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Domenico Pratico, MDDomenico Praticò, MD


Professor, Pharmacology

Professor, Microbiology and Immunology

Professor, Center for Translational Medicine

Telephone:  215-707-9380

Fax:  215-707-9890

Email: praticod@temple.edu


Department of Pharmacology

Department of Microbiology

Center for Translational Medicine


Educational Background:


MD, University of Rome "La Sapienza", Rome, Italy, 1986


Internship, Hospital of the University of Rome "La Sapienza"


Residency, Hospital of the University of Rome "La Sapienza", 1986-1991


Fellowship, Hemocoagulation, Hospital of the University of Rome "La Sapienza", 1990-1991; Cardiovascular Science, University of Dublin, Ireland, 1992-1994

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board certification(s):


Internal Medicine, University of Rome "La Sapienza", 1991


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professional affiliations:


  • Society for Neuroscience
  • Italian Research Council
  • American Federation for Medical Research
  • American Heart Association (member of Arteriosclerosis, Thrombosis and Vascular Biology Council)
  • New York Academy of Science
  • International Academy of Cardiology

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Research Interests:


Dr. Praticò’s research area is clinical pharmacology with a special focus on the cellular and molecular aspects of cell oxidative biology and a particular interest in small molecules such as bioactive oxidized lipids.


This area is very broad and extends to multiple disciplines including aging, cardiovascular diseases as well as neurodegeneration. Our work in the biology of oxidized bioactive lipids has significantly contributed to the current understanding of their importance as biomarkers, mediators of cellular and molecular events involved in the pathogenesis of several clinical conditions, and therapeutic targets for preventing and treating human diseases. In our lab we employ cellular and animal models of human diseases, and in this context particular emphasis is given to the translation of any observation made in these systems into a better understanding of human physiology and pathology. Our group is committed to foster collaborative scientific research of the highest quality, and at the same time to provide outstanding teaching and mentoring for young scientists. 


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book chapters and non pubmed publications:


Praticò, D. Causes and consequences of oxidative stress in neurodegenerative diseases. In: Genotype, Proteotype and Phenotype relationships in neurodegenerative diseases. Eds. J. Cummings and Y. Christen. Springer Publisher; pp.37-44 (2005) (chapter)

Cyrus, T., Praticò, D. Antioxidants and chronic cardiovascular diseases: animal studies. In: Antioxidants and Cardiovascular Disease. 2nd Edition. Eds. M.G. Bourassa, J-C Tardif. Springer Publishers; pp. 227-253 (2006) (chapter)

Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis. In: The encyclopedia of Vitamin E. Eds.V.R. Preedy and R.R. Watson. CABI Publishing, Wallingford, UK; pp. 623-632 (2006) (chapter)

Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis: Animal and Human trials. In: Vitamin E: New Research. Ed. Matthew H. Braunstein. Nova Science Publishers; pp.177-199 (2006) (chapter)

Praticò, D. Antioxidants and endothelium protection. In: Endothelial dysfunction and vascular disease. Eds. R. De Caterina and P. Libby. Blackwell Futura Publishing; pp. 315-322 (2007) (chapter)

de Leon, M.J., Mosconi, L., Blennow, K., De Santi, S., Zinkowski, R., Mehta, P.D., Praticò, D., Tsui, W., Saint Louis, L.A., Sobanska, L., Brys, M., Li, Y., Rich, K., Rinne, J., Rusinek, H. Imaging and CSF studies in the preclinical diagnosis of Alzheimer’s disease. In: Imaging and the Aging Brain. Eds. DeLeon MJ, Snider DA, and Federoff H. Blackwell Publishing; pp.114-45.2 (2007) (chapter)

Praticò, D., Polidori, M.C., Mecocci, P. Vitamin E, dementia and cognitive function. In: Vitamins and the prevention of human diseases. Eds. Herrmann W., Obeid R. De Gruyter Publishing; pp.503-514 (2010) (chapter).


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26448035. Chu J, Wisniewski T, Pratic˛ D, GATA1-mediated transcriptional regulation of the ?-secretase activating protein increases A▀ formation in Down syndrome. Ann Neurol :()2015 Oct 8

26219917. Lauretti E, Pratic˛ D, Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell :()2015 Jul 29

26077691. Di Meco A, Joshi YB, Lauretti E, Pratic˛ D, Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice. Mol Psychiatry :()2015 Jun 16

26076991. Chu J, Li JG, Hoffman NE, Stough AM, Madesh M, Pratic˛ D, Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence. Sci Rep 5:(11086)2015 Jun 16

25802082. Giannopoulos PF, Chu J, Sperow M, Li JG, Yu WH, Kirby LG, Abood M, Pratic˛ D, Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy. Biol Psychiatry 78:10(693-701)2015 Nov 15

25708815. Joshi YB, Giannopoulos PF, Pratic˛ D, The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease. Trends Pharmacol Sci 36:3(181-6)2015 Mar

25642165. Joshi YB, Pratic˛ D, The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotype. Front Cell Neurosci 8:(436)2014

25560760. Chu J, Li JG, Giannopoulos PF, Blass BE, Childers W, Abou-Gharbia M, Pratic˛ D, Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, A▀ and tau neuropathology in the triple-transgenic mice. Mol Psychiatry 20:11(1329-38)2015 Nov

25533523. Chu J, Li JG, Hoffman NE, Madesh M, Pratic˛ D, Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway. J Neurochem 133:3(432-9)2015 May

25457549. Lauretti E, Di Meco A, Chu J, Pratic˛ D, Modulation of AD neuropathology and memory impairments by the isoprostane F2a is mediated by the thromboxane receptor. Neurobiol Aging 36:2(812-20)2015 Feb

25122659. Joshi YB, Giannopoulos PF, Chu J, Sperow M, Kirby LG, Abood ME, Pratic˛ D, Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease. Hum Mol Genet 23:25(6894-902)2014 Dec 20

25061050. Li JG, Pratic˛ D, High levels of homocysteine results in cerebral amyloid angiopathy in mice. J Alzheimers Dis 43:1(29-35)2015

25052851. Chu J, Li JG, Joshi YB, Giannopoulos PF, Hoffman NE, Madesh M, Pratic˛ D, Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease. Biol Psychiatry 77:8(720-8)2015 Apr 15

24973121. Di Meco A, Lauretti E, Vagnozzi AN, Pratic˛ D, Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice. Neurobiol Aging 35:11(2458-64)2014 Nov

24901945. Zis P, McHugh P, McQuillin A, Pratic˛ D, Dickinson M, Shende S, Walker Z, Strydom A, Memory decline in Down syndrome and its relationship to iPF2alpha, a urinary marker of oxidative stress. PLoS One 9:6(e97709)2014

24662099. Chu J, Lauretti E, Craige CP, Pratic˛ D, Pharmacological modulation of GSAP reduces amyloid-▀ levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles. J Alzheimers Dis 41:3(729-37)2014

24644038. Li JG, Chu J, Barrero C, Merali S, Pratic˛ D, Homocysteine exacerbates ▀-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles. Ann Neurol 75:6(851-63)2014 Jun

24629673. Di Meco A, Joshi YB, Pratic˛ D, Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging 35:8(1813-20)2014 Aug

24332986. Joshi YB, Giannopoulos PF, Chu J, Pratic˛ D, Modulation of lipopolysaccharide-induced memory insult, ?-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase. Neurobiol Aging 35:5(1024-31)2014 May

24301651. Chu J, Lauretti E, Di Meco A, Pratic˛ D, FLAP pharmacological blockade modulates metabolism of endogenous tau in vivoá. Transl Psychiatry 3:(e333)2013 Dec 3

24300237. Joshi YB, Di Meco A, Pratic˛ D, Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice. Neurobiol Aging 35:5(1032-6)2014 May

24269629. Giannopoulos PF, Joshi YB, Pratic˛ D, Novel lipid signaling pathways in Alzheimer's disease pathogenesis. Biochem Pharmacol 88:4(560-4)2014 Apr 15

24008686. Joshi YB, Di Meco A, Praticˇ D, Modulation of amyloid-▀ production by leukotriene B4 via the ?-secretase pathway. J Alzheimers Dis 38:3(503-6)2014

23951061. Chu J, Li JG, Pratic˛ D, Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles. PLoS One 8:8(e70991)2013

23862663. Giannopoulos PF, Joshi YB, Chu J, Pratic˛ D, The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo. Aging Cell 12:6(1082-90)2013 Dec

23683389. Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, Kirby LG, Pratic˛ D, 5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease. Biol Psychiatry 74:5(348-56)2013 Sep 1

23634895. Joshi YB, Chu J, Pratic˛ D, Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg mice. Aging Cell 12:4(706-11)2013 Aug

23478745. Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, Kirby LG, Pratic˛ D, Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease. Mol Psychiatry 19:4(511-8)2014 Apr

23400723. Pratic˛ D, Antioxidants for Alzheimer disease. JAMA Neurol 70:2(270)2013 Feb

23352590. Chu J, Li JG, Ceballos-Diaz C, Golde T, Pratic˛ D, The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence. Biol Psychiatry 74:5(321-8)2013 Sep 1

23332172. Chu J, Pratic˛ D, 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. Neurobiol Aging 34:6(1549-54)2013 Jun

23034916. Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Pratic˛ D, 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Ann Neurol 72:3(442-54)2012 Sep

22764362. Pomara N, Bruno D, Sarreal AS, Hernando RT, Nierenberg J, Petkova E, Sidtis JJ, Wisniewski TM, Mehta PD, Pratico D, Zetterberg H, Blennow K, Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder. Am J Psychiatry 169:5(523-30)2012 May

22697885. Chu J, Pratic˛ D, Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model. J Neuroinflammation 9:(127)2012 Jun 14

22695619. Pratic˛ D, Alzheimer's disease and the quest for its biological measures. J Alzheimers Dis 33 Suppl 1:(S237-41)2013

22584618. Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G, Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord 33:4(219-25)2012

22531419. Joshi YB, Chu J, Pratic˛ D, Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis 31:1(167-76)2012

22422715. Joshi YB, Pratic˛ D, Vitamin E in aging, dementia, and Alzheimer's disease. Biofactors 38:2(90-7)2012 Mar-Apr

22275252. Chu J, Zhuo JM, Pratic˛ D, Transcriptional regulation of ▀-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments. Ann Neurol 71:1(57-67)2012 Jan

22222029. Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Pratico D, Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice. Mol Neurodegener 7:1(1)2012 Jan 5

21684021. Zhuo JM, Wang H, Pratic˛ D, Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci 32:9(562-71)2011 Sep

21435457. Chu J, Pratic˛ D, Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of ?-secretase. Am J Pathol 178:4(1762-9)2011 Apr

21280074. Chu J, Pratic˛ D, 5-lipoxygenase as an endogenous modulator of amyloid ▀ formation in vivo. Ann Neurol 69:1(34-46)2011 Jan

21253592. Puccio S, Chu J, Pratic˛ D, Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence. PLoS One 6:1(e15163)2011 Jan 6

20817151. Mosconi L, Glodzik L, Mistur R, McHugh P, Rich KE, Javier E, Williams S, Pirraglia E, De Santi S, Mehta PD, Zinkowski R, Blennow K, Pratico D, de Leon MJ, Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's. Biol Psychiatry 68:10(913-21)2010 Nov 15

20570249. Yang H, Zhuo JM, Chu J, Chinnici C, Pratic˛ D, Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol Psychiatry 68:10(922-9)2010 Nov 15

20555139. Zhuo JM, Pratic˛ D, Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice. J Alzheimers Dis 21:1(133-40)2010

20519634. Zhuo JM, Pratic˛ D, Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease. FASEB J 24:10(3895-902)2010 Oct

20164556. Zhuo JM, Kruger WD, Pratic˛ D, The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia. J Alzheimers Dis 20:2(569-76)2010

20116452. Pratic˛ D, The neurobiology of isoprostanes and Alzheimer's disease. Biochim Biophys Acta 1801:8(930-3)2010 Aug

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