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Associate Professor, Pharmacology Telephone: 215-707-9380 Fax: 215-707-7068 Email: praticod@temple.edu
Department of Pharmacology
Dr. Praticò’s research area is clinical pharmacology with a special focus on the cellular and molecular aspects of cell oxidative biology and a particular interest in small molecules such as bioactive oxidized lipids.
This area is very broad and extends to multiple disciplines including aging, cardiovascular diseases as well as neurodegeneration. Our work in the biology of oxidized bioactive lipids has significantly contributed to the current understanding of their importance as biomarkers, mediators of cellular and molecular events involved in the pathogenesis of several clinical conditions, and therapeutic targets for preventing and treating human diseases. In our lab we employ cellular and animal models of human diseases, and in this context particular emphasis is given to the translation of any observation made in these systems into a better understanding of human physiology and pathology. Our group is committed to foster collaborative scientific research of the highest quality, and at the same time to provide outstanding teaching and mentoring for young scientists.
Praticò, D., Guzzo, A., Alessandri, C., Bonavita, M.S., Violi, F. Dose-dependent inhibition of platelet aggregation by aspirin in whole blood. Adv. Vasc. Pathol. pp. 665-671 (1990) (chapter).
Praticò, D., Lawson, J.A., FitzGerald, G.A. Cyclooxygenase-dependent formation of 8-iso prostaglandin F2? by human platelets. Adv. Prostagl. Thromb. Leuk. Res. 23:229-231 (1995) (chapter).
Praticò, D., Catella F., FitzGerald G.A. Antagonism of platelet integrins and specific thrombin inhibition: the human pharmacology of anti-thrombotic drugs. Atherosclerosis X: 1041-1047; (1995) (chapter).
Reilly, M., Praticò, D., Lanken, P., Delanty, N., Rokach, J., Lawson, J.A., FitzGerald, G.A. Isoprostanes in the assessment of oxidant stress in vivo. In: Molecular and Cellular Basis of Inflammation. Eds. C.N. Serhan and P.A. Ward; pp. 127-139 (1998) (chapter).
Praticò, D., Delanty, N. Oxidative injury of the central nervous system - focus on Alzheimer’s disease. Am. J. Med. 109:577-585 (2000) (review).
Praticò, D. Oxidative imbalance and lipid peroxidation in Alzheimer’s disease. Drug Dev. Res. 56:446-451 (2002) (review).
Praticò, D. Oxidative stress in the development of Alzheimer’s disease and other dementias. In: Alzheimer’s disease: The basics. Eds. R.W. Richter and B. Zoeller Richter. The Humana Press Inc. pp. 33-38 (2003) (chapter).
Praticò, D., Rokach, J., Lawson, J.A., FitzGerald, G.A. F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases. Chem. Phys. Lipids 128:165-171 (2004)(Review).
Rokach, J., Kim, S., Bellone, S., Lawson, J.A., Praticò, D., Powell, W.S., FitzGerald, G.A. Total synthesis of isoprostanes: discovery and quantitation in biological systems. Chem. Phys. Lipids 128:35-56 (2004) (review).
Praticò, D. Alzheimer’s disease and non-steroidal anti-inflammatory drugs: old therapeutic tools with novel mechanisms of action? Curr. Med. Chem. CNS 5: 111-117 (2005) (review).
Praticò, D. Causes and consequences of oxidative stress in neurodegerative diseases. In: Genotype, Proteotype and Phenotype relationships in neurodegenerative diseases. Eds. J. Cummings and Y. Christen. Springer Publisher; pp.37-44 (2005) (chapter).
Cyrus, T., Praticò, D. Antioxidants and chronic cardiovascular diseases: animal studies. In: Antioxidants and Cardiovascular Disease. 2nd Edition. Eds. M.G. Bourassa, J-C Tardif. Springer Publishers; pp. 227-253 (2006) (chapter).
Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis. In The encyclopedia of Vitamin E. Eds.V.R. Preedy and R.R. Watson. CABI Publishing, Wallingford, UK; pp. 623-632 (2006) (chapter).
Cyrus, T., Praticò, D. Vitamin E and Atherosclerosis: Animal and Human trials. In Vitamin E: New Research. Ed. Matthew H. Braunstein. Nova Science Publishers; pp.177-199 (2006) (chapter).
Praticò, D. Antioxidants and endothelium protection. In: Endothelial dysfunction and vascular disease. Eds. R. De Caterina and P. Libby. Blackwell Futura Publishing; pp. 315-322 (2007) (chapter).
de Leon, M.J., Mosconi, L., Blennow, K., De Santi, S., Zinkowski, R., Mehta, P.D., Praticò, D., Tsui, W., Saint Louis, L.A., Sobanska, L., Brys, M., Li, Y., Rich, K., Rinne, J., Rusinek, H. Imaging and CSF studies in the preclinical diagnosis of Alzheimer’s disease. In Imaging and the Aging Brain. Eds. DeLeon MJ, Snider DA, and Federoff H. Blackwell Publishing; pp.114-45.2 (2007) (chapter).
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Domenico Praticò, MD