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Madesh Muniswamy, PhD

Sudarsan Rajan, PhD

 

Assistant Professor (Research), Center for Translational Medicine

Telephone: 215-707-9756

Fax: 215-707-9890

Email: sudarsan@temple.edu

 

Center for Translational Medicine

 

 

Educational Background:

 

BSc, Biochemistry, Islamiah College, Univerisity of Madras, India, 1991

 

MSc, Medical Biochemistry, JIPMER, Pondicherry University, India, 1994

 

PhD, Biochemistry, Madurai Kamaraj University, India, 2002

 

Postdoctoral Training, University of Cincinnati, 2007

 

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PRofessional Affliations

 

  • Professional Member, American Heart Association - Council on Basic Cardiovascular Science
  • North American Section of International Society for Heart Research (ISHR)

 

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Research Interests:

 

Sudarsan Rajan, PhD, has his expertise in development of gene targeted/ transgenic mouse models for cardiovascular research with special focus on contractile and regulatory proteins. His current research is now focused on mitochondrial bioenergetics and calcium uptake.

 

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Books, book chapters, and other publications

 

Book Chapters:


Wieczorek DF, Jagatheesan G and Rajan S. The Role of Tropomyosin in Heart Disease. In: Tropomyosin (Ed.) Peter Gunning. Book Series: Adv Exp Med Bioi. 2008; 644:132-42. [ISBN: 978-0-387-85765-7}.


Other Publications:


Rajan S, Alves ML, Pen a J, Jegga AG, Aronow BJ, Wolska BM and Wieczorek DF. Microarray Analysis of Active Cardiac Remodeling Genes in a Familial Hypertrophic Cardiomyopathy Mouse Model Rescued by a Phospholamban Knockout. Physiol Genomics. 2013 Jun 25.

Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, Wolska B, Solaro RJ and Wieczorek DF. (2010)Molecular and Functional Characterization of a Novel Cardiac Specific Human Tropomyosin Isoform. Circulation. 121 :410-18. [Epub 2010 Jan 11.] (Accompanied by Editorial Focus)

Jagatheesan G, Rajan S and Wieczorek DF (2009) Investigations into tropomyosin function using mouse models. J Mol Cell Cardiol. 2009 Oct 14. [Epub ahead of print]

Wieczorek DF, Jagatheesan G and Rajan S. (2008) The role of tropomyosin in heart disease. Book Series: "Tropomyosin" (Ed.) Peter Gunning; Adv Exp Med BioI. 644:132-42 [ISBN: 978-0-387-85765-7]

Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, and Wieczorek DF. (2007) Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res. 101 (2):205-14 [Epub 2007 Jun 7]

Rajan S, Radhakrishnan J, Rajamanickam C. Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of a2- macroglobulin induces cardiac hypertrophy in the rat heart. Basic Res Cardiol. 2003 Feb; 98(1): 39-49.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25214462. Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF, The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor a modulation, uncoupling nuclear and membrane activation. EMBO Mol Med 6:10(1328-46)2014 Sep 11

25077561. Doonan PJ, Chandramoorthy HC, Hoffman NE, Zhang X, Cárdenas C, Shanmughapriya S, Rajan S, Vallem S, Chen X, Foskett JK, Cheung JY, Houser SR, Madesh M, LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation. FASEB J :()2014 Jul 30

24843127. Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN, Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells. Proc Natl Acad Sci U S A 111:22(E2319-28)2014 Jun 3

24509847. Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S, Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. J Biol Chem 289:13(8818-27)2014 Mar 28

24430870. Hoffman NE, Chandramoorthy HC, Shanmughapriya S, Zhang XQ, Vallem S, Doonan PJ, Malliankaraman K, Guo S, Rajan S, Elrod JW, Koch WJ, Cheung JY, Madesh M, SLC25A23 augments mitochondrial Ca²? uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol Biol Cell 25:6(936-47)2014 Mar

24332854. Hoffman NE, Chandramoorthy HC, Shamugapriya S, Zhang X, Rajan S, Mallilankaraman K, Gandhirajan RK, Vagnozzi RJ, Ferrer LM, Sreekrishnanilayam K, Natarajaseenivasan K, Vallem S, Force T, Choi ET, Cheung JY, Madesh M, MICU1 motifs define mitochondrial calcium uniporter binding and activity. Cell Rep 5:6(1576-88)2013 Dec 26

23800848. Rajan S, Pena JR, Jegga AG, Aronow BJ, Wolska BM, Wieczorek DF, Microarray analysis of active cardiac remodeling genes in a familial hypertrophic cardiomyopathy mouse model rescued by a phospholamban knockout. Physiol Genomics 45:17(764-73)2013 Sep 3

23609439. Yar S, Chowdhury SA, Davis RT 3rd, Kobayashi M, Monasky MM, Rajan S, Wolska BM, Gaponenko V, Kobayashi T, Wieczorek DF, Solaro RJ, Conserved Asp-137 is important for both structure and regulatory functions of cardiac a-tropomyosin (a-TM) in a novel transgenic mouse model expressing a-TM-D137L. J Biol Chem 288:23(16235-46)2013 Jun 7

24843647. Eames SC, Kinkel MD, Rajan S, Prince VE, Philipson LH, Transgenic zebrafish model of the C43G human insulin gene mutation. J Diabetes Investig 4:2(157-67)2013 Mar 18

21221740. Karam CN, Warren CM, Rajan S, de Tombe PP, Wieczorek DF, Solaro RJ, Expression of tropomyosin-? induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation. J Muscle Res Cell Motil 31:5-6(315-22)2011 Mar

20803058. Jagatheesan G, Rajan S, Ahmed RP, Petrashevskaya N, Boivin G, Arteaga GM, Tae HJ, Liggett SB, Solaro RJ, Wieczorek DF, Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. J Muscle Res Cell Motil 31:3(227-39)2010 Sep

20065163. Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, Wolska BM, Solaro RJ, Wieczorek DF, Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation 121:3(410-8)2010 Jan 26

19835881. Jagatheesan G, Rajan S, Wieczorek DF, Investigations into tropomyosin function using mouse models. J Mol Cell Cardiol 48:5(893-8)2010 May

19429821. Jagatheesan G, Rajan S, Schulz EM, Ahmed RP, Petrashevskaya N, Schwartz A, Boivin GP, Arteaga GM, Wang T, Wang YG, Ashraf M, Liggett SB, Lorenz J, Solaro RJ, Wieczorek DF, An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. Am J Physiol Heart Circ Physiol 297:1(H181-90)2009 Jul

19209819. Wieczorek DF, Jagatheesan G, Rajan S, The role of tropomyosin in heart disease. Adv Exp Med Biol 644:(132-42)2008

18095372. Warren CM, Arteaga GM, Rajan S, Ahmed RP, Wieczorek DF, Solaro RJ, Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy. Proteomics 8:1(100-5)2008 Jan

17556658. Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF, Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res 101:2(205-14)2007 Jul 20

17416600. Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF, Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol 293:2(H949-58)2007 Aug

16882888. Rajan S, Williams SS, Jagatheesan G, Ahmed RP, Fuller-Bicer G, Schwartz A, Aronow BJ, Wieczorek DF, Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy. Physiol Genomics 27:3(309-17)2006 Nov 27

16862575. Rajan SS, Yang X, Shuvalova L, Collart F, Anderson WF, Crystal structure of YfiR, an unusual TetR/CamR-type putative transcriptional regulator from Bacillus subtilis. Proteins 65:1(255-7)2006 Oct 1

15820677. Rajan S, Plant LD, Rabin ML, Butler MH, Goldstein SA, Sumoylation silences the plasma membrane leak K+ channel K2P1. Cell 121:1(37-47)2005 Apr 8

15581359. Rajan SS, Yang X, Shuvalova L, Collart F, Anderson WF, YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology. Biochemistry 43:49(15472-9)2004 Dec 14

15191887. Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga G, de Tombe PP, Solaro RJ, Wieczorek DF, Physiological significance of troponin T binding domains in striated muscle tropomyosin. Am J Physiol Heart Circ Physiol 287:4(H1484-94)2004 Oct

12690096. Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Vahebi S, DeTombe P, Solaro RJ, Labitzke E, Hilliard G, Wieczorek DF, Functional importance of the carboxyl-terminal region of striated muscle tropomyosin. J Biol Chem 278:25(23204-11)2003 Jun 20

7933979. Boivin GP, Keller GL, Rajan S, Organ-to-body weight ratio in the Egyptian spiny mouse Acomys cahirinus. Lab Anim Sci 44:3(286-7)1994 Jun

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