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Seervio H. Ramirez, PhD


Servio H. Ramirez, PhD


Associate Professor, Pathology and Laboratory Medicine

Telephone:  215-707-2741

Fax:  215-707-8132

Email: servio.ramirez@temple.edu



Ramirez Lab Website: http://www.ramirezneurolab.com/


Department of Pathology and Laboratory Medicine


Educational Background:


BS, Biotechnology, Rochester Institute of Technology, Rochester, NY, 1998


MS, PhD, Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 2004


Postdoctoral Fellowship, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 2005-2008


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research Interests:

  • Cerebral vascular biology
  • Molecular/signaling mechanisms leading to regulation of the Blood Brain Barrier
  • Assay development for evaluating Blood Brain Barrier function
  • Biomarkers for neurotrauma
  • Neuroregeneration, focusing on understanding the interaction between brain endothelium and neural progenitor cells
  • HIV-1 neuropathogenesis

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professional affiliations:


  • Society of NeuroImmune Pharmacology
  • International Society of NeuroImmunology
  • International Brain Barriers Society
  • Society for Neuroscience
  • American Society of Gene Therapy

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24729609. Singh MV, Davidson DC, Jackson JW, Singh VB, Silva J, Ramirez SH, Maggirwar SB, Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. J Immunol 192:10(4674-84)2014 May 15

20631174. Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, Persidsky Y, Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis. J Neurosci 30:28(9454-64)2010 Jul 14

15233744. Kovács AD, Chakraborty-Sett S, Ramirez SH, Sniderhan LF, Williamson AL, Maggirwar SB, Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neurons. Eur J Neurosci 20:2(345-52)2004 Jul

15211592. Ramirez SH, Fan S, Maguire CA, Perry S, Hardiek K, Ramkumar V, Gelbard HA, Dewhurst S, Maggirwar SB, Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. J Neurosci Res 77:2(258-69)2004 Jul 15

11520908. Ramirez SH, Sanchez JF, Dimitri CA, Gelbard HA, Dewhurst S, Maggirwar SB, Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism. J Neurochem 78:4(874-89)2001 Aug

11403684. Tong N, Sanchez JF, Maggirwar SB, Ramirez SH, Guo H, Dewhurst S, Gelbard HA, Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. Eur J Neurosci 13:10(1913-22)2001 May

10646503. Maggirwar SB, Ramirez S, Tong N, Gelbard HA, Dewhurst S, Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells. J Neurochem 74:2(527-39)2000 Feb

10428053. Maggirwar SB, Tong N, Ramirez S, Gelbard HA, Dewhurst S, HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. J Neurochem 73:2(578-86)1999 Aug

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