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Domenico Praticò, MD

Professor, Pharmacology

Professor, Microbiology and Immunology

Professor, Center for Translational Medicine

Telephone:  215-707-9380

Fax:  215-707-9890

Email: praticod@temple.edu

Department of Pharmacology

Department of Microbiology

Center for Translational Medicine

MD, University of Rome "La Sapienza", Rome, Italy, 1986

 

Internship, Hospital of the University of Rome "La Sapienza"

 

Residency, Hospital of the University of Rome "La Sapienza", 1986-1991

 

Fellowship, Hemocoagulation, Hospital of the University of Rome "La Sapienza", 1990-1991; Cardiovascular Science, University of Dublin, Ireland, 1992-1994

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Internal Medicine, University of Rome "La Sapienza", 1991

 

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• Society for Neuroscience
• Italian Research Council
• American Federation for Medical Research
• American Heart Association (member of Arteriosclerosis, Thrombosis and Vascular Biology Council)
• New York Academy of Science
• International Academy of Cardiology

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Dr. Praticò’s research area is clinical pharmacology with a special focus on the cellular and molecular aspects of cell oxidative biology and a particular interest in small molecules such as bioactive oxidized lipids.

This area is very broad and extends to multiple disciplines including aging, cardiovascular diseases as well as neurodegeneration. Our work in the biology of oxidized bioactive lipids has significantly contributed to the current understanding of their importance as biomarkers, mediators of cellular and molecular events involved in the pathogenesis of several clinical conditions, and therapeutic targets for preventing and treating human diseases. In our lab we employ cellular and animal models of human diseases, and in this context particular emphasis is given to the translation of any observation made in these systems into a better understanding of human physiology and pathology. Our group is committed to foster collaborative scientific research of the highest quality, and at the same time to provide outstanding teaching and mentoring for young scientists. 

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Praticò, D. Causes and consequences of oxidative stress in neurodegenerative diseases. In: Genotype, Proteotype and Phenotype relationships in neurodegenerative diseases. Eds. J. Cummings and Y. Christen. Springer Publisher; pp.37-44 (2005) (chapter)

Cyrus, T., Praticò, D. Antioxidants and chronic cardiovascular diseases: animal studies. In: Antioxidants and Cardiovascular Disease. 2nd Edition. Eds. M.G. Bourassa, J-C Tardif. Springer Publishers; pp. 227-253 (2006) (chapter)

Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis. In: The encyclopedia of Vitamin E. Eds.V.R. Preedy and R.R. Watson. CABI Publishing, Wallingford, UK; pp. 623-632 (2006) (chapter)

Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis: Animal and Human trials. In: Vitamin E: New Research. Ed. Matthew H. Braunstein. Nova Science Publishers; pp.177-199 (2006) (chapter)

Praticò, D. Antioxidants and endothelium protection. In: Endothelial dysfunction and vascular disease. Eds. R. De Caterina and P. Libby. Blackwell Futura Publishing; pp. 315-322 (2007) (chapter)

de Leon, M.J., Mosconi, L., Blennow, K., De Santi, S., Zinkowski, R., Mehta, P.D., Praticò, D., Tsui, W., Saint Louis, L.A., Sobanska, L., Brys, M., Li, Y., Rich, K., Rinne, J., Rusinek, H. Imaging and CSF studies in the preclinical diagnosis of Alzheimer’s disease. In: Imaging and the Aging Brain. Eds. DeLeon MJ, Snider DA, and Federoff H. Blackwell Publishing; pp.114-45.2 (2007) (chapter)

Praticò, D., Polidori, M.C., Mecocci, P. Vitamin E, dementia and cognitive function. In: Vitamins and the prevention of human diseases. Eds. Herrmann W., Obeid R. De Gruyter Publishing; pp.503-514 (2010) (chapter).

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23683389. Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, Kirby LG, Praticò D, 5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit, Synaptic Dysfunction, and Neuropathology in a Mouse Model of Alzheimer's Disease. Biol Psychiatry :()2013 May 15

23634895. Joshi YB, Chu J, Praticò D, Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg mice. Aging Cell :()2013 May 2

23478745. Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, Kirby LG, Praticò D, Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease. Mol Psychiatry :()2013 Mar 12

23400723. Praticò D, Antioxidants for Alzheimer disease. JAMA Neurol 70:2(270)2013 Feb

23357209. Joshi YB, Praticò D, The involvement of 5-lipoxygenase activating protein in anxiety-like behavior. J Psychiatr Res 47:5(694-8)2013 May

23352590. Chu J, Li JG, Ceballos-Diaz C, Golde T, Praticò D, The Influence of 5-Lipoxygenase on Alzheimer's Disease-Related Tau Pathology: In Vivo and In Vitro Evidence. Biol Psychiatry :()2013 Jan 23

23332172. Chu J, Praticò D, 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. Neurobiol Aging 34:6(1549-54)2013 Jun

23034916. Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Praticò D, 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Ann Neurol 72:3(442-54)2012 Sep

22764362. Pomara N, Bruno D, Sarreal AS, Hernando RT, Nierenberg J, Petkova E, Sidtis JJ, Wisniewski TM, Mehta PD, Pratico D, Zetterberg H, Blennow K, Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder. Am J Psychiatry 169:5(523-30)2012 May

22697885. Chu J, Praticò D, Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model. J Neuroinflammation 9:(127)2012 Jun 14

22695619. Praticò D, Alzheimer's disease and the quest for its biological measures. J Alzheimers Dis 33 Suppl 1:(S237-41)2013

22695538. Teunissen CE, Sombekke M, van Winsen L, Killestein J, Barkhof F, Polman CH, Dijkstra CD, Blankenstein MA, Pratico D, Increased plasma 8,12-iso-iPF2alpha- VI levels in relapsing multiple sclerosis patients are not predictive of disease progression. Mult Scler 18:8(1092-8)2012 Aug

22584618. Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G, Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord 33:4(219-25)2012

22531419. Joshi YB, Chu J, Praticò D, Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis 31:1(167-76)2012

22422715. Joshi YB, Praticò D, Vitamin E in aging, dementia, and Alzheimer's disease. Biofactors 38:2(90-7)2012 Mar-Apr

22275252. Chu J, Zhuo JM, Praticò D, Transcriptional regulation of ß-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments. Ann Neurol 71:1(57-67)2012 Jan

22222029. Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Pratico D, Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice. Mol Neurodegener 7:1(1)2012 Jan 5

22220211. Joshi YB, Praticò D, Knockout of 5-lipoxygenase results in age-dependent anxiety-like behavior in female mice. PLoS One 6:12(e29448)2011

21684021. Zhuo JM, Wang H, Praticò D, Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci 32:9(562-71)2011 Sep

21653942. Cheng Z, Jiang X, Kruger WD, Praticò D, Gupta S, Mallilankaraman K, Madesh M, Schafer AI, Durante W, Yang X, Wang H, Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood 118:7(1998-2006)2011 Aug 18

21435457. Chu J, Praticò D, Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of ?-secretase. Am J Pathol 178:4(1762-9)2011 Apr

21280074. Chu J, Praticò D, 5-lipoxygenase as an endogenous modulator of amyloid ß formation in vivo. Ann Neurol 69:1(34-46)2011 Jan

21253592. Puccio S, Chu J, Praticò D, Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence. PLoS One 6:1(e15163)2011 Jan 6

21051716. Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Grieco S, Lee J, Lyubarsky A, Pratico D, Connelly J, Spino M, Harris ZL, Dunaief JL, The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. Invest Ophthalmol Vis Sci 52:2(959-68)2011 Feb 16

21051668. Korporaal SJ, Meurs I, Hauer AD, Hildebrand RB, Hoekstra M, Cate HT, Praticò D, Akkerman JW, Van Berkel TJ, Kuiper J, Van Eck M, Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol. Arterioscler Thromb Vasc Biol 31:1(34-42)2011 Jan

20938947. Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, Lyon CJ, Pratico D, Finegold MJ, Wong ST, Webb P, Baxter JD, Moore DD, Hsueh WA, Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology 52:6(2001-11)2010 Dec

20817151. Mosconi L, Glodzik L, Mistur R, McHugh P, Rich KE, Javier E, Williams S, Pirraglia E, De Santi S, Mehta PD, Zinkowski R, Blennow K, Pratico D, de Leon MJ, Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's. Biol Psychiatry 68:10(913-21)2010 Nov 15

20570249. Yang H, Zhuo JM, Chu J, Chinnici C, Praticò D, Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol Psychiatry 68:10(922-9)2010 Nov 15

20555139. Zhuo JM, Praticò D, Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice. J Alzheimers Dis 21:1(133-40)2010

20519634. Zhuo JM, Praticò D, Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease. FASEB J 24:10(3895-902)2010 Oct

20431066. Hildebrand RB, Lammers B, Meurs I, Korporaal SJ, De Haan W, Zhao Y, Kruijt JK, Praticò D, Schimmel AW, Holleboom AG, Hoekstra M, Kuivenhoven JA, Van Berkel TJ, Rensen PC, Van Eck M, Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency. Arterioscler Thromb Vasc Biol 30:7(1439-45)2010 Jul

20164556. Zhuo JM, Kruger WD, Praticò D, The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia. J Alzheimers Dis 20:2(569-76)2010

20116452. Praticò D, The neurobiology of isoprostanes and Alzheimer's disease. Biochim Biophys Acta 1801:8(930-3)2010 Aug

20005283. Zhuo JM, Praticò D, Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet. Exp Gerontol 45:3(195-201)2010 Mar

19939226. Zhuo JM, Portugal GS, Kruger WD, Wang H, Gould TJ, Pratico D, Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. Curr Alzheimer Res 7:2(140-9)2010 Mar

19936103. Chu J, Praticò D, The 5-lipoxygenase as a common pathway for pathological brain and vascular aging. Cardiovasc Psychiatry Neurol 2009:(174657)2009

19798476. van der Giet M, Tölle M, Pratico D, Lufft V, Schuchardt M, Hörl MP, Zidek W, Tietge UJ, Increased type IIA secretory phospholipase A(2) expression contributes to oxidative stress in end-stage renal disease. J Mol Med (Berl) 88:1(75-83)2010 Jan

19764861. Praticò D, Dogné JM, Vascular biology of eicosanoids and atherogenesis. Expert Rev Cardiovasc Ther 7:9(1079-89)2009 Sep

19735918. Cyrus T, Ding T, Praticò D, Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition. Atherosclerosis 208:2(376-81)2010 Feb

19542607. Polidori MC, Praticó D, Mangialasche F, Mariani E, Aust O, Anlasik T, Mang N, Pientka L, Stahl W, Sies H, Mecocci P, Nelles G, High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimers Dis 17:4(921-7)2009

19278942. Pratico D, High-dose B vitamin supplements and Alzheimer disease. JAMA 301:10(1020-1; author reply 1021-2)2009 Mar 11

19265038. Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, Boyadjian R, Bikineyeva A, Praticò D, Harrison DG, Hsueh WA, Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res 104:6(e42-54)2009 Mar 27

19221425. Brys M, Glodzik L, Mosconi L, Switalski R, De Santi S, Pirraglia E, Rich K, Kim BC, Mehta P, Zinkowski R, Pratico D, Wallin A, Zetterberg H, Tsui WH, Rusinek H, Blennow K, de Leon MJ, Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease. J Alzheimers Dis 16:2(351-62)2009

19220291. Zhao L, Ding T, Cyrus T, Cheng Y, Tian H, Ma M, Falotico R, Praticò D, Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor. Br J Pharmacol 156:5(774-85)2009 Mar

19076432. Praticò D, Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows. Ann N Y Acad Sci 1147:(70-8)2008 Dec

19019188. Mattsson N, Yaong M, Rosengren L, Blennow K, Månsson JE, Andersen O, Zetterberg H, Haghighi S, Zho I, Pratico D, Elevated cerebrospinal fluid levels of prostaglandin E2 and 15-(S)-hydroxyeicosatetraenoic acid in multiple sclerosis. J Intern Med 265:4(459-64)2009 Apr

18983885. Strydom A, Dickinson MJ, Shende S, Pratico D, Walker Z, Oxidative stress and cognitive ability in adults with Down syndrome. Prog Neuropsychopharmacol Biol Psychiatry 33:1(76-80)2009 Feb 1

18838179. Praticò D, Oxidative stress hypothesis in Alzheimer's disease: a reappraisal. Trends Pharmacol Sci 29:12(609-15)2008 Dec

18541983. Connolly J, Siderowf A, Clark CM, Mu D, Pratico D, F2 isoprostane levels in plasma and urine do not support increased lipid peroxidation in cognitively impaired Parkinson disease patients. Cogn Behav Neurol 21:2(83-6)2008 Jun

18514200. Praticò D, Prostanoid and isoprostanoid pathways in atherogenesis. Atherosclerosis 201:1(8-16)2008 Nov

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