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Dr. A. Koneti Raoa. koneti Rao, MD

 

Sol Sherry Professor of Medicine

Co-Director, Sol Sherry Thrombosis Research Center

Professor, Pathology and Laboratory Medicine

Professor, Pharmacology

 

Telephone:  215-707-4684

Fax:  215-707-2783

Email:   koneti@temple.edu

 

Sol Sherry Thrombosis Research Center

Department of Medicine, Section of Hematology

Department of Pathology

Department of Pharmacology

 

Educational Background:

 

1964-1967, M.E.A. School, New Delhi, India

Honors:  Ranked first in order of merit at school. Awarded Distinction (Honors) in the subjects of Physics, Chemistry, Mathematics and Biology.

 

1967-1968, Hindu College, University of Delhi, India

Degree:  Pre-Medical.   Graduated with Honors in Physics and Chemistry.

 

1968-1973, All India Institute of Medical Sciences,

New Delhi, India

Degree:  M.B., B.S., Awarded Institute Prize for Distinction (Ranked first) in Pharmacology.

 

1974-1975, Intern in Internal Medicine

Albert Einstein Medical Center, Philadelphia, PA

 

1975-1977, Resident in Internal Medicine

Thomas Jefferson University Hospital, Philadelphia, PA

 

1977-1978, Fellow in Hematology/Oncology

Temple University Health Sciences Center, Philadelphia, PA

 

1978-1979, Fellow in Hematology

Cardeza Foundation for Hematologic Research

Thomas Jefferson University Hospital, Philadelphia, PA.

 

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Research Interests:

 

Molecular Mechanisms in Inherited Disorders of Platelet Signal Transduction (NIH and March of Dimes). A. Koneti Rao, MD [PI] - Patients with inherited platelet bleeding disorders are not uncommonly encountered in clinical practice. However, in the vast majority of these patients, the underlying molecular mechanisms leading to the platelet dysfunction are unknown. Our studies have focused on platelet signaling processes in these patients and have delineated hitherto undescribed abnormalities in key signaling proteins, including phospholipase C-beta-2, GTP binding protein G-alpha-q and protein kinase-C-theta. In addition we have focused over the last several years on the genes regulated in megakaryocytes and platelets by transcription factor RUNX1. Our studies show that MYL9. ALOX12, PF4, and PRKCQ are direct targets of RUNX1. The insights from these studies will lead to better understanding of the normal platelet mechanisms and the identification of novel targets to develop newer antiplatelet agents.

 

Hyperglycemia, Hyperinsulinemia, and Tissue Factor Pathway of Blood Coagulation (NIH). A. Koneti Rao, MD [Co-PI; G. Boden, PI] - Diabetes mellitus is well-recognized risk factor for cardiovascular disease. These patients have a high incidence of acute events including heart attacks and strokes. The impact of hyperglycemia (high blood glucose) and hyperinsulinemia (high blood insulin) on the activation of blood coagulation mechanisms has not been fully clarified. These studies, performed in collaboration with Dr. Guenther Boden, focus on the activation of the tissue factor pathway induced by hyperglycemia and hyperinsulinemia in healthy subjects and patients with diabetes mellitus, Type 1 and 2. Studies to date reveal a strong evidence for the activation of tissue factor pathway by both hyperglycemia and hyperinsulinemia, with the highest levels being observed with the combination of both. Further studies will lead to an understanding of the effect of antithrombotic agents on the expression of tissue factor in diabetes mellitus.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24335028. Rao AK, Spotlight on FLI1, RUNX1, and platelet dysfunction. Blood 122:25(4004-6)2013 Dec 12

23714316. Rao AK, Hematology/Oncology Clinics of North America. Disorders of the platelets. Preface. Hematol Oncol Clin North Am 27:3(xiii-xiv)2013 Jun

23714313. Rao AK, Inherited platelet function disorders: overview and disorders of granules, secretion, and signal transduction. Hematol Oncol Clin North Am 27:3(585-611)2013 Jun

22612792. Singh A, Foster GD, Gunawardana J, McCoy TA, Nguyen T, Vander Veur S, Komaroff E, Rao AK, Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state. Br J Haematol 158:4(523-7)2012 Aug

22410811. Singh A, Boden G, Homko C, Gunawardana J, Rao AK, Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia. Diabetes Care 35:6(1322-7)2012 Jun

21252065. Jalagadugula G, Mao G, Kaur G, Dhanasekaran DN, Rao AK, Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1. Arterioscler Thromb Vasc Biol 31:4(921-7)2011 Apr

21129147. Aneja K, Jalagadugula G, Mao G, Singh A, Rao AK, Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4. J Thromb Haemost 9:2(383-91)2011 Feb

20876458. Jalagadugula G, Mao G, Kaur G, Goldfinger LE, Dhanasekaran DN, Rao AK, Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency. Blood 116:26(6037-45)2010 Dec 23

20597033. Bhavaraju K, Mayanglambam A, Rao AK, Kunapuli SP, P2Y(12) antagonists as antiplatelet agents - Recent developments. Curr Opin Drug Discov Devel 13:4(497-506)2010 Jul

20181616. Kaur G, Jalagadugula G, Mao G, Rao AK, RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency. Blood 115:15(3128-35)2010 Apr 15

20133474. Rao AK, The tale of two COXs. Blood 115:5(921-2)2010 Feb 4

19162305. Vaidyula VR, Criner GJ, Grabianowski C, Rao AK, Circulating tissue factor procoagulant activity is elevated in stable moderate to severe chronic obstructive pulmonary disease. Thromb Res 124:3(259-61)2009 Jul

18989526. Jalagadugula G, Dhanasekaran DN, Rao AK, Phorbol 12-myristate 13-acetate (PMA) responsive sequence in Galphaq promoter during megakaryocytic differentiation. Regulation by EGR-1 and MAP kinase pathway. Thromb Haemost 100:5(821-8)2008 Nov

18000605. Gentile NT, Vaidyula VR, Kanamalla U, DeAngelis M, Gaughan J, Rao AK, Factor VIIa and tissue factor procoagulant activity in diabetes mellitus after acute ischemic stroke: impact of hyperglycemia. Thromb Haemost 98:5(1007-13)2007 Nov

17785358. Boden G, Vaidyula VR, Homko C, Cheung P, Rao AK, Circulating tissue factor procoagulant activity and thrombin generation in patients with type 2 diabetes: effects of insulin and glucose. J Clin Endocrinol Metab 92:11(4352-8)2007 Nov

17547839. Boden G, Rao AK, Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation. Curr Diab Rep 7:3(223-7)2007 Jun

17213471. Boden G, Vaidyula V, Homko C, Mozzoli M, Rao AK, Differential effects of somatostatin on circulating tissue factor procoagulant activity and protein. Am J Physiol Endocrinol Metab 292:5(E1333-9)2007 May

17139367. Rao AK, Vaidyula VR, Bagga S, Jalagadugula G, Gaughan J, Wilhite DB, Comerota AJ, Effect of antiplatelet agents clopidogrel, aspirin, and cilostazol on circulating tissue factor procoagulant activity in patients with peripheral arterial disease. Thromb Haemost 96:6(738-43)2006 Dec

17127486. Vaidyula VR, Boden G, Rao AK, Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects. Platelets 17:8(577-85)2006 Dec

17059412. Sun L, Gorospe JR, Hoffman EP, Rao AK, Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling. J Thromb Haemost 5:1(146-54)2007 Jan

16995904. Jalagadugula G, Dhanasekaran DN, Kim S, Kunapuli SP, Rao AK, Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells. J Thromb Haemost 4:12(2678-86)2006 Dec

16380494. Vaidyula VR, Rao AK, Mozzoli M, Homko C, Cheung P, Boden G, Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand. Diabetes 55:1(202-8)2006 Jan

15497095. Rao AK, Jalagadugula G, Sun L, Inherited defects in platelet signaling mechanisms. Semin Thromb Hemost 30:5(525-35)2004 Oct

15190516. Rao AK, Molecular and biochemical basis for the platelet dysfunction in myeloproliferative disorders. Semin Hematol 41:2 Suppl 3(6-9)2004 Apr

14560218. Wilhite DB, Comerota AJ, Schmieder FA, Throm RC, Gaughan JP, Rao AK, Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time. J Vasc Surg 38:4(710-3)2003 Oct

14525764. Sun L, Mao G, Rao AK, Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation. Blood 103:3(948-54)2004 Feb 1

12871400. Rao AK, Inherited defects in platelet signaling mechanisms. J Thromb Haemost 1:4(671-81)2003 Apr

12716374. Vaidyula VR, Rao AK, Role of Galphaq and phospholipase C-beta2 in human platelets activation by thrombin receptors PAR1 and PAR4: studies in human platelets deficient in Galphaq and phospholipase C-beta2. Br J Haematol 121:3(491-6)2003 May

11848441. Gabbeta J, Vaidyula VR, Dhanasekaran DN, Rao AK, Human platelet Galphaq deficiency is associated with decreased Galphaq gene expression in platelets but not neutrophils. Thromb Haemost 87:1(129-33)2002 Jan

11806993. Mao GF, Vaidyula VR, Kunapuli SP, Rao AK, Lineage-specific defect in gene expression in human platelet phospholipase C-beta2 deficiency. Blood 99:3(905-11)2002 Feb 1

11122160. Kaplan R, Gabbeta J, Sun L, Mao GF, Rao AK, Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease. Br J Haematol 111:3(954-64)2000 Dec

10669622. Rao AK, Gabbeta J, Congenital disorders of platelet signal transduction. Arterioscler Thromb Vasc Biol 20:2(285-9)2000 Feb

10559031. Chouhan VD, Comerota AJ, Sun L, Harada R, Gaughan JP, Rao AK, Inhibition of tissue factor pathway during intermittent pneumatic compression: A possible mechanism for antithrombotic effect. Arterioscler Thromb Vasc Biol 19:11(2812-7)1999 Nov

10475415. Khan MM, Gikakis N, Miyamoto S, Rao AK, Cooper SL, Edmunds LH Jr, Colman RW, Aprotinin inhibits thrombin formation and monocyte tissue factor in simulated cardiopulmonary bypass. Ann Thorac Surg 68:2(473-8)1999 Aug

10456468. Rao AK, Sun L, Hiramatsu Y, Gorman JH 3rd, Edmunds LH Jr, Glycoprotein IIb/IIIa receptor antagonist tirofiban inhibits thrombin generation during cardiopulmonary bypass in baboons. Thromb Haemost 82:1(140-4)1999 Jul

10331423. Rao AK, Chouhan V, Chen X, Sun L, Boden G, Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men. Diabetes 48:5(1156-61)1999 May

9840687. Rao AK, Kaplan R, Sheth S, Inherited thrombophilic states. Semin Thromb Hemost 24 Suppl 1:(3-12)1998

9704660. Rao AK, Congenital disorders of platelet function: disorders of signal transduction and secretion. Am J Med Sci 316:2(69-76)1998 Aug

9700850. Gabbeta J, Dhanasekaran N, Rao AK, G alpha q cDNA sequence from human platelets. Thromb Res 91:1(29-32)1998 Jul 1

9575605. Rao AK, Sheth S, Kaplan R, Inherited hypercoagulable states. Vasc Med 2:4(313-20)1997 Nov

9526952. Yang X, Sun L, Gabbeta J, Rao AK, Platelet activation with combination of ionophore A23187 and a direct protein kinase C activator induces normal secretion in patients with impaired receptor mediated secretion and abnormal signal transduction. Thromb Res 88:3(317-28)1997 Nov 1

9339937. Comerota AJ, Chouhan V, Harada RN, Sun L, Hosking J, Veermansunemi R, Comerota AJ Jr, Schlappy D, Rao AK, The fibrinolytic effects of intermittent pneumatic compression: mechanism of enhanced fibrinolysis. Ann Surg 226:3(306-13; discussion 313-4)1997 Sep

9238049. Gabbeta J, Yang X, Kowalska MA, Sun L, Dhanasekaran N, Rao AK, Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. Proc Natl Acad Sci U S A 94:16(8750-5)1997 Aug 5

9157594. Chouhan VD, De La Cadena RA, Nagaswami C, Weisel JW, Kajani M, Rao AK, Simultaneous occurrence of human antibodies directed against fibrinogen, thrombin, and factor V following exposure to bovine thrombin: effects on blood coagulation, protein C activation and platelet function. Thromb Haemost 77:2(343-9)1997 Feb

8921778. Rao AK, Sun L, Chesebro JH, Fuster V, Harrington RA, Schwartz D, Gallo P, Matos D, Topol EJ, Distinct effects of recombinant desulfatohirudin (Revasc) and heparin on plasma levels of fibrinopeptide A and prothrombin fragment F1.2 in unstable angina. A multicenter trial. Circulation 94:10(2389-95)1996 Nov 15

8879629. Goldberg SL, Shubert J, Rao AK, Redei I, Klumpp TR, Mangan KF, Treatment of hepatic veno-occlusive disease with low-dose tissue plasminogen activator: impact on coagulation profile. Bone Marrow Transplant 18:3(633-6)1996 Sep

8781423. Yang X, Sun L, Ghosh S, Rao AK, Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation. Blood 88:5(1676-83)1996 Sep 1

8607116. McLane MA, Gabbeta J, Rao AK, Beviglia L, Lazarus RA, Niewiarowski S, A comparison of the effect of decorsin and two disintegrins, albolabrin and eristostatin, on platelet function. Thromb Haemost 74:5(1316-22)1995 Nov

8560416. Rao AK, Ghosh S, Sun L, Yang X, Disa J, Pickens P, Polansky M, Mechanisms of platelet dysfunction and response to DDAVP in patients with congenital platelet function defects. A double-blind placebo-controlled trial. Thromb Haemost 74:4(1071-8)1995 Oct

8238002. Colman RW, Rao AK, Rubin RN, Refractory thrombocytopenia in a 27-year-old female following allogeneic bone marrow transplantation. Am J Hematol 44:4(284-8)1993 Dec

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