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Michael R. Ruggieri, Sr, PhDmichael r. ruggieri, sr, phd

 

Associate Professor, Department of Anatomy and Cell Biology

Telephone: 215-707-4567

Email: michael.ruggieri@temple.edu

 

 

Department of Anatomy and Cell Biology

 

 

 

Educational Background:

 

BA, Psychology, Temple University, Philadelphia, PA

 

PhD, Pharmacology, University of Pennsylvania, Philadelphia, PA

 

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Research Interests:

 

I have been working in clinically translatable basic science investigations, primarily mechanisms of neural control of visceral smooth muscle. The general approach has been to use animal models of clinically relevant human disorders to identify potential etiologic and pathogenic mechanisms and then verify these mechanisms in human tissue specimens, eventually leading to clinical trials. These clinical conditions have included gastroesophageal reflux disease, lower urinary tract denervation, bladder outlet obstruction, interstitial cystitis/painful bladder syndrome, and overactive bladder. For example, my laboratory was one of the first groups to demonstrate that human urinary bladder muscle strips from patients with certain pathologic conditions show purinergic nerve mediated contractions (J. Urol. 144, 176, 1990). Very recently, in collaboration with Gastroenterologist Dr. Larry Miller, from North Shore – Long Island Jewish Health System, we identified a defect in certain smooth muscle fibers of the gastroesophageal junction in Barrett’s esophagitis that reveals a mechanism for gastroesophageal reflux (Neurogastroenterol. Motil. 26, 430, 2014). This NIH funded project has also uncovered a specific nicotinic receptor subtype as a potential target for development of drugs to treat gastroesophageal reflux disease. Additional currently funded projects include neurosurgical reinnervation of the urinary bladder, urethra and anal sphincter to restore continence and emptying functions to the urinary bladder and colon following spinal injury with co-principal investigator Dr. Mary Barbe of the Department of Anatomy and Cell Biology at Temple University. In collaboration with Dr. Wenhui Hu of the Department of Neuroscience, Temple University, we are investigating the effects of selective up and down regulation of NFκB in astroglial versus neuronal cells on gastrointestinal inflammation and contractile function. In another NIH funded project, in collaboration with Dr. Anna Malykhina at the Department of Surgery, University of Pennsylvania, we are studying the pathologic changes in bladder sensory and motor function in a mouse model of coronovirus-induced encephalomyelitis as a model of multiple sclerosis (MS) and characterize the urologic phenotype as compared to lesion location in MS patients.

 

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Professional Affiliations:

  • American Society of Pharmacology and Experimental Therapeutics
  • American Urological Association
  • International Continence Society
  • Society for Basic Urological Research
  • Society for Neuroscience
  • Society for Urodynamics and Female Urology

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25444958. Gomez-Amaya SM, Barbe MF, Lamarre NS, Brown JM, Braverman AS, Ruggieri MR Sr, Neuromuscular nicotinic receptors mediate bladder contractions following bladder reinnervation with somatic to autonomic nerve transfer after decentralization by spinal root transection. J Urol :()2014 Oct 16

25310403. Lamarre NS, Braverman AS, Malykhina AP, Barbe MF, Ruggieri MR Sr, Alterations in nerve-evoked bladder contractions in a coronavirus-induced mouse model of multiple sclerosis. PLoS One 9:10(e109314)2014

25066874. Gomez-Amaya SM, Barbe MF, Brown JM, Lamarre NS, Braverman AS, Massicotte VS, Ruggieri MR Sr, Bladder Reinnervation Using a Primarily Motor Donor Nerve (Femoral Nerve Branches) Is Functionally Superior to Using a Primarily Sensory Donor Nerve (Genitofemoral Nerve). J Urol :()2014 Jul 24

25007876. McMillan MT, Pan XQ, Smith AL, Newman DK, Weiss SR, Ruggieri MR Sr, Malykhina AP, Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis. Am J Physiol Renal Physiol 307:5(F612-22)2014 Sep 1

24827539. Ruggieri MR Sr, Braverman AS, Vegesna AK, Miller LS, Nicotinic receptor subtypes mediating relaxation of the normal human clasp and sling fibers of the upper gastric sphincter. Neurogastroenterol Motil 26:7(1015-25)2014 Jul

24730986. Gomez-Amaya SM, Ruggieri MR Sr, Arias Serrato SA, Massicotte VS, Barbe MF, Gross Anatomical Study of the Nerve Supply of Genitourinary Structures in Female Mongrel Hound Dogs. Anat Histol Embryol :()2014 Apr 15

23786223. Ruggieri MR, Braverman AS, Gastric body cholinergic contractile signal transduction in M2 and M3 receptor knockout mice. J Recept Signal Transduct Res 33:4(249-54)2013 Aug

22998376. Vegesna AK, Sloan JA, Singh B, Phillips SJ, Braverman AS, Barbe MF, Ruggieri MR Sr, Miller LS, Characterization of the distal esophagus high-pressure zone with manometry, ultrasound and micro-computed tomography. Neurogastroenterol Motil 25:1(53-60.e6)2013 Jan

21953679. Ruggieri MR Sr, Braverman AS, Bernal RM, Lamarre NS, Brown JM, Barbe MF, Reinnervation of urethral and anal sphincters with femoral motor nerve to pudendal nerve transfer. Neurourol Urodyn 30:8(1695-704)2011 Nov

21950822. Miller LS, Vegesna AK, Brasseur JG, Braverman AS, Ruggieri MR, The esophagogastric junction. Ann N Y Acad Sci 1232:(323-30)2011 Sep

21761966. Barbe MF, Brown JM, Pontari MA, Dean GE, Braverman AS, Ruggieri MR, Feasibility of a femoral nerve motor branch for transfer to the pudendal nerve for restoring continence: a cadaveric study. J Neurosurg Spine 15:5(526-31)2011 Nov

21464333. Braverman AS, Vegesna AK, Miller LS, Barbe MF, Tiwana M, Hussain K, Ruggieri MR Sr, Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction. J Pharmacol Exp Ther 338:1(37-46)2011 Jul

21290238. Ruggieri MR Sr, Cannabinoids: potential targets for bladder dysfunction. Handb Exp Pharmacol :202(425-51)2011

21254198. Barbe MF, Ruggieri MR Sr, Innervation of parasympathetic postganglionic neurons and bladder detrusor muscle directly after sacral root transection and repair using nerve transfer. Neurourol Urodyn 30:4(599-605)2011 Apr

20303095. Pontari MA, Mohamed FB, Lebovitch S, Moonat S, Lebed B, Ruggieri MR, Faro SH, Central nervous system findings on functional magnetic resonance imaging in patients before and after treatment with anticholinergic medication. J Urol 183:5(1899-905)2010 May

20133950. Vegesna AK, Braverman AS, Miller LS, Tallarida RJ, Tiwana MI, Khayyam U, Ruggieri MR Sr, Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors. Am J Physiol Gastrointest Liver Physiol 298:4(G530-4)2010 Apr

19126780. Braverman AS, Miller LS, Vegesna AK, Tiwana MI, Tallarida RJ, Ruggieri MR Sr, Quantitation of the contractile response mediated by two receptors: M2 and M3 muscarinic receptor-mediated contractions of human gastroesophageal smooth muscle. J Pharmacol Exp Ther 329:1(218-24)2009 Apr

18506057. Agelan A, Braverman AS, Dean GE, Ruggieri MR Sr, Refinement in the management of the denervated canine urinary bladder using an abdominal vesicostomy. ILAR J 49:(E8-14)2007 Dec 6

18405756. Pontari MA, Ruggieri MR, Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol 179:5 Suppl(S61-7)2008 May

18373487. Ruggieri MR, Braverman AS, D'Andrea L, Betz R, Barbe MF, Functional reinnervation of the canine bladder after spinal root transection and genitofemoral nerve transfer at one and three months after denervation. J Neurotrauma 25:4(401-9)2008 Apr

18352835. Ruggieri MR, Braverman AS, D'Andrea L, McCarthy J, Barbe MF, Functional reinnervation of the canine bladder after spinal root transection and immediate somatic nerve transfer. J Neurotrauma 25:3(214-24)2008 Mar

18339971. Braverman AS, Tallarida RJ, Ruggieri MR Sr, The use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractions. J Pharmacol Exp Ther 325:3(954-60)2008 Jun

17270657. Lamarre NS, Ruggieri MR Sr, Braverman AS, Gerstein MI, Mydlo JH, Effect of obese and lean Zucker rat sera on human and rat prostate cancer cells: implications in obesity-related prostate tumor biology. Urology 69:1(191-5)2007 Jan

17123299. Braverman AS, Lebed B, Linder M, Ruggieri MR, M2 mediated contractions of human bladder from organ donors is associated with an increase in urothelial muscarinic receptors. Neurourol Urodyn 26:1(63-70)2007

16879497. Ruggieri MR Sr, Braverman AS, Regulation of bladder muscarinic receptor subtypes by experimental pathologies. Auton Autacoid Pharmacol 26:3(311-25)2006 Jul

16866625. Ruggieri MR, Braverman AS, D'Andrea L, Simpkiss B, Kozin SH, Pontari MA, Betz R, Barbe MF, Functional reinnervation of the canine bladder after spinal root transection and immediate end-on-end repair. J Neurotrauma 23:7(1125-36)2006 Jul

16607369. Ruggieri MR Sr, Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction. Nat Clin Pract Urol 3:4(206-15)2006 Apr

16304675. Braverman AS, Ruggieri MR Sr, Muscarinic receptor transcript and protein density in hypertrophied and atrophied rat urinary bladder. Neurourol Urodyn 25:1(55-61)2006

16243962. Braverman AS, Doumanian LR, Ruggieri MR Sr, M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder. J Pharmacol Exp Ther 316:2(875-80)2006 Feb

16243961. Braverman AS, Tibb AS, Ruggieri MR Sr, M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. J Pharmacol Exp Ther 316:2(869-74)2006 Feb

16217275. Ruggieri MR Sr, Braverman AS, Pontari MA, Combined use of alpha-adrenergic and muscarinic antagonists for the treatment of voiding dysfunction. J Urol 174:5(1743-8)2005 Nov

15310980. Pontari MA, Ruggieri MR, Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol 172:3(839-45)2004 Sep

14751843. Pontari MA, Braverman AS, Ruggieri MR Sr, The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction. Am J Physiol Regul Integr Comp Physiol 286:5(R874-80)2004 May

12185001. Braverman AS, Tallarida RJ, Ruggieri MR Sr, Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction. Am J Physiol Regul Integr Comp Physiol 283:3(R663-8)2002 Sep

10840459. Ruggieri MR, Filer-Maerten S, Hieble JP, Hay DW, Role of neurokinin receptors in the behavioral effect of intravesical antigen infusion in guinea pig bladder. J Urol 164:1(197-202)2000 Jul

10494124. Baselli EC, Brandes SB, Luthin GR, Ruggieri MR, The effect of pregnancy and contractile activity on bladder muscarinic receptor subtypes. Neurourol Urodyn 18:5(511-20)1999

10411032. Pontari MA, Hanno PM, Ruggieri MR, Comparison of bladder blood flow in patients with and without interstitial cystitis. J Urol 162:2(330-4)1999 Aug

10349596. Braverman AS, Ruggieri MR, Selective alkylation of rat urinary bladder muscarinic receptors with 4-DAMP mustard reveals a contractile function for the M2 muscarinic receptor. J Recept Signal Transduct Res 19:5(819-33)1999 Sep

9950918. Pontari MA, Ruggieri MR, Sex differences and role of nitric oxide in blood flow of canine urinary bladder. Am J Physiol 276:2 Pt 2(R407-13)1999 Feb

9791087. Braverman AS, Luthin GR, Ruggieri MR, M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder. Am J Physiol 275:5 Pt 2(R1654-60)1998 Nov

9679866. Ruggieri MR Sr, Neurokinin receptors in feline interstitial cystitis. J Urol 160:2(298)1998 Aug

9651883. Pontari MA, Luthin GR, Braverman AS, Ruggieri MR, Characterization of muscarinic cholinergic receptor subtypes in rat prostate. J Recept Signal Transduct Res 18:2-3(151-66)1998 Mar-May

9514147. Kohn IJ, Filer-Maerten S, Whitmore KE, Hanno PM, Ruggieri MR, Lack of effect following repeated in vivo exposure of the rabbit urinary bladder to urine from interstitial cystitis patients at low infusion volumes. Neurourol Urodyn 17:2(147-52)1998

9486312. Braverman AS, Kohn IJ, Luthin GR, Ruggieri MR, Prejunctional M1 facilitory and M2 inhibitory muscarinic receptors mediate rat bladder contractility. Am J Physiol 274:2 Pt 2(R517-23)1998 Feb

7636762. Ruggieri MR, Colton MD, Wang P, Wang J, Smyth RJ, Pontari MA, Luthin GR, Human prostate muscarinic receptor subtypes. J Pharmacol Exp Ther 274:2(976-82)1995 Aug

8571837. Brandes SB, Ruggieri MR, Muscarinic receptor subtypes in normal, fetal, and gravid rabbit bladder, heart and uterus. Adv Exp Med Biol 385:(241-9)1995

8126801. Smyth RJ, Uhlman EJ, Ruggieri MR, Identification and characterization of a high-affinity peripheral-type benzodiazepine receptor in rabbit urinary bladder. J Urol 151:4(1102-6)1994 Apr

8284840. Ruggieri MR, Chelsky MJ, Rosen SI, Shickley TJ, Hanno PM, Current findings and future research avenues in the study of interstitial cystitis. Urol Clin North Am 21:1(163-76)1994 Feb

8283521. Chelsky MJ, Rosen SI, Knight LC, Maurer AH, Hanno PM, Ruggieri MR, Bladder permeability in interstitial cystitis is similar to that of normal volunteers: direct measurement by transvesical absorption of 99mtechnetium-diethylenetriaminepentaacetic acid. J Urol 151:2(346-9)1994 Feb

8256398. Ruggieri MR, Hanno PM, Whitmore KE, Balagani RK, Effect of repeated instillation of interstitial cystitis urine on the rabbit urinary bladder. Urology 42:6(646-52)1993 Dec

 

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