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Joseph E. Rabinowitz, PhD

Assistant Professor, Pharmacology

Assistant Professor, Center for Translational Medicine

Telephone:  215-707-9670

Fax:  215-707-9890

Email: j.rabinowitz@temple.edu

Department of Pharmacology

Center for Translational Medicine

Undergraduate degree: University of Tucson, Tucson, AZ, 1985

 

PhD, Case Western Reserve University, Cleveland, OH, 1996

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• American Society of Gene and Cell Therapy
• American Heart Association

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Dr. Rabinowitz's laboratory is most interested in increasing the transduction efficiency of viral gene delivery vehicles derived from the human parvovirus Adeno-associated virus (AAV). This virus is a small (20-30nm) non-enveloped non-pathogenic single stranded DNA containing dependovirus in the parvovirus family. Multiple AAV serotypes have been isolated over the last forty years and each of these serotypes has a tendency to transduce specific tissue targets. Additionally, each of these serotypes transduces tissues with a different efficiency. One goal of this laboratory is to determine domains on the viral shells of the different AAV serotypes, which govern their distinct tropisms. This lab is also interested in altering those domains so the normal viral tropisms are reduced so that when tropism determining epitopes are added to the virus shell a new target is acquired.

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Bowles DE, Rabinowitz JE, and Samulski RJ. The genus dependovirus: In Parvoviruses.  Edited by Marshall E. Bloom, Susan F. Cotmore, R. Michael Linden, Colin R. Parrish and Jonathan R. Kerr, 2006.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23472081. Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ, Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. PLoS One 8:3(e57324)2013

23224879. Cheung JY, Zhang XQ, Song J, Gao E, Chan TO, Rabinowitz JE, Koch WJ, Feldman AM, Wang J, Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1). Adv Exp Med Biol 961:(175-90)2013

21193587. Wang J, Gao E, Rabinowitz J, Song J, Zhang XQ, Koch WJ, Tucker AL, Chan TO, Feldman AM, Cheung JY, Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol 300:3(H859-68)2011 Mar

21029739. Wang J, Faust SM, Rabinowitz JE, The next step in gene delivery: molecular engineering of adeno-associated virus serotypes. J Mol Cell Cardiol 50:5(793-802)2011 May

20718822. Cheung JY, Zhang XQ, Song J, Gao E, Rabinowitz JE, Chan TO, Wang J, Phospholemman: a novel cardiac stress protein. Clin Transl Sci 3:4(189-96)2010 Aug

20590676. Zincarelli C, Soltys S, Rengo G, Koch WJ, Rabinowitz JE, Comparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heart. Clin Transl Sci 3:3(81-9)2010 Jun

19103992. Rengo G, Lymperopoulos A, Zincarelli C, Donniacuo M, Soltys S, Rabinowitz JE, Koch WJ, Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation 119:1(89-98)2009 Jan 6

18414476. Zincarelli C, Soltys S, Rengo G, Rabinowitz JE, Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection. Mol Ther 16:6(1073-80)2008 Jun

17470693. Pleger ST, Most P, Boucher M, Soltys S, Chuprun JK, Pleger W, Gao E, Dasgupta A, Rengo G, Remppis A, Katus HA, Eckhart AD, Rabinowitz JE, Koch WJ, Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue. Circulation 115:19(2506-15)2007 May 15

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