (1985) 83:3(994-1001)1997 Sep

9271276. Ali AT, Montgomery WD, Santamore WP, Spence PA, Preventing gastroepiploic artery spasm: papaverine vs calcium channel blockade. J Surg Res 71:1(41-8)1997 Jul 15

9242950. Cruz MP, Michele JJ, Mannion JD, Magno M, George DT, Santamore WP, Cardiomyoplasty. Latissimus dorsi muscle function and blood flow during isolation. ASAIO J 43:4(338-44)1997 Jul-Aug

9203589. Barnea O, Santamore WP, Intraoperative monitoring of IMA flow: what does it mean? Ann Thorac Surg 63:6 Suppl(S12-7)1997 Jun

9203587. Borst C, Santamore WP, Smedira NG, Bredée JJ, Minimally invasive coronary artery bypass grafting: on the beating heart and via limited access. Ann Thorac Surg 63:6 Suppl(S1-5)1997 Jun

9066413. Riordan CJ, Locher JP Jr, Santamore WP, Villafane J, Austin EH 3rd, Monitoring systemic venous oxygen saturations in the hypoplastic left heart syndrome. Ann Thorac Surg 63:3(835-7)1997 Mar

8951661. Randsbaek F, Riordan CJ, Storey JH, Montgomery WD, Santamore WP, Austin EH 3rd, Animal model of the univentricular heart and single ventricular physiology. J Invest Surg 9:5(375-84)1996 Sep-Oct

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