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Stephen Arnoff Gaddamanugu L. Prasad, PhD

 

Associate Professor, Physiology

Telephone:  215-707-3460

Fax:  215-707-5737

Email: gaddamanugu.prasad@temple.edu

 

Department of Physiology

 

Educational Background:

 

Medical degree, Indian Institute of Science, Bangalore, India, 1985

 

Internship, Indian Institute of Science, 1984-1986

 

Visiting Fellow, NCI, NIH Bethesda, Maryland, Laboratory of Dr. Herbert L Cooper, 1987-1990

 

Visiting Associate, NCI, NIH Bethseda, Maryland, Laboratory of Dr. Herbert L Cooper, 1990-1992

 

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Research Interests:

  • Cytoskeletal proteins in malignant transformation of cells
  • Mechanisms of tumor cell survival
  • Nanotechnology solutions for development of anticancer drugs and detection of cancer cells

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25237954. Prasad GL, Kumar R, Suri V, Primary cerebellopontine angle choroid plexus papilloma in a child: A rare occurrence. Neurol India 62:4(432-3)2014 Jul-Aug

25227164. Prasad GL, Gupta DK, Mahapatra AK, Borkar SA, Sharma BS, Surgical results of growing skull fractures in children: a single centre study of 43 cases. Childs Nerv Syst :()2014 Sep 17

24927667. Malpass GE, Arimilli S, Prasad GL, Howlett AC, Regulation of gene expression by tobacco product preparations in cultured human dermal fibroblasts. Toxicol Appl Pharmacol 279:2(211-9)2014 Sep 1

24780532. Gao H, Prasad GL, Zacharias W, Combusted but not smokeless tobacco products cause DNA damage in oral cavity cells. Environ Toxicol Pharmacol 37:3(1079-89)2014 May

24273212. Prasad GL, Naik BR, Ko JE, Nagaraju GP, Effects of naloxone, serotonin, and dopamine on reproduction of the freshwater crab Barytelphusa guerini. J Exp Zool A Ecol Genet Physiol 321:3(173-82)2014 Mar

24101273. Borkar SA, Prasad GL, Gupta DK, Sinha S, Mahapatra AK, Compound elevated skull fracture: a clinical series of three patients with a review of the literature. Turk Neurosurg 23:4(514-7)2013

24014178. Bodhicharla R, Ryde IT, Prasad GL, Meyer JN, The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans. Environ Mol Mutagen 55:1(43-50)2014 Jan

23851003. Arimilli S, Damratoski BE, Prasad GL, Combustible and non-combustible tobacco product preparations differentially regulate human peripheral blood mononuclear cell functions. Toxicol In Vitro 27:6(1992-2004)2013 Sep

23629517. Malpass GE, Arimilli S, Prasad GL, Howlett AC, Complete artificial saliva alters expression of proinflammatory cytokines in human dermal fibroblasts. Toxicol Sci 134:1(18-25)2013 Jul

23560004. Prasad GL, Borkar SA, Subbarao KC, Sharma MC, Mahapatra AK, Neurenteric cyst of the ventral cervicomedullary region. J Pediatr Neurosci 7:3(188-90)2012 Sep

23559998. Prasad GL, Borkar SA, Satyarthee GD, Mahapatra AK, Split cord malformation with dorsally located bony spur: Report of four cases and review of literature. J Pediatr Neurosci 7:3(167-70)2012 Sep

23224370. Arimilli S, Damratoski BE, Chen P, Jones BA, Prasad GL, Rapid isolation of leukocyte subsets from fresh and cryopreserved peripheral blood mononuclear cells in clinical research. Cryo Letters 33:5(376-84)2012 Sep-Oct

22996032. Arimilli S, Damratoski BE, Bombick B, Borgerding MF, Prasad GL, Evaluation of cytotoxicity of different tobacco product preparations. Regul Toxicol Pharmacol 64:3(350-60)2012 Dec

22960471. Gao H, Prasad GL, Zacharias W, Differential cell-specific cytotoxic responses of oral cavity cells to tobacco preparations. Toxicol In Vitro 27:1(282-91)2013 Feb

22824699. Prasad GL, Borkar SA, Subbarao KC, Suri V, Mahapatra AK, Primary spinal cord glioblastoma multiforme: a report of two cases. Neurol India 60:3(333-5)2012 May-Jun

22408664. Borkar SA, Prasad GL, Satyarthee GD, Mahapatra AK, Spontaneous spinal extradural hematoma in a child with hemophilia B, surgery or medical management - A dilemma? J Pediatr Neurosci 6:2(131-3)2011 Jul

21546298. Singh G, Sharma MC, Agarwal S, Prasad GL, Mishra S, Singh MM, Garg A, Suri V, Sarkar C, Epithelial-myoepithelial carcinoma of the lacrimal gland: a rare case. Ann Diagn Pathol 16:4(292-7)2012 Aug

21132210. Nagaraju GP, Kumari NS, Prasad GL, Naik BR, Borst DW, Computational analysis and structure predictions of CHH-related peptides from Litopenaeus vannamei. Integr Biol (Camb) 3:3(218-24)2011 Mar

20937572. Nagaraju GP, Prasad GL, Taliaferro-Smith L, Aruna BV, Naik BR, Sekhar YN, Computational analysis of the structural basis of ligand binding to the crustacean retinoid X receptor. Comp Biochem Physiol Part D Genomics Proteomics 5:4(317-24)2010 Dec

20011146. Nagaraju GP, Kumari NS, Prasad GL, Rajitha B, Meenu M, Rao MS, Naik BR, Structural prediction and analysis of VIH-related peptides from selected crustacean species. Bioinformation 4:1(6-11)2009 Aug 17

19934581. Borkar SA, Prasad GL, Agrawal D, Sharma BS, Cerebellar hemorrhage following supratentorial decompressive craniectomy for severe traumatic brain injury. Neurol India 57:5(681-2)2009 Sep-Oct

17243738. Pathak P, Prasad GL, Meziani MJ, Joudeh AA, Sun YP, Nanosized paclitaxel particles from supercritical carbon dioxide processing and their biological evaluation. Langmuir 23:5(2674-9)2007 Feb 27

17169152. Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL, C60-fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects. J Nanobiotechnology 4:(14)2006 Dec 14

17059469. Kahner BN, Shankar H, Murugappan S, Prasad GL, Kunapuli SP, Nucleotide receptor signaling in platelets. J Thromb Haemost 4:11(2317-26)2006 Nov

16757342. Prasad GL, Regulation of the expression of tropomyosins and actin cytoskeleton by ras transformation. Methods Enzymol 407:(410-22)2006

16170368. Bharadwaj S, Thanawala R, Bon G, Falcioni R, Prasad GL, Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion. Oncogene 24:56(8291-303)2005 Dec 15

16122869. Bharadwaj S, Shah V, Tariq F, Damartoski B, Prasad GL, Amino terminal, but not the carboxy terminal, sequences of tropomyosin-1 are essential for the induction of stress fiber assembly in neoplastic cells. Cancer Lett 229:2(253-60)2005 Nov 18

14722123. Bharadwaj S, Hitchcock-DeGregori S, Thorburn A, Prasad GL, N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1. J Biol Chem 279:14(14039-48)2004 Apr 2

13679858. Raval GN, Bharadwaj S, Levine EA, Willingham MC, Geary RL, Kute T, Prasad GL, Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors. Oncogene 22:40(6194-203)2003 Sep 18

12213212. Mahadev K, Raval G, Bharadwaj S, Willingham MC, Lange EM, Vonderhaar B, Salomon D, Prasad GL, Suppression of the transformed phenotype of breast cancer by tropomyosin-1. Exp Cell Res 279:1(40-51)2002 Sep 10

12065096. Bharadwaj S, Prasad GL, Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. Cancer Lett 183:2(205-13)2002 Sep 26

11360195. Shah V, Bharadwaj S, Kaibuchi K, Prasad GL, Cytoskeletal organization in tropomyosin-mediated reversion of ras-transformation: Evidence for Rho kinase pathway. Oncogene 20:17(2112-21)2001 Apr 19

10696235. Shah V, Braverman R, Prasad GL, Suppression of neoplastic transformation and regulation of cytoskeleton by tropomyosins. Somat Cell Mol Genet 24:5(273-80)1998 Sep

10208425. Prasad GL, Masuelli L, Raj MH, Harindranath N, Suppression of src-induced transformed phenotype by expression of tropomyosin-1. Oncogene 18:11(2027-31)1999 Mar 18

9253511. Prasad GL, Lee HS, Iwahashi M, Milenic DE, Abrams S, Schlom J, Kashmiri SV, In vivo gene inoculation of a recombinant single-chain antitumor antibody induces anti-immunoglobulin response. Cancer Gene Ther 4:4(253-9)1997 Jul-Aug

8760295. Braverman RH, Cooper HL, Lee HS, Prasad GL, Anti-oncogenic effects of tropomyosin: isoform specificity and importance of protein coding sequences. Oncogene 13:3(537-45)1996 Aug 1

8076628. Prasad GL, Fuldner RA, Braverman R, McDuffie E, Cooper HL, Expression, cytoskeletal utilization and dimer formation of tropomyosin derived from retroviral-mediated cDNA transfer. Metabolism of tropomyosin from transduced cDNA. Eur J Biochem 224:1(1-10)1994 Aug 15

8346214. Prasad GL, Fuldner RA, Cooper HL, Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene. Proc Natl Acad Sci U S A 90:15(7039-43)1993 Aug 1

1390337. Prasad GL, Valverius EM, McDuffie E, Cooper HL, Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells. Cell Growth Differ 3:8(507-13)1992 Aug

2059197. Prasad GL, Meissner S, Sheer DG, Cooper HL, A cDNA encoding a muscle-type tropomyosin cloned from a human epithelial cell line: identity with human fibroblast tropomyosin TM1. Biochem Biophys Res Commun 177:3(1068-75)1991 Jun 28

2317800. Bhattacharya B, Prasad GL, Valverius EM, Salomon DS, Cooper HL, Tropomyosins of human mammary epithelial cells: consistent defects of expression in mammary carcinoma cell lines. Cancer Res 50:7(2105-12)1990 Apr 1

3034901. Kunapuli SP, Prasad GL, Kumar A, Expression of human angiotensinogen cDNA in Escherichia coli. J Biol Chem 262:16(7672-5)1987 Jun 5

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patents and licenses:

  • Epithelial Cell Specific Differentiation Marker, US Patent Numbers 5,424,191 and 5,776,676
  • Tropomyosin antibodies (licensed) to a leading company
  • Fullerene-doxorubicin conjugates for cancer chemotherapy (invention disclosure filed)
       

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