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Servio H. Ramirez, PhD

Assistant Professor, Pathology and Laboratory Medicine

Telephone:  215-707-2741

Fax:  215-707-8132

Email: servio.ramirez@temple.edu

Department of Pathology and Laboratory Medicine

BS, Biotechnology, Rochester Institute of Technology, Rochester, NY, 1998

 

MS, PhD, Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 2004

 

Postdoctoral Fellowship, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 2005-2008

 

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• Cerebral vascular biology
• Molecular/signaling mechanisms leading to regulation of the Blood Brain Barrier
• Assay development for evaluating Blood Brain Barrier function
• Biomarkers for neurotrauma
• Neuroregeneration, focusing on understanding the interaction between brain endothelium and neural progenitor cells
• HIV-1 neuropathogenesis

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• Society of NeuroImmune Pharmacology
• International Society of NeuroImmunology
• International Brain Barriers Society
• Society for Neuroscience
• American Society of Gene Therapy

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19654589. Ramirez SH, Potula R, Fan S, Eidem T, Papugani A, Reichenbach N, Dykstra H, Weksler BB, Romero IA, Couraud PO, Persidsky Y, Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells. J Cereb Blood Flow Metab :()2009 Aug 5

19034671. Gendelman HE, Ding S, Gong N, Liu J, Ramirez SH, Persidsky Y, Mosley RL, Wang T, Volsky DJ, Xiong H, Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration. J Neuroimmune Pharmacol 4:1(47-59)2009 Mar

18845238. Haorah J, Ramirez SH, Floreani N, Gorantla S, Morsey B, Persidsky Y, Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radic Biol Med 45:11(1542-50)2008 Dec 1

18670212. Potula R, Ramirez SH, Knipe B, Leibhart J, Schall K, Heilman D, Morsey B, Mercer A, Papugani A, Dou H, Persidsky Y, Peroxisome proliferator-activated receptor-gamma activation suppresses HIV-1 replication in an animal model of encephalitis. AIDS 22:13(1539-49)2008 Aug 20

18209083. Ramirez SH, Heilman D, Morsey B, Potula R, Haorah J, Persidsky Y, Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. J Immunol 180:3(1854-65)2008 Feb 1

18187566. Yamamoto M, Ramirez SH, Sato S, Kiyota T, Cerny RL, Kaibuchi K, Persidsky Y, Ikezu T, Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol 172:2(521-33)2008 Feb

18040800. Persidsky Y, Ramirez SH, Haorah J, Kanmogne GD, Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J Neuroimmune Pharmacol 1:3(223-36)2006 Sep

17948266. Liu J, Johnson TV, Lin J, Ramirez SH, Bronich TK, Caplan S, Persidsky Y, Gendelman HE, Kipnis J, T cell independent mechanism for copolymer-1-induced neuroprotection. Eur J Immunol 37:11(3143-54)2007 Nov

17943953. Haorah J, Schall K, Ramirez SH, Persidsky Y, Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuse. Glia 56:1(78-88)2008 Jan 1

17250680. Haorah J, Ramirez SH, Schall K, Smith D, Pandya R, Persidsky Y, Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J Neurochem 101:2(566-76)2007 Apr

16154247. Maguire CA, Sapinoro R, Girgis N, Rodriguez-Colon SM, Ramirez SH, Williams J, Dewhurst S, Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens. Vaccine 24:5(671-82)2006 Jan 30

15737413. Fan S, Maguire CA, Ramirez SH, Bradel-Tretheway B, Sapinoro R, Sui Z, Chakraborty-Sett S, Dewhurst S, Valproic acid enhances gene expression from viral gene transfer vectors. J Virol Methods 125:1(23-33)2005 Apr

15548427. Fan S, Ramirez SH, Garcia TM, Dewhurst S, Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. Brain Res Mol Brain Res 132:1(38-50)2004 Dec 6

15233744. Kovács AD, Chakraborty-Sett S, Ramirez SH, Sniderhan LF, Williamson AL, Maggirwar SB, Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neurons. Eur J Neurosci 20:2(345-52)2004 Jul

15211592. Ramirez SH, Fan S, Maguire CA, Perry S, Hardiek K, Ramkumar V, Gelbard HA, Dewhurst S, Maggirwar SB, Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. J Neurosci Res 77:2(258-69)2004 Jul 15

11520908. Ramirez SH, Sanchez JF, Dimitri CA, Gelbard HA, Dewhurst S, Maggirwar SB, Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism. J Neurochem 78:4(874-89)2001 Aug

11403684. Tong N, Sanchez JF, Maggirwar SB, Ramirez SH, Guo H, Dewhurst S, Gelbard HA, Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. Eur J Neurosci 13:10(1913-22)2001 May

10646503. Maggirwar SB, Ramirez S, Tong N, Gelbard HA, Dewhurst S, Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells. J Neurochem 74:2(527-39)2000 Feb

10428053. Maggirwar SB, Tong N, Ramirez S, Gelbard HA, Dewhurst S, HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. J Neurochem 73:2(578-86)1999 Aug

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